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The map label for this gene is hdrA-1

Identifier: 11498271

GI number: 11498271

Start: 598729

End: 599943

Strand: Reverse

Name: hdrA-1

Synonym: AF0663

Alternate gene names: 11498271

Gene position: 599943-598729 (Counterclockwise)

Preceding gene: 11498274

Following gene: 11498270

Centisome position: 27.54

GC content: 50.29

Gene sequence:

>1215_bases
ATGGCTGGCGAAATACTTGTTATAGGAGGCGGAATTTCTGGACTGACTGCTGCTATAGAAGCTGCCGAAACGGGATATGA
TGTGATTCTCTTGGAAAAGAACCCGTACCTTGGCGGAAGAGTATCACAGCTGAACAAGTACTTCCCAAAGCTTTGCCCAC
CGTTCTGCGGGCTTGAAATCCTCTTCAAGAGAATGAAGAGCACACCAAAGCTGAAGTACTTCACAAACGCCGAGGTTCAG
GAGATAAGCGGAGAGTCGGGGAATTTTACGGTTAAAGTCAAACTCAAGCCGAGATACGTCAACGAGAACTGCACAGCATG
CGGGGCTTGCAAGGAGGTTTGCCCGATTGAGGCTCCGGACGAGTACAACTTCGGACTGAAAAAGAAGAAGGCCATCGATT
TGCCTAACATCATGGCGATGCCCTTCCAGTACTACATTGACGACAAATACTGCAATAAGTGCGGTGAATGCGTTTCTGCA
TGCAAGTACAACGCCATAGACCTCAATGAAGAGGAGAGGGAGATGACCCTGAATGTGTCATCCATAATTGTTGCGACAGG
CTGGAAGCCCTACGATGCAACCAAACTTGATAACCTCGGCTACGGAAAATACAAGAACGTCATAACCAACATGGAGATGG
AGAGGCTTGCATCGCCAAACGGGCCGACTGGTGGCGTTATTCAGACGATGGACGGTAAGCCAATAGAAACAATCGCATTC
GTTCAGTGCGCCGGAAGCAGGGATGAGAACCACCTGCCCTACTGCTCTGCAATCTGCTGCTTAGCGAGCTTGAAGCAGGC
AACCTATGTGAGGGAGCAGTATCCTGATGCGAAGATATACATCTTCTACATCGACATCAGAGCCTTTGGAAGATACGAGG
ACTTTTTCGCAAAAGTTAAGGCTGACGAAAAAATCGAACTCATCAAGGGAAAGGTTGCGAAGGTTGAGGAGGTTGACGGA
AAGCTTGTTGTGACTGCTGAAGACACGCTTACCGGTGTGAAAAGCAAGAAAGAGGTCGACATGGTTGTTCTCGCCACAGG
CATGCAGCCTGCCATCGAGCCCATTCCCGGGCTTGAGCTTGACGAGTATGGATTCGTTAAGCCAAAGCCGGGCATCATTC
CGGTAGGTGTTGCGGCGATGCCCATGGAGGTCGCCTCAGCCAACGAAACCGCAACGGCAGCAGCGCTGAAGGCTATTCAG
CTTGCAAGGAGGTGA

Upstream 100 bases:

>100_bases
CGGTTTCCAAAAATCCTGGATTTCGAATGTGGCTTAATTTCGATACATTTATTAACTTCTTTTCAAGCCAGAGGTTGAAA
CAGGCAATCAGGTGTTAGCT

Downstream 100 bases:

>100_bases
AATGATGGAGAAAGTTGGTGTTTACATCTGTACCGGTTGTGATATCGATAAGCTGGACATCGAAAGGCTGAAAAACGTTG
CAAAGGAGGAGTTTGGAATT

Product: heterodisulfide reductase, subunit A (hdrA-1)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 404; Mature: 403

Protein sequence:

>404_residues
MAGEILVIGGGISGLTAAIEAAETGYDVILLEKNPYLGGRVSQLNKYFPKLCPPFCGLEILFKRMKSTPKLKYFTNAEVQ
EISGESGNFTVKVKLKPRYVNENCTACGACKEVCPIEAPDEYNFGLKKKKAIDLPNIMAMPFQYYIDDKYCNKCGECVSA
CKYNAIDLNEEEREMTLNVSSIIVATGWKPYDATKLDNLGYGKYKNVITNMEMERLASPNGPTGGVIQTMDGKPIETIAF
VQCAGSRDENHLPYCSAICCLASLKQATYVREQYPDAKIYIFYIDIRAFGRYEDFFAKVKADEKIELIKGKVAKVEEVDG
KLVVTAEDTLTGVKSKKEVDMVVLATGMQPAIEPIPGLELDEYGFVKPKPGIIPVGVAAMPMEVASANETATAAALKAIQ
LARR

Sequences:

>Translated_404_residues
MAGEILVIGGGISGLTAAIEAAETGYDVILLEKNPYLGGRVSQLNKYFPKLCPPFCGLEILFKRMKSTPKLKYFTNAEVQ
EISGESGNFTVKVKLKPRYVNENCTACGACKEVCPIEAPDEYNFGLKKKKAIDLPNIMAMPFQYYIDDKYCNKCGECVSA
CKYNAIDLNEEEREMTLNVSSIIVATGWKPYDATKLDNLGYGKYKNVITNMEMERLASPNGPTGGVIQTMDGKPIETIAF
VQCAGSRDENHLPYCSAICCLASLKQATYVREQYPDAKIYIFYIDIRAFGRYEDFFAKVKADEKIELIKGKVAKVEEVDG
KLVVTAEDTLTGVKSKKEVDMVVLATGMQPAIEPIPGLELDEYGFVKPKPGIIPVGVAAMPMEVASANETATAAALKAIQ
LARR
>Mature_403_residues
AGEILVIGGGISGLTAAIEAAETGYDVILLEKNPYLGGRVSQLNKYFPKLCPPFCGLEILFKRMKSTPKLKYFTNAEVQE
ISGESGNFTVKVKLKPRYVNENCTACGACKEVCPIEAPDEYNFGLKKKKAIDLPNIMAMPFQYYIDDKYCNKCGECVSAC
KYNAIDLNEEEREMTLNVSSIIVATGWKPYDATKLDNLGYGKYKNVITNMEMERLASPNGPTGGVIQTMDGKPIETIAFV
QCAGSRDENHLPYCSAICCLASLKQATYVREQYPDAKIYIFYIDIRAFGRYEDFFAKVKADEKIELIKGKVAKVEEVDGK
LVVTAEDTLTGVKSKKEVDMVVLATGMQPAIEPIPGLELDEYGFVKPKPGIIPVGVAAMPMEVASANETATAAALKAIQL
ARR

Specific function: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). May act as the catalytic subunit [H]

COG id: COG1148

COG function: function code C; Heterodisulfide reductase, subunit A and related polyferredoxins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 4 4Fe-4S ferredoxin-type domains [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001450
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR003953
- InterPro:   IPR012285 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF00037 Fer4 [H]

EC number: =1.8.98.1 [H]

Molecular weight: Translated: 44361; Mature: 44230

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
3.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGEILVIGGGISGLTAAIEAAETGYDVILLEKNPYLGGRVSQLNKYFPKLCPPFCGLEI
CCCCEEEEECCHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCHHH
LFKRMKSTPKLKYFTNAEVQEISGESGNFTVKVKLKPRYVNENCTACGACKEVCPIEAPD
HHHHHCCCCCEEEECCCHHHHCCCCCCCEEEEEEEECEECCCCCCHHHHHHHCCCCCCCC
EYNFGLKKKKAIDLPNIMAMPFQYYIDDKYCNKCGECVSACKYNAIDLNEEEREMTLNVS
CCCCCCCCCCCCCCCCHHCCCEEEEECHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEE
SIIVATGWKPYDATKLDNLGYGKYKNVITNMEMERLASPNGPTGGVIQTMDGKPIETIAF
EEEEEECCCCCCCCCCCCCCCCHHHHHHHCCHHHHHCCCCCCCCCEEEECCCCCCCEEEE
VQCAGSRDENHLPYCSAICCLASLKQATYVREQYPDAKIYIFYIDIRAFGRYEDFFAKVK
EEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEECCCHHHHHHHHC
ADEKIELIKGKVAKVEEVDGKLVVTAEDTLTGVKSKKEVDMVVLATGMQPAIEPIPGLEL
CCCEEEEHHCCHHHHEECCCEEEEEECHHHHCCCCCCCCCEEEEECCCCCCCCCCCCCCC
DEYGFVKPKPGIIPVGVAAMPMEVASANETATAAALKAIQLARR
CCCCCCCCCCCEEECCHHHCCHHHHCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AGEILVIGGGISGLTAAIEAAETGYDVILLEKNPYLGGRVSQLNKYFPKLCPPFCGLEI
CCCEEEEECCHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCHHH
LFKRMKSTPKLKYFTNAEVQEISGESGNFTVKVKLKPRYVNENCTACGACKEVCPIEAPD
HHHHHCCCCCEEEECCCHHHHCCCCCCCEEEEEEEECEECCCCCCHHHHHHHCCCCCCCC
EYNFGLKKKKAIDLPNIMAMPFQYYIDDKYCNKCGECVSACKYNAIDLNEEEREMTLNVS
CCCCCCCCCCCCCCCCHHCCCEEEEECHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEE
SIIVATGWKPYDATKLDNLGYGKYKNVITNMEMERLASPNGPTGGVIQTMDGKPIETIAF
EEEEEECCCCCCCCCCCCCCCCHHHHHHHCCHHHHHCCCCCCCCCEEEECCCCCCCEEEE
VQCAGSRDENHLPYCSAICCLASLKQATYVREQYPDAKIYIFYIDIRAFGRYEDFFAKVK
EEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEECCCHHHHHHHHC
ADEKIELIKGKVAKVEEVDGKLVVTAEDTLTGVKSKKEVDMVVLATGMQPAIEPIPGLEL
CCCEEEEHHCCHHHHEECCCEEEEEECHHHHCCCCCCCCCEEEEECCCCCCCCCCCCCCC
DEYGFVKPKPGIIPVGVAAMPMEVASANETATAAALKAIQLARR
CCCCCCCCCCCEEECCHHHCCHHHHCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9063468; 11930014 [H]