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The map label for this gene is gltT [H]

Identifier: 114800433

GI number: 114800433

Start: 396465

End: 397778

Strand: Reverse

Name: gltT [H]

Synonym: HNE_0400

Alternate gene names: 114800433

Gene position: 397778-396465 (Counterclockwise)

Preceding gene: 114799648

Following gene: 114800549

Centisome position: 10.74

GC content: 62.25

Gene sequence:

>1314_bases
ATGAAGGCCTGGTTTGCAATCGATCTGTGGAAGCGTGTGCTGCTCGGCCTCGTCCTGGGCACGCTGATAGGTCTGGCCTT
CCGCTATGGCCTTGGCCCGGAGCGGGGCAGCGAACTCGTCACCACCTGGTTCAAGCCGGTCGGCGACGCCTTCATCAGCC
TGATCCAGATGCTGGTTGTGCCACTGATCTTCACCACCCTGGTTTCCGGCGTGCTGGCAATGGGCGATCCCAAACGTCTC
GGCAGCCTCGGCGGCCGCGCGATGGCGATGTATATGATCACCACCGTCTTCGCGATCTGCTTCGGCCTGCTGATGGGGAC
GCTGGTTCAACCCGGCGCGGGCTTTGATACGTCCATCGCCTCGACCACAGACATTGAAGAAACCCGCTCGCGCCTCGCCG
CCAACGCGCCGCCCGGCACGGTGGGCGAGCAGCTGATGAATACGCTGCTCTCGATCATCCCGAAAAATCCGATTGATGCC
CTCGCCAGGGGCGATGTGTTGCAGATCATCTTCTTTGCCATCCTTCTGGGCATCGGCATCATGATGGCCGGGGAAGCGGG
CAAGCCGGTCGAAAAGCTCTTCGCCTCAGCCTCTGAAGCGATCATGAAGCTGACCCTGATCGTTATGGAAACCGCGCCGC
TGGGCGTGCTGGCCCTGATGGCCTGGGTGATGGGAGACCGGGGGCTCAGCGTGCTCACCGTACTCGGCAAGATGACGCTG
GCCCATTACAGCGCCTGTATCCTGCACATCCTGTTCACCTATGGCTTCATCGTGAAGGGCGTGCTGCGCCTGCCGCTCCT
TCCCTTCCTGCGCGGCGTGTTTGACGCGCAGATGGTGGCCTTCTCGACCTCCTCTTCCAACGCCACCCTGCCAATGACGA
TTTCCTGCGCCACCAAGAATCTCGGCATCGGCAAGCCGATTGCCTCCTCGGTCCTGCCGCTGGGCGCCACGATCAACATG
GACGGCACGGCGCTCTACCAGGGGCTGATCGCCCTCTTTGCCGTTCAGGCGCTTGGCATCCCGATGGAGCCGAGCATGTA
TCTGACCATCATTCTCATGGCGACACTGGTCTCGATCGGCACGGCGGGCGTGCCCTCGGTCAGCCTGCTGCTGGCCACCA
CCACGCTCAGCATCGTCGGCGCCAACCCCGAACAGATCGTGCTGATCATCGCCGTCCTGTTCCCGTTCGACCGTATCCTC
GACATGATGCGCACAGTGACCAACATCACCGGTGACCTTGCTGTCGGCACAGCCGTCGCCAAATGGGAAGGCGACCTGGA
CGAAGACGTCTTCCGGGCAAAAGACCCGGTCTGA

Upstream 100 bases:

>100_bases
CCCCAATGGCAAGCGCTGGCGCAATCGCTGCAGCCCCGACAGTTGCCTTCTCCAGCCCTGCCCCCTACCGTTGCCTCAGG
GTAACTGCTGGGAGTGGCGT

Downstream 100 bases:

>100_bases
CCCGCAAAACCCCTTCTCCCCCAGGGGGAGAAGGAGGGGTTAGGGATGAGGGGGCGAGGCCAGACGCTATTGCCTCGAGC
CTCGCAAACCCGCGCCGCCT

Product: sodium/dicarboxylate symporter

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 437; Mature: 437

Protein sequence:

>437_residues
MKAWFAIDLWKRVLLGLVLGTLIGLAFRYGLGPERGSELVTTWFKPVGDAFISLIQMLVVPLIFTTLVSGVLAMGDPKRL
GSLGGRAMAMYMITTVFAICFGLLMGTLVQPGAGFDTSIASTTDIEETRSRLAANAPPGTVGEQLMNTLLSIIPKNPIDA
LARGDVLQIIFFAILLGIGIMMAGEAGKPVEKLFASASEAIMKLTLIVMETAPLGVLALMAWVMGDRGLSVLTVLGKMTL
AHYSACILHILFTYGFIVKGVLRLPLLPFLRGVFDAQMVAFSTSSSNATLPMTISCATKNLGIGKPIASSVLPLGATINM
DGTALYQGLIALFAVQALGIPMEPSMYLTIILMATLVSIGTAGVPSVSLLLATTTLSIVGANPEQIVLIIAVLFPFDRIL
DMMRTVTNITGDLAVGTAVAKWEGDLDEDVFRAKDPV

Sequences:

>Translated_437_residues
MKAWFAIDLWKRVLLGLVLGTLIGLAFRYGLGPERGSELVTTWFKPVGDAFISLIQMLVVPLIFTTLVSGVLAMGDPKRL
GSLGGRAMAMYMITTVFAICFGLLMGTLVQPGAGFDTSIASTTDIEETRSRLAANAPPGTVGEQLMNTLLSIIPKNPIDA
LARGDVLQIIFFAILLGIGIMMAGEAGKPVEKLFASASEAIMKLTLIVMETAPLGVLALMAWVMGDRGLSVLTVLGKMTL
AHYSACILHILFTYGFIVKGVLRLPLLPFLRGVFDAQMVAFSTSSSNATLPMTISCATKNLGIGKPIASSVLPLGATINM
DGTALYQGLIALFAVQALGIPMEPSMYLTIILMATLVSIGTAGVPSVSLLLATTTLSIVGANPEQIVLIIAVLFPFDRIL
DMMRTVTNITGDLAVGTAVAKWEGDLDEDVFRAKDPV
>Mature_437_residues
MKAWFAIDLWKRVLLGLVLGTLIGLAFRYGLGPERGSELVTTWFKPVGDAFISLIQMLVVPLIFTTLVSGVLAMGDPKRL
GSLGGRAMAMYMITTVFAICFGLLMGTLVQPGAGFDTSIASTTDIEETRSRLAANAPPGTVGEQLMNTLLSIIPKNPIDA
LARGDVLQIIFFAILLGIGIMMAGEAGKPVEKLFASASEAIMKLTLIVMETAPLGVLALMAWVMGDRGLSVLTVLGKMTL
AHYSACILHILFTYGFIVKGVLRLPLLPFLRGVFDAQMVAFSTSSSNATLPMTISCATKNLGIGKPIASSVLPLGATINM
DGTALYQGLIALFAVQALGIPMEPSMYLTIILMATLVSIGTAGVPSVSLLLATTTLSIVGANPEQIVLIIAVLFPFDRIL
DMMRTVTNITGDLAVGTAVAKWEGDLDEDVFRAKDPV

Specific function: This carrier protein is part of the Na(+)-dependent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI4827012, Length=479, Percent_Identity=31.1064718162839, Blast_Score=178, Evalue=9e-45,
Organism=Homo sapiens, GI169790839, Length=447, Percent_Identity=31.9910514541387, Blast_Score=173, Evalue=2e-43,
Organism=Homo sapiens, GI194239697, Length=484, Percent_Identity=30.1652892561983, Blast_Score=168, Evalue=8e-42,
Organism=Homo sapiens, GI40254478, Length=410, Percent_Identity=31.219512195122, Blast_Score=159, Evalue=4e-39,
Organism=Homo sapiens, GI66773030, Length=469, Percent_Identity=31.5565031982942, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI5032093, Length=445, Percent_Identity=31.4606741573034, Blast_Score=142, Evalue=7e-34,
Organism=Homo sapiens, GI21314632, Length=410, Percent_Identity=29.5121951219512, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI262359914, Length=385, Percent_Identity=30.1298701298701, Blast_Score=136, Evalue=5e-32,
Organism=Homo sapiens, GI223468566, Length=296, Percent_Identity=34.1216216216216, Blast_Score=125, Evalue=8e-29,
Organism=Homo sapiens, GI223468564, Length=285, Percent_Identity=34.3859649122807, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI301601644, Length=147, Percent_Identity=36.734693877551, Blast_Score=90, Evalue=4e-18,
Organism=Escherichia coli, GI1790514, Length=423, Percent_Identity=36.4066193853428, Blast_Score=229, Evalue=3e-61,
Organism=Escherichia coli, GI1789947, Length=440, Percent_Identity=30.6818181818182, Blast_Score=199, Evalue=2e-52,
Organism=Escherichia coli, GI1788024, Length=405, Percent_Identity=28.3950617283951, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI1789473, Length=335, Percent_Identity=27.7611940298507, Blast_Score=98, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI71983106, Length=463, Percent_Identity=30.4535637149028, Blast_Score=174, Evalue=6e-44,
Organism=Caenorhabditis elegans, GI71983099, Length=463, Percent_Identity=30.4535637149028, Blast_Score=174, Evalue=6e-44,
Organism=Caenorhabditis elegans, GI71996953, Length=459, Percent_Identity=29.1938997821351, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI193206505, Length=450, Percent_Identity=30.8888888888889, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17537407, Length=453, Percent_Identity=31.3465783664459, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI193206654, Length=427, Percent_Identity=26.9320843091335, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17541374, Length=431, Percent_Identity=26.4501160092807, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24583025, Length=432, Percent_Identity=29.8611111111111, Blast_Score=154, Evalue=8e-38,
Organism=Drosophila melanogaster, GI17137668, Length=432, Percent_Identity=29.8611111111111, Blast_Score=154, Evalue=8e-38,
Organism=Drosophila melanogaster, GI24583023, Length=432, Percent_Identity=29.8611111111111, Blast_Score=154, Evalue=8e-38,
Organism=Drosophila melanogaster, GI281360481, Length=471, Percent_Identity=26.3269639065817, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI281360483, Length=471, Percent_Identity=26.3269639065817, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI17137666, Length=471, Percent_Identity=26.3269639065817, Blast_Score=98, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 46286; Mature: 46286

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: PS00713 NA_DICARBOXYL_SYMP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAWFAIDLWKRVLLGLVLGTLIGLAFRYGLGPERGSELVTTWFKPVGDAFISLIQMLVV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
PLIFTTLVSGVLAMGDPKRLGSLGGRAMAMYMITTVFAICFGLLMGTLVQPGAGFDTSIA
HHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
STTDIEETRSRLAANAPPGTVGEQLMNTLLSIIPKNPIDALARGDVLQIIFFAILLGIGI
CCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHH
MMAGEAGKPVEKLFASASEAIMKLTLIVMETAPLGVLALMAWVMGDRGLSVLTVLGKMTL
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHH
AHYSACILHILFTYGFIVKGVLRLPLLPFLRGVFDAQMVAFSTSSSNATLPMTISCATKN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCEEEEEEEECCCC
LGIGKPIASSVLPLGATINMDGTALYQGLIALFAVQALGIPMEPSMYLTIILMATLVSIG
CCCCCHHHHHHCCCCCEECCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHC
TAGVPSVSLLLATTTLSIVGANPEQIVLIIAVLFPFDRILDMMRTVTNITGDLAVGTAVA
CCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
KWEGDLDEDVFRAKDPV
HCCCCCCHHHHHCCCCC
>Mature Secondary Structure
MKAWFAIDLWKRVLLGLVLGTLIGLAFRYGLGPERGSELVTTWFKPVGDAFISLIQMLVV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
PLIFTTLVSGVLAMGDPKRLGSLGGRAMAMYMITTVFAICFGLLMGTLVQPGAGFDTSIA
HHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
STTDIEETRSRLAANAPPGTVGEQLMNTLLSIIPKNPIDALARGDVLQIIFFAILLGIGI
CCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHH
MMAGEAGKPVEKLFASASEAIMKLTLIVMETAPLGVLALMAWVMGDRGLSVLTVLGKMTL
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHH
AHYSACILHILFTYGFIVKGVLRLPLLPFLRGVFDAQMVAFSTSSSNATLPMTISCATKN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCEEEEEEEECCCC
LGIGKPIASSVLPLGATINMDGTALYQGLIALFAVQALGIPMEPSMYLTIILMATLVSIG
CCCCCHHHHHHCCCCCEECCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHC
TAGVPSVSLLLATTTLSIVGANPEQIVLIIAVLFPFDRILDMMRTVTNITGDLAVGTAVA
CCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
KWEGDLDEDVFRAKDPV
HCCCCCCHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]