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The map label for this gene is fum-2

Identifier: 11498699

GI number: 11498699

Start: 986383

End: 987201

Strand: Reverse

Name: fum-2

Synonym: AF1099

Alternate gene names: 11498699

Gene position: 987201-986383 (Counterclockwise)

Preceding gene: 11498707

Following gene: 11498698

Centisome position: 45.32

GC content: 51.16

Gene sequence:

>819_bases
ATGGAATATAATGATGTGGTTGAGGCAGTTATTTCCGCTTTGAAGAAGGCACACACCGAGCTGCCGGAGGATGTCGTGAC
GGCAATAAAGAAAGCGTACGATTCTGAGGAGAATGATATTGCTAAAAGGAATTTGGAGGCCATACTTAAGAATATTGAGG
CTGCAAAAAAGCTGGGAGTTCCGATGTGTCAGGATACTGGAATTCCTGTGTTCTTTGTTGAGGTTGGGAGGGAGCTATGC
CTCGACTTTGACCTGAAGGAGGCGATTGTAGAGGGAGTTAGGAAAGCAACGGCGGAAATACCTCTGAGGCCCAACGCAGT
TCATCCGATAACGAGGGAGAACAGCGGAGACAACACTGGCTTGGGAATTCCGCAGATAAACGTCGAGCTGGTTAAGGGAG
ATGAGCTGAGAATGGTCGTGATGCCGAAAGGGGCAGGGAGTGAGAACGTCTCAGCCCTTAAAATGATGCTCCCCACTCAG
GTTGACAAGATTAAGGACTTTGTTGTCGAAACTGTCAAAAACGCTGGAGGAAAGCCCTGTCCCCCCATCTTCGTTGGTGT
TGGTGTGGGCTCGACCTTTGATGGGGCAGCAAAGCTCGCTAAAAAGGCTTTGCTGAGAAACGTTCTGGAGATGAACGACT
TCGAGCTTGAGCTGCTTGAGGCGGTGAATGAGCTTGGAATCGGTGCAATGGGGCTTGGAGGTAAATATACTGCTCTGGCC
GTGCTGGTTGAGTTTGGCCACTGCCACACTGCCTCGCTGCCGGTTGCCGTGAACATCCAGTGCTGGGCGAACAGAAGGGC
TGAGGTCGTGCTGAGGTGA

Upstream 100 bases:

>100_bases
ACAATTAAAACATAATTACGACTTATACCTTATAAACCTTTGCGGCTATGGTGCTCCGGTAAAAACCGCTACTATTTTAA
GGGCTGTGCGGAGTAACTTC

Downstream 100 bases:

>100_bases
TGGTTATGGAGTATGAGCTCAGAACACCTCTCGTTAAGGACCAGATTCTGAAGCTGAAGGTTGGTGATGTTGTTTACATC
ACTGGAGAGATTTTCACCGC

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase [H]

Number of amino acids: Translated: 272; Mature: 272

Protein sequence:

>272_residues
MEYNDVVEAVISALKKAHTELPEDVVTAIKKAYDSEENDIAKRNLEAILKNIEAAKKLGVPMCQDTGIPVFFVEVGRELC
LDFDLKEAIVEGVRKATAEIPLRPNAVHPITRENSGDNTGLGIPQINVELVKGDELRMVVMPKGAGSENVSALKMMLPTQ
VDKIKDFVVETVKNAGGKPCPPIFVGVGVGSTFDGAAKLAKKALLRNVLEMNDFELELLEAVNELGIGAMGLGGKYTALA
VLVEFGHCHTASLPVAVNIQCWANRRAEVVLR

Sequences:

>Translated_272_residues
MEYNDVVEAVISALKKAHTELPEDVVTAIKKAYDSEENDIAKRNLEAILKNIEAAKKLGVPMCQDTGIPVFFVEVGRELC
LDFDLKEAIVEGVRKATAEIPLRPNAVHPITRENSGDNTGLGIPQINVELVKGDELRMVVMPKGAGSENVSALKMMLPTQ
VDKIKDFVVETVKNAGGKPCPPIFVGVGVGSTFDGAAKLAKKALLRNVLEMNDFELELLEAVNELGIGAMGLGGKYTALA
VLVEFGHCHTASLPVAVNIQCWANRRAEVVLR
>Mature_272_residues
MEYNDVVEAVISALKKAHTELPEDVVTAIKKAYDSEENDIAKRNLEAILKNIEAAKKLGVPMCQDTGIPVFFVEVGRELC
LDFDLKEAIVEGVRKATAEIPLRPNAVHPITRENSGDNTGLGIPQINVELVKGDELRMVVMPKGAGSENVSALKMMLPTQ
VDKIKDFVVETVKNAGGKPCPPIFVGVGVGSTFDGAAKLAKKALLRNVLEMNDFELELLEAVNELGIGAMGLGGKYTALA
VLVEFGHCHTASLPVAVNIQCWANRRAEVVLR

Specific function: Unknown

COG id: COG1951

COG function: function code C; Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I fumarase family [H]

Homologues:

Organism=Escherichia coli, GI1789442, Length=277, Percent_Identity=32.4909747292419, Blast_Score=145, Evalue=2e-36,
Organism=Escherichia coli, GI1790564, Length=274, Percent_Identity=31.7518248175182, Blast_Score=91, Evalue=9e-20,
Organism=Escherichia coli, GI1787897, Length=273, Percent_Identity=30.03663003663, Blast_Score=86, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004646 [H]

Pfam domain/function: PF05681 Fumerase [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 29341; Mature: 29341

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEYNDVVEAVISALKKAHTELPEDVVTAIKKAYDSEENDIAKRNLEAILKNIEAAKKLGV
CCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCC
PMCQDTGIPVFFVEVGRELCLDFDLKEAIVEGVRKATAEIPLRPNAVHPITRENSGDNTG
CCCCCCCCCEEHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
LGIPQINVELVKGDELRMVVMPKGAGSENVSALKMMLPTQVDKIKDFVVETVKNAGGKPC
CCCCCEEEEEEECCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
PPIFVGVGVGSTFDGAAKLAKKALLRNVLEMNDFELELLEAVNELGIGAMGLGGKYTALA
CCEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCHHHHHH
VLVEFGHCHTASLPVAVNIQCWANRRAEVVLR
HHHHHCCCCCCCCCEEEEEEECCCCCEEEEEC
>Mature Secondary Structure
MEYNDVVEAVISALKKAHTELPEDVVTAIKKAYDSEENDIAKRNLEAILKNIEAAKKLGV
CCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCC
PMCQDTGIPVFFVEVGRELCLDFDLKEAIVEGVRKATAEIPLRPNAVHPITRENSGDNTG
CCCCCCCCCEEHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
LGIPQINVELVKGDELRMVVMPKGAGSENVSALKMMLPTQVDKIKDFVVETVKNAGGKPC
CCCCCEEEEEEECCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
PPIFVGVGVGSTFDGAAKLAKKALLRNVLEMNDFELELLEAVNELGIGAMGLGGKYTALA
CCEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCHHHHHH
VLVEFGHCHTASLPVAVNIQCWANRRAEVVLR
HHHHHCCCCCCCCCEEEEEEECCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]