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Identifier: 11498802

GI number: 11498802

Start: 1073567

End: 1075792

Strand: Reverse

Name: Not Available

Synonym: AF1203

Alternate gene names: 11498802

Gene position: 1075792-1073567 (Counterclockwise)

Preceding gene: 11498803

Following gene: 11498801

Centisome position: 49.38

GC content: 54.0

Gene sequence:

>2226_bases
GTGGATGGCGCTGATAATCGCCCTCATGTTCATTTATTTTGGCTTCGGATTTTACGGAGCCAGAAGAAGAAAGTAATCCC
TTCCATTTTTTTGAGAGGTGCTGAAATGTCCGAGCATGTCGTAAAAACTACCTGCAAGAGCTGTCACGGCGGATGCAGGG
TGCTCGTTAAGGTAAAGTCAGGGAAAATAGTGCACATAGAGGGTGATCCCAGCTCGCTTACCAGAGGAACGATGTGTCCA
AAGGGACTGGCGAGCATCAAGGAGGTTTACAACCCTTCGAGGCTCAAATATCCGCTGAAGAGAGTTGGCGAGAGAGGAGA
GGGAGAGTGGAAAAGAATAAGCTGGAAGGAGGCTCTGGATACGATAGCGGAAAAAATGAAGGAATACATCGAGGAGTACG
GCCCCTCCTCAATTTTAATCGGTCAGGGAACAGGGAGAGGCTACAACCGCTACACGTTCAGATTTGCGAGGTCGATAGGA
TCGCCAAACGTCCTCCTGCCTGCACATTTCTGCTATGCTCCAAGGCTCGCAGCCTTTGGCATTACCGTCGGTGGCAGGCT
GTACTGCGACTACCACGGATGGGGTGGGGAGTACCCCAAAACCATAGTCCACTGGGGAAAGCAGCTTGAGTACACCAACG
CCGACGGCGAGATGGCGGTCTGGTTTTTGAGGGCTCTGGAGGAGGCAGAGCACTTCATCCTCGTTGACCCGAAGGCAACT
CCCGTTGCACACAGAGCGGACCTCTGGCTGCCCGTAAGGCCGGGGACTGACGCTGCGCTCGCGTTGGGTATGCTCAACGT
CATCATCAGCGAGGAGCTCTACGACAAAGACTTCGTGGAGCAGTGGACTCACGGCTTCGACAGGCTGAGGGAGAGAGTTG
AAGAGTACAGCCCTGACAAGGTGAGCAGAATCACGTGGGTGCCCGAGGATAAGATAAAGCTCGCCGCGGAGTGGTTCGCA
ACATCAAGACCGGGCTGCATACAGATAGGTCAGGCTCTGGAAGCGGGAAACAACTCCATTCAAACTCTCAGAGCAATAAT
CTGTCTGATGGCGGTAACCGGCAACATAGAGAGGCCTGGCGGAATGGTGAACTGGGTGCCTCCAGAAACAGGGGAGATGG
AGGAGTTCGCCTTAGAGGTTCCGCCACCTGAAGAGCTGCCCATCGGCGCTGACAGGTACAAACTTCTCGCCCTTCCGCCC
TTCGCAATGTGCCACTTCGAGAGCGTTTGTGAGGACCTGCTCAATGGGGAGAGAAGAATAAAAATGATGCACCTTCAGGG
AACGAATCCCGTGCTGGCCTACGCCAACTCGAAAGACGTGCTCAAGGCATTGCTCAACGTGGAGTTCATCTCGGTTGTTG
ACCTCTACATGTCACCGACGGCAAAGTATGCCGACATCGTTCTCCCAGCGGCACACTGGCTCGAAACCGACGATATTTAC
GACATGCACCCCAGATTCTTCGTCTCGGCGATAGTCAGGGCGGTTGAACCTGTTGGGGAAGCTCTGCCCGACAACGTGAT
ATTCAACGAACTCGGCAAGAGGCTTGCACCGAAGTACTGGTTCAGCGACGTTTACGAAATGCTGAACTACCAGCTCAGGA
AGGCGGGGATTACATGGGAGGAGTTCAAGGAAATCGGCGTGCTGGCAAGAACCGGAAAGGAGCACTACTACAAGTACAAA
ACCAACTACTGGAGGGAGGGAGGAGGATTTCCAACACCGACCGGCAAAATAGAGCTTTACTCAACCATCCTCGAAAACCT
CAACTACGACCCGCTTCCCCACTACCGGGAGCCGAATGAAAGCCCCTACAGCACGCCGGAGCTGAGCGAGAAGTATCCGC
TGATACTCTCCACAGGCGGGAGGGTGCCGTACTACTTCCACTCCCAGTACCGCCAGAATCCGTGGTTAAGAGAGCTGCAG
CCCGACCCAGTAGCCCTGATACATCCAGAAACTGCTGAGAAATATGGAATAAAGGACGGAGACTGGATATGGATTGAGAC
CCCGCGTGGAAGGATAAGGCAGAGGGCGAGGCTTTTTGAGGCTATGAATCCTCGCTACGTGTTCGCTCAGGCTTCATGGT
ACTATCCGGAAAAACCCGACCTCGGTATTTTCGAGAGCAACGCCAACGTTCTGACGAGCAACAAACCTCCCTTCGACCCC
TGCATTGGCTCCACGACCTTCAGGGCTATGCTTTGCAGGATTTACAGATGCGACGGGGGTGAGTGA

Upstream 100 bases:

>100_bases
CAGTGTGGGAATAGCTCTGGTGGGATACGTCATCTCGCTATTCCTTGACTGGAGCGAGGAAGAGGGTGATGAAGATGATG
CTTGAAGTCGGAACCGTGAC

Downstream 100 bases:

>100_bases
ATTGTCAAAACTGACCTTCGTTCACGACCGCAGGAAATGCATTGGCTGCTATGCCTGCGTAATAGCATGCAAGGTCGAGC
ACAGCTCCGAGAACTTCGAC

Product: molybdopterin oxidoreductase, molybdopterin binding subunit

Products: CO2; NADH; H2 [C]

Alternate protein names: NA

Number of amino acids: Translated: 741; Mature: 741

Protein sequence:

>741_residues
MDGADNRPHVHLFWLRILRSQKKKVIPSIFLRGAEMSEHVVKTTCKSCHGGCRVLVKVKSGKIVHIEGDPSSLTRGTMCP
KGLASIKEVYNPSRLKYPLKRVGERGEGEWKRISWKEALDTIAEKMKEYIEEYGPSSILIGQGTGRGYNRYTFRFARSIG
SPNVLLPAHFCYAPRLAAFGITVGGRLYCDYHGWGGEYPKTIVHWGKQLEYTNADGEMAVWFLRALEEAEHFILVDPKAT
PVAHRADLWLPVRPGTDAALALGMLNVIISEELYDKDFVEQWTHGFDRLRERVEEYSPDKVSRITWVPEDKIKLAAEWFA
TSRPGCIQIGQALEAGNNSIQTLRAIICLMAVTGNIERPGGMVNWVPPETGEMEEFALEVPPPEELPIGADRYKLLALPP
FAMCHFESVCEDLLNGERRIKMMHLQGTNPVLAYANSKDVLKALLNVEFISVVDLYMSPTAKYADIVLPAAHWLETDDIY
DMHPRFFVSAIVRAVEPVGEALPDNVIFNELGKRLAPKYWFSDVYEMLNYQLRKAGITWEEFKEIGVLARTGKEHYYKYK
TNYWREGGGFPTPTGKIELYSTILENLNYDPLPHYREPNESPYSTPELSEKYPLILSTGGRVPYYFHSQYRQNPWLRELQ
PDPVALIHPETAEKYGIKDGDWIWIETPRGRIRQRARLFEAMNPRYVFAQASWYYPEKPDLGIFESNANVLTSNKPPFDP
CIGSTTFRAMLCRIYRCDGGE

