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Identifier: 11497886

GI number: 11497886

Start: 246755

End: 247342

Strand: Reverse

Name: Not Available

Synonym: AF0270

Alternate gene names: 11497886

Gene position: 247342-246755 (Counterclockwise)

Preceding gene: 11497887

Following gene: 11497885

Centisome position: 11.35

GC content: 50.51

Gene sequence:

>588_bases
ATGAAGCTGCCGGAAGCCTTTAAAGGGAAGTGGTTCGTTCTGTTCAGCCACCCTGCAGACTTCACTCCAGTCTGCACAAC
CGAGTTTGTGGCTTTTCAGAATAGATACGACGAGTTCAGGAAGCTTAACTGCGAGCTGATTGGCCTTAGCATCGACCAGG
TGTTCTCGCACATTAAATGGATAGAGTGGATTAAGGAAAAGCTCGACATCGAAATCGAGTTCCCCGTGATTGCCGACGAT
ACGGGCAGAGTCGCTGAGATGCTCGGTTTGATTCATCCAGCCAAGGGAACGAACACAGTAAGGGCGGTTTTCATCGTTGA
TCCAGAGGCGGTTATCAGGGCAGTAATCTACTACCCGCAGGAGCTGGGAAGAAACATGGACGAAATCCTTAGGGCTGTGA
AGGCTTTGCAGGTCAGCGACCAGAACGGTGTTGCGATGCCTGCCAACTGGCCCAACAATGAGCTTGTTGGTGATGCTGTG
ATTATTCCCCCACCAATCAGCGAAGCTGAGGCAAAAGAGAGGCTTGAAAAGGCTAAGGCTGGAGATATCAGCTGCTACGA
CTGGTGGTTCTGCTACAAGAAGATTTGA

Upstream 100 bases:

>100_bases
ATTAGAATTTAGAATATCTCTTTAACGAGGAGGTGATTGATTTGGCGCCGCTTTTGGGGGATAATTCCCGGAAATTGAAG
TCGTTACAACACACGGCAGG

Downstream 100 bases:

>100_bases
GGTGTGTTGATGGCAAAGAAGCTCGCTATTTTTCTTTTTAATGACGATGAAATGTGCATGCTCCACGCCTTTCTTTACCT
AAGGGAACTCAACGAGAGAG

Product: alkyl hydroperoxide reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 195; Mature: 195

Protein sequence:

>195_residues
MKLPEAFKGKWFVLFSHPADFTPVCTTEFVAFQNRYDEFRKLNCELIGLSIDQVFSHIKWIEWIKEKLDIEIEFPVIADD
TGRVAEMLGLIHPAKGTNTVRAVFIVDPEAVIRAVIYYPQELGRNMDEILRAVKALQVSDQNGVAMPANWPNNELVGDAV
IIPPPISEAEAKERLEKAKAGDISCYDWWFCYKKI

Sequences:

>Translated_195_residues
MKLPEAFKGKWFVLFSHPADFTPVCTTEFVAFQNRYDEFRKLNCELIGLSIDQVFSHIKWIEWIKEKLDIEIEFPVIADD
TGRVAEMLGLIHPAKGTNTVRAVFIVDPEAVIRAVIYYPQELGRNMDEILRAVKALQVSDQNGVAMPANWPNNELVGDAV
IIPPPISEAEAKERLEKAKAGDISCYDWWFCYKKI
>Mature_195_residues
MKLPEAFKGKWFVLFSHPADFTPVCTTEFVAFQNRYDEFRKLNCELIGLSIDQVFSHIKWIEWIKEKLDIEIEFPVIADD
TGRVAEMLGLIHPAKGTNTVRAVFIVDPEAVIRAVIYYPQELGRNMDEILRAVKALQVSDQNGVAMPANWPNNELVGDAV
IIPPPISEAEAKERLEKAKAGDISCYDWWFCYKKI

Specific function: Directly Reduces Organic Hydroperoxides In Its Reduced Dithiol Form. [C]

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain

Homologues:

Organism=Homo sapiens, GI4758638, Length=177, Percent_Identity=41.8079096045198, Blast_Score=124, Evalue=4e-29,
Organism=Homo sapiens, GI32189392, Length=145, Percent_Identity=40.6896551724138, Blast_Score=124, Evalue=5e-29,
Organism=Homo sapiens, GI4505591, Length=152, Percent_Identity=36.1842105263158, Blast_Score=117, Evalue=6e-27,
Organism=Homo sapiens, GI32455266, Length=152, Percent_Identity=36.1842105263158, Blast_Score=117, Evalue=6e-27,
Organism=Homo sapiens, GI32455264, Length=152, Percent_Identity=36.1842105263158, Blast_Score=117, Evalue=6e-27,
Organism=Homo sapiens, GI5453549, Length=170, Percent_Identity=34.1176470588235, Blast_Score=116, Evalue=1e-26,
Organism=Homo sapiens, GI5802974, Length=172, Percent_Identity=36.6279069767442, Blast_Score=115, Evalue=2e-26,
Organism=Homo sapiens, GI32483377, Length=172, Percent_Identity=36.6279069767442, Blast_Score=115, Evalue=3e-26,
Organism=Homo sapiens, GI33188454, Length=56, Percent_Identity=55.3571428571429, Blast_Score=77, Evalue=1e-14,
Organism=Escherichia coli, GI1786822, Length=148, Percent_Identity=33.1081081081081, Blast_Score=90, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17554494, Length=174, Percent_Identity=34.4827586206897, Blast_Score=118, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI25153706, Length=176, Percent_Identity=35.7954545454545, Blast_Score=112, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI193204376, Length=156, Percent_Identity=35.8974358974359, Blast_Score=109, Evalue=9e-25,
Organism=Caenorhabditis elegans, GI32565831, Length=156, Percent_Identity=35.8974358974359, Blast_Score=109, Evalue=9e-25,
Organism=Saccharomyces cerevisiae, GI6319407, Length=173, Percent_Identity=46.242774566474, Blast_Score=147, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6323613, Length=175, Percent_Identity=32.5714285714286, Blast_Score=91, Evalue=8e-20,
Organism=Saccharomyces cerevisiae, GI6320661, Length=147, Percent_Identity=31.2925170068027, Blast_Score=89, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24652434, Length=187, Percent_Identity=40.1069518716578, Blast_Score=127, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24652436, Length=187, Percent_Identity=40.1069518716578, Blast_Score=127, Evalue=4e-30,
Organism=Drosophila melanogaster, GI17975518, Length=187, Percent_Identity=40.1069518716578, Blast_Score=127, Evalue=4e-30,
Organism=Drosophila melanogaster, GI17738015, Length=167, Percent_Identity=34.7305389221557, Blast_Score=117, Evalue=5e-27,
Organism=Drosophila melanogaster, GI24581278, Length=164, Percent_Identity=42.0731707317073, Blast_Score=116, Evalue=8e-27,
Organism=Drosophila melanogaster, GI17157991, Length=145, Percent_Identity=39.3103448275862, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24641739, Length=145, Percent_Identity=39.3103448275862, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24656348, Length=160, Percent_Identity=34.375, Blast_Score=110, Evalue=7e-25,
Organism=Drosophila melanogaster, GI17864676, Length=160, Percent_Identity=34.375, Blast_Score=110, Evalue=7e-25,
Organism=Drosophila melanogaster, GI21357347, Length=145, Percent_Identity=36.551724137931, Blast_Score=106, Evalue=9e-24,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): TDXH_ARCFU (O29969)

Other databases:

- EMBL:   AE000782
- PIR:   F69283
- RefSeq:   NP_069108.1
- ProteinModelPortal:   O29969
- SMR:   O29969
- GeneID:   1483485
- GenomeReviews:   AE000782_GR
- KEGG:   afu:AF0270
- NMPDR:   fig|224325.1.peg.267
- TIGR:   AF_0270
- HOGENOM:   HBG493509
- OMA:   EVKTTHG
- BioCyc:   AFUL224325:AF_0270-MONOMER
- BRENDA:   1.11.1.15
- HAMAP:   MF_00401
- InterPro:   IPR000866
- InterPro:   IPR019479
- InterPro:   IPR022915
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335
- Gene3D:   G3DSA:3.40.30.10

Pfam domain/function: PF10417 1-cysPrx_C; PF00578 AhpC-TSA; SSF52833 Thiordxn-like_fd

EC number: =1.11.1.15

Molecular weight: Translated: 22274; Mature: 22274

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS51352 THIOREDOXIN_2

Important sites: ACT_SITE 45-45

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLPEAFKGKWFVLFSHPADFTPVCTTEFVAFQNRYDEFRKLNCELIGLSIDQVFSHIKW
CCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCEEEEEECHHHHHHHHHH
IEWIKEKLDIEIEFPVIADDTGRVAEMLGLIHPAKGTNTVRAVFIVDPEAVIRAVIYYPQ
HHHHHHHHCEEEEEEEEECCCHHHHHHHHHHCCCCCCCEEEEEEEECHHHHHHHHHHCHH
ELGRNMDEILRAVKALQVSDQNGVAMPANWPNNELVGDAVIIPPPISEAEAKERLEKAKA
HHCCCHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHCC
GDISCYDWWFCYKKI
CCCCEEHHEEEEECC
>Mature Secondary Structure
MKLPEAFKGKWFVLFSHPADFTPVCTTEFVAFQNRYDEFRKLNCELIGLSIDQVFSHIKW
CCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCEEEEEECHHHHHHHHHH
IEWIKEKLDIEIEFPVIADDTGRVAEMLGLIHPAKGTNTVRAVFIVDPEAVIRAVIYYPQ
HHHHHHHHCEEEEEEEEECCCHHHHHHHHHHCCCCCCCEEEEEEEECHHHHHHHHHHCHH
ELGRNMDEILRAVKALQVSDQNGVAMPANWPNNELVGDAVIIPPPISEAEAKERLEKAKA
HHCCCHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHCC
GDISCYDWWFCYKKI
CCCCEEHHEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9389475