Click here to switch to the map view.

The map label for this gene is hemD

Identifier: 114800364

GI number: 114800364

Start: 3396755

End: 3397468

Strand: Direct

Name: hemD

Synonym: HNE_3228

Alternate gene names: NA

Gene position: 3396755-3397468 (Clockwise)

Preceding gene: 114797250

Following gene: 114799645

Centisome position: 91.68

GC content: 69.47

Gene sequence:

>714_bases
TTGAATCTGGCGGTGATCGTCACGCGCACACAGCCGGGCGCGGACGAAACCGCCGCCCGTCTCACCGCGCTGGGCTACCA
CGCCATCCTCTCGCCCATGCTGTCGATCCTGGAAACAGGGCTCGCCCCGGCCGCCCTTGAGGGCGTGCGCGACATCATCT
TTACCAGCGCCAATGGCGTGCGGGCCTTTGGATCAGCGCGCCTTCCCGCCTCCGGCTTCACAGCCTGGTGCGTTGGCCCT
TCCACGGCCACAGCCGCGCGCGAGGCAGGCTTTGACCAGGTGGTGGAGGGCGACGGCGATGCAAGCGACCTTGCAAGGCT
CATCCTCACCGCCCGCGCCGAACTTTCCGGCCCTCTCCTCCACATCGCCAATGACGCCGCCGCCGGACATCTGGTCGCCA
GCCTGAAGGCGGCAGGCCTCGATGCCCGCTTTGCTGCGGCCTACCAGACGGTTGCCGCGCCCTCCCTATCGGCCGGCGCC
CTCGCCGCGCTGGCCGAAGGCCCAGCCATTCTGCTGATCCATTCGGCAAAGGGCGCTGAGGCCCTCGTGCAATCTGGCGC
GGCGCTGGACCGTGCCGCGGCCATCGCGATTTCAGCGCCCGCTGCCGTGCCCCTTGAAAAGACCCCGCTGGCCGGCCTCT
GGATTGCCGCGCGGCCCAACGAAGACGCGCTGATGGCCGCCCTTGAAGAAGCGGCCACCTCGCTGCGCGCCTGA

Upstream 100 bases:

>100_bases
AGGATGCCACCGATGCCCAGCTGGTCCTCTTGGGCCGGGCCGTCGCGCAGGAGATCATCTTCGCGGCCAAGGAAGCCCTT
CCCGTTTTCGGAGACGAGCG

Downstream 100 bases:

>100_bases
GGCGCCTGCTTTGCCGTAGAGGCGCGGTGTGCCACACTCATGCCCAAGAGTTAGACCACCGAAGGCGACATGACAGATAC
TCCCCCACCCGGTCAGGAAC

Product: uroporphyrinogen-III synthase

Products: uroporphyrinogen III; H2O

Alternate protein names: NA

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MNLAVIVTRTQPGADETAARLTALGYHAILSPMLSILETGLAPAALEGVRDIIFTSANGVRAFGSARLPASGFTAWCVGP
STATAAREAGFDQVVEGDGDASDLARLILTARAELSGPLLHIANDAAAGHLVASLKAAGLDARFAAAYQTVAAPSLSAGA
LAALAEGPAILLIHSAKGAEALVQSGAALDRAAAIAISAPAAVPLEKTPLAGLWIAARPNEDALMAALEEAATSLRA

Sequences:

>Translated_237_residues
MNLAVIVTRTQPGADETAARLTALGYHAILSPMLSILETGLAPAALEGVRDIIFTSANGVRAFGSARLPASGFTAWCVGP
STATAAREAGFDQVVEGDGDASDLARLILTARAELSGPLLHIANDAAAGHLVASLKAAGLDARFAAAYQTVAAPSLSAGA
LAALAEGPAILLIHSAKGAEALVQSGAALDRAAAIAISAPAAVPLEKTPLAGLWIAARPNEDALMAALEEAATSLRA
>Mature_237_residues
MNLAVIVTRTQPGADETAARLTALGYHAILSPMLSILETGLAPAALEGVRDIIFTSANGVRAFGSARLPASGFTAWCVGP
STATAAREAGFDQVVEGDGDASDLARLILTARAELSGPLLHIANDAAAGHLVASLKAAGLDARFAAAYQTVAAPSLSAGA
LAALAEGPAILLIHSAKGAEALVQSGAALDRAAAIAISAPAAVPLEKTPLAGLWIAARPNEDALMAALEEAATSLRA

Specific function: Unknown

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 4.2.1.75

Molecular weight: Translated: 23659; Mature: 23659

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLAVIVTRTQPGADETAARLTALGYHAILSPMLSILETGLAPAALEGVRDIIFTSANGV
CCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCC
RAFGSARLPASGFTAWCVGPSTATAAREAGFDQVVEGDGDASDLARLILTARAELSGPLL
EECCCCCCCCCCCEEEEECCCHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHHHHCCCEE
HIANDAAAGHLVASLKAAGLDARFAAAYQTVAAPSLSAGALAALAEGPAILLIHSAKGAE
EEECCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHCCCCEEEEEECCCCHH
ALVQSGAALDRAAAIAISAPAAVPLEKTPLAGLWIAARPNEDALMAALEEAATSLRA
HHHHCCCHHHHHHEEEEECCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNLAVIVTRTQPGADETAARLTALGYHAILSPMLSILETGLAPAALEGVRDIIFTSANGV
CCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCC
RAFGSARLPASGFