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Identifier: 11498708

GI number: 11498708

Start: 993501

End: 994007

Strand: Reverse

Name: Not Available

Synonym: AF1108

Alternate gene names: 11498708

Gene position: 994007-993501 (Counterclockwise)

Preceding gene: 11498709

Following gene: 11498707

Centisome position: 45.63

GC content: 49.9

Gene sequence:

>507_bases
ATGGCGGTTCTGAGCGGGGATGAGATCAGGAAGTTGATTCAGAAAGAGGGGTTAATCAGGGACTACGTAGATTTGGAGAC
GCAGATTCAGCCCAACGGTTTTGACTGCACTCTGAGAAGCGTTTACAGGTTGAGAGGTTGTGGTAGGGTTGACTTCGACA
ACAGCAGAAGAGAGCTACCTGAGCTTGAGGAGGTGGAATTCAGAGATTGGGTTTACCTTCCCAAAGGCGTTTACAGAGCG
AAACTGAATGAAGTTGTCAGGCTGGGAAACGATATTATGGCAATAGCCCGTCCGAGGTCAACGCTTATCAGATGTGGAGC
AAACGTTCTCACCGCAGTCTGGGACGCTGGATACGAGGGGAGGAGTGAAGTGAGCATAGTTGTACACAACGATTACGGGA
TATGGCTTTCGAGGAACGCCAGAATCATTCAGCTTGTGTTCATAAGGCTCTCCTCACCGACCAAAGGGTACGAGGGGGTT
TACAAGGGGGAGAACATTGACTCGTAG

Upstream 100 bases:

>100_bases
GCAAAGATAACGGGGAAGTACGACTACATCGACGCATACTACGTTGACTACCCCGACATCTTGAGGAAAAAGAAATAACT
CCTTCCCACAAAACCGCTGC

Downstream 100 bases:

>100_bases
AAAGTGTTTAATATTTTAGTGACATACCAGATTCTGTGCTAGTGGCTGAAGTTTACGGACTGTTCGGAGTCAAAACCGCC
TTTGGCGTAACTCCTGTAGT

Product: deoxyuridine 5'-triphosphate nucleotidohydrolase

Products: NA

Alternate protein names: dUTPase; dUTP pyrophosphatase

Number of amino acids: Translated: 168; Mature: 167

Protein sequence:

>168_residues
MAVLSGDEIRKLIQKEGLIRDYVDLETQIQPNGFDCTLRSVYRLRGCGRVDFDNSRRELPELEEVEFRDWVYLPKGVYRA
KLNEVVRLGNDIMAIARPRSTLIRCGANVLTAVWDAGYEGRSEVSIVVHNDYGIWLSRNARIIQLVFIRLSSPTKGYEGV
YKGENIDS

Sequences:

>Translated_168_residues
MAVLSGDEIRKLIQKEGLIRDYVDLETQIQPNGFDCTLRSVYRLRGCGRVDFDNSRRELPELEEVEFRDWVYLPKGVYRA
KLNEVVRLGNDIMAIARPRSTLIRCGANVLTAVWDAGYEGRSEVSIVVHNDYGIWLSRNARIIQLVFIRLSSPTKGYEGV
YKGENIDS
>Mature_167_residues
AVLSGDEIRKLIQKEGLIRDYVDLETQIQPNGFDCTLRSVYRLRGCGRVDFDNSRRELPELEEVEFRDWVYLPKGVYRAK
LNEVVRLGNDIMAIARPRSTLIRCGANVLTAVWDAGYEGRSEVSIVVHNDYGIWLSRNARIIQLVFIRLSSPTKGYEGVY
KGENIDS

Specific function: This enzyme is involved in nucleotide metabolism:it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA

COG id: COG0717

COG function: function code F; Deoxycytidine deaminase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dCTP deaminase family. Archaeal dUTPase subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DUT_ARCFU (O29157)

Other databases:

- EMBL:   AE000782
- PIR:   C69388
- RefSeq:   NP_069937.1
- ProteinModelPortal:   O29157
- GeneID:   1484330
- GenomeReviews:   AE000782_GR
- KEGG:   afu:AF1108
- NMPDR:   fig|224325.1.peg.1096
- TIGR:   AF_1108
- HOGENOM:   HBG541035
- OMA:   TAVWDAG
- ProtClustDB:   PRK02253
- BioCyc:   AFUL224325:AF_1108-MONOMER
- BRENDA:   3.6.1.23
- HAMAP:   MF_00635
- InterPro:   IPR008180

Pfam domain/function: PF00692 dUTPase

EC number: =3.6.1.23

Molecular weight: Translated: 19227; Mature: 19096

Theoretical pI: Translated: 7.19; Mature: 7.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVLSGDEIRKLIQKEGLIRDYVDLETQIQPNGFDCTLRSVYRLRGCGRVDFDNSRRELP
CCCCCHHHHHHHHHHCCCHHHHHCCEEEECCCCCCHHHHHHHHHHCCCCCCCCCCHHCCC
ELEEVEFRDWVYLPKGVYRAKLNEVVRLGNDIMAIARPRSTLIRCGANVLTAVWDAGYEG
CCCCCCCCCEEECCCHHHHHHHHHHHHCCCCEEEEECCHHHHHHHCHHHHHHHHHCCCCC
RSEVSIVVHNDYGIWLSRNARIIQLVFIRLSSPTKGYEGVYKGENIDS
CCEEEEEEECCCCEEEECCCEEEEEEEEEECCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AVLSGDEIRKLIQKEGLIRDYVDLETQIQPNGFDCTLRSVYRLRGCGRVDFDNSRRELP
CCCCHHHHHHHHHHCCCHHHHHCCEEEECCCCCCHHHHHHHHHHCCCCCCCCCCHHCCC
ELEEVEFRDWVYLPKGVYRAKLNEVVRLGNDIMAIARPRSTLIRCGANVLTAVWDAGYEG
CCCCCCCCCEEECCCHHHHHHHHHHHHCCCCEEEEECCHHHHHHHCHHHHHHHHHCCCCC
RSEVSIVVHNDYGIWLSRNARIIQLVFIRLSSPTKGYEGVYKGENIDS
CCEEEEEEECCCCEEEECCCEEEEEEEEEECCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9389475