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The map label for this gene is ilvC

Identifier: 114800540

GI number: 114800540

Start: 442135

End: 443154

Strand: Reverse

Name: ilvC

Synonym: HNE_0447

Alternate gene names: 114800540

Gene position: 443154-442135 (Counterclockwise)

Preceding gene: 114798195

Following gene: 114797502

Centisome position: 11.96

GC content: 60.49

Gene sequence:

>1020_bases
ATGAAAATCTACTACGAAAAAGACGCGGACATCTCGCTGATCCAGAAACTGAAAGTCGCCGTGGTCGGCTATGGCAGCCA
GGGCCATGCCCATGCGCTGAACCTGAAAGATTCCGGCGTGAAGCAGATCAAGGTTGCGCTTCAGGAAGGCTCCGCCTCGC
GCAAGAAAGCCGAAGCAGCGGGCCTGGAAGTTGTGTCTGTCGCCGACGCCGCCAAATGGGCCGACGTGCTGATGATCCTC
GTTCCGGACGAAAAGCAGGCTGTGCTTTACGCCAACGAGATCGAGCCCCACCTGCGCGCGGGCCAGCACCTGATGTTCGG
CCACGGCTTCAACATCCACTACAACCTGATCCGTCCGCGCGCGGATGTTGACGTGTCGCTGTCGGCGCCCAAAGGCCCTG
GCCACACGCTGCGCAACCAGTACCAGATGGGCTTTGGCCTACCGGGCCTGATCGCCATTCATCAGGACGCCACGGGCAGC
GCCCAGGCGGTTGCCCTTTCCTATTCGAAAGCCATCGGCAACACCCGCGCCGGCGTCATCGAAACATCCTTCCGTGAAGA
GACGGAAACCGACCTCTTCGGTGAGCAGGCTGTTCTCTGCGGCGGGATCGTCGAGCTGATCAAGGCGGGTTATGAGACGC
TGGTGGAAGCCGGTTACGCGCCAGAGATGGCCTATTTCGAGTGCCTGCACGAGACCAAGCTGATCGTTGACCTGATCTAT
GAAGGCGGCATCGCCAACATGAACTATTCGATCTCCAACACCGCCGAGTATGGCGAGTATGTCACCGGGCCGCGCCTGGT
GAACGCCGAGACGAAGAAGGAAATGAAGAAGGTTCTCGAAGACATCCAGAACGGGACCTTTGCCCGCAACTGGGTTCTGG
AAAACCAGGCCGGCGCGCCGGGCTTCCACGCCATGCGCCAGCGCATGAGCAGCCACCCGATCGAAGAGGTCGGCGAAAAG
CTGCGCGGCATGATGCACTGGGCGCAGAATGACCGCCTCGTGGACAAGAGCCGCAACTAG

Upstream 100 bases:

>100_bases
TCATCGGGGTCGCCAATTTCAGTGGCGACTGGAGCTGCGACGCCGTTTGACCTGACAAACCCCTCCCTCAACTTTCATCC
ACCGGAGCTTTTGCAAGCCT

Downstream 100 bases:

>100_bases
GGGCCTGGCCATCCATGACTGACAGGTCTCCGCAGCGCTCAGATTTTTCGCATCGCATTGCGACGCCAGAGGACGCTGCG
GAGATCAGCCTGCTGATGGA

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MKIYYEKDADISLIQKLKVAVVGYGSQGHAHALNLKDSGVKQIKVALQEGSASRKKAEAAGLEVVSVADAAKWADVLMIL
VPDEKQAVLYANEIEPHLRAGQHLMFGHGFNIHYNLIRPRADVDVSLSAPKGPGHTLRNQYQMGFGLPGLIAIHQDATGS
AQAVALSYSKAIGNTRAGVIETSFREETETDLFGEQAVLCGGIVELIKAGYETLVEAGYAPEMAYFECLHETKLIVDLIY
EGGIANMNYSISNTAEYGEYVTGPRLVNAETKKEMKKVLEDIQNGTFARNWVLENQAGAPGFHAMRQRMSSHPIEEVGEK
LRGMMHWAQNDRLVDKSRN

Sequences:

>Translated_339_residues
MKIYYEKDADISLIQKLKVAVVGYGSQGHAHALNLKDSGVKQIKVALQEGSASRKKAEAAGLEVVSVADAAKWADVLMIL
VPDEKQAVLYANEIEPHLRAGQHLMFGHGFNIHYNLIRPRADVDVSLSAPKGPGHTLRNQYQMGFGLPGLIAIHQDATGS
AQAVALSYSKAIGNTRAGVIETSFREETETDLFGEQAVLCGGIVELIKAGYETLVEAGYAPEMAYFECLHETKLIVDLIY
EGGIANMNYSISNTAEYGEYVTGPRLVNAETKKEMKKVLEDIQNGTFARNWVLENQAGAPGFHAMRQRMSSHPIEEVGEK
LRGMMHWAQNDRLVDKSRN
>Mature_339_residues
MKIYYEKDADISLIQKLKVAVVGYGSQGHAHALNLKDSGVKQIKVALQEGSASRKKAEAAGLEVVSVADAAKWADVLMIL
VPDEKQAVLYANEIEPHLRAGQHLMFGHGFNIHYNLIRPRADVDVSLSAPKGPGHTLRNQYQMGFGLPGLIAIHQDATGS
AQAVALSYSKAIGNTRAGVIETSFREETETDLFGEQAVLCGGIVELIKAGYETLVEAGYAPEMAYFECLHETKLIVDLIY
EGGIANMNYSISNTAEYGEYVTGPRLVNAETKKEMKKVLEDIQNGTFARNWVLENQAGAPGFHAMRQRMSSHPIEEVGEK
LRGMMHWAQNDRLVDKSRN

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=289, Percent_Identity=35.9861591695502, Blast_Score=141, Evalue=6e-35,
Organism=Saccharomyces cerevisiae, GI6323387, Length=261, Percent_Identity=33.7164750957854, Blast_Score=118, Evalue=1e-27,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC_HYPNA (Q0C516)

Other databases:

- EMBL:   CP000158
- RefSeq:   YP_759177.1
- ProteinModelPortal:   Q0C516
- SMR:   Q0C516
- STRING:   Q0C516
- GeneID:   4288885
- GenomeReviews:   CP000158_GR
- KEGG:   hne:HNE_0447
- NMPDR:   fig|228405.5.peg.440
- TIGR:   HNE_0447
- eggNOG:   COG0059
- HOGENOM:   HBG286525
- OMA:   MAYAKGI
- PhylomeDB:   Q0C516
- ProtClustDB:   PRK05479
- BioCyc:   HNEP81032:HNE_0447-MONOMER
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21371
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 37230; Mature: 37230

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: NA

Important sites: ACT_SITE 108-108

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIYYEKDADISLIQKLKVAVVGYGSQGHAHALNLKDSGVKQIKVALQEGSASRKKAEAA
CEEEEECCCCHHHHHHHEEEEEEECCCCCEEEECCCCCCHHHHHHHHHCCCCHHHHHHHH
GLEVVSVADAAKWADVLMILVPDEKQAVLYANEIEPHLRAGQHLMFGHGFNIHYNLIRPR
CCEEEEHHHHHCCEEEEEEEECCCCCEEEEECCCCHHHHCCCEEEEECCCEEEEEEECCC
ADVDVSLSAPKGPGHTLRNQYQMGFGLPGLIAIHQDATGSAQAVALSYSKAIGNTRAGVI
CCCEEEEECCCCCCHHHHHHHHCCCCCCCEEEEECCCCCCCCEEEEEHHHHHCCCCCCEE
ETSFREETETDLFGEQAVLCGGIVELIKAGYETLVEAGYAPEMAYFECLHETKLIVDLIY
ECCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
EGGIANMNYSISNTAEYGEYVTGPRLVNAETKKEMKKVLEDIQNGTFARNWVLENQAGAP
CCCCCCCCEECCCCHHHCCCCCCCEEECHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCC
GFHAMRQRMSSHPIEEVGEKLRGMMHWAQNDRLVDKSRN
HHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MKIYYEKDADISLIQKLKVAVVGYGSQGHAHALNLKDSGVKQIKVALQEGSASRKKAEAA
CEEEEECCCCHHHHHHHEEEEEEECCCCCEEEECCCCCCHHHHHHHHHCCCCHHHHHHHH
GLEVVSVADAAKWADVLMILVPDEKQAVLYANEIEPHLRAGQHLMFGHGFNIHYNLIRPR
CCEEEEHHHHHCCEEEEEEEECCCCCEEEEECCCCHHHHCCCEEEEECCCEEEEEEECCC
ADVDVSLSAPKGPGHTLRNQYQMGFGLPGLIAIHQDATGSAQAVALSYSKAIGNTRAGVI
CCCEEEEECCCCCCHHHHHHHHCCCCCCCEEEEECCCCCCCCEEEEEHHHHHCCCCCCEE
ETSFREETETDLFGEQAVLCGGIVELIKAGYETLVEAGYAPEMAYFECLHETKLIVDLIY
ECCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
EGGIANMNYSISNTAEYGEYVTGPRLVNAETKKEMKKVLEDIQNGTFARNWVLENQAGAP
CCCCCCCCEECCCCHHHCCCCCCCEEECHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCC
GFHAMRQRMSSHPIEEVGEKLRGMMHWAQNDRLVDKSRN
HHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA