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The map label for this gene is noxA-1

Identifier: 11497870

GI number: 11497870

Start: 230864

End: 232183

Strand: Reverse

Name: noxA-1

Synonym: AF0254

Alternate gene names: 11497870

Gene position: 232183-230864 (Counterclockwise)

Preceding gene: 11497872

Following gene: 11497867

Centisome position: 10.66

GC content: 49.32

Gene sequence:

>1320_bases
GTGAAGGTTGCAATTATAGGCGGTGGCGCTGCTGGAATGAGTGCAGCTTCAAGAGTGAAAGCTTTAAGACCCAACTGGGA
CGTCAAGGTTTTTGAGAAGTCGAGATGGGTTAGTCACGCTCCTTGCGGAATTCCCTTTTTCGTTGGAGGCGCTGTCGAGA
AGTTCGATGAGCTTTGCGCTTACGACATAGATTACTTCAAGCGTGAGAGGGGTATTGATGTTCATACCAACGCGAGGGTT
GTGGAAATTGAGGAGGGTAGGCTAACCGTTGATGAGGGTGGGAAAGAAGCATCCTATGAGTGGGACAAGTTGCTATTCGC
CACTGGATCAAAAGCAGTTCGGCTAAATGTGGAAGGAGAGAACTTGGAGGGCGTTATTTACGTTGACGACATCGAAAATG
CGGAGAGAGTCAAAATAGAGGCAATGAAAGTCGATAACGTGGTTGTTGTTGGCTCTGGCTATATAGGAGTGGAAATGGCG
GATGCTATAACAAGACTTGGAAAAAACGTCACAGTCATTGAGGTGATGGAGCGACCACTTCCCGAGTATGACGCTGAAAT
TGCCGCAATAATTAAATCAGAGATGGAGAAATACGTAAACCTAAGACTGAGTGAAAAAGTGACGGCTTTTGAAGGAAAAG
ACAGAGTAGAAAAAGTTGTAACAAACAAGGGCGAGTATCCATGCGAATTGGCAATAATAGCTGTTGGAGTTGCGCCCAAC
ACTGACCTCGCGAAAGGTTTCGTTGAGCTTGGTGTTAAGGGGGCAATCAGGACGAACAGCAGGATGGAAACGAGCAGAGA
AAATGTTTACGCTGCTGGAGACTGTGCGGAGTCGATCAATATCGTAACAGGCAGGGAGGACTGGATACCGCTCGCCGCTC
CGGCAAACAAGATGGGGTACGTTGCGGGTGTCAACATGGCCGGGCTTGAAATGCACTACCCGGGCTCGCTGAAAAGCCAG
CTAACCGGTTTCAAGGACATCGAAATAGGAAAGGCGGGTTTAAGCGAGAATGAGGCAATAAGGTTTGGATATGAGGTTGT
TTCAGCCTTCATAACTTCAAGAACCTCCGCTCGCTACCTTCCAGGCGGTTTAATCCACCTGAAAGTCGTTGCCGACAGAA
ATGGTAAGCTGCTCGGCCTGCAGGCGGTGGGGAAGGACGTGGCGATGAGAGTTTACGCTGCCTCAGCACTTCTGCACAAA
AATGGAGATGTGAAAGACCTTTTCTTCTGCGACTTCCCCTACTATCCGCCCGTTTCGAGAGTTTGGGACCCGCTGGTTGT
CGCGGCGAGGAACATATTCAGGAAGCTCGGATTGCCGTAG

Upstream 100 bases:

>100_bases
ATCCCACCCCCGGCGCTGAAACTTTGGTGCTTTTCTGAGCCACAAAGATGGCACTGCTAAGCCTCAGAAAACCTTAAAAA
ATTCGGATTTTATTGAGGTT

Downstream 100 bases:

>100_bases
CTACTCGTATTCGATTGTCGCTGGAGGTTTGGGGGTTATGTCGTAAACAACTCTCGAAACTTTGTCTATCTCTCCGGTAA
TTCTCAGTGCGATTCTCCTC

Product: NADH oxidase (noxA-1)

Products: NA

Alternate protein names: CoA-disulfide reductase; CoADR [H]

Number of amino acids: Translated: 439; Mature: 439

Protein sequence:

>439_residues
MKVAIIGGGAAGMSAASRVKALRPNWDVKVFEKSRWVSHAPCGIPFFVGGAVEKFDELCAYDIDYFKRERGIDVHTNARV
VEIEEGRLTVDEGGKEASYEWDKLLFATGSKAVRLNVEGENLEGVIYVDDIENAERVKIEAMKVDNVVVVGSGYIGVEMA
DAITRLGKNVTVIEVMERPLPEYDAEIAAIIKSEMEKYVNLRLSEKVTAFEGKDRVEKVVTNKGEYPCELAIIAVGVAPN
TDLAKGFVELGVKGAIRTNSRMETSRENVYAAGDCAESINIVTGREDWIPLAAPANKMGYVAGVNMAGLEMHYPGSLKSQ
LTGFKDIEIGKAGLSENEAIRFGYEVVSAFITSRTSARYLPGGLIHLKVVADRNGKLLGLQAVGKDVAMRVYAASALLHK
NGDVKDLFFCDFPYYPPVSRVWDPLVVAARNIFRKLGLP

Sequences:

>Translated_439_residues
MKVAIIGGGAAGMSAASRVKALRPNWDVKVFEKSRWVSHAPCGIPFFVGGAVEKFDELCAYDIDYFKRERGIDVHTNARV
VEIEEGRLTVDEGGKEASYEWDKLLFATGSKAVRLNVEGENLEGVIYVDDIENAERVKIEAMKVDNVVVVGSGYIGVEMA
DAITRLGKNVTVIEVMERPLPEYDAEIAAIIKSEMEKYVNLRLSEKVTAFEGKDRVEKVVTNKGEYPCELAIIAVGVAPN
TDLAKGFVELGVKGAIRTNSRMETSRENVYAAGDCAESINIVTGREDWIPLAAPANKMGYVAGVNMAGLEMHYPGSLKSQ
LTGFKDIEIGKAGLSENEAIRFGYEVVSAFITSRTSARYLPGGLIHLKVVADRNGKLLGLQAVGKDVAMRVYAASALLHK
NGDVKDLFFCDFPYYPPVSRVWDPLVVAARNIFRKLGLP
>Mature_439_residues
MKVAIIGGGAAGMSAASRVKALRPNWDVKVFEKSRWVSHAPCGIPFFVGGAVEKFDELCAYDIDYFKRERGIDVHTNARV
VEIEEGRLTVDEGGKEASYEWDKLLFATGSKAVRLNVEGENLEGVIYVDDIENAERVKIEAMKVDNVVVVGSGYIGVEMA
DAITRLGKNVTVIEVMERPLPEYDAEIAAIIKSEMEKYVNLRLSEKVTAFEGKDRVEKVVTNKGEYPCELAIIAVGVAPN
TDLAKGFVELGVKGAIRTNSRMETSRENVYAAGDCAESINIVTGREDWIPLAAPANKMGYVAGVNMAGLEMHYPGSLKSQ
LTGFKDIEIGKAGLSENEAIRFGYEVVSAFITSRTSARYLPGGLIHLKVVADRNGKLLGLQAVGKDVAMRVYAASALLHK
NGDVKDLFFCDFPYYPPVSRVWDPLVVAARNIFRKLGLP

Specific function: Lipoamide Dehydrogenase Is A Component Of The Glycine Cleavage System As Well As Of The Alpha-Ketoacid Dehydrogenase Complexes. [C]

COG id: COG0446

COG function: function code R; Uncharacterized NAD(FAD)-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI226437568, Length=316, Percent_Identity=27.8481012658228, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI21389617, Length=316, Percent_Identity=27.8481012658228, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI65787454, Length=316, Percent_Identity=27.8481012658228, Blast_Score=92, Evalue=8e-19,
Organism=Escherichia coli, GI1786307, Length=379, Percent_Identity=24.802110817942, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1789065, Length=290, Percent_Identity=23.7931034482759, Blast_Score=73, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17559934, Length=216, Percent_Identity=29.6296296296296, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24585130, Length=219, Percent_Identity=28.310502283105, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24639257, Length=216, Percent_Identity=27.7777777777778, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI281359715, Length=216, Percent_Identity=27.7777777777778, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI281359713, Length=216, Percent_Identity=27.7777777777778, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24639250, Length=216, Percent_Identity=27.7777777777778, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI18543267, Length=216, Percent_Identity=27.7777777777778, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24639252, Length=216, Percent_Identity=27.7777777777778, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017758
- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.14 [H]

