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The map label for this gene is acd-4

Identifier: 11498279

GI number: 11498279

Start: 604076

End: 605320

Strand: Reverse

Name: acd-4

Synonym: AF0671

Alternate gene names: 11498279

Gene position: 605320-604076 (Counterclockwise)

Preceding gene: 11498280

Following gene: 11498274

Centisome position: 27.79

GC content: 53.17

Gene sequence:

>1245_bases
ATGCTCGAAAACGACGCCCTTCTTACTGAAGAGGAGATTAAGATAAGGGAGGAGGCAAAGGAGCTTGTTAATGCTATTGA
CCCCGAGCTTCTGAGGAAAATGGACAGGGATGAGGTTGACTACCCCTTCGAGTTTCTTGAGGAAGCTGCGAAGAGGAAAA
TGCTTGGATTGAGATTTCCGGAAGAGTACGGGGGGAGAGGGCTTAGCTGGACTGCTGAGAGCGTTGCTGTTGAGGAGGTT
GGCGTTCTGGGCAACGGAATAGGGTGCAGTTATGCGATGGTCAGCATTGTTGGGGAAGCAATTTACCGCTTCGGTCAGGA
GTGGCAGAAGGAGGAGTTTCTGAAGCCGATAATAAAGGGTAAGAAAGTCTCTGCCGAAGGACTGACGGAGCCGAGAGGAG
GGAGCGACTTCTTCGGAACAACAACGAGGGCGGAGAAGAAGGGGAATGTGTGGGTGCTGAATGGTGCGAAGAGGTTCATA
GCTGGTGGCAAGGTAGCGGACTTCTACCTGATTTACGCCAGAACTGATCCAACTGCTCCAGGCCACAAGGCCCTTACAGC
TTTTCTGGTTGAGAGGGACATGGGCGTTGAGGTGGAGGAGCTCTACAACCTCCTCGGCTTCAGGGGAATGGGGACTGCGA
GGATTGTGTTTAAGGATGTTGAAGTGCCAGATGAGTACAGGCTGGGAGAGGTTAATGGGGCCAGAGTGATTTTCAACAGG
ATGATGATTCCCGAAAGGATGACCTCCGCTGCAGGAGCGCTTGGAACCGCAAGGGCGGCGCTGGAGGTGGCGGTGAAGTA
CTCCAACAAAAGGAAAGCCTTCGGCAGGAAAATAAGGGAGTTTCAGGGAGTCAACTTCATGGTTGCTGAGGCTGTGACGA
AGCTTGACGCTGCAAGGGCTTTAACCTACAACGCTGCGAGGGCTGTGGACCTCTACGATGCGGGAAAGGGCCCCGACCCA
AGAAGGCTGGTCAGCGAGGCGAAGTACTTTGCAACCGACGTAGGATGGGATGTTGTCAACAAAGCAATGCAGATTCTCGG
TGGAATAGGCTACACCCAGGTTTATCCGGTCGAGAGGATGCTGAGAGACATGCGTCTCGCCCCTATATGGACTGGCAGCA
ACGAAATCATGAAGGTGCTGATACAGCACGAAACCTACAAGATGATGGGGCTGCCGTCAAAGGACAGGGATGTTGAGAAG
GACGCGATGGACTGGTACAAGGAGTGGGAGAAGGTTTACGAGTGA

Upstream 100 bases:

>100_bases
TTCCGGAGGAAATTGCGATTGTTGATGATATGCCTCTCACGAGCACGGGAAAAATTAACAAACTTTCGTTAAGAAAAATG
CTGTTGGAGAGGTGATGTAA

Downstream 100 bases:

>100_bases
CTTACAGCAAACTCCTCGGTATCAGCCCCTGCATCAGCATGCAGTCGGCCAAAACCAAAGCCACCATTGCCTCAACCACG
GGCACGGCCCTTGGAACTAT

Product: acyl-CoA dehydrogenase (acd-4)

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 414; Mature: 414

Protein sequence:

>414_residues
MLENDALLTEEEIKIREEAKELVNAIDPELLRKMDRDEVDYPFEFLEEAAKRKMLGLRFPEEYGGRGLSWTAESVAVEEV
GVLGNGIGCSYAMVSIVGEAIYRFGQEWQKEEFLKPIIKGKKVSAEGLTEPRGGSDFFGTTTRAEKKGNVWVLNGAKRFI
AGGKVADFYLIYARTDPTAPGHKALTAFLVERDMGVEVEELYNLLGFRGMGTARIVFKDVEVPDEYRLGEVNGARVIFNR
MMIPERMTSAAGALGTARAALEVAVKYSNKRKAFGRKIREFQGVNFMVAEAVTKLDAARALTYNAARAVDLYDAGKGPDP
RRLVSEAKYFATDVGWDVVNKAMQILGGIGYTQVYPVERMLRDMRLAPIWTGSNEIMKVLIQHETYKMMGLPSKDRDVEK
DAMDWYKEWEKVYE

Sequences:

>Translated_414_residues
MLENDALLTEEEIKIREEAKELVNAIDPELLRKMDRDEVDYPFEFLEEAAKRKMLGLRFPEEYGGRGLSWTAESVAVEEV
GVLGNGIGCSYAMVSIVGEAIYRFGQEWQKEEFLKPIIKGKKVSAEGLTEPRGGSDFFGTTTRAEKKGNVWVLNGAKRFI
AGGKVADFYLIYARTDPTAPGHKALTAFLVERDMGVEVEELYNLLGFRGMGTARIVFKDVEVPDEYRLGEVNGARVIFNR
MMIPERMTSAAGALGTARAALEVAVKYSNKRKAFGRKIREFQGVNFMVAEAVTKLDAARALTYNAARAVDLYDAGKGPDP
RRLVSEAKYFATDVGWDVVNKAMQILGGIGYTQVYPVERMLRDMRLAPIWTGSNEIMKVLIQHETYKMMGLPSKDRDVEK
DAMDWYKEWEKVYE
>Mature_414_residues
MLENDALLTEEEIKIREEAKELVNAIDPELLRKMDRDEVDYPFEFLEEAAKRKMLGLRFPEEYGGRGLSWTAESVAVEEV
GVLGNGIGCSYAMVSIVGEAIYRFGQEWQKEEFLKPIIKGKKVSAEGLTEPRGGSDFFGTTTRAEKKGNVWVLNGAKRFI
AGGKVADFYLIYARTDPTAPGHKALTAFLVERDMGVEVEELYNLLGFRGMGTARIVFKDVEVPDEYRLGEVNGARVIFNR
MMIPERMTSAAGALGTARAALEVAVKYSNKRKAFGRKIREFQGVNFMVAEAVTKLDAARALTYNAARAVDLYDAGKGPDP
RRLVSEAKYFATDVGWDVVNKAMQILGGIGYTQVYPVERMLRDMRLAPIWTGSNEIMKVLIQHETYKMMGLPSKDRDVEK
DAMDWYKEWEKVYE

Specific function: Unknown

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI226958412, Length=379, Percent_Identity=32.7176781002639, Blast_Score=199, Evalue=5e-51,
Organism=Homo sapiens, GI4501859, Length=379, Percent_Identity=32.1899736147757, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI226958414, Length=341, Percent_Identity=33.1378299120235, Blast_Score=193, Evalue=2e-49,
Organism=Homo sapiens, GI187960098, Length=373, Percent_Identity=33.7801608579088, Blast_Score=182, Evalue=5e-46,
Organism=Homo sapiens, GI4557231, Length=373, Percent_Identity=33.7801608579088, Blast_Score=182, Evalue=5e-46,
Organism=Homo sapiens, GI7656849, Length=351, Percent_Identity=33.9031339031339, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI4557233, Length=352, Percent_Identity=32.9545454545455, Blast_Score=176, Evalue=2e-44,
Organism=Homo sapiens, GI21361497, Length=359, Percent_Identity=33.983286908078, Blast_Score=171, Evalue=8e-43,
Organism=Homo sapiens, GI4501857, Length=349, Percent_Identity=32.6647564469914, Blast_Score=162, Evalue=7e-40,
Organism=Homo sapiens, GI76496475, Length=389, Percent_Identity=30.8483290488432, Blast_Score=159, Evalue=5e-39,
Organism=Homo sapiens, GI4557235, Length=389, Percent_Identity=30.8483290488432, Blast_Score=159, Evalue=5e-39,
Organism=Homo sapiens, GI4503943, Length=382, Percent_Identity=26.1780104712042, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI7669494, Length=360, Percent_Identity=27.2222222222222, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI38505218, Length=289, Percent_Identity=27.681660899654, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI48976061, Length=291, Percent_Identity=25.7731958762887, Blast_Score=86, Evalue=8e-17,
Organism=Homo sapiens, GI211971008, Length=291, Percent_Identity=25.7731958762887, Blast_Score=85, Evalue=1e-16,
Organism=Escherichia coli, GI87081958, Length=382, Percent_Identity=31.151832460733, Blast_Score=142, Evalue=5e-35,
Organism=Escherichia coli, GI1786223, Length=355, Percent_Identity=30.4225352112676, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI87082384, Length=262, Percent_Identity=29.7709923664122, Blast_Score=93, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17538396, Length=377, Percent_Identity=32.6259946949602, Blast_Score=201, Evalue=4e-52,
Organism=Caenorhabditis elegans, GI17569725, Length=383, Percent_Identity=32.1148825065274, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17534899, Length=388, Percent_Identity=32.2164948453608, Blast_Score=185, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI17570075, Length=384, Percent_Identity=31.7708333333333, Blast_Score=177, Evalue=9e-45,
Organism=Caenorhabditis elegans, GI17533517, Length=349, Percent_Identity=32.6647564469914, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17508101, Length=372, Percent_Identity=30.9139784946237, Blast_Score=169, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17506239, Length=375, Percent_Identity=28.5333333333333, Blast_Score=159, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI71985184, Length=351, Percent_Identity=29.0598290598291, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17505929, Length=332, Percent_Identity=28.9156626506024, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17551932, Length=354, Percent_Identity=28.8135593220339, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI71990804, Length=259, Percent_Identity=31.6602316602317, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI71982178, Length=276, Percent_Identity=32.2463768115942, Blast_Score=128, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI17534353, Length=379, Percent_Identity=26.1213720316623, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI71985192, Length=279, Percent_Identity=29.7491039426523, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI32563615, Length=247, Percent_Identity=27.1255060728745, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17531909, Length=237, Percent_Identity=29.535864978903, Blast_Score=92, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI86563381, Length=274, Percent_Identity=27.3722627737226, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI86563383, Length=274, Percent_Identity=27.3722627737226, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24646207, Length=386, Percent_Identity=30.8290155440415, Blast_Score=186, Evalue=3e-47,
Organism=Drosophila melanogaster, GI24660351, Length=387, Percent_Identity=32.0413436692506, Blast_Score=180, Evalue=2e-45,
Organism=Drosophila melanogaster, GI21356377, Length=381, Percent_Identity=31.496062992126, Blast_Score=178, Evalue=6e-45,
Organism=Drosophila melanogaster, GI21355753, Length=385, Percent_Identity=32.987012987013, Blast_Score=177, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24666513, Length=372, Percent_Identity=29.3010752688172, Blast_Score=167, Evalue=9e-42,
Organism=Drosophila melanogaster, GI281363737, Length=381, Percent_Identity=31.2335958005249, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI19920834, Length=387, Percent_Identity=28.1653746770026, Blast_Score=125, Evalue=6e-29,
Organism=Drosophila melanogaster, GI24652780, Length=368, Percent_Identity=22.2826086956522, Blast_Score=65, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.3

Molecular weight: Translated: 46604; Mature: 46604

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS00072 ACYL_COA_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLENDALLTEEEIKIREEAKELVNAIDPELLRKMDRDEVDYPFEFLEEAAKRKMLGLRFP
CCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCC
EEYGGRGLSWTAESVAVEEVGVLGNGIGCSYAMVSIVGEAIYRFGQEWQKEEFLKPIIKG
HHHCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KKVSAEGLTEPRGGSDFFGTTTRAEKKGNVWVLNGAKRFIAGGKVADFYLIYARTDPTAP
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCHHHHCCCCEEEEEEEEEECCCCCC
GHKALTAFLVERDMGVEVEELYNLLGFRGMGTARIVFKDVEVPDEYRLGEVNGARVIFNR
CHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHH
MMIPERMTSAAGALGTARAALEVAVKYSNKRKAFGRKIREFQGVNFMVAEAVTKLDAARA
HHCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
LTYNAARAVDLYDAGKGPDPRRLVSEAKYFATDVGWDVVNKAMQILGGIGYTQVYPVERM
HHHCCHHEEEHHCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHEHHHHHH
LRDMRLAPIWTGSNEIMKVLIQHETYKMMGLPSKDRDVEKDAMDWYKEWEKVYE
HHHCCCCEEEECHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLENDALLTEEEIKIREEAKELVNAIDPELLRKMDRDEVDYPFEFLEEAAKRKMLGLRFP
CCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCC
EEYGGRGLSWTAESVAVEEVGVLGNGIGCSYAMVSIVGEAIYRFGQEWQKEEFLKPIIKG
HHHCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KKVSAEGLTEPRGGSDFFGTTTRAEKKGNVWVLNGAKRFIAGGKVADFYLIYARTDPTAP
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCHHHHCCCCEEEEEEEEEECCCCCC
GHKALTAFLVERDMGVEVEELYNLLGFRGMGTARIVFKDVEVPDEYRLGEVNGARVIFNR
CHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHH
MMIPERMTSAAGALGTARAALEVAVKYSNKRKAFGRKIREFQGVNFMVAEAVTKLDAARA
HHCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
LTYNAARAVDLYDAGKGPDPRRLVSEAKYFATDVGWDVVNKAMQILGGIGYTQVYPVERM
HHHCCHHEEEHHCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHEHHHHHH
LRDMRLAPIWTGSNEIMKVLIQHETYKMMGLPSKDRDVEKDAMDWYKEWEKVYE
HHHCCCCEEEECHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]