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The map label for this gene is fabG [C]

Identifier: 114800383

GI number: 114800383

Start: 2984839

End: 2985759

Strand: Direct

Name: fabG [C]

Synonym: HNE_2820

Alternate gene names: 114800383

Gene position: 2984839-2985759 (Clockwise)

Preceding gene: 114797922

Following gene: 114797599

Centisome position: 80.56

GC content: 63.52

Gene sequence:

>921_bases
ATGTCCGAGATCCGTTTTGACGACCGCGTCGCCATTGTCACCGGCGCTGGCGGCGGCCTTGGCCGCGCTCACGCGCTTGA
ACTTGCCCGCCGCGGCGCAAAAATCGTGGTAAACGACCTGGGCGGCTCGCGCGATGGCTCGGGCGGCAGCTCGGACGCGG
CGCAGGCCGTTGTGAAGGAAATCGAAGCCCTCGGCGGCCAGGCCATCGCAAATGGCTCGTCGGTTTCGGACGTTGACGGC
GTGAAGCGCATGATCGACGACACGATGGCCAAATGGGGCCGGATCGACATCCTCATCGCGAATGCCGGCATCCTGCGGGA
CCGCTCCTTCTCCAAAATGAGCGTTGAAGACATCGACCTCGTTCTGGCAGTTCACCTGCGCGGCTCCTTCCTGCCGATCC
ACGCGGCCTGGGACATCATGAAGGCCCAGAATTACGGCCGTATCGTCGTGACCACCTCCTCGACCGGTCTCTATGGCAAC
TTTGGCCAGGCCAATTATGGCGCCGCAAAGCTCGGCGTGGTCGGCATGATGAACACCCTGAAAATCGAAGGCGCGAAGAA
CGACATCAAGATCAACGCCGTCTGCCCGATTGCGGCGACGCGGATGACCGAGGACATCATGTCCGAGCAGATGCTCGACG
CGCTGAAGCCGGAATATGTGACGCCGGGCGTGCTCAACCTCGTGAAGGAAGATGCCCCGACCGGCATGATCCTCTCGGCC
GGCGCAGGCGCCTTCTCGATGGCGCGGATCGTGGAAACGGCCGGCGTGTTCGTGGGCCAGGGCGAGGCGCTGACGGTGGA
AGCCGTTGCCGCCAAATGGGACCAGATCACCGACGTGAACACCACGCGTCCGGCGTTCAAATCCGGCGGCGAGCATGGCC
AGAACATCTTCGCTTCGGTGGCGGCTGCCGCTGCGAAGTAA

Upstream 100 bases:

>100_bases
CCTGCGGCAAGGGGTGACGCAGCGGAGATGCTTGACGTTGACGTGAACGTCTGGTGTGACACCGGCCAAACCTAGGACCA
CCGTTTACAGGGAGATACCC

Downstream 100 bases:

>100_bases
GCCGCAAGGCTTGCCAAAACGGGCTTAAAAGGCGCAAGGCTGGACTCTGGAAACGGAGTTTCAGCCATGCGCCTTTTTCT
TTTTGCGGTTTCGTTTGTTC

Product: short chain dehydrogenase/reductase family oxidoreductase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 306; Mature: 305

Protein sequence:

>306_residues
MSEIRFDDRVAIVTGAGGGLGRAHALELARRGAKIVVNDLGGSRDGSGGSSDAAQAVVKEIEALGGQAIANGSSVSDVDG
VKRMIDDTMAKWGRIDILIANAGILRDRSFSKMSVEDIDLVLAVHLRGSFLPIHAAWDIMKAQNYGRIVVTTSSTGLYGN
FGQANYGAAKLGVVGMMNTLKIEGAKNDIKINAVCPIAATRMTEDIMSEQMLDALKPEYVTPGVLNLVKEDAPTGMILSA
GAGAFSMARIVETAGVFVGQGEALTVEAVAAKWDQITDVNTTRPAFKSGGEHGQNIFASVAAAAAK

