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Identifier: 11497983

GI number: 11497983

Start: 336055

End: 336651

Strand: Reverse

Name: Not Available

Synonym: AF0371

Alternate gene names: 11497983

Gene position: 336651-336055 (Counterclockwise)

Preceding gene: 11497984

Following gene: 11497982

Centisome position: 15.45

GC content: 49.58

Gene sequence:

>597_bases
ATGATTGAGAAAGCAATTTCAAGGCGCATTAAAGAGTTCAGGCAGCTTGGAGAAAAAGGGGAGGTGGAGTTCGACTTCAG
GCCCTTTCTTGATTTCAGTGTGAAGGCAACCATCAGAACTGAGCTTGCCTTCTGCATATCAACAGCCAACTCCTCCGCCA
CAGCAGGCTTGAAGTTCCAGAGGCTTTTAGGACAGGGAGTGGGGGTCAAGGAGGCGCTCACCTTGGCTGGAGTGAGATTC
CACAACAGAAAGGCTGAGTACATCAGGGAGGCTTTTAAAAGCTTCAAGCTGGTGGAGAAGGCTCTGGAGGCTGAAAGCAG
TAAGGCTAGGGAGATTCTTCTCAAGATAAAGGGGCTGGGAATGAAGGAGGCAAGCCACTTTCTCAGGAATGTCGGGAGAG
AGGATGTTGCTATAATAGACAGGCACATTCTGAGGTGGCTTGAAAGGCAGGGCTACGAAGTTCCCGGCACGATGACGGCG
AAGAAGTATCTCGAAGTTGAGAAAATTCTTATGGAAATTTCGGAGGAGAGGGGAGAGAGTCTTGCAGAAATGGATTTGAG
AATCTGGGCCGAGATGACGGGTAAGGTCTTGAAGTGA

Upstream 100 bases:

>100_bases
CAGCAATTCTCGATTCAGCCATAGAGGTCTGTGAGAAGAGCGGGATTGCAGCAGTCTCCTTCGCCACAAACATCGCTGTT
GAGGGAGAGGCGCTTCTGCT

Downstream 100 bases:

>100_bases
GGTGTTGAAATGAGGTCGATATTCTGGGATGATGGGTTGAAGCTGATTGACCAGACGAAGCTTCCCGAGAAGCTGGAGGT
AATTGAGTGCAGAAACGTTG

Product: N-glycosylase/DNA lyase

Products: NA

Alternate protein names: 8-oxoguanine DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase; AP lyase

Number of amino acids: Translated: 198; Mature: 198

Protein sequence:

>198_residues
MIEKAISRRIKEFRQLGEKGEVEFDFRPFLDFSVKATIRTELAFCISTANSSATAGLKFQRLLGQGVGVKEALTLAGVRF
HNRKAEYIREAFKSFKLVEKALEAESSKAREILLKIKGLGMKEASHFLRNVGREDVAIIDRHILRWLERQGYEVPGTMTA
KKYLEVEKILMEISEERGESLAEMDLRIWAEMTGKVLK

Sequences:

>Translated_198_residues
MIEKAISRRIKEFRQLGEKGEVEFDFRPFLDFSVKATIRTELAFCISTANSSATAGLKFQRLLGQGVGVKEALTLAGVRF
HNRKAEYIREAFKSFKLVEKALEAESSKAREILLKIKGLGMKEASHFLRNVGREDVAIIDRHILRWLERQGYEVPGTMTA
KKYLEVEKILMEISEERGESLAEMDLRIWAEMTGKVLK
>Mature_198_residues
MIEKAISRRIKEFRQLGEKGEVEFDFRPFLDFSVKATIRTELAFCISTANSSATAGLKFQRLLGQGVGVKEALTLAGVRF
HNRKAEYIREAFKSFKLVEKALEAESSKAREILLKIKGLGMKEASHFLRNVGREDVAIIDRHILRWLERQGYEVPGTMTA
KKYLEVEKILMEISEERGESLAEMDLRIWAEMTGKVLK

Specific function: Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 7-oxoG) from DNA. Also nicks DNA at apurinic/apyrimidinic sites (AP sites)

COG id: COG1059

COG function: function code L; Thermostable 8-oxoguanine DNA glycosylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type-2 OGG1 family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): OGG1_ARCFU (O29876)

Other databases:

- EMBL:   AE000782
- PIR:   C69296
- RefSeq:   NP_069207.1
- ProteinModelPortal:   O29876
- SMR:   O29876
- GeneID:   1483586
- GenomeReviews:   AE000782_GR
- KEGG:   afu:AF0371
- NMPDR:   fig|224325.1.peg.366
- TIGR:   AF_0371
- HOGENOM:   HBG430608
- OMA:   FSELSFC
- ProtClustDB:   PRK01229
- BioCyc:   AFUL224325:AF_0371-MONOMER
- BRENDA:   4.2.99.18
- HAMAP:   MF_00241
- InterPro:   IPR012092
- InterPro:   IPR011257
- InterPro:   IPR003265
- InterPro:   IPR023170
- Gene3D:   G3DSA:1.10.340.30
- Gene3D:   G3DSA:1.10.1670.10
- PIRSF:   PIRSF005954
- SMART:   SM00478

Pfam domain/function: PF00730 HhH-GPD; SSF48150 DNA_glycsylse

EC number: =4.2.99.18

Molecular weight: Translated: 22640; Mature: 22640

Theoretical pI: Translated: 10.01; Mature: 10.01

Prosite motif: NA

Important sites: ACT_SITE 122-122

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEKAISRRIKEFRQLGEKGEVEFDFRPFLDFSVKATIRTELAFCISTANSSATAGLKFQ
CCHHHHHHHHHHHHHCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
RLLGQGVGVKEALTLAGVRFHNRKAEYIREAFKSFKLVEKALEAESSKAREILLKIKGLG
HHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCC
MKEASHFLRNVGREDVAIIDRHILRWLERQGYEVPGTMTAKKYLEVEKILMEISEERGES
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCHH
LAEMDLRIWAEMTGKVLK
HHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIEKAISRRIKEFRQLGEKGEVEFDFRPFLDFSVKATIRTELAFCISTANSSATAGLKFQ
CCHHHHHHHHHHHHHCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
RLLGQGVGVKEALTLAGVRFHNRKAEYIREAFKSFKLVEKALEAESSKAREILLKIKGLG
HHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCC
MKEASHFLRNVGREDVAIIDRHILRWLERQGYEVPGTMTAKKYLEVEKILMEISEERGES
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCHH
LAEMDLRIWAEMTGKVLK
HHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9389475