Click here to switch to the map view.

The map label for this gene is acaB-8

Identifier: 11498050

GI number: 11498050

Start: 394564

End: 395727

Strand: Reverse

Name: acaB-8

Synonym: AF0438

Alternate gene names: 11498050

Gene position: 395727-394564 (Counterclockwise)

Preceding gene: 11498051

Following gene: 11498049

Centisome position: 18.17

GC content: 54.04

Gene sequence:

>1164_bases
ATGAGAGTTGGAGTTATCGGCGTTGGATGTTCAAGGTTTGGGAGAAGAGATGATGCTGTAATTCAGGAGCTTGCCTATGA
GGCTGTTAAGGAGGCGCTTGACGATGCAGGGATAACTCAGGATGAGGTTGAGCTGAGCGTTGTTGGATCAGTAAATACGA
GGGGATACGAGCTGATGCCTGCTGTTCCTGTAAACGAGTATTGCGGTTTTGCGGGTAAGGGGCCTCTGAGGGTGGAGGCT
GCCTGTGCAACAGGAGCTGCTGCGGTTTATACAGCGTACACATCAATCGCTTCAGGCATGGCTGACGTGGCCATAGCCAT
TGGCGTGGAGAAGATGACTGAGGTTGACACTGCCACCTCCCTCGCTATCGGCGGCAGGGCGGGGAATTATCTGTGGGAGT
TCCACCAGTACGGCACGACCTTTCCCGCTTACTACGCAATGCACGCAACCGCCCACATGGCGAAGTATGGAACTACTGAG
GAGCAGATGGCAAAGGTTGCGGTTAAGGCTCACAGAAACGCTGCCAGAAACCCGAAGGCGCACTTCCAGAAGGAGATTGC
CGTTGAGGACGTGCTGAATTCGAGGTACATCACCTATCCACTGAAGCTCTACGACTGCTCCCCGATAAGCGATGGCTCGG
CAGCAGCAATTCTGGCGAGTGAGGAGAAGATAAGGGAGCTCGGCATTGACGATGTCGTGTGGATTGACTCGGTTGGCTAC
GCATCAGACACCTCAAATATGACCAACAGGGAGAGCTTTGTCGGCCTTAAAGCTACGGTTCTGGCGAGGGAGATGGCTTA
CAGGAAGGCTGGCATAGAGGAGCCGGTAAAGCAGCTTGATTTTGCTACTGTGCACGACTGCTTTACCATCGCCGAGATTA
TGGCCTACGAAGACCTCGGCTTCTGCAGGAAGGGCGAGGGAGGGAAGCTTGTGGAGAGCGGGGAGACAGAGCTGGGCGGA
AAGCTTCCTGTAAATACCTTCGGCGGTTTAAAGGCGAAAGGTCATCCGTTGGCAGCAACAGGAGTTGCGATGGTTTACGA
AATCGTAAAGCAGCTGCGTGGAGAGGCTGGGGAGTTGCAGGTTGAACTGAGGAACAACAGGGCTTTGCTGCACAATGTGG
GCGGGACGGGACATTTTGCCTTTGTCATGATTTTCGGGAGGTGA

Upstream 100 bases:

>100_bases
ACCATCAGAACCAAAACATAGTTCCAACTCTACGCATAGAGCTGCAAGGCAAAATTCATATTTCACGAAAACATTAAATA
TTACACGACTACTTTTTTCA

Downstream 100 bases:

>100_bases
GAGGATGTTTATCGAGAGTCGTGAGCTCGTGATGAAGCACCGCATTCCCGTGGCAAAGACAGAAAGGTACTGGAAGGGGC
TTGAAGAGGGGAAGGTTTTC

Product: acetyl-CoA acetyltransferase

Products: CoA; 3-oxoacyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MRVGVIGVGCSRFGRRDDAVIQELAYEAVKEALDDAGITQDEVELSVVGSVNTRGYELMPAVPVNEYCGFAGKGPLRVEA
ACATGAAAVYTAYTSIASGMADVAIAIGVEKMTEVDTATSLAIGGRAGNYLWEFHQYGTTFPAYYAMHATAHMAKYGTTE
EQMAKVAVKAHRNAARNPKAHFQKEIAVEDVLNSRYITYPLKLYDCSPISDGSAAAILASEEKIRELGIDDVVWIDSVGY
ASDTSNMTNRESFVGLKATVLAREMAYRKAGIEEPVKQLDFATVHDCFTIAEIMAYEDLGFCRKGEGGKLVESGETELGG
KLPVNTFGGLKAKGHPLAATGVAMVYEIVKQLRGEAGELQVELRNNRALLHNVGGTGHFAFVMIFGR

Sequences:

>Translated_387_residues
MRVGVIGVGCSRFGRRDDAVIQELAYEAVKEALDDAGITQDEVELSVVGSVNTRGYELMPAVPVNEYCGFAGKGPLRVEA
ACATGAAAVYTAYTSIASGMADVAIAIGVEKMTEVDTATSLAIGGRAGNYLWEFHQYGTTFPAYYAMHATAHMAKYGTTE
EQMAKVAVKAHRNAARNPKAHFQKEIAVEDVLNSRYITYPLKLYDCSPISDGSAAAILASEEKIRELGIDDVVWIDSVGY
ASDTSNMTNRESFVGLKATVLAREMAYRKAGIEEPVKQLDFATVHDCFTIAEIMAYEDLGFCRKGEGGKLVESGETELGG
KLPVNTFGGLKAKGHPLAATGVAMVYEIVKQLRGEAGELQVELRNNRALLHNVGGTGHFAFVMIFGR
>Mature_387_residues
MRVGVIGVGCSRFGRRDDAVIQELAYEAVKEALDDAGITQDEVELSVVGSVNTRGYELMPAVPVNEYCGFAGKGPLRVEA
ACATGAAAVYTAYTSIASGMADVAIAIGVEKMTEVDTATSLAIGGRAGNYLWEFHQYGTTFPAYYAMHATAHMAKYGTTE
EQMAKVAVKAHRNAARNPKAHFQKEIAVEDVLNSRYITYPLKLYDCSPISDGSAAAILASEEKIRELGIDDVVWIDSVGY
ASDTSNMTNRESFVGLKATVLAREMAYRKAGIEEPVKQLDFATVHDCFTIAEIMAYEDLGFCRKGEGGKLVESGETELGG
KLPVNTFGGLKAKGHPLAATGVAMVYEIVKQLRGEAGELQVELRNNRALLHNVGGTGHFAFVMIFGR

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI19923233, Length=390, Percent_Identity=34.8717948717949, Blast_Score=182, Evalue=6e-46,
Organism=Homo sapiens, GI302344760, Length=320, Percent_Identity=35.3125, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI302344767, Length=313, Percent_Identity=35.4632587859425, Blast_Score=163, Evalue=2e-40,
Organism=Homo sapiens, GI302344762, Length=390, Percent_Identity=32.0512820512821, Blast_Score=153, Evalue=2e-37,
Organism=Homo sapiens, GI55956775, Length=357, Percent_Identity=30.5322128851541, Blast_Score=130, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17537653, Length=390, Percent_Identity=30.5128205128205, Blast_Score=163, Evalue=2e-40,
Organism=Drosophila melanogaster, GI19921506, Length=398, Percent_Identity=35.929648241206, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI24585051, Length=398, Percent_Identity=35.427135678392, Blast_Score=194, Evalue=8e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020617
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: 2.3.1.16

Molecular weight: Translated: 41621; Mature: 41621

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVGVIGVGCSRFGRRDDAVIQELAYEAVKEALDDAGITQDEVELSVVGSVNTRGYELMP
CEEEEEEECHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCEEEEC
AVPVNEYCGFAGKGPLRVEAACATGAAAVYTAYTSIASGMADVAIAIGVEKMTEVDTATS
CCCHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
LAIGGRAGNYLWEFHQYGTTFPAYYAMHATAHMAKYGTTEEQMAKVAVKAHRNAARNPKA
EEECCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHH
HFQKEIAVEDVLNSRYITYPLKLYDCSPISDGSAAAILASEEKIRELGIDDVVWIDSVGY
HHHHHHHHHHHHCCCEEEEEEEEEECCCCCCCCCEEEEECHHHHHHCCCCCEEEEECCCC
ASDTSNMTNRESFVGLKATVLAREMAYRKAGIEEPVKQLDFATVHDCFTIAEIMAYEDLG
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHHHHHHHHCC
FCRKGEGGKLVESGETELGGKLPVNTFGGLKAKGHPLAATGVAMVYEIVKQLRGEAGELQ
CCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEE
VELRNNRALLHNVGGTGHFAFVMIFGR
EEEECCEEEEEECCCCCEEEEEEEECC
>Mature Secondary Structure
MRVGVIGVGCSRFGRRDDAVIQELAYEAVKEALDDAGITQDEVELSVVGSVNTRGYELMP
CEEEEEEECHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCEEEEC
AVPVNEYCGFAGKGPLRVEAACATGAAAVYTAYTSIASGMADVAIAIGVEKMTEVDTATS
CCCHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
LAIGGRAGNYLWEFHQYGTTFPAYYAMHATAHMAKYGTTEEQMAKVAVKAHRNAARNPKA
EEECCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHH
HFQKEIAVEDVLNSRYITYPLKLYDCSPISDGSAAAILASEEKIRELGIDDVVWIDSVGY
HHHHHHHHHHHHCCCEEEEEEEEEECCCCCCCCCEEEEECHHHHHHCCCCCEEEEECCCC
ASDTSNMTNRESFVGLKATVLAREMAYRKAGIEEPVKQLDFATVHDCFTIAEIMAYEDLG
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHHHHHHHHCC
FCRKGEGGKLVESGETELGGKLPVNTFGGLKAKGHPLAATGVAMVYEIVKQLRGEAGELQ
CCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEE
VELRNNRALLHNVGGTGHFAFVMIFGR
EEEECCEEEEEECCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acetyl-CoA

Specific reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA

General reaction: Acyl group transfer; Claisen condensation [C]

Inhibitor: Tris (hydroxy methyl) aminomethane [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]