Molecular weight: Translated: 47980; Mature: 47980

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVAIIGGGAAGMSAASRVKALRPNWDVKVFEKSRWVSHAPCGIPFFVGGAVEKFDELCA
CEEEEEECCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCEEECHHHHHHHHHHH
YDIDYFKRERGIDVHTNARVVEIEEGRLTVDEGGKEASYEWDKLLFATGSKAVRLNVEGE
HHHHHHHHHCCCEEECCCEEEEEECCEEEECCCCCCCCCCHHEEEEECCCEEEEEEECCC
NLEGVIYVDDIENAERVKIEAMKVDNVVVVGSGYIGVEMADAITRLGKNVTVIEVMERPL
CCEEEEEEECCCCCCEEEEEEEEECCEEEEECCEECHHHHHHHHHHCCCCEEEEEHHCCC
PEYDAEIAAIIKSEMEKYVNLRLSEKVTAFEGKDRVEKVVTNKGEYPCELAIIAVGVAPN
CCCCHHHHHHHHHHHHHHHCEEECCCEEECCCHHHHHHHHHCCCCCCEEEEEEEEECCCC
TDLAKGFVELGVKGAIRTNSRMETSRENVYAAGDCAESINIVTGREDWIPLAAPANKMGY
CHHHHHHHHHCCCCEEECCCCCHHCCCCEEECCCCCCCCEEEECCCCCEEECCCCCCCCE
VAGVNMAGLEMHYPGSLKSQLTGFKDIEIGKAGLSENEAIRFGYEVVSAFITSRTSARYL
EECCCCCCEEEECCCCHHHHHCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCC
PGGLIHLKVVADRNGKLLGLQAVGKDVAMRVYAASALLHKNGDVKDLFFCDFPYYPPVSR
CCCEEEEEEEECCCCCEEEEEHHCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHH
VWDPLVVAARNIFRKLGLP
HHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKVAIIGGGAAGMSAASRVKALRPNWDVKVFEKSRWVSHAPCGIPFFVGGAVEKFDELCA
CEEEEEECCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCEEECHHHHHHHHHHH
YDIDYFKRERGIDVHTNARVVEIEEGRLTVDEGGKEASYEWDKLLFATGSKAVRLNVEGE
HHHHHHHHHCCCEEECCCEEEEEECCEEEECCCCCCCCCCHHEEEEECCCEEEEEEECCC
NLEGVIYVDDIENAERVKIEAMKVDNVVVVGSGYIGVEMADAITRLGKNVTVIEVMERPL
CCEEEEEEECCCCCCEEEEEEEEECCEEEEECCEECHHHHHHHHHHCCCCEEEEEHHCCC
PEYDAEIAAIIKSEMEKYVNLRLSEKVTAFEGKDRVEKVVTNKGEYPCELAIIAVGVAPN
CCCCHHHHHHHHHHHHHHHCEEECCCEEECCCHHHHHHHHHCCCCCCEEEEEEEEECCCC
TDLAKGFVELGVKGAIRTNSRMETSRENVYAAGDCAESINIVTGREDWIPLAAPANKMGY
CHHHHHHHHHCCCCEEECCCCCHHCCCCEEECCCCCCCCEEEECCCCCEEECCCCCCCCE
VAGVNMAGLEMHYPGSLKSQLTGFKDIEIGKAGLSENEAIRFGYEVVSAFITSRTSARYL
EECCCCCCEEEECCCCHHHHHCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCC
PGGLIHLKVVADRNGKLLGLQAVGKDVAMRVYAASALLHKNGDVKDLFFCDFPYYPPVSR
CCCEEEEEEEECCCCCEEEEEHHCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHH
VWDPLVVAARNIFRKLGLP
HHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA