Click here to switch to the map view.

The map label for this gene is mtaP

Identifier: 11499377

GI number: 11499377

Start: 1606033

End: 1606764

Strand: Reverse

Name: mtaP

Synonym: AF1788

Alternate gene names: 11499377

Gene position: 1606764-1606033 (Counterclockwise)

Preceding gene: 11499378

Following gene: 11499376

Centisome position: 73.76

GC content: 49.73

Gene sequence:

>732_bases
ATGATCGGCATAATCGGGGGCACGCACATTCTCGAAATTAAGGTTCTGAAAGATGTTGAGGAGACGAGAATTGAGACTCC
CTACGGAACAGCGGAAATCGATGTTGGAAGGGTTGATGGCATTGACGTGGCAATAATTCAAAGGCACGGGAAGAGAAAGG
ACAAGCCGCCTCACAGAATAAACCATGCCGCTAACTTCTACGCCCTGAAGTCGCTCGGCGTTAAATACGTCATCGGCATG
GGCTCCGTTGGAGCTCTCAGGGAAGAGTACAGCCTGCCATCCCTCATCATCCCCCACGATTACATCGACTTCTTCAGCGG
CGTTACTATTTACAACGACTCGCTCGTCCACGTCACGCCCGGGTTTGACGAGTATCTCAGAGAGGTGCTTGTTGAAGTTG
CAAGAAAAATTTCAAGCTTTCCGGTGATTGACAAAGGAGTTTACTTCCAGACGCGAGGCCCGAGACTTGAAACCAAGGCC
GAGATTGCGATGATAAAGAGCTTCGCAGACTGCGTGGGCATGACCGCAGGGAGCGAGGCAACCATAGCCAGAGAGCTTGG
ACTGAGTTACGCCATCGTCTGCACGATGGATAACTACGCCCACGGAATAAAGAACCAGAGCATCGATTACAGGGAAATAG
TTGAGAAGGCTAAGGAAAATGCGAGAGAATGCCTCAAAATTGTTGAGGAAGCTGTTAAAAAGGTCTGGGAAGAGAAAATC
CAGAGGACATAA

Upstream 100 bases:

>100_bases
TTTTCCCCGGAAAATTTGAGGACGTGCTCGAGTTCATGGAGCTGAAGGGCCTGATAGAAAAGAGAACTGAGGGAGGTAGG
GTTTACTGGAGGCTGAGCGA

Downstream 100 bases:

>100_bases
ATCTTATATAGAAACTCATATACATCATTGTAGATGTACGCCGCCCTGATAGAATCAGTCGTCAAGATCCTTCAGAAGGC
TGAATTTTCCGTTGCAGACT

Product: methylthioadenosine phosphorylase (mtaP)

Products: ribose-1-phosphate; xanthine [C]

Alternate protein names: NA

Number of amino acids: Translated: 243; Mature: 243

Protein sequence:

>243_residues
MIGIIGGTHILEIKVLKDVEETRIETPYGTAEIDVGRVDGIDVAIIQRHGKRKDKPPHRINHAANFYALKSLGVKYVIGM
GSVGALREEYSLPSLIIPHDYIDFFSGVTIYNDSLVHVTPGFDEYLREVLVEVARKISSFPVIDKGVYFQTRGPRLETKA
EIAMIKSFADCVGMTAGSEATIARELGLSYAIVCTMDNYAHGIKNQSIDYREIVEKAKENARECLKIVEEAVKKVWEEKI
QRT

Sequences:

>Translated_243_residues
MIGIIGGTHILEIKVLKDVEETRIETPYGTAEIDVGRVDGIDVAIIQRHGKRKDKPPHRINHAANFYALKSLGVKYVIGM
GSVGALREEYSLPSLIIPHDYIDFFSGVTIYNDSLVHVTPGFDEYLREVLVEVARKISSFPVIDKGVYFQTRGPRLETKA
EIAMIKSFADCVGMTAGSEATIARELGLSYAIVCTMDNYAHGIKNQSIDYREIVEKAKENARECLKIVEEAVKKVWEEKI
QRT
>Mature_243_residues
MIGIIGGTHILEIKVLKDVEETRIETPYGTAEIDVGRVDGIDVAIIQRHGKRKDKPPHRINHAANFYALKSLGVKYVIGM
GSVGALREEYSLPSLIIPHDYIDFFSGVTIYNDSLVHVTPGFDEYLREVLVEVARKISSFPVIDKGVYFQTRGPRLETKA
EIAMIKSFADCVGMTAGSEATIARELGLSYAIVCTMDNYAHGIKNQSIDYREIVEKAKENARECLKIVEEAVKKVWEEKI
QRT

Specific function: The Nucleoside Phosphorylases Catalyze The Phosphorolytic Breakdown Of The N-Glycosidic Bond In The Nucleoside Molecule, With The Formation Of The Corresponding Free Bases And Pentose-1-Phosphate. This Protein Can Degrade All Purine Nucleosides Except Ade

COG id: COG0005

COG function: function code F; Purine nucleoside phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP/MTAP phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI47132622, Length=258, Percent_Identity=27.5193798449612, Blast_Score=110, Evalue=8e-25,
Organism=Escherichia coli, GI1788746, Length=221, Percent_Identity=23.9819004524887, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71980569, Length=258, Percent_Identity=28.6821705426357, Blast_Score=108, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6323045, Length=221, Percent_Identity=30.7692307692308, Blast_Score=83, Evalue=5e-17,
Organism=Drosophila melanogaster, GI20130079, Length=257, Percent_Identity=29.1828793774319, Blast_Score=127, Evalue=7e-30,
Organism=Drosophila melanogaster, GI221459247, Length=262, Percent_Identity=28.2442748091603, Blast_Score=106, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010044
- InterPro:   IPR000845
- InterPro:   IPR001369
- InterPro:   IPR018099 [H]

Pfam domain/function: PF01048 PNP_UDP_1 [H]

EC number: 2.4.2.- [C]

Molecular weight: Translated: 27202; Mature: 27202

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGIIGGTHILEIKVLKDVEETRIETPYGTAEIDVGRVDGIDVAIIQRHGKRKDKPPHRI
CEEEECCCEEEEEHHHHHHHHHHCCCCCCCCEEECCCCCCCEEEEEECCCCCCCCCCHHH
NHAANFYALKSLGVKYVIGMGSVGALREEYSLPSLIIPHDYIDFFSGVTIYNDSLVHVTP
HHHHHHHHHHHCCEEEEECCCCHHHHHHHHCCCCEECCHHHHHHHCCEEEECCCEEEECC
GFDEYLREVLVEVARKISSFPVIDKGVYFQTRGPRLETKAEIAMIKSFADCVGMTAGSEA
CHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCH
TIARELGLSYAIVCTMDNYAHGIKNQSIDYREIVEKAKENARECLKIVEEAVKKVWEEKI
HHHHHHCCEEEEEEEECHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QRT
CCC
>Mature Secondary Structure
MIGIIGGTHILEIKVLKDVEETRIETPYGTAEIDVGRVDGIDVAIIQRHGKRKDKPPHRI
CEEEECCCEEEEEHHHHHHHHHHCCCCCCCCEEECCCCCCCEEEEEECCCCCCCCCCHHH
NHAANFYALKSLGVKYVIGMGSVGALREEYSLPSLIIPHDYIDFFSGVTIYNDSLVHVTP
HHHHHHHHHHHCCEEEEECCCCHHHHHHHHCCCCEECCHHHHHHHCCEEEECCCEEEECC
GFDEYLREVLVEVARKISSFPVIDKGVYFQTRGPRLETKAEIAMIKSFADCVGMTAGSEA
CHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCH
TIARELGLSYAIVCTMDNYAHGIKNQSIDYREIVEKAKENARECLKIVEEAVKKVWEEKI
HHHHHHCCEEEEEEEECHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QRT
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: xanthosine; phosphate [C]

Specific reaction: xanthosine + phosphate = ribose-1-phosphate + xanthine [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]