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The map label for this gene is mvaA

Identifier: 11499325

GI number: 11499325

Start: 1558523

End: 1559833

Strand: Reverse

Name: mvaA

Synonym: AF1736

Alternate gene names: 11499325

Gene position: 1559833-1558523 (Counterclockwise)

Preceding gene: 11499326

Following gene: 11499322

Centisome position: 71.6

GC content: 51.49

Gene sequence:

>1311_bases
ATGCAGGTTCTTAGACTCGACCGAAGACATTATAAATCAGGGAAGATTAGAAGAGCCATGAGTTCTCGCATTCCCGGATT
TTACAAGCTCAGCGTGGAGGAAAGGCTGAAGAAGGTTGCTGAATTCGCTGGATTGAGCGATGAGGAGGTTAAAGCAGTTT
TATCTCAGGGTTTGCCCCTCGACGTTGCTGACAGGATGATTGAGAACGTTATCGGCACCTTTGAGCTTCCGCTGGGCATA
GCCACCAATTTCCTGATTGATGGGAAGGATTACCTCATCCCGATGGCCATTGAGGAGCCAAGTGTTGTTGCCGCAGCAAG
CAACGCAGCCAGAATGGCGAGGGAGAGCGGTGGATTCACCACAGACTACACCGGCTCGCTCATGATTGGCCAGATTCAGG
TTACAAAGCTTCTCAACCCAAATGCGGCGAAATTTGAGGTTCTCAGGCAAAAGGATGAAATTATAGAGAGGGCCAACGAA
TGCGACCCGATGCTCGTAAACCTCGGAGGGGGCTGCAAGGATATAGAGGCGAGAGTCATTGACACCATAATGGGGAAGAT
GCTCATAGTCCACTTAATTGTTGATGTAAAGGATGCCATGGGGGCAAATGCGGTAAACACGATGTGCGAGAAGGTTGCTC
CCTTCATTGAGAGAATCACTGGAGGGAAAGTTTATCTCCGCATCATCTCGAACCTTGCAGCCTACAGGCTGGCGAGGGCG
AAGGCTGTTTTTGACAAAGATGTTATCGGCGGAGAGGAGGTTGTTGAGGGGATCATGCTCGCCTACGCCTTTGCAGCAGC
TGATCCCTTCAGATGTGCCACGCACAACAAGGGAATCATGAACGGCATCTCAGCCTTGATGATTGCAACGGGCAACGACT
TCAGGGCTATTGAGGCTGGAGCCCACAGCTACGCTGCTATTGGCGGCTATAAACCCCTCACTACCTACGAGGTTGACAGG
AAGGGGAATCTGGTTGGAACGATAGAGATTCCAATGGCTGTGGGGGTGATTGGGGGGGCAACGAAGGTCAATCCGCTGGC
AAAAATCTCGCTGAAGATTCTTGGAGTAAACACTGCCGAGGAGCTGGCGAGAGTAGCTGCAGCTCTCGGCCTTGCTCAGA
ACTTTGCAGCTTTAAGGGCTTTGGCAACTGAAGGAATACAGAGGGGGCACATGGAGCTTCACGCCAGAAACCTCGCCATA
ATGGCCGGTGCAACAGGAGATGAGGTTGACAGGGTTGTTGAGATAATGGTCAGGGACGGAAAGATAAGGCTGGACTACGC
CAAGGAGGTTCTGGAGAGGTTAAGAAGCTGA

Upstream 100 bases:

>100_bases
AAACGGAGGAGCACTTTGAAAGTGCCCTTAAACTCTTCAGGCCCTTTAAATTGGTTATAAAGGAATACGTTGATGGAATA
ATGGTCTGCGAAGGAAACAC

Downstream 100 bases:

>100_bases
ACTCACTTAATTTTTACCAAGAGCGGCGAAACTGCAAGAAGCAAGAAGGCCAGAACGGAGAATGCTGCGGCAACAGCAGG
TTCTATCTCTGCCCCTGCCG

Product: 3-hydroxy-3-methylglutaryl-coenzyme A reductase (mvaA)

Products: NA

Alternate protein names: HMG-CoA reductase

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MQVLRLDRRHYKSGKIRRAMSSRIPGFYKLSVEERLKKVAEFAGLSDEEVKAVLSQGLPLDVADRMIENVIGTFELPLGI
ATNFLIDGKDYLIPMAIEEPSVVAAASNAARMARESGGFTTDYTGSLMIGQIQVTKLLNPNAAKFEVLRQKDEIIERANE
CDPMLVNLGGGCKDIEARVIDTIMGKMLIVHLIVDVKDAMGANAVNTMCEKVAPFIERITGGKVYLRIISNLAAYRLARA
KAVFDKDVIGGEEVVEGIMLAYAFAAADPFRCATHNKGIMNGISALMIATGNDFRAIEAGAHSYAAIGGYKPLTTYEVDR
KGNLVGTIEIPMAVGVIGGATKVNPLAKISLKILGVNTAEELARVAAALGLAQNFAALRALATEGIQRGHMELHARNLAI
MAGATGDEVDRVVEIMVRDGKIRLDYAKEVLERLRS

Sequences:

>Translated_436_residues
MQVLRLDRRHYKSGKIRRAMSSRIPGFYKLSVEERLKKVAEFAGLSDEEVKAVLSQGLPLDVADRMIENVIGTFELPLGI
ATNFLIDGKDYLIPMAIEEPSVVAAASNAARMARESGGFTTDYTGSLMIGQIQVTKLLNPNAAKFEVLRQKDEIIERANE
CDPMLVNLGGGCKDIEARVIDTIMGKMLIVHLIVDVKDAMGANAVNTMCEKVAPFIERITGGKVYLRIISNLAAYRLARA
KAVFDKDVIGGEEVVEGIMLAYAFAAADPFRCATHNKGIMNGISALMIATGNDFRAIEAGAHSYAAIGGYKPLTTYEVDR
KGNLVGTIEIPMAVGVIGGATKVNPLAKISLKILGVNTAEELARVAAALGLAQNFAALRALATEGIQRGHMELHARNLAI
MAGATGDEVDRVVEIMVRDGKIRLDYAKEVLERLRS
>Mature_436_residues
MQVLRLDRRHYKSGKIRRAMSSRIPGFYKLSVEERLKKVAEFAGLSDEEVKAVLSQGLPLDVADRMIENVIGTFELPLGI
ATNFLIDGKDYLIPMAIEEPSVVAAASNAARMARESGGFTTDYTGSLMIGQIQVTKLLNPNAAKFEVLRQKDEIIERANE
CDPMLVNLGGGCKDIEARVIDTIMGKMLIVHLIVDVKDAMGANAVNTMCEKVAPFIERITGGKVYLRIISNLAAYRLARA
KAVFDKDVIGGEEVVEGIMLAYAFAAADPFRCATHNKGIMNGISALMIATGNDFRAIEAGAHSYAAIGGYKPLTTYEVDR
KGNLVGTIEIPMAVGVIGGATKVNPLAKISLKILGVNTAEELARVAAALGLAQNFAALRALATEGIQRGHMELHARNLAI
MAGATGDEVDRVVEIMVRDGKIRLDYAKEVLERLRS

Specific function: Converts HMG-CoA to mevalonate

COG id: COG1257

COG function: function code I; Hydroxymethylglutaryl-CoA reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA reductase family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HMDH_ARCFU (O28538)

Other databases:

- EMBL:   AE000782
- PIR:   G69466
- RefSeq:   NP_070564.1
- ProteinModelPortal:   O28538
- SMR:   O28538
- GeneID:   1484959
- GenomeReviews:   AE000782_GR
- KEGG:   afu:AF1736
- NMPDR:   fig|224325.1.peg.1725
- TIGR:   AF_1736
- HOGENOM:   HBG477902
- OMA:   GIQRGHM
- ProtClustDB:   CLSK782718
- BioCyc:   AFUL224325:AF_1736-MONOMER
- BRENDA:   1.1.1.34
- InterPro:   IPR002202
- InterPro:   IPR004553
- InterPro:   IPR023074
- InterPro:   IPR023076
- InterPro:   IPR009023
- InterPro:   IPR009029
- Gene3D:   G3DSA:3.90.770.10
- PANTHER:   PTHR10572
- PRINTS:   PR00071
- TIGRFAMs:   TIGR00532

Pfam domain/function: PF00368 HMG-CoA_red; SSF55035 HMG_CoA_NAD_bind; SSF56542 HMG_CoA_sub_bind

EC number: =1.1.1.34

Molecular weight: Translated: 47147; Mature: 47147

Theoretical pI: Translated: 7.96; Mature: 7.96

Prosite motif: PS00066 HMG_COA_REDUCTASE_1; PS00318 HMG_COA_REDUCTASE_2; PS01192 HMG_COA_REDUCTASE_3; PS50065 HMG_COA_REDUCTASE_4

Important sites: ACT_SITE 99-99 ACT_SITE 277-277 ACT_SITE 293-293 ACT_SITE 390-390

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVLRLDRRHYKSGKIRRAMSSRIPGFYKLSVEERLKKVAEFAGLSDEEVKAVLSQGLPL
CCCCHHHHHHCCCCHHHHHHHHCCCCEEEECHHHHHHHHHHHCCCCHHHHHHHHHCCCCH
DVADRMIENVIGTFELPLGIATNFLIDGKDYLIPMAIEEPSVVAAASNAARMARESGGFT
HHHHHHHHHHHCCCCCCHHHHHHEEECCCCEEEEEEECCCCEEEECHHHHHHHHHCCCCC
TDYTGSLMIGQIQVTKLLNPNAAKFEVLRQKDEIIERANECDPMLVNLGGGCKDIEARVI
CCCCCCEEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHH
DTIMGKMLIVHLIVDVKDAMGANAVNTMCEKVAPFIERITGGKVYLRIISNLAAYRLARA
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
KAVFDKDVIGGEEVVEGIMLAYAFAAADPFRCATHNKGIMNGISALMIATGNDFRAIEAG
HHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEECCCCCHHHHHHHEEEEECCCCCEEEECC
AHSYAAIGGYKPLTTYEVDRKGNLVGTIEIPMAVGVIGGATKVNPLAKISLKILGVNTAE
CCCCCEECCCCCCEEEEECCCCCEEEEEEECEEEEEECCCCCCCCCEEEEEEEEECCCHH
ELARVAAALGLAQNFAALRALATEGIQRGHMELHARNLAIMAGATGDEVDRVVEIMVRDG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEECCEEEEECCCCHHHHHHHHHHHCCC
KIRLDYAKEVLERLRS
EEEEHHHHHHHHHHCC
>Mature Secondary Structure
MQVLRLDRRHYKSGKIRRAMSSRIPGFYKLSVEERLKKVAEFAGLSDEEVKAVLSQGLPL
CCCCHHHHHHCCCCHHHHHHHHCCCCEEEECHHHHHHHHHHHCCCCHHHHHHHHHCCCCH
DVADRMIENVIGTFELPLGIATNFLIDGKDYLIPMAIEEPSVVAAASNAARMARESGGFT
HHHHHHHHHHHCCCCCCHHHHHHEEECCCCEEEEEEECCCCEEEECHHHHHHHHHCCCCC
TDYTGSLMIGQIQVTKLLNPNAAKFEVLRQKDEIIERANECDPMLVNLGGGCKDIEARVI
CCCCCCEEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHH
DTIMGKMLIVHLIVDVKDAMGANAVNTMCEKVAPFIERITGGKVYLRIISNLAAYRLARA
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
KAVFDKDVIGGEEVVEGIMLAYAFAAADPFRCATHNKGIMNGISALMIATGNDFRAIEAG
HHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEECCCCCHHHHHHHEEEEECCCCCEEEECC
AHSYAAIGGYKPLTTYEVDRKGNLVGTIEIPMAVGVIGGATKVNPLAKISLKILGVNTAE
CCCCCEECCCCCCEEEEECCCCCEEEEEEECEEEEEECCCCCCCCCEEEEEEEEECCCHH
ELARVAAALGLAQNFAALRALATEGIQRGHMELHARNLAIMAGATGDEVDRVVEIMVRDG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEECCEEEEECCCCHHHHHHHHHHHCCC
KIRLDYAKEVLERLRS
EEEEHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9389475