Sequences:

>Translated_741_residues
MDGADNRPHVHLFWLRILRSQKKKVIPSIFLRGAEMSEHVVKTTCKSCHGGCRVLVKVKSGKIVHIEGDPSSLTRGTMCP
KGLASIKEVYNPSRLKYPLKRVGERGEGEWKRISWKEALDTIAEKMKEYIEEYGPSSILIGQGTGRGYNRYTFRFARSIG
SPNVLLPAHFCYAPRLAAFGITVGGRLYCDYHGWGGEYPKTIVHWGKQLEYTNADGEMAVWFLRALEEAEHFILVDPKAT
PVAHRADLWLPVRPGTDAALALGMLNVIISEELYDKDFVEQWTHGFDRLRERVEEYSPDKVSRITWVPEDKIKLAAEWFA
TSRPGCIQIGQALEAGNNSIQTLRAIICLMAVTGNIERPGGMVNWVPPETGEMEEFALEVPPPEELPIGADRYKLLALPP
FAMCHFESVCEDLLNGERRIKMMHLQGTNPVLAYANSKDVLKALLNVEFISVVDLYMSPTAKYADIVLPAAHWLETDDIY
DMHPRFFVSAIVRAVEPVGEALPDNVIFNELGKRLAPKYWFSDVYEMLNYQLRKAGITWEEFKEIGVLARTGKEHYYKYK
TNYWREGGGFPTPTGKIELYSTILENLNYDPLPHYREPNESPYSTPELSEKYPLILSTGGRVPYYFHSQYRQNPWLRELQ
PDPVALIHPETAEKYGIKDGDWIWIETPRGRIRQRARLFEAMNPRYVFAQASWYYPEKPDLGIFESNANVLTSNKPPFDP
CIGSTTFRAMLCRIYRCDGGE
>Mature_741_residues
MDGADNRPHVHLFWLRILRSQKKKVIPSIFLRGAEMSEHVVKTTCKSCHGGCRVLVKVKSGKIVHIEGDPSSLTRGTMCP
KGLASIKEVYNPSRLKYPLKRVGERGEGEWKRISWKEALDTIAEKMKEYIEEYGPSSILIGQGTGRGYNRYTFRFARSIG
SPNVLLPAHFCYAPRLAAFGITVGGRLYCDYHGWGGEYPKTIVHWGKQLEYTNADGEMAVWFLRALEEAEHFILVDPKAT
PVAHRADLWLPVRPGTDAALALGMLNVIISEELYDKDFVEQWTHGFDRLRERVEEYSPDKVSRITWVPEDKIKLAAEWFA
TSRPGCIQIGQALEAGNNSIQTLRAIICLMAVTGNIERPGGMVNWVPPETGEMEEFALEVPPPEELPIGADRYKLLALPP
FAMCHFESVCEDLLNGERRIKMMHLQGTNPVLAYANSKDVLKALLNVEFISVVDLYMSPTAKYADIVLPAAHWLETDDIY
DMHPRFFVSAIVRAVEPVGEALPDNVIFNELGKRLAPKYWFSDVYEMLNYQLRKAGITWEEFKEIGVLARTGKEHYYKYK
TNYWREGGGFPTPTGKIELYSTILENLNYDPLPHYREPNESPYSTPELSEKYPLILSTGGRVPYYFHSQYRQNPWLRELQ
PDPVALIHPETAEKYGIKDGDWIWIETPRGRIRQRARLFEAMNPRYVFAQASWYYPEKPDLGIFESNANVLTSNKPPFDP
CIGSTTFRAMLCRIYRCDGGE

Specific function: Oxidoreductase which produces hydrogen sulfide from thiosulfate (Potential) [H]

COG id: COG0243

COG function: function code C; Anaerobic dehydrogenases, typically selenocysteine-containing

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI3868721, Length=692, Percent_Identity=27.3121387283237, Blast_Score=221, Evalue=9e-59,
Organism=Escherichia coli, GI87081797, Length=761, Percent_Identity=29.1721419185283, Blast_Score=211, Evalue=9e-56,
Organism=Escherichia coli, GI1787870, Length=743, Percent_Identity=27.321668909825, Blast_Score=196, Evalue=6e-51,
Organism=Escherichia coli, GI171474008, Length=770, Percent_Identity=25.5844155844156, Blast_Score=185, Evalue=9e-48,
Organism=Escherichia coli, GI1787231, Length=724, Percent_Identity=24.7237569060773, Blast_Score=132, Evalue=1e-31,
Organism=Escherichia coli, GI87081994, Length=773, Percent_Identity=23.9327296248383, Blast_Score=125, Evalue=8e-30,
Organism=Escherichia coli, GI3868720, Length=406, Percent_Identity=25.8620689655172, Blast_Score=112, Evalue=7e-26,
Organism=Escherichia coli, GI145693196, Length=764, Percent_Identity=23.2984293193717, Blast_Score=112, Evalue=1e-25,
Organism=Escherichia coli, GI3868719, Length=406, Percent_Identity=26.1083743842365, Blast_Score=107, Evalue=4e-24,
Organism=Escherichia coli, GI1788534, Length=761, Percent_Identity=22.7332457293035, Blast_Score=102, Evalue=1e-22,
Organism=Escherichia coli, GI1787778, Length=364, Percent_Identity=23.9010989010989, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009010
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006963
- InterPro:   IPR006655
- InterPro:   IPR006311 [H]

Pfam domain/function: PF04879 Molybdop_Fe4S4; PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: 1.2.1.2 [C]

Molecular weight: Translated: 84553; Mature: 84553

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDGADNRPHVHLFWLRILRSQKKKVIPSIFLRGAEMSEHVVKTTCKSCHGGCRVLVKVKS
CCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEEEECC
GKIVHIEGDPSSLTRGTMCPKGLASIKEVYNPSRLKYPLKRVGERGEGEWKRISWKEALD
CCEEEEECCCCCCCCCCCCHHHHHHHHHHCCCHHCCCHHHHCCCCCCCCHHCCCHHHHHH
TIAEKMKEYIEEYGPSSILIGQGTGRGYNRYTFRFARSIGSPNVLLPAHFCYAPRLAAFG
HHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHCCCCCEEECHHHHHHCHHHHEE
ITVGGRLYCDYHGWGGEYPKTIVHWGKQLEYTNADGEMAVWFLRALEEAEHFILVDPKAT
EEECCEEEEEECCCCCCCCHHHHHCCCCEEEECCCCHHHHHHHHHHHHCCCEEEECCCCC
PVAHRADLWLPVRPGTDAALALGMLNVIISEELYDKDFVEQWTHGFDRLRERVEEYSPDK
CCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCH
VSRITWVPEDKIKLAAEWFATSRPGCIQIGQALEAGNNSIQTLRAIICLMAVTGNIERPG
HCEEEECCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCC
GMVNWVPPETGEMEEFALEVPPPEELPIGADRYKLLALPPFAMCHFESVCEDLLNGERRI
CEEECCCCCCCCHHHEEEECCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCEEE
KMMHLQGTNPVLAYANSKDVLKALLNVEFISVVDLYMSPTAKYADIVLPAAHWLETDDIY
EEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHEEECHHHHCCCCCCC
DMHPRFFVSAIVRAVEPVGEALPDNVIFNELGKRLAPKYWFSDVYEMLNYQLRKAGITWE
CCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHH
EFKEIGVLARTGKEHYYKYKTNYWREGGGFPTPTGKIELYSTILENLNYDPLPHYREPNE
HHHHHHHHHCCCCHHEEEECCCCEECCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCC
SPYSTPELSEKYPLILSTGGRVPYYFHSQYRQNPWLRELQPDPVALIHPETAEKYGIKDG
CCCCCCCCCCCCCEEEECCCCCCEEECHHHCCCCCHHCCCCCCEEEECCCCHHHCCCCCC
DWIWIETPRGRIRQRARLFEAMNPRYVFAQASWYYPEKPDLGIFESNANVLTSNKPPFDP
CEEEEECCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCEEECCCCEEECCCCCCCC
CIGSTTFRAMLCRIYRCDGGE
CCCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MDGADNRPHVHLFWLRILRSQKKKVIPSIFLRGAEMSEHVVKTTCKSCHGGCRVLVKVKS
CCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEEEECC
GKIVHIEGDPSSLTRGTMCPKGLASIKEVYNPSRLKYPLKRVGERGEGEWKRISWKEALD
CCEEEEECCCCCCCCCCCCHHHHHHHHHHCCCHHCCCHHHHCCCCCCCCHHCCCHHHHHH
TIAEKMKEYIEEYGPSSILIGQGTGRGYNRYTFRFARSIGSPNVLLPAHFCYAPRLAAFG
HHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHCCCCCEEECHHHHHHCHHHHEE
ITVGGRLYCDYHGWGGEYPKTIVHWGKQLEYTNADGEMAVWFLRALEEAEHFILVDPKAT
EEECCEEEEEECCCCCCCCHHHHHCCCCEEEECCCCHHHHHHHHHHHHCCCEEEECCCCC
PVAHRADLWLPVRPGTDAALALGMLNVIISEELYDKDFVEQWTHGFDRLRERVEEYSPDK
CCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCH
VSRITWVPEDKIKLAAEWFATSRPGCIQIGQALEAGNNSIQTLRAIICLMAVTGNIERPG
HCEEEECCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCC
GMVNWVPPETGEMEEFALEVPPPEELPIGADRYKLLALPPFAMCHFESVCEDLLNGERRI
CEEECCCCCCCCHHHEEEECCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCEEE
KMMHLQGTNPVLAYANSKDVLKALLNVEFISVVDLYMSPTAKYADIVLPAAHWLETDDIY
EEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHEEECHHHHCCCCCCC
DMHPRFFVSAIVRAVEPVGEALPDNVIFNELGKRLAPKYWFSDVYEMLNYQLRKAGITWE
CCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHH
EFKEIGVLARTGKEHYYKYKTNYWREGGGFPTPTGKIELYSTILENLNYDPLPHYREPNE
HHHHHHHHHCCCCHHEEEECCCCEECCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCC
SPYSTPELSEKYPLILSTGGRVPYYFHSQYRQNPWLRELQPDPVALIHPETAEKYGIKDG
CCCCCCCCCCCCCEEEECCCCCCEEECHHHCCCCCHHCCCCCCEEEECCCCHHHCCCCCC
DWIWIETPRGRIRQRARLFEAMNPRYVFAQASWYYPEKPDLGIFESNANVLTSNKPPFDP
CEEEEECCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCEEECCCCEEECCCCCCCC
CIGSTTFRAMLCRIYRCDGGE
CCCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NAD+ [C]

Metal ions: Fe; Mo; Se [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.032 {NAD+}} 0.54 {deamino-NAD+}} 0.19 {3-pyridinecarboxaldehyde-NAD+}} 1.16 {3-acetylpyridine-NAD+}} 0.17 {thio-NAD+}} [C]

Substrates: Formate; NAD(+) [C]

Specific reaction: Formate + NAD(+) = CO2 + NADH. formate = CO2 + H2 [C]

General reaction: Redox reaction [C]

Inhibitor: Azide; Br-; Cl-; CN-; F-; HCO3-; HCOS-; NO2-; NO3-; OCN-; SCN- [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7751291; 11677609; 7737516 [H]