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The map label for this gene is srp54

Identifier: 11498230

GI number: 11498230

Start: 558670

End: 559971

Strand: Reverse

Name: srp54

Synonym: AF0622

Alternate gene names: 11498230

Gene position: 559971-558670 (Counterclockwise)

Preceding gene: 11498234

Following gene: 11498229

Centisome position: 25.71

GC content: 48.85

Gene sequence:

>1302_bases
ATGGCTCTTGAATCTCTCAAGGAAGTTGCAAGGAAAATTGCGGGGTCATCGAGCATTGATAAGAAATTCGTCGAGGAGAT
GGTTAAGGAGATACAGAGAGCCCTCATCAAGGCTGATGTCAATGTCAGGCAGGTTAAGGAAATCAGCGATGCGATAAAGA
AAAGGGCTCTAAGCGAGGACGTTCTTCCCGCTCTCAACGCAAAGGAGCAGATTCTCAAAATCGTTTACGAGGAGTTGCTC
AGGGGAGTGGGAGAGGGGCTTGAGATACCGCTGAAAAAGGCCAAGATTATGCTCGTCGGTCTTCAGGGGAGCGGTAAGAC
CACAACAACGGCCAAAATGGCCAAATACTTCAAAGACAGGGGGATGAAGGTTGCTGTTGTTGCAGCCGACACATGGAGAC
CTGCAGCCTACGAGCAGCTAAGGCAGCTTGCGGAGGAGTACGGAATAACGTTCTACGGCGAGAAGGGGGAAAAAGATGCG
GTCAAAATAGTCAAAAACGCGCTGGAAAAGCTCAAAGACCACGACATGATAATCATAGACACAGCCGGAAGGCATGCGCT
CGAAGATGAGCTGATTGATGAGATGATAAAGATTGCAGAGGTTGCGAGGCCGGACTACAAGCTGCTCGTGCTTGATGCAG
CGATAGGCCAGCTTGCAAGCAAGCAAGCTCAGGCGTTTCACGAGGCTATAGGAATCAATGGCATAATCATCACGAAGTTC
GATGGAACGGCGAAGGGTGGTGGTGCTTTGTCGGCAGCGAGGCAGATTGGAATACCGATAGCATTCATAGGAACGGGAGA
GAAGGTGGAGGACTTCGAACGCTTTGATCCCGCTGGCTTCGTTTCGAGACTGCTTGGAATGGGAGATATCAAGGCGCTAA
TGGAGAAGATTGAGAGGATTGCAAGCGAGGAGGAGCTAGATCCTGAAGCATTCCTGAAGGGAACCTTCACGCTGAAAGAC
ATTTACAAGCAGATAGAGGCAATGAACAAAATGGGGCCGGTTAGAAAGATTTTCGAGATGCTCCCCTTTGGCCTGGGATT
GAAGGTTGATAATGACGTAATGGAGATGACGCAGGAGAAAATGAAGAAATTCAGAGTGATTATGGATTCGATGACTGAGG
AGGAGTTGCTGAATCCAAAAATCATCGATTCTTCGAGGATAAGGAGGATAGCAATCGGGAGCGGAACCTCTCCTCAGGAG
GTCAAGGAGCTTCTGAACTACTACAAGACGATGAAGAACCTTATGAAGAAGATGAAGAAGAACAAGCTGCCAATAAAGGG
TCTGGGGAAGCTGGGTTTCTGA

Upstream 100 bases:

>100_bases
GAACTCGGCAAACTCGGCAAACAACATCATCGATTTTAGTCTGCCTGGTTCAATAAAATACTATCGCCAACCTTTTAATA
CTTCCTGCTTAGTTATATCA

Downstream 100 bases:

>100_bases
TGAAGGCAGGCATCGATGAGGCTGGAAAGGGCTGCGTCATCGGCCCACTGGTTGTTGCAGGAGTGGCTTGCAGCGATGAG
GATAGGCTGAGAAAGCTTGG

Product: signal recognition particle protein Srp54

Products: NA

Alternate protein names: SRP54

Number of amino acids: Translated: 433; Mature: 432

Protein sequence:

>433_residues
MALESLKEVARKIAGSSSIDKKFVEEMVKEIQRALIKADVNVRQVKEISDAIKKRALSEDVLPALNAKEQILKIVYEELL
RGVGEGLEIPLKKAKIMLVGLQGSGKTTTTAKMAKYFKDRGMKVAVVAADTWRPAAYEQLRQLAEEYGITFYGEKGEKDA
VKIVKNALEKLKDHDMIIIDTAGRHALEDELIDEMIKIAEVARPDYKLLVLDAAIGQLASKQAQAFHEAIGINGIIITKF
DGTAKGGGALSAARQIGIPIAFIGTGEKVEDFERFDPAGFVSRLLGMGDIKALMEKIERIASEEELDPEAFLKGTFTLKD
IYKQIEAMNKMGPVRKIFEMLPFGLGLKVDNDVMEMTQEKMKKFRVIMDSMTEEELLNPKIIDSSRIRRIAIGSGTSPQE
VKELLNYYKTMKNLMKKMKKNKLPIKGLGKLGF

Sequences:

>Translated_433_residues
MALESLKEVARKIAGSSSIDKKFVEEMVKEIQRALIKADVNVRQVKEISDAIKKRALSEDVLPALNAKEQILKIVYEELL
RGVGEGLEIPLKKAKIMLVGLQGSGKTTTTAKMAKYFKDRGMKVAVVAADTWRPAAYEQLRQLAEEYGITFYGEKGEKDA
VKIVKNALEKLKDHDMIIIDTAGRHALEDELIDEMIKIAEVARPDYKLLVLDAAIGQLASKQAQAFHEAIGINGIIITKF
DGTAKGGGALSAARQIGIPIAFIGTGEKVEDFERFDPAGFVSRLLGMGDIKALMEKIERIASEEELDPEAFLKGTFTLKD
IYKQIEAMNKMGPVRKIFEMLPFGLGLKVDNDVMEMTQEKMKKFRVIMDSMTEEELLNPKIIDSSRIRRIAIGSGTSPQE
VKELLNYYKTMKNLMKKMKKNKLPIKGLGKLGF
>Mature_432_residues
ALESLKEVARKIAGSSSIDKKFVEEMVKEIQRALIKADVNVRQVKEISDAIKKRALSEDVLPALNAKEQILKIVYEELLR
GVGEGLEIPLKKAKIMLVGLQGSGKTTTTAKMAKYFKDRGMKVAVVAADTWRPAAYEQLRQLAEEYGITFYGEKGEKDAV
KIVKNALEKLKDHDMIIIDTAGRHALEDELIDEMIKIAEVARPDYKLLVLDAAIGQLASKQAQAFHEAIGINGIIITKFD
GTAKGGGALSAARQIGIPIAFIGTGEKVEDFERFDPAGFVSRLLGMGDIKALMEKIERIASEEELDPEAFLKGTFTLKDI
YKQIEAMNKMGPVRKIFEMLPFGLGLKVDNDVMEMTQEKMKKFRVIMDSMTEEELLNPKIIDSSRIRRIAIGSGTSPQEV
KELLNYYKTMKNLMKKMKKNKLPIKGLGKLGF

Specific function: Binds to the signal sequence of presecretory protein when they emerge from the ribosomes

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family

Homologues:

Organism=Homo sapiens, GI4507215, Length=438, Percent_Identity=40.4109589041096, Blast_Score=307, Evalue=1e-83,
Organism=Homo sapiens, GI226371618, Length=396, Percent_Identity=41.4141414141414, Blast_Score=280, Evalue=2e-75,
Organism=Homo sapiens, GI89061728, Length=146, Percent_Identity=47.2602739726027, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI23308697, Length=317, Percent_Identity=25.2365930599369, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI295424842, Length=317, Percent_Identity=25.2365930599369, Blast_Score=91, Evalue=3e-18,
Organism=Escherichia coli, GI1788963, Length=419, Percent_Identity=36.7541766109785, Blast_Score=251, Evalue=5e-68,
Organism=Escherichia coli, GI1789874, Length=221, Percent_Identity=39.3665158371041, Blast_Score=149, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI17539958, Length=431, Percent_Identity=40.3712296983759, Blast_Score=306, Evalue=1e-83,
Organism=Caenorhabditis elegans, GI193206261, Length=211, Percent_Identity=31.2796208530806, Blast_Score=95, Evalue=9e-20,
Organism=Saccharomyces cerevisiae, GI6325345, Length=406, Percent_Identity=42.3645320197044, Blast_Score=294, Evalue=2e-80,
Organism=Saccharomyces cerevisiae, GI6320498, Length=330, Percent_Identity=25.4545454545455, Blast_Score=90, Evalue=7e-19,
Organism=Drosophila melanogaster, GI17647949, Length=450, Percent_Identity=39.1111111111111, Blast_Score=268, Evalue=4e-72,
Organism=Drosophila melanogaster, GI24641198, Length=216, Percent_Identity=29.6296296296296, Blast_Score=92, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SRP54_ARCFU (O29633)

Other databases:

- EMBL:   AE000782
- PIR:   F69327
- RefSeq:   NP_069456.1
- PDB:   2JQE
- PDBsum:   2JQE
- ProteinModelPortal:   O29633
- SMR:   O29633
- GeneID:   1483840
- GenomeReviews:   AE000782_GR
- KEGG:   afu:AF0622
- NMPDR:   fig|224325.1.peg.615
- TIGR:   AF_0622
- HOGENOM:   HBG562580
- OMA:   SKKEHII
- ProtClustDB:   PRK00771
- BioCyc:   AFUL224325:AF_0622-MONOMER
- HAMAP:   MF_00306
- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004125
- InterPro:   IPR022941
- Gene3D:   G3DSA:1.20.120.140
- Gene3D:   G3DSA:1.10.260.30
- SMART:   SM00382
- SMART:   SM00962
- SMART:   SM00963

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB; SSF47446 Signal_recog_particle_SRP54_M; SSF47364 SRP54

EC number: NA

Molecular weight: Translated: 48228; Mature: 48097

Theoretical pI: Translated: 9.67; Mature: 9.67

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALESLKEVARKIAGSSSIDKKFVEEMVKEIQRALIKADVNVRQVKEISDAIKKRALSED
CCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
VLPALNAKEQILKIVYEELLRGVGEGLEIPLKKAKIMLVGLQGSGKTTTTAKMAKYFKDR
HHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHC
GMKVAVVAADTWRPAAYEQLRQLAEEYGITFYGEKGEKDAVKIVKNALEKLKDHDMIIID
CCEEEEEEECCCCHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEE
TAGRHALEDELIDEMIKIAEVARPDYKLLVLDAAIGQLASKQAQAFHEAIGINGIIITKF
CCCCHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
DGTAKGGGALSAARQIGIPIAFIGTGEKVEDFERFDPAGFVSRLLGMGDIKALMEKIERI
CCCCCCCHHHHHHHHHCCCEEEECCCCHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHH
ASEEELDPEAFLKGTFTLKDIYKQIEAMNKMGPVRKIFEMLPFGLGLKVDNDVMEMTQEK
HCCCCCCHHHHHHHCHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCHHHHHHHHHH
MKKFRVIMDSMTEEELLNPKIIDSSRIRRIAIGSGTSPQEVKELLNYYKTMKNLMKKMKK
HHHHHHHHHHHHHHHHCCCCCCCHHHCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
NKLPIKGLGKLGF
CCCCCCCCCCCCC
>Mature Secondary Structure 
ALESLKEVARKIAGSSSIDKKFVEEMVKEIQRALIKADVNVRQVKEISDAIKKRALSED
CHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
VLPALNAKEQILKIVYEELLRGVGEGLEIPLKKAKIMLVGLQGSGKTTTTAKMAKYFKDR
HHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHC
GMKVAVVAADTWRPAAYEQLRQLAEEYGITFYGEKGEKDAVKIVKNALEKLKDHDMIIID
CCEEEEEEECCCCHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEE
TAGRHALEDELIDEMIKIAEVARPDYKLLVLDAAIGQLASKQAQAFHEAIGINGIIITKF
CCCCHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
DGTAKGGGALSAARQIGIPIAFIGTGEKVEDFERFDPAGFVSRLLGMGDIKALMEKIERI
CCCCCCCHHHHHHHHHCCCEEEECCCCHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHH
ASEEELDPEAFLKGTFTLKDIYKQIEAMNKMGPVRKIFEMLPFGLGLKVDNDVMEMTQEK
HCCCCCCHHHHHHHCHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCHHHHHHHHHH
MKKFRVIMDSMTEEELLNPKIIDSSRIRRIAIGSGTSPQEVKELLNYYKTMKNLMKKMKK
HHHHHHHHHHHHHHHHCCCCCCCHHHCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
NKLPIKGLGKLGF
CCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9389475; 10684931