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The map label for this gene is gppA [H]

Identifier: 114800396

GI number: 114800396

Start: 2361319

End: 2362806

Strand: Reverse

Name: gppA [H]

Synonym: HNE_2259

Alternate gene names: 114800396

Gene position: 2362806-2361319 (Counterclockwise)

Preceding gene: 114799243

Following gene: 114800235

Centisome position: 63.77

GC content: 61.16

Gene sequence:

>1488_bases
ATGAGTTTCCCGAAATCCAGGCTCGCAGGCATCATCGATATCGGGTCCAACTCGGTGCGTCTGGTTATCTGCGAGGTAAT
GGGCGCGTCGATCCTGCAGACGTTCAATGAAAAGGTGATGGCGGGCCTTGGCGAAGGCGTTCCCAAGACGGGGCAGCTTT
CCCCCAAGGGCGTCGAGGCGGCGCTGAAAGCGCTTAGCCGCTACCGTGCTATTCTCCGTGCCCTGAATGTTGAGACCTAT
CAGGCGGTCGCCACTGCGGCGGTGCGCACGGCGAGCGATGGGGATGCGTTTCTCAAACAGGCGGGCAAGATTCTCGGCCG
GCCGGTTCGCCTTCTCAGCGGTGAGGATGAGGCGCGCCTTTCTGCGCGCGGAGTTGATCTGAGTATTCACAATCCGGTCG
GCCTGATCGGCGACCTGGGCGGATCAAGCCTGGAGTTAAAGCGGATTGGCCTGGAGAAGGGGCCGGACGCCGGTGAAAGC
CTCATGCTTGGCCCCTTGGCGCTTGGGGACGTAGTGACCGACCCCAAGGAGCTGCGCAAACGTATCCGCGATGGCTTGAA
GGCCAGTGGCGTGTTGAAGGGTGCCAAGGGGCGTTTCTACGCCGTAGGCGGCGCTTGGCGCGCATTTGGCAGGCTGGTTA
TGGAGATGGACAAGTATCCGCTTCACGTATTGCAGGGGTTTCATATCAATGAAGGGCAGGTGGCGCGCGCGGCCAAGCTG
TGTGTCGATTCGCTCACCAACCCTGCCGCGCGGCAGCAGATCGAAACGATAGACAAGCGCCGGGCGAAATATTTCCCGAT
GGCGGCTGTTCTGCTCGAGGAAATCCTTGCTCTTGGGGCACTGGAGGGGGTGACGATCTCTGCGGCAGGCGTGCGCGAAG
GCGTATTGCATGATCTGCTGGATATGCCCCTGGATGATCCGCTGACGGATGGGATCATCGCATATGCCCGCCTCGACCAT
AACCAGATTGCCTTCGGGCGAGGACTGCACGAATTCATTTCTCCGGCACTGGTGCCTCAAAACGATCTTTTCGGATCACC
GGCAGCAGACATCCGTATCGAGATGGCCGCCTGCATGATGGCGGACAGCGCCGGGCGGTTCCATCCCGATCACCGGGCGG
AGATGGCCTATGACCAAGCCTTGCGCGCGCCCTATCTGGGCGTGACACATCCGGAACGGGCGATGATCGCCCATGCGATC
GGCTGCCGGTATGAGAAGGATTTCAAGCGCCCGAACGAGCATATCATGCTGACCACTGAGCAGCAGGCTGAACGGGCAAA
GCAGATCGGTCTGCTCATGCGCCTTGGCGCCGTCTTTTCCGGGCGCTCCGGGCCGATCCTGCAGCGCGCATCGCTGCATC
TGGAAGGCGATACCCTGACGCTCAAGGTCAGCCGGAAGGATGCCAATCTGATTTCGGAAACGGTGGAACGCCGCCTCTCC
CAGGCGGCAAGCATGCTGAGGCTGAAATCGGCGACGCTGGTGCGCTAG

Upstream 100 bases:

>100_bases
CACACGGATATTTTATGGACAATCCCAGCCTTTCCGGTCGTGGCAGCGCGCTGGAGGTCAGTCTACCGCCACGCCTGTCC
TATCGTGAGACCCATCCGAA

Downstream 100 bases:

>100_bases
GCGCGGCCTAAACGTCGAACAGGCGCACCTGTCCGCCATTGAAGGACACGGCCAGCTTGCCGGAGAGCAGCGCAATCGCT
TTCTGTCCGAACATGTCGTA

Product: Ppx/GppA family phosphatase

Products: NA

Alternate protein names: Guanosine pentaphosphate phosphohydrolase; pppGpp-5'-phosphohydrolase [H]

Number of amino acids: Translated: 495; Mature: 494

Protein sequence:

>495_residues
MSFPKSRLAGIIDIGSNSVRLVICEVMGASILQTFNEKVMAGLGEGVPKTGQLSPKGVEAALKALSRYRAILRALNVETY
QAVATAAVRTASDGDAFLKQAGKILGRPVRLLSGEDEARLSARGVDLSIHNPVGLIGDLGGSSLELKRIGLEKGPDAGES
LMLGPLALGDVVTDPKELRKRIRDGLKASGVLKGAKGRFYAVGGAWRAFGRLVMEMDKYPLHVLQGFHINEGQVARAAKL
CVDSLTNPAARQQIETIDKRRAKYFPMAAVLLEEILALGALEGVTISAAGVREGVLHDLLDMPLDDPLTDGIIAYARLDH
NQIAFGRGLHEFISPALVPQNDLFGSPAADIRIEMAACMMADSAGRFHPDHRAEMAYDQALRAPYLGVTHPERAMIAHAI
GCRYEKDFKRPNEHIMLTTEQQAERAKQIGLLMRLGAVFSGRSGPILQRASLHLEGDTLTLKVSRKDANLISETVERRLS
QAASMLRLKSATLVR

Sequences:

>Translated_495_residues
MSFPKSRLAGIIDIGSNSVRLVICEVMGASILQTFNEKVMAGLGEGVPKTGQLSPKGVEAALKALSRYRAILRALNVETY
QAVATAAVRTASDGDAFLKQAGKILGRPVRLLSGEDEARLSARGVDLSIHNPVGLIGDLGGSSLELKRIGLEKGPDAGES
LMLGPLALGDVVTDPKELRKRIRDGLKASGVLKGAKGRFYAVGGAWRAFGRLVMEMDKYPLHVLQGFHINEGQVARAAKL
CVDSLTNPAARQQIETIDKRRAKYFPMAAVLLEEILALGALEGVTISAAGVREGVLHDLLDMPLDDPLTDGIIAYARLDH
NQIAFGRGLHEFISPALVPQNDLFGSPAADIRIEMAACMMADSAGRFHPDHRAEMAYDQALRAPYLGVTHPERAMIAHAI
GCRYEKDFKRPNEHIMLTTEQQAERAKQIGLLMRLGAVFSGRSGPILQRASLHLEGDTLTLKVSRKDANLISETVERRLS
QAASMLRLKSATLVR
>Mature_494_residues
SFPKSRLAGIIDIGSNSVRLVICEVMGASILQTFNEKVMAGLGEGVPKTGQLSPKGVEAALKALSRYRAILRALNVETYQ
AVATAAVRTASDGDAFLKQAGKILGRPVRLLSGEDEARLSARGVDLSIHNPVGLIGDLGGSSLELKRIGLEKGPDAGESL
MLGPLALGDVVTDPKELRKRIRDGLKASGVLKGAKGRFYAVGGAWRAFGRLVMEMDKYPLHVLQGFHINEGQVARAAKLC
VDSLTNPAARQQIETIDKRRAKYFPMAAVLLEEILALGALEGVTISAAGVREGVLHDLLDMPLDDPLTDGIIAYARLDHN
QIAFGRGLHEFISPALVPQNDLFGSPAADIRIEMAACMMADSAGRFHPDHRAEMAYDQALRAPYLGVTHPERAMIAHAIG
CRYEKDFKRPNEHIMLTTEQQAERAKQIGLLMRLGAVFSGRSGPILQRASLHLEGDTLTLKVSRKDANLISETVERRLSQ
AASMLRLKSATLVR

Specific function: Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in th

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family. GppA subfamily [H]

Homologues:

Organism=Escherichia coli, GI48994966, Length=325, Percent_Identity=27.0769230769231, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1788848, Length=311, Percent_Identity=25.7234726688103, Blast_Score=65, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.40 [H]

Molecular weight: Translated: 53483; Mature: 53352

Theoretical pI: Translated: 9.57; Mature: 9.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFPKSRLAGIIDIGSNSVRLVICEVMGASILQTFNEKVMAGLGEGVPKTGQLSPKGVEA
CCCCHHHCCEEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHH
ALKALSRYRAILRALNVETYQAVATAAVRTASDGDAFLKQAGKILGRPVRLLSGEDEARL
HHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHCCCCHHHH
SARGVDLSIHNPVGLIGDLGGSSLELKRIGLEKGPDAGESLMLGPLALGDVVTDPKELRK
HHCCCEEEECCCCCCEECCCCCCEEEEECCCCCCCCCCCCEEECCHHHHHHCCCHHHHHH
RIRDGLKASGVLKGAKGRFYAVGGAWRAFGRLVMEMDKYPLHVLQGFHINEGQVARAAKL
HHHCCCCCCCEEECCCCCEEEECHHHHHHHHHHHHHCCCCHHHHCCCCCCCCHHHHHHHH
CVDSLTNPAARQQIETIDKRRAKYFPMAAVLLEEILALGALEGVTISAAGVREGVLHDLL
HHHHCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHH
DMPLDDPLTDGIIAYARLDHNQIAFGRGLHEFISPALVPQNDLFGSPAADIRIEMAACMM
HCCCCCCCCCCEEEEEECCCCHHHHHCCHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHH
ADSAGRFHPDHRAEMAYDQALRAPYLGVTHPERAMIAHAIGCRYEKDFKRPNEHIMLTTE
HCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCHHHHCCCCCEEEEEEH
QQAERAKQIGLLMRLGAVFSGRSGPILQRASLHLEGDTLTLKVSRKDANLISETVERRLS
HHHHHHHHHHHHHHHHHHHCCCCCCCEECCEEEECCCEEEEEEECCHHHHHHHHHHHHHH
QAASMLRLKSATLVR
HHHHHHHHHHHHCCC
>Mature Secondary Structure 
SFPKSRLAGIIDIGSNSVRLVICEVMGASILQTFNEKVMAGLGEGVPKTGQLSPKGVEA
CCCHHHCCEEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHH
ALKALSRYRAILRALNVETYQAVATAAVRTASDGDAFLKQAGKILGRPVRLLSGEDEARL
HHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHCCCCHHHH
SARGVDLSIHNPVGLIGDLGGSSLELKRIGLEKGPDAGESLMLGPLALGDVVTDPKELRK
HHCCCEEEECCCCCCEECCCCCCEEEEECCCCCCCCCCCCEEECCHHHHHHCCCHHHHHH
RIRDGLKASGVLKGAKGRFYAVGGAWRAFGRLVMEMDKYPLHVLQGFHINEGQVARAAKL
HHHCCCCCCCEEECCCCCEEEECHHHHHHHHHHHHHCCCCHHHHCCCCCCCCHHHHHHHH
CVDSLTNPAARQQIETIDKRRAKYFPMAAVLLEEILALGALEGVTISAAGVREGVLHDLL
HHHHCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHH
DMPLDDPLTDGIIAYARLDHNQIAFGRGLHEFISPALVPQNDLFGSPAADIRIEMAACMM
HCCCCCCCCCCEEEEEECCCCHHHHHCCHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHH
ADSAGRFHPDHRAEMAYDQALRAPYLGVTHPERAMIAHAIGCRYEKDFKRPNEHIMLTTE
HCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCHHHHCCCCCEEEEEEH
QQAERAKQIGLLMRLGAVFSGRSGPILQRASLHLEGDTLTLKVSRKDANLISETVERRLS
HHHHHHHHHHHHHHHHHHHCCCCCCCEECCEEEECCCEEEEEEECCHHHHHHHHHHHHHH
QAASMLRLKSATLVR
HHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA