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The map label for this gene is lysC

Identifier: 11498307

GI number: 11498307

Start: 631671

End: 633059

Strand: Reverse

Name: lysC

Synonym: AF0700

Alternate gene names: 11498307

Gene position: 633059-631671 (Counterclockwise)

Preceding gene: 11498308

Following gene: 11498306

Centisome position: 29.06

GC content: 51.48

Gene sequence:

>1389_bases
ATGAGAATCGTAATGAAGTTCGGAGGAGTGAGCGTTAAAGATGGGGAAAACATTTACCATTGCGCTAATCTCGTTAAAAA
GTTCTCGGAGGGAAATGAAGTTGTAGTCGTTGTCTCAGCGATGCAGGGTGTGACTGATGCACTTTTAAAGGCCGCGCACC
GCTGCTGCTCTGAACCATCTGCCGGATTCATCAAGATGTTCATCGCGGATATGATGAAGAGACACTACGAGGCGATCGAG
TATGCGGTCAGGAACGACGAAATCAAGGCAAAGGTGATTGCAGCTGTAGAGCGACTTCTTGATGAGCTTGAAAAGGTTCT
CCTCGGAATCAGCTACCTTGGCGAGCTTACGAGGAGAAGTGAGGACTATATAGTCTCCTTCGGCGAGAGGCTCTCAGCTC
CAATATTTTCAGCAGCCCTTCTTTCCCTCGGCGTTGATTCTGTAGCTCTCACTGGAGGGGATGCAGGAATAATCACGGAC
AGGAACTTTGGGAGGGCAAAGCCGCTTCCCGGGGTTTACACAACAATCAGAAACAGGCTTGAGCCTTTGCTGACGATAAA
GAAAACTATTCCCGTCGTTACGGGCTTCATAGGCGCAACGGATGACGGCAGCATAACAACCCTCGGCAGAGGAGGGAGCG
ACTACACCGCAACAATACTCGCCGCAGCCCTTGACGCGGACGAGGTGTGGCTGTGGAAGGAAGTTGACGGAATAATGACC
TGCGACCCCAAGTACGTGCCCAATGCGAGGGTGATTCCGGAGATATCCTATCAGGAGGCAATGGAGCTGTCCCACTTCGG
AGCAAAGATACTTCACCCGAGAGCCTTGGAGCCGGTGATGAGGAAGAACATTCCAGTAAGAATCAAGAACACCTTCAACC
CCGATGCTCCGGGAACCGTGATTGGCCCGACAACGAAGGATTCAAGCGAGATAGTGAAGGCTTTAAGCCTCATTCCGCAG
GCGGGGATAGTCAACGTCAGCGGTGCGGGCTTCGATTTTGCGGAGATAATGTCGGAGGTTTTTGGCAGACTTGCTGAGGA
GAGGGTAAACGTCATTATGGTAGCTCAGAGCTCCTCAGAGCTGAATCTGTCGATAGTGGTCGATATCCGGGACTTGGAGA
AGGCCTACAACGCCCTGAAAAGCTTGGAAAACGGCGTGATAAAGGTCGAAAAGATTCCCTACATAGCGGTCGTGAGCGCA
GTTGGTTCGGGAATGGCTGGAACGCCGGGCGTTGCAGGAAAGATTTTCTCAGCGCTTGGCAAGAACGGAATAAACGTAAT
AATGATCAGCCAGAGCTGCTCTGAGTACAACGTTTCGTTCGTCGTTGACGGTAGCGATGGCGTTAATGCTGTGAAGGTAG
TGCACGATGAGTTCGGGCTCGGCAATTAA

Upstream 100 bases:

>100_bases
ATAAACTTGATTATGAAAAATGTAGAAAGCTCTTTTACAGGTTCTGGAGCCCCAGATAGCTCAGCAAGATTTATATTTCT
TGCTTAGGGCAGGAAATAGG

Downstream 100 bases:

>100_bases
CCTGCTGAGGGAGAGGGCAAGGAGGGCTGCCGACCTCGTTGCAAGGCACGACTTCATCAGAATATACACACACCATGATG
CAGATGGAATCTCAGCTGGT

Product: aspartate kinase

Products: NA

Alternate protein names: Aspartate kinase [H]

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MRIVMKFGGVSVKDGENIYHCANLVKKFSEGNEVVVVVSAMQGVTDALLKAAHRCCSEPSAGFIKMFIADMMKRHYEAIE
YAVRNDEIKAKVIAAVERLLDELEKVLLGISYLGELTRRSEDYIVSFGERLSAPIFSAALLSLGVDSVALTGGDAGIITD
RNFGRAKPLPGVYTTIRNRLEPLLTIKKTIPVVTGFIGATDDGSITTLGRGGSDYTATILAAALDADEVWLWKEVDGIMT
CDPKYVPNARVIPEISYQEAMELSHFGAKILHPRALEPVMRKNIPVRIKNTFNPDAPGTVIGPTTKDSSEIVKALSLIPQ
AGIVNVSGAGFDFAEIMSEVFGRLAEERVNVIMVAQSSSELNLSIVVDIRDLEKAYNALKSLENGVIKVEKIPYIAVVSA
VGSGMAGTPGVAGKIFSALGKNGINVIMISQSCSEYNVSFVVDGSDGVNAVKVVHDEFGLGN

Sequences:

>Translated_462_residues
MRIVMKFGGVSVKDGENIYHCANLVKKFSEGNEVVVVVSAMQGVTDALLKAAHRCCSEPSAGFIKMFIADMMKRHYEAIE
YAVRNDEIKAKVIAAVERLLDELEKVLLGISYLGELTRRSEDYIVSFGERLSAPIFSAALLSLGVDSVALTGGDAGIITD
RNFGRAKPLPGVYTTIRNRLEPLLTIKKTIPVVTGFIGATDDGSITTLGRGGSDYTATILAAALDADEVWLWKEVDGIMT
CDPKYVPNARVIPEISYQEAMELSHFGAKILHPRALEPVMRKNIPVRIKNTFNPDAPGTVIGPTTKDSSEIVKALSLIPQ
AGIVNVSGAGFDFAEIMSEVFGRLAEERVNVIMVAQSSSELNLSIVVDIRDLEKAYNALKSLENGVIKVEKIPYIAVVSA
VGSGMAGTPGVAGKIFSALGKNGINVIMISQSCSEYNVSFVVDGSDGVNAVKVVHDEFGLGN
>Mature_462_residues
MRIVMKFGGVSVKDGENIYHCANLVKKFSEGNEVVVVVSAMQGVTDALLKAAHRCCSEPSAGFIKMFIADMMKRHYEAIE
YAVRNDEIKAKVIAAVERLLDELEKVLLGISYLGELTRRSEDYIVSFGERLSAPIFSAALLSLGVDSVALTGGDAGIITD
RNFGRAKPLPGVYTTIRNRLEPLLTIKKTIPVVTGFIGATDDGSITTLGRGGSDYTATILAAALDADEVWLWKEVDGIMT
CDPKYVPNARVIPEISYQEAMELSHFGAKILHPRALEPVMRKNIPVRIKNTFNPDAPGTVIGPTTKDSSEIVKALSLIPQ
AGIVNVSGAGFDFAEIMSEVFGRLAEERVNVIMVAQSSSELNLSIVVDIRDLEKAYNALKSLENGVIKVEKIPYIAVVSA
VGSGMAGTPGVAGKIFSALGKNGINVIMISQSCSEYNVSFVVDGSDGVNAVKVVHDEFGLGN

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=474, Percent_Identity=31.8565400843882, Blast_Score=230, Evalue=1e-61,
Organism=Escherichia coli, GI1790455, Length=469, Percent_Identity=30.9168443496802, Blast_Score=166, Evalue=4e-42,
Organism=Escherichia coli, GI1790376, Length=474, Percent_Identity=24.8945147679325, Blast_Score=99, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6320893, Length=502, Percent_Identity=29.8804780876494, Blast_Score=201, Evalue=2e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 49590; Mature: 49590

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIVMKFGGVSVKDGENIYHCANLVKKFSEGNEVVVVVSAMQGVTDALLKAAHRCCSEPS
CEEEEEECCEEECCCCCHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHCCCC
AGFIKMFIADMMKRHYEAIEYAVRNDEIKAKVIAAVERLLDELEKVLLGISYLGELTRRS
CHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
EDYIVSFGERLSAPIFSAALLSLGVDSVALTGGDAGIITDRNFGRAKPLPGVYTTIRNRL
CHHHEEHHHHHCCHHHHHHHHHCCCCCEEEECCCCEEEECCCCCCCCCCCHHHHHHHHHH
EPLLTIKKTIPVVTGFIGATDDGSITTLGRGGSDYTATILAAALDADEVWLWKEVDGIMT
HHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHCCCCCEEEEEECCCEEE
CDPKYVPNARVIPEISYQEAMELSHFGAKILHPRALEPVMRKNIPVRIKNTFNPDAPGTV
CCCCCCCCCCCCCCCCHHHHHHHHHCCHHHCCCHHHHHHHHCCCCEEEECCCCCCCCCCE
IGPTTKDSSEIVKALSLIPQAGIVNVSGAGFDFAEIMSEVFGRLAEERVNVIMVAQSSSE
ECCCCCCHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCC
LNLSIVVDIRDLEKAYNALKSLENGVIKVEKIPYIAVVSAVGSGMAGTPGVAGKIFSALG
EEEEEEEEHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHCCCCCCCCCHHHHHHHHHC
KNGINVIMISQSCSEYNVSFVVDGSDGVNAVKVVHDEFGLGN
CCCCEEEEEECCCCCCCEEEEEECCCCCCEEEEEECCCCCCC
>Mature Secondary Structure
MRIVMKFGGVSVKDGENIYHCANLVKKFSEGNEVVVVVSAMQGVTDALLKAAHRCCSEPS
CEEEEEECCEEECCCCCHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHCCCC
AGFIKMFIADMMKRHYEAIEYAVRNDEIKAKVIAAVERLLDELEKVLLGISYLGELTRRS
CHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
EDYIVSFGERLSAPIFSAALLSLGVDSVALTGGDAGIITDRNFGRAKPLPGVYTTIRNRL
CHHHEEHHHHHCCHHHHHHHHHCCCCCEEEECCCCEEEECCCCCCCCCCCHHHHHHHHHH
EPLLTIKKTIPVVTGFIGATDDGSITTLGRGGSDYTATILAAALDADEVWLWKEVDGIMT
HHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHCCCCCEEEEEECCCEEE
CDPKYVPNARVIPEISYQEAMELSHFGAKILHPRALEPVMRKNIPVRIKNTFNPDAPGTV
CCCCCCCCCCCCCCCCHHHHHHHHHCCHHHCCCHHHHHHHHCCCCEEEECCCCCCCCCCE
IGPTTKDSSEIVKALSLIPQAGIVNVSGAGFDFAEIMSEVFGRLAEERVNVIMVAQSSSE
ECCCCCCHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCC
LNLSIVVDIRDLEKAYNALKSLENGVIKVEKIPYIAVVSAVGSGMAGTPGVAGKIFSALG
EEEEEEEEHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHCCCCCCCCCHHHHHHHHHC
KNGINVIMISQSCSEYNVSFVVDGSDGVNAVKVVHDEFGLGN
CCCCEEEEEECCCCCCCEEEEEECCCCCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]