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The map label for this gene is lysA

Identifier: 11498406

GI number: 11498406

Start: 711825

End: 713084

Strand: Reverse

Name: lysA

Synonym: AF0800

Alternate gene names: 11498406

Gene position: 713084-711825 (Counterclockwise)

Preceding gene: 11498407

Following gene: 11498405

Centisome position: 32.73

GC content: 51.59

Gene sequence:

>1260_bases
ATGTTCTCAACTAGCGACGGAATTCTGACAGTGGAGGGTGTGAAGGTAACGGAGATTGTCAGGGAAACTGGCACGCCCGT
TTACGTCACTTCAAGGGCCCTACTTGAGAGAAACCTAGAGGCTTACAAAAAAGCCTTCTCCAACGAAGGGCTGCTTTATG
CTGTAAAGGCCAATAACAACCTCGCTTTGATGAGGATAATCGCCTCTCATGGCTTTGGTGCTGATGTTTTTAGCGATGGT
GAGCTGTACCTTGCATCTCTCGCAGGCTTCAGGAAGGATATGGTTCTCTTCAACGGCAACTCGAAAAGCAGAAAAGAGAT
AGAAATGGGGGTTACTGCTGGAGTCAAGTTCAGCGTTGACAGTCTGGATGAGCTCAGAACTATTTCGAAAATTGCTAAGG
AGGTTGGAAAGGAGGTTGAGATTGCTTTCAGGGTCAATCCCGACGTTGACCCGAAAACTCATCCGAAAATCGCTACGGGG
CTTAGAGAGTCAAAGTTCGGCATTCCGCATGAAATGGTGAGGGAGGCTTACGAGATGGCTTTGAAGCTGGACGGTGTTGT
TCCGGTTGGAATACACTGCCATATCGGCAGCCAGATACTCGACCTCTCCCCGTTCGTGCACGCGCTGAACAAGGTTATGG
ACATCGCCGTGGATATCGAGAAGCTTGGTGTTGAGCTGAGCTTTGTGGACATGGGTGGTGGGCTCGGAATTGACTACGAG
GGGAAGGGCGCTCCAACCCCCAAGGACCTCGCAAGCGCAATTCTACCTGAATTCGAAGGAAGAAAGGCTGATTTAACTTC
CGACCCGCAGCTCTGGCTGGAACCTGGAAGGAGCATTGTTGGCAACACAACCGTCTTGATTACAAGAGTGAACGCCGTGA
AGAAGGGCTACAAGAACTTTGTTGCTGTTGATGCCGGCTTCAACGTCCTAATCCGTCCCGCGATGTACGGTTCCTACCAC
AGGGTGGCGGTAGCGAACAAGATGGATGCCGAGCCTGAGGAGGTTTATACGGTCGTTGGGCCGATATGCGAGAGTGGAGA
TGTTCTGGCCAGGGACAGGAAGCTACCCAAAGTTGAAGTGGGTGATTTAATCGCCGTTTTCGACGCGGGAGCCTACGGTT
TCGTGATGAGCAGCCAGTACAACGGCAGGCCGAGGTGCGCAGAGGTGCTTGTGAGCGGGGATAGATGGGACGTAATCAGG
GAGAAGGAGAGCTACGGTGATTTAATCGAGAAGCAAAGGTTACCTGAATGGCTGCTATGA

Upstream 100 bases:

>100_bases
GAGAAGGGAGTGCTGCCGGCAGACTGGAAGTACAATCCGGATAGACTCAAAATTGAGATTTCGAAGTAACTGTTTTTAAT
CCCTCCACACTTTTAATTTC

Downstream 100 bases:

>100_bases
GGATTTTAATTTTTGGGGACACCCATATCCCGGAGAGGGCTGATGAAATTCCGAGGGAGTTCACCGACTACCTCGTGGAC
TTCGACATGGTAGTAATCAC

Product: diaminopimelate decarboxylase (lysA)

Products: NA

Alternate protein names: DAP decarboxylase

Number of amino acids: Translated: 419; Mature: 419

Protein sequence:

>419_residues
MFSTSDGILTVEGVKVTEIVRETGTPVYVTSRALLERNLEAYKKAFSNEGLLYAVKANNNLALMRIIASHGFGADVFSDG
ELYLASLAGFRKDMVLFNGNSKSRKEIEMGVTAGVKFSVDSLDELRTISKIAKEVGKEVEIAFRVNPDVDPKTHPKIATG
LRESKFGIPHEMVREAYEMALKLDGVVPVGIHCHIGSQILDLSPFVHALNKVMDIAVDIEKLGVELSFVDMGGGLGIDYE
GKGAPTPKDLASAILPEFEGRKADLTSDPQLWLEPGRSIVGNTTVLITRVNAVKKGYKNFVAVDAGFNVLIRPAMYGSYH
RVAVANKMDAEPEEVYTVVGPICESGDVLARDRKLPKVEVGDLIAVFDAGAYGFVMSSQYNGRPRCAEVLVSGDRWDVIR
EKESYGDLIEKQRLPEWLL

Sequences:

>Translated_419_residues
MFSTSDGILTVEGVKVTEIVRETGTPVYVTSRALLERNLEAYKKAFSNEGLLYAVKANNNLALMRIIASHGFGADVFSDG
ELYLASLAGFRKDMVLFNGNSKSRKEIEMGVTAGVKFSVDSLDELRTISKIAKEVGKEVEIAFRVNPDVDPKTHPKIATG
LRESKFGIPHEMVREAYEMALKLDGVVPVGIHCHIGSQILDLSPFVHALNKVMDIAVDIEKLGVELSFVDMGGGLGIDYE
GKGAPTPKDLASAILPEFEGRKADLTSDPQLWLEPGRSIVGNTTVLITRVNAVKKGYKNFVAVDAGFNVLIRPAMYGSYH
RVAVANKMDAEPEEVYTVVGPICESGDVLARDRKLPKVEVGDLIAVFDAGAYGFVMSSQYNGRPRCAEVLVSGDRWDVIR
EKESYGDLIEKQRLPEWLL
>Mature_419_residues
MFSTSDGILTVEGVKVTEIVRETGTPVYVTSRALLERNLEAYKKAFSNEGLLYAVKANNNLALMRIIASHGFGADVFSDG
ELYLASLAGFRKDMVLFNGNSKSRKEIEMGVTAGVKFSVDSLDELRTISKIAKEVGKEVEIAFRVNPDVDPKTHPKIATG
LRESKFGIPHEMVREAYEMALKLDGVVPVGIHCHIGSQILDLSPFVHALNKVMDIAVDIEKLGVELSFVDMGGGLGIDYE
GKGAPTPKDLASAILPEFEGRKADLTSDPQLWLEPGRSIVGNTTVLITRVNAVKKGYKNFVAVDAGFNVLIRPAMYGSYH
RVAVANKMDAEPEEVYTVVGPICESGDVLARDRKLPKVEVGDLIAVFDAGAYGFVMSSQYNGRPRCAEVLVSGDRWDVIR
EKESYGDLIEKQRLPEWLL

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family

Homologues:

Organism=Homo sapiens, GI4505489, Length=391, Percent_Identity=24.5524296675192, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI22538418, Length=372, Percent_Identity=24.7311827956989, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI21361583, Length=372, Percent_Identity=24.7311827956989, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1789203, Length=427, Percent_Identity=32.3185011709602, Blast_Score=176, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17562780, Length=390, Percent_Identity=27.1794871794872, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24586472, Length=358, Percent_Identity=22.6256983240223, Blast_Score=80, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCDA_ARCFU (O29458)

Other databases:

- EMBL:   AE000782
- PIR:   H69349
- RefSeq:   NP_069634.1
- ProteinModelPortal:   O29458
- SMR:   O29458
- GeneID:   1484018
- GenomeReviews:   AE000782_GR
- KEGG:   afu:AF0800
- NMPDR:   fig|224325.1.peg.793
- TIGR:   AF_0800
- HOGENOM:   HBG672375
- OMA:   GADVFSA
- ProtClustDB:   CLSK862636
- BioCyc:   AFUL224325:AF_0800-MONOMER
- BRENDA:   4.1.1.20
- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183
- Gene3D:   G3DSA:2.40.37.10
- PRINTS:   PR01181
- PRINTS:   PR01179
- TIGRFAMs:   TIGR01048

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC; SSF50621 Racem_decarbox_C

EC number: =4.1.1.20

Molecular weight: Translated: 45872; Mature: 45872

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: PS00878 ODR_DC_2_1; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSTSDGILTVEGVKVTEIVRETGTPVYVTSRALLERNLEAYKKAFSNEGLLYAVKANNN
CCCCCCCEEEECCCHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHCCCCEEEEEECCCC
LALMRIIASHGFGADVFSDGELYLASLAGFRKDMVLFNGNSKSRKEIEMGVTAGVKFSVD
EEEEEEEHHCCCCCCCCCCCCCHHHHHHCCCCCEEEEECCCCCCHHEEECEECCEEEECC
SLDELRTISKIAKEVGKEVEIAFRVNPDVDPKTHPKIATGLRESKFGIPHEMVREAYEMA
CHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCHHHHCCCHHCCCCCHHHHHHHHHHH
LKLDGVVPVGIHCHIGSQILDLSPFVHALNKVMDIAVDIEKLGVELSFVDMGGGLGIDYE
HHCCCCEEEEEEEECCCHHHHCCHHHHHHHHHHHHHHHHHHHCEEEEEEECCCCCCCCCC
GKGAPTPKDLASAILPEFEGRKADLTSDPQLWLEPGRSIVGNTTVLITRVNAVKKGYKNF
CCCCCCHHHHHHHHCCCCCCCCCCCCCCCCHHCCCCCCHHCCCEEEEEEHHHHHHCHHCE
VAVDAGFNVLIRPAMYGSYHRVAVANKMDAEPEEVYTVVGPICESGDVLARDRKLPKVEV
EEEECCCCEEEEECCCCCCEEEEECCCCCCCHHHHHHHCCCCCCCCCEEECCCCCCCCCC
GDLIAVFDAGAYGFVMSSQYNGRPRCAEVLVSGDRWDVIREKESYGDLIEKQRLPEWLL
CCEEEEEECCCEEEEEECCCCCCCHHHHHEECCCCCHHHHCHHHHHHHHHHHCCCHHCC
>Mature Secondary Structure
MFSTSDGILTVEGVKVTEIVRETGTPVYVTSRALLERNLEAYKKAFSNEGLLYAVKANNN
CCCCCCCEEEECCCHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHCCCCEEEEEECCCC
LALMRIIASHGFGADVFSDGELYLASLAGFRKDMVLFNGNSKSRKEIEMGVTAGVKFSVD
EEEEEEEHHCCCCCCCCCCCCCHHHHHHCCCCCEEEEECCCCCCHHEEECEECCEEEECC
SLDELRTISKIAKEVGKEVEIAFRVNPDVDPKTHPKIATGLRESKFGIPHEMVREAYEMA
CHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCHHHHCCCHHCCCCCHHHHHHHHHHH
LKLDGVVPVGIHCHIGSQILDLSPFVHALNKVMDIAVDIEKLGVELSFVDMGGGLGIDYE
HHCCCCEEEEEEEECCCHHHHCCHHHHHHHHHHHHHHHHHHHCEEEEEEECCCCCCCCCC
GKGAPTPKDLASAILPEFEGRKADLTSDPQLWLEPGRSIVGNTTVLITRVNAVKKGYKNF
CCCCCCHHHHHHHHCCCCCCCCCCCCCCCCHHCCCCCCHHCCCEEEEEEHHHHHHCHHCE
VAVDAGFNVLIRPAMYGSYHRVAVANKMDAEPEEVYTVVGPICESGDVLARDRKLPKVEV
EEEECCCCEEEEECCCCCCEEEEECCCCCCCHHHHHHHCCCCCCCCCEEECCCCCCCCCC
GDLIAVFDAGAYGFVMSSQYNGRPRCAEVLVSGDRWDVIREKESYGDLIEKQRLPEWLL
CCEEEEEECCCEEEEEECCCCCCCHHHHHEECCCCCHHHHCHHHHHHHHHHHCCCHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9389475