Sequences:

>Translated_306_residues
MSEIRFDDRVAIVTGAGGGLGRAHALELARRGAKIVVNDLGGSRDGSGGSSDAAQAVVKEIEALGGQAIANGSSVSDVDG
VKRMIDDTMAKWGRIDILIANAGILRDRSFSKMSVEDIDLVLAVHLRGSFLPIHAAWDIMKAQNYGRIVVTTSSTGLYGN
FGQANYGAAKLGVVGMMNTLKIEGAKNDIKINAVCPIAATRMTEDIMSEQMLDALKPEYVTPGVLNLVKEDAPTGMILSA
GAGAFSMARIVETAGVFVGQGEALTVEAVAAKWDQITDVNTTRPAFKSGGEHGQNIFASVAAAAAK
>Mature_305_residues
SEIRFDDRVAIVTGAGGGLGRAHALELARRGAKIVVNDLGGSRDGSGGSSDAAQAVVKEIEALGGQAIANGSSVSDVDGV
KRMIDDTMAKWGRIDILIANAGILRDRSFSKMSVEDIDLVLAVHLRGSFLPIHAAWDIMKAQNYGRIVVTTSSTGLYGNF
GQANYGAAKLGVVGMMNTLKIEGAKNDIKINAVCPIAATRMTEDIMSEQMLDALKPEYVTPGVLNLVKEDAPTGMILSAG
AGAFSMARIVETAGVFVGQGEALTVEAVAAKWDQITDVNTTRPAFKSGGEHGQNIFASVAAAAAK

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4504505, Length=286, Percent_Identity=50.3496503496504, Blast_Score=271, Evalue=4e-73,
Organism=Homo sapiens, GI15277342, Length=248, Percent_Identity=31.4516129032258, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI40254992, Length=207, Percent_Identity=33.3333333333333, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI25282469, Length=257, Percent_Identity=27.6264591439689, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI40807363, Length=229, Percent_Identity=28.3842794759825, Blast_Score=85, Evalue=8e-17,
Organism=Homo sapiens, GI310128830, Length=284, Percent_Identity=27.4647887323944, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI310115468, Length=284, Percent_Identity=27.4647887323944, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI4503817, Length=190, Percent_Identity=26.8421052631579, Blast_Score=73, Evalue=4e-13,
Organism=Escherichia coli, GI1787335, Length=208, Percent_Identity=34.6153846153846, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI87082100, Length=200, Percent_Identity=32.5, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1789208, Length=216, Percent_Identity=29.6296296296296, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1789057, Length=220, Percent_Identity=29.5454545454545, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1787905, Length=215, Percent_Identity=26.9767441860465, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1790717, Length=204, Percent_Identity=25.4901960784314, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI1786812, Length=191, Percent_Identity=27.2251308900524, Blast_Score=62, Evalue=5e-11,
Organism=Escherichia coli, GI87082160, Length=196, Percent_Identity=26.0204081632653, Blast_Score=62, Evalue=6e-11,
Organism=Escherichia coli, GI2367175, Length=192, Percent_Identity=30.7291666666667, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17568967, Length=279, Percent_Identity=49.4623655913978, Blast_Score=263, Evalue=9e-71,
Organism=Caenorhabditis elegans, GI193203117, Length=233, Percent_Identity=29.1845493562232, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI193203115, Length=228, Percent_Identity=29.8245614035088, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI25147288, Length=203, Percent_Identity=34.4827586206897, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17555706, Length=217, Percent_Identity=33.6405529953917, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17567345, Length=175, Percent_Identity=34.2857142857143, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71994604, Length=197, Percent_Identity=32.48730964467, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17508895, Length=241, Percent_Identity=26.5560165975104, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17562910, Length=201, Percent_Identity=30.3482587064677, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17564282, Length=189, Percent_Identity=27.5132275132275, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17559104, Length=200, Percent_Identity=28.5, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17561402, Length=208, Percent_Identity=28.3653846153846, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71982365, Length=202, Percent_Identity=27.2277227722772, Blast_Score=68, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI193204405, Length=197, Percent_Identity=26.9035532994924, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71994600, Length=198, Percent_Identity=29.2929292929293, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=277, Percent_Identity=46.9314079422383, Blast_Score=247, Evalue=2e-66,
Organism=Drosophila melanogaster, GI18859837, Length=284, Percent_Identity=46.4788732394366, Blast_Score=251, Evalue=6e-67,
Organism=Drosophila melanogaster, GI24639444, Length=191, Percent_Identity=34.5549738219895, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24640492, Length=239, Percent_Identity=25.1046025104602, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24649181, Length=191, Percent_Identity=31.413612565445, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21357041, Length=196, Percent_Identity=32.1428571428571, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI28571526, Length=193, Percent_Identity=30.0518134715026, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI23397609, Length=199, Percent_Identity=29.6482412060301, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24581726, Length=279, Percent_Identity=24.7311827956989, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24644339, Length=196, Percent_Identity=26.530612244898, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI281364892, Length=174, Percent_Identity=29.3103448275862, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21355631, Length=180, Percent_Identity=30.5555555555556, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21357673, Length=197, Percent_Identity=29.9492385786802, Blast_Score=68, Evalue=9e-12,
Organism=Drosophila melanogaster, GI17737361, Length=223, Percent_Identity=29.5964125560538, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 31880; Mature: 31749

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEIRFDDRVAIVTGAGGGLGRAHALELARRGAKIVVNDLGGSRDGSGGSSDAAQAVVKE
CCCCCCCCEEEEEEECCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHHHHHH
IEALGGQAIANGSSVSDVDGVKRMIDDTMAKWGRIDILIANAGILRDRSFSKMSVEDIDL
HHHCCCCEECCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCEEECCCCCCCCHHHHEE
VLAVHLRGSFLPIHAAWDIMKAQNYGRIVVTTSSTGLYGNFGQANYGAAKLGVVGMMNTL
EEEEEECCCEEEHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHCCEEE
KIEGAKNDIKINAVCPIAATRMTEDIMSEQMLDALKPEYVTPGVLNLVKEDAPTGMILSA
EEECCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCEEEEC
GAGAFSMARIVETAGVFVGQGEALTVEAVAAKWDQITDVNTTRPAFKSGGEHGQNIFASV
CCCHHHHHHHHHHHCEEEECCCEEEEHHHHHHHHHCCCCCCCCCHHHCCCCCHHHHHHHH
AAAAAK
HHHHCC
>Mature Secondary Structure 
SEIRFDDRVAIVTGAGGGLGRAHALELARRGAKIVVNDLGGSRDGSGGSSDAAQAVVKE
CCCCCCCEEEEEEECCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHHHHHH
IEALGGQAIANGSSVSDVDGVKRMIDDTMAKWGRIDILIANAGILRDRSFSKMSVEDIDL
HHHCCCCEECCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCEEECCCCCCCCHHHHEE
VLAVHLRGSFLPIHAAWDIMKAQNYGRIVVTTSSTGLYGNFGQANYGAAKLGVVGMMNTL
EEEEEECCCEEEHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHCCEEE
KIEGAKNDIKINAVCPIAATRMTEDIMSEQMLDALKPEYVTPGVLNLVKEDAPTGMILSA
EEECCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCEEEEC
GAGAFSMARIVETAGVFVGQGEALTVEAVAAKWDQITDVNTTRPAFKSGGEHGQNIFASV
CCCHHHHHHHHHHHCEEEECCCEEEEHHHHHHHHHCCCCCCCCCHHHCCCCCHHHHHHHH
AAAAAK
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]