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Identifier: 11498086

GI number: 11498086

Start: 434914

End: 436026

Strand: Reverse

Name: Not Available

Synonym: AF0475

Alternate gene names: 11498086

Gene position: 436026-434914 (Counterclockwise)

Preceding gene: 11498087

Following gene: 11498084

Centisome position: 20.02

GC content: 49.78

Gene sequence:

>1113_bases
GTGAGCAGAATTGATGACATAGAAAGGGACATCAAGAAGGCTGAAAAGGTGGTGGAACACTACGTAACGCTTGAGGAGAA
GAAGGAGCTCTCAATAATCGAGAAATTTCTGACTCTGTGGATCTTTCTCGCAATAATTGGGGGAGTTGCCCTCGGCTATG
TCTATCCTGACATTGCGAACATCATCGGCTCTCTCAGCATTGGCACAACATCCATTCCCATTGCCATTGGCCTTATTCTG
ATGATGTACCCACCTCTCGCCAAGGTCAGGTATGAGGAGATGGGAAAGGTATTCAGCAACCTCAAGCTTCTCGCCTTCTC
TCTAACGCAGAACTGGATTGTGGGGCCAGTGGTGATGTTTTTGCTTGCCATCGCTCTTCTGAGGGACATGCCGGAGTTCA
TGATTGGTGTTATCCTCGTTGGGCTGGCGAGATGCATTGCAATGGTCATAGTATGGAACGAGCTTGCTGAGGGTGACAGA
GAGCTTGCGGTTGGGCTTGTGGCCTTTAACGCCATCTTCCAGATTCTCTTCTATGCGGTTTACATCTACATCTTCATCAC
CTTCGCTCTGAACGCCCTCGGGCTGGTTGAGGGAGTTGAGGCCAACGTGAGCATAGTCGAGGCAGCAAAGACTGTCTTCA
TCTACCTCGGAATTCCCTTCATCATGGGCGTTGCCACAAGGTACGGCAGCTTCAGGCTTAAGGGAAGAGAGTGGTTTGAA
AACGTTCTGGCTCCGAAAATAAGCCTCATCACGCCCGCAGCACTGCTCTTCACCATCGTCGTGATGTTCTCACTGAAGGG
CGAGTACATCGTCGAGCTGCCGATGCAGGTTGTTAGAGTTGCAATCCCGCTGACGCTATACTTCCTCATCATGTGGTTCA
TAACCTTCTTCATAGCCTACAAGCTGGGTGTTGACTATCCGAAAACCACCGCTGTTTCATTCACCGCTGCAAGCAACGAC
TTTGAGCTGGCAATTGCAGTAGCTGTTGCCATCTGGGGGATACACAGCAATCAGGCCTTTGCCACAGTGATTGGACCGCT
CATAGAGGTTCCGGTTTTGATTATGCTGGTCAACGTTGCTCTTAAGCTGAGAGATAAGCTTTACAAAGCCTAA

Upstream 100 bases:

>100_bases
ATGAGAACGAAGAGGTTTGCTGCCTTATTCTCGTTAAGGCGGAGTTGGTGGACGAGGAGATGAGGAGCATTATCGCACCT
ATGCTTAAGGGGGTGGTAGG

Downstream 100 bases:

>100_bases
TTCTCTTTTTGTATTTCTTTAAACTCCCTGAGGCAAGTCTTACAGCACAAAACGTAGACTTTGTTTTTTAGCCTGTAAAC
AATCGGTTCATCGCACATCT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 370; Mature: 369

Protein sequence:

>370_residues
MSRIDDIERDIKKAEKVVEHYVTLEEKKELSIIEKFLTLWIFLAIIGGVALGYVYPDIANIIGSLSIGTTSIPIAIGLIL
MMYPPLAKVRYEEMGKVFSNLKLLAFSLTQNWIVGPVVMFLLAIALLRDMPEFMIGVILVGLARCIAMVIVWNELAEGDR
ELAVGLVAFNAIFQILFYAVYIYIFITFALNALGLVEGVEANVSIVEAAKTVFIYLGIPFIMGVATRYGSFRLKGREWFE
NVLAPKISLITPAALLFTIVVMFSLKGEYIVELPMQVVRVAIPLTLYFLIMWFITFFIAYKLGVDYPKTTAVSFTAASND
FELAIAVAVAIWGIHSNQAFATVIGPLIEVPVLIMLVNVALKLRDKLYKA

Sequences:

>Translated_370_residues
MSRIDDIERDIKKAEKVVEHYVTLEEKKELSIIEKFLTLWIFLAIIGGVALGYVYPDIANIIGSLSIGTTSIPIAIGLIL
MMYPPLAKVRYEEMGKVFSNLKLLAFSLTQNWIVGPVVMFLLAIALLRDMPEFMIGVILVGLARCIAMVIVWNELAEGDR
ELAVGLVAFNAIFQILFYAVYIYIFITFALNALGLVEGVEANVSIVEAAKTVFIYLGIPFIMGVATRYGSFRLKGREWFE
NVLAPKISLITPAALLFTIVVMFSLKGEYIVELPMQVVRVAIPLTLYFLIMWFITFFIAYKLGVDYPKTTAVSFTAASND
FELAIAVAVAIWGIHSNQAFATVIGPLIEVPVLIMLVNVALKLRDKLYKA
>Mature_369_residues
SRIDDIERDIKKAEKVVEHYVTLEEKKELSIIEKFLTLWIFLAIIGGVALGYVYPDIANIIGSLSIGTTSIPIAIGLILM
MYPPLAKVRYEEMGKVFSNLKLLAFSLTQNWIVGPVVMFLLAIALLRDMPEFMIGVILVGLARCIAMVIVWNELAEGDRE
LAVGLVAFNAIFQILFYAVYIYIFITFALNALGLVEGVEANVSIVEAAKTVFIYLGIPFIMGVATRYGSFRLKGREWFEN
VLAPKISLITPAALLFTIVVMFSLKGEYIVELPMQVVRVAIPLTLYFLIMWFITFFIAYKLGVDYPKTTAVSFTAASNDF
ELAIAVAVAIWGIHSNQAFATVIGPLIEVPVLIMLVNVALKLRDKLYKA

Specific function: Seems to confer resistance to arsenite by allowing cells to extrude this compound. Could be part of an arsenite extrusion pump [H]

COG id: COG0798

COG function: function code P; Arsenite efflux pump ACR3 and related permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ACR3 family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6325459, Length=336, Percent_Identity=34.5238095238095, Blast_Score=173, Evalue=3e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004706
- InterPro:   IPR002657 [H]

Pfam domain/function: PF01758 SBF [H]

EC number: NA

Molecular weight: Translated: 41184; Mature: 41053

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRIDDIERDIKKAEKVVEHYVTLEEKKELSIIEKFLTLWIFLAIIGGVALGYVYPDIAN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IIGSLSIGTTSIPIAIGLILMMYPPLAKVRYEEMGKVFSNLKLLAFSLTQNWIVGPVVMF
HHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
LLAIALLRDMPEFMIGVILVGLARCIAMVIVWNELAEGDRELAVGLVAFNAIFQILFYAV
HHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
YIYIFITFALNALGLVEGVEANVSIVEAAKTVFIYLGIPFIMGVATRYGSFRLKGREWFE
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECHHHHHH
NVLAPKISLITPAALLFTIVVMFSLKGEYIVELPMQVVRVAIPLTLYFLIMWFITFFIAY
HHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLGVDYPKTTAVSFTAASNDFELAIAVAVAIWGIHSNQAFATVIGPLIEVPVLIMLVNVA
HHCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
LKLRDKLYKA
HHHHHHHHCC
>Mature Secondary Structure 
SRIDDIERDIKKAEKVVEHYVTLEEKKELSIIEKFLTLWIFLAIIGGVALGYVYPDIAN
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IIGSLSIGTTSIPIAIGLILMMYPPLAKVRYEEMGKVFSNLKLLAFSLTQNWIVGPVVMF
HHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
LLAIALLRDMPEFMIGVILVGLARCIAMVIVWNELAEGDRELAVGLVAFNAIFQILFYAV
HHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
YIYIFITFALNALGLVEGVEANVSIVEAAKTVFIYLGIPFIMGVATRYGSFRLKGREWFE
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECHHHHHH
NVLAPKISLITPAALLFTIVVMFSLKGEYIVELPMQVVRVAIPLTLYFLIMWFITFFIAY
HHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLGVDYPKTTAVSFTAASNDFELAIAVAVAIWGIHSNQAFATVIGPLIEVPVLIMLVNVA
HHCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
LKLRDKLYKA
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7704261; 8969508; 9384377; 7489895; 9537360 [H]