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The map label for this gene is manC

Identifier: 11498697

GI number: 11498697

Start: 984354

End: 985700

Strand: Reverse

Name: manC

Synonym: AF1097

Alternate gene names: 11498697

Gene position: 985700-984354 (Counterclockwise)

Preceding gene: 11498698

Following gene: 11498696

Centisome position: 45.25

GC content: 53.01

Gene sequence:

>1347_bases
ATGAAAACTCTGATACTCGCAGGCGGAAAGGGGACGAGGCTCTGGCCTTTAAGCAGGGAGCTCATGCCGAAGCAGTTCAT
CAAGCTCTTCTCGGAGTCACTATTCCAGAAAACCGTAAAGAGGGCTCTTTATCTGTCCTCCCCCGACGAAATCTACGTGA
TTACAAACAAGGAGTACCGCTTCAGAGTTCTCGACGACTTAGAGGAGATCGGAATTTCAATTCCGGAGGAGAACATCATT
CTGGAGCCGGAAGCGAAGAACACCTTGCCCGCAATCTGTCTTGGCGTCAAGGCGGCTGGAGAGGGGAAGTTTGCCGTCTT
ACCATCCGACCATCTTATTAAAGCGGATGAGGAGTACCTGAATGCCTTCAGGTCTGCAGAGAAGCTTTCTGAAAACTACA
TCGTGACCTTCGGGATAACCCCAACCCGCCCTCACACGGGCTACGGCTACATCAAGCCGGGAAAAGAGCTGGAGGGCGGT
TTCGAGGTTGAGCAGTTCAAGGAGAAGCCTTCCAGGGAGCTGGCCGAGGAGTACGTCTCCAAGGGATACCTATGGAACAG
CGGCATGTTCGTCTTTGACTCCAAAGTATTCGTTGAAGAGTTGAAGGAGCTCGCCCCCGAGTTCGCAAAGGTGCTTGAGG
AGGGTGAAGAAGCTTACAAGCAAATTCCAGAAGCCTCATTCGACTACGCCATACTCGAGAAGTCGGGAAGGGTTGCAGTG
GTTCCAATCAAAACCTTCTGGAGCGACCTCGGCAACTTCGATTCGATTTATGAGGTCATGGAGAAGGATGAGAGGGGGAA
CGCTATCAAGAGCGAGAGTTGCATTCCGGTCGACTCGGAGAACAACCTCGTTATTACGCAGCGCCTCACAGCCCTGATAG
GCCTGAGGGATTTGATTGTCATCGACACCGACGACGCTCTGCTAGTTGCGAGAAGGGGGGAGGCTGAGAAGGTCAGGGAG
GTTTACAGGCTGCTCGCCGAGAAGGGGGACAAGGCCGTTGAGGTTCACAGAACGGCCCACAGGCCCTGGGGAAGCTACAC
GGTCCTTGAGGAGAACAAGAGCTACAAGATAAAAAGGATAACGGTAAAGCCGAAGAAAAGGCTGAGCCTCCAGCGCCACT
ACCACAGGAGCGAGCACTGGGTGGTGGTTAAGGGCACAGCCAGAATTGTAGTTGATGGAAATGAAATTCTTCTGAGGAGC
GGGGAGAGCACCTTCGTTCCCGCAGGAGCGATTCACAGAATCGAGAATCCCGGAAAAATCCCCCTCGAAATCATAGAGAT
ACAGATCGGGGAGTATCTGGAAGAGGACGACATAGAGCGATTCGAGGACGACTTCGGGAGGAGATAG

Upstream 100 bases:

>100_bases
GGGTAGGGGACATCCTGGTGGCCTTCGGAGCCACAGACCCGGGTTCGATTCCCGGCGGGGGCGTCAGAAAGTATTTTATT
AATTTCACTGATTTCAGGAT

Downstream 100 bases:

>100_bases
CTCACACTGTGTGACCATCATAACCGGTGAAAATTTTTCACTCTTTTACCTGCCAAATCGAAAGGGTTATATACCAGTTA
TGGTAATAATGATAATGCTA

Product: mannose-6-phosphate isomerase/mannose-1-phosphate guanylyl transferase (manC)

Products: NA

Alternate protein names: Mannose-6-phosphate isomerase; Phosphohexomutase; Phosphomannose isomerase; PMI; Mannose-1-phosphate guanylyltransferase; GDP-mannose pyrophosphorylase; GMP; GMPP; GTP--mannose-1-phosphate guanylyltransferase [H]

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MKTLILAGGKGTRLWPLSRELMPKQFIKLFSESLFQKTVKRALYLSSPDEIYVITNKEYRFRVLDDLEEIGISIPEENII
LEPEAKNTLPAICLGVKAAGEGKFAVLPSDHLIKADEEYLNAFRSAEKLSENYIVTFGITPTRPHTGYGYIKPGKELEGG
FEVEQFKEKPSRELAEEYVSKGYLWNSGMFVFDSKVFVEELKELAPEFAKVLEEGEEAYKQIPEASFDYAILEKSGRVAV
VPIKTFWSDLGNFDSIYEVMEKDERGNAIKSESCIPVDSENNLVITQRLTALIGLRDLIVIDTDDALLVARRGEAEKVRE
VYRLLAEKGDKAVEVHRTAHRPWGSYTVLEENKSYKIKRITVKPKKRLSLQRHYHRSEHWVVVKGTARIVVDGNEILLRS
GESTFVPAGAIHRIENPGKIPLEIIEIQIGEYLEEDDIERFEDDFGRR

Sequences:

>Translated_448_residues
MKTLILAGGKGTRLWPLSRELMPKQFIKLFSESLFQKTVKRALYLSSPDEIYVITNKEYRFRVLDDLEEIGISIPEENII
LEPEAKNTLPAICLGVKAAGEGKFAVLPSDHLIKADEEYLNAFRSAEKLSENYIVTFGITPTRPHTGYGYIKPGKELEGG
FEVEQFKEKPSRELAEEYVSKGYLWNSGMFVFDSKVFVEELKELAPEFAKVLEEGEEAYKQIPEASFDYAILEKSGRVAV
VPIKTFWSDLGNFDSIYEVMEKDERGNAIKSESCIPVDSENNLVITQRLTALIGLRDLIVIDTDDALLVARRGEAEKVRE
VYRLLAEKGDKAVEVHRTAHRPWGSYTVLEENKSYKIKRITVKPKKRLSLQRHYHRSEHWVVVKGTARIVVDGNEILLRS
GESTFVPAGAIHRIENPGKIPLEIIEIQIGEYLEEDDIERFEDDFGRR
>Mature_448_residues
MKTLILAGGKGTRLWPLSRELMPKQFIKLFSESLFQKTVKRALYLSSPDEIYVITNKEYRFRVLDDLEEIGISIPEENII
LEPEAKNTLPAICLGVKAAGEGKFAVLPSDHLIKADEEYLNAFRSAEKLSENYIVTFGITPTRPHTGYGYIKPGKELEGG
FEVEQFKEKPSRELAEEYVSKGYLWNSGMFVFDSKVFVEELKELAPEFAKVLEEGEEAYKQIPEASFDYAILEKSGRVAV
VPIKTFWSDLGNFDSIYEVMEKDERGNAIKSESCIPVDSENNLVITQRLTALIGLRDLIVIDTDDALLVARRGEAEKVRE
VYRLLAEKGDKAVEVHRTAHRPWGSYTVLEENKSYKIKRITVKPKKRLSLQRHYHRSEHWVVVKGTARIVVDGNEILLRS
GESTFVPAGAIHRIENPGKIPLEIIEIQIGEYLEEDDIERFEDDFGRR

Specific function: Produces a precursor for alginate polymerization. The alginate layer provides a protective barrier against host immune defenses and antibiotics [H]

COG id: COG0836

COG function: function code M; Mannose-1-phosphate guanylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 2 family [H]

Homologues:

Organism=Escherichia coli, GI1788362, Length=475, Percent_Identity=41.4736842105263, Blast_Score=346, Evalue=2e-96,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR006375
- InterPro:   IPR001538
- InterPro:   IPR005835
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01050 MannoseP_isomer; PF00483 NTP_transferase [H]

EC number: =5.3.1.8; =2.7.7.13 [H]

Molecular weight: Translated: 51090; Mature: 51090

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTLILAGGKGTRLWPLSRELMPKQFIKLFSESLFQKTVKRALYLSSPDEIYVITNKEYR
CCEEEEECCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCEEEEEECCCEE
FRVLDDLEEIGISIPEENIILEPEAKNTLPAICLGVKAAGEGKFAVLPSDHLIKADEEYL
EEHHHHHHHCCCCCCCCCEEECCCCCCCCCEEEEEEEECCCCCEEECCCCCCCCCCHHHH
NAFRSAEKLSENYIVTFGITPTRPHTGYGYIKPGKELEGGFEVEQFKEKPSRELAEEYVS
HHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHH
KGYLWNSGMFVFDSKVFVEELKELAPEFAKVLEEGEEAYKQIPEASFDYAILEKSGRVAV
CCEEECCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCEEE
VPIKTFWSDLGNFDSIYEVMEKDERGNAIKSESCIPVDSENNLVITQRLTALIGLRDLIV
EEHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHCCCEEEE
IDTDDALLVARRGEAEKVREVYRLLAEKGDKAVEVHRTAHRPWGSYTVLEENKSYKIKRI
EECCCEEEEEECCCHHHHHHHHHHHHHCCCCEEEEHHHHCCCCCCEEEEECCCCEEEEEE
TVKPKKRLSLQRHYHRSEHWVVVKGTARIVVDGNEILLRSGESTFVPAGAIHRIENPGKI
EECCHHHHHHHHHHCCCCCEEEEECCEEEEECCCEEEEECCCCCCCCCHHHHCCCCCCCC
PLEIIEIQIGEYLEEDDIERFEDDFGRR
CEEEEEEEHHHHCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MKTLILAGGKGTRLWPLSRELMPKQFIKLFSESLFQKTVKRALYLSSPDEIYVITNKEYR
CCEEEEECCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCEEEEEECCCEE
FRVLDDLEEIGISIPEENIILEPEAKNTLPAICLGVKAAGEGKFAVLPSDHLIKADEEYL
EEHHHHHHHCCCCCCCCCEEECCCCCCCCCEEEEEEEECCCCCEEECCCCCCCCCCHHHH
NAFRSAEKLSENYIVTFGITPTRPHTGYGYIKPGKELEGGFEVEQFKEKPSRELAEEYVS
HHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHH
KGYLWNSGMFVFDSKVFVEELKELAPEFAKVLEEGEEAYKQIPEASFDYAILEKSGRVAV
CCEEECCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCEEE
VPIKTFWSDLGNFDSIYEVMEKDERGNAIKSESCIPVDSENNLVITQRLTALIGLRDLIV
EEHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHCCCEEEE
IDTDDALLVARRGEAEKVREVYRLLAEKGDKAVEVHRTAHRPWGSYTVLEENKSYKIKRI
EECCCEEEEEECCCHHHHHHHHHHHHHCCCCEEEEHHHHCCCCCCEEEEECCCCEEEEEE
TVKPKKRLSLQRHYHRSEHWVVVKGTARIVVDGNEILLRSGESTFVPAGAIHRIENPGKI
EECCHHHHHHHHHHCCCCCEEEEECCEEEEECCCEEEEECCCCCCCCCHHHHCCCCCCCC
PLEIIEIQIGEYLEEDDIERFEDDFGRR
CEEEEEEEHHHHCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12534463 [H]