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The map label for this gene is asd

Identifier: 11499101

GI number: 11499101

Start: 1359746

End: 1360777

Strand: Reverse

Name: asd

Synonym: AF1506

Alternate gene names: 11499101

Gene position: 1360777-1359746 (Counterclockwise)

Preceding gene: 11499102

Following gene: 11499100

Centisome position: 62.47

GC content: 54.65

Gene sequence:

>1032_bases
ATGCGATACAGTGTCGGAGTACTTGGGGCTACCGGAATGGTGGGGCAGAAGTTCATCCAGATGCTTGCAGAGCATCCCTG
GTTCAAGCTGACGAGCCTTGCAGCGTCGGAAAGAAGAGTGGGGAAGAAGTATGGTGAAGAAGTGGACTGGATAGTCTCCA
GAGAGGTTCCGGACATTGCCAAGGACATCGAAATGGTGCCAATGGACCCTAAGCATGTGGATGCTGACATCGTCTTCTCA
GCGCTGCCCTCAGACATCGCAAGAGAGGTTGAGCCGAAGTTTGCCGAGGCTGGATTTGTCGTTGCGAGCAATGCATCAGC
CTACAGAATGGCTGAAGACGTCCCCCTTGTCATTCCTGAGGTGAATCCCGAGCATCTCGGCCTGATTGAAGTGCAAAAGA
AAAACAGGGGCTGGGATGGCTTCATCGTGACGAATCCCAACTGCACGACCATCGTTCTCGTCCTCTCGCTGAAGCCGCTG
ATGGACCTCGGCCTCAGGACTGTGAGGGTTGCTTCAATGCAGGCCTTGAGCGGTGCAGGTTATCCTGGCGTCCCCTCCCT
CGCCATAACCGACAACGTGATTCCCTTCATAAAGGGTGAGGAGGACAAAGTGGAGGAGGAGCCGCTCAAGCTTCTCGGCA
AGTTTAACGGCCGGAAGATTGAGTTTGCGGACATAAAAGTCTCAGCCTCCTGCCACAGAGTCCCCGTCATTGATGGTCAC
ACTGAAGCTGTCTGGGTTGAGTTTGACCGGGAGGTGAGCGTTGAAGAGGCCAAGGCAGCCTTCGAGTCCCTTAAGCCCCT
CGACCTGCCAACTTCGCCAGAGAAGGTCATAATTGTCAGGGAGGAGCCGGACAGGCCCCAGCCCAGACTCGACAGGGATG
CTGGAAACGGGATGAGCATCACGGTTGGCAGGATAAGGAAGGATGGTGAGAGGGGGCTGAAGTACATAGTATTGGGCCAC
AACACCGTCAGAGGAGCAGCGGGAGCAAGCATCCTTAACGCTGAACTGATGATAAAGGAGAAGATTATCTAA

Upstream 100 bases:

>100_bases
CGAGATGACTCTGAGGGCAAACATAATGCTCGCTTTGAACGGGGCAGAGGAGAAGGAGTTGCACCACTAACTTTTTTAAA
TTGCCCCCTGTCCTTCAACC

Downstream 100 bases:

>100_bases
CAAAACTGAAATATATTTGAACCACTTCTATTTTTTGAGGTGCTTGGTTGCAGCCAGAGAGAGAGCTTACAATATCTTCT
GCACTTAAGCAGGTTCTTGT

Product: aspartate-semialdehyde dehydrogenase

Products: NA

Alternate protein names: ASA dehydrogenase; ASADH

Number of amino acids: Translated: 343; Mature: 343

Protein sequence:

>343_residues
MRYSVGVLGATGMVGQKFIQMLAEHPWFKLTSLAASERRVGKKYGEEVDWIVSREVPDIAKDIEMVPMDPKHVDADIVFS
ALPSDIAREVEPKFAEAGFVVASNASAYRMAEDVPLVIPEVNPEHLGLIEVQKKNRGWDGFIVTNPNCTTIVLVLSLKPL
MDLGLRTVRVASMQALSGAGYPGVPSLAITDNVIPFIKGEEDKVEEEPLKLLGKFNGRKIEFADIKVSASCHRVPVIDGH
TEAVWVEFDREVSVEEAKAAFESLKPLDLPTSPEKVIIVREEPDRPQPRLDRDAGNGMSITVGRIRKDGERGLKYIVLGH
NTVRGAAGASILNAELMIKEKII

Sequences:

>Translated_343_residues
MRYSVGVLGATGMVGQKFIQMLAEHPWFKLTSLAASERRVGKKYGEEVDWIVSREVPDIAKDIEMVPMDPKHVDADIVFS
ALPSDIAREVEPKFAEAGFVVASNASAYRMAEDVPLVIPEVNPEHLGLIEVQKKNRGWDGFIVTNPNCTTIVLVLSLKPL
MDLGLRTVRVASMQALSGAGYPGVPSLAITDNVIPFIKGEEDKVEEEPLKLLGKFNGRKIEFADIKVSASCHRVPVIDGH
TEAVWVEFDREVSVEEAKAAFESLKPLDLPTSPEKVIIVREEPDRPQPRLDRDAGNGMSITVGRIRKDGERGLKYIVLGH
NTVRGAAGASILNAELMIKEKII
>Mature_343_residues
MRYSVGVLGATGMVGQKFIQMLAEHPWFKLTSLAASERRVGKKYGEEVDWIVSREVPDIAKDIEMVPMDPKHVDADIVFS
ALPSDIAREVEPKFAEAGFVVASNASAYRMAEDVPLVIPEVNPEHLGLIEVQKKNRGWDGFIVTNPNCTTIVLVLSLKPL
MDLGLRTVRVASMQALSGAGYPGVPSLAITDNVIPFIKGEEDKVEEEPLKLLGKFNGRKIEFADIKVSASCHRVPVIDGH
TEAVWVEFDREVSVEEAKAAFESLKPLDLPTSPEKVIIVREEPDRPQPRLDRDAGNGMSITVGRIRKDGERGLKYIVLGH
NTVRGAAGASILNAELMIKEKII

Specific function: This enzyme catalyzes the second step in the common metabolic pathway to synthesize Thr and Met from Asp

COG id: COG0136

COG function: function code E; Aspartate-semialdehyde dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aspartate-semialdehyde dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1788658, Length=377, Percent_Identity=25.1989389920424, Blast_Score=73, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6320362, Length=358, Percent_Identity=43.2960893854749, Blast_Score=270, Evalue=2e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DHAS_ARCFU (O28766)

Other databases:

- EMBL:   AE000782
- PIR:   A69438
- RefSeq:   NP_070335.1
- ProteinModelPortal:   O28766
- SMR:   O28766
- GeneID:   1484733
- GenomeReviews:   AE000782_GR
- KEGG:   afu:AF1506
- NMPDR:   fig|224325.1.peg.1496
- TIGR:   AF_1506
- HOGENOM:   HBG518238
- OMA:   GHTESIF
- ProtClustDB:   PRK08664
- BioCyc:   AFUL224325:AF_1506-MONOMER
- BRENDA:   1.2.1.11
- GO:   GO:0005737
- InterPro:   IPR000319
- InterPro:   IPR005676
- InterPro:   IPR012080
- InterPro:   IPR016040
- InterPro:   IPR000534
- InterPro:   IPR012280
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF000148
- SMART:   SM00859
- TIGRFAMs:   TIGR00978

Pfam domain/function: PF01118 Semialdhyde_dh; PF02774 Semialdhyde_dhC

EC number: =1.2.1.11

Molecular weight: Translated: 37697; Mature: 37697

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS01103 ASD

Important sites: ACT_SITE 148-148

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYSVGVLGATGMVGQKFIQMLAEHPWFKLTSLAASERRVGKKYGEEVDWIVSREVPDIA
CCEEEEECCCCCHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHCCCEEEEECCCCCHHH
KDIEMVPMDPKHVDADIVFSALPSDIAREVEPKFAEAGFVVASNASAYRMAEDVPLVIPE
HCCEECCCCCCCCCHHHHHHHCCHHHHHHCCCCHHHCCEEEECCCCCEEECCCCCEEECC
VNPEHLGLIEVQKKNRGWDGFIVTNPNCTTIVLVLSLKPLMDLGLRTVRVASMQALSGAG
CCCCCEEEEEEECCCCCCCEEEEECCCCCEEEEEEEHHHHHHHCHHHHHHHHHHHHCCCC
YPGVPSLAITDNVIPFIKGEEDKVEEEPLKLLGKFNGRKIEFADIKVSASCHRVPVIDGH
CCCCCCEEEECCCCCEEECCHHCCHHHHHHHHHCCCCCEEEEEEEEEECCCCEEEEECCC
TEAVWVEFDREVSVEEAKAAFESLKPLDLPTSPEKVIIVREEPDRPQPRLDRDAGNGMSI
CCEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCEE
TVGRIRKDGERGLKYIVLGHNTVRGAAGASILNAELMIKEKII
EEEEECCCCCCCCEEEEEECCCCCCCCCCCEEEHEEEEEECCC
>Mature Secondary Structure
MRYSVGVLGATGMVGQKFIQMLAEHPWFKLTSLAASERRVGKKYGEEVDWIVSREVPDIA
CCEEEEECCCCCHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHCCCEEEEECCCCCHHH
KDIEMVPMDPKHVDADIVFSALPSDIAREVEPKFAEAGFVVASNASAYRMAEDVPLVIPE
HCCEECCCCCCCCCHHHHHHHCCHHHHHHCCCCHHHCCEEEECCCCCEEECCCCCEEECC
VNPEHLGLIEVQKKNRGWDGFIVTNPNCTTIVLVLSLKPLMDLGLRTVRVASMQALSGAG
CCCCCEEEEEEECCCCCCCEEEEECCCCCEEEEEEEHHHHHHHCHHHHHHHHHHHHCCCC
YPGVPSLAITDNVIPFIKGEEDKVEEEPLKLLGKFNGRKIEFADIKVSASCHRVPVIDGH
CCCCCCEEEECCCCCEEECCHHCCHHHHHHHHHCCCCCEEEEEEEEEECCCCEEEEECCC
TEAVWVEFDREVSVEEAKAAFESLKPLDLPTSPEKVIIVREEPDRPQPRLDRDAGNGMSI
CCEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCEE
TVGRIRKDGERGLKYIVLGHNTVRGAAGASILNAELMIKEKII
EEEEECCCCCCCCEEEEEECCCCCCCCCCCEEEHEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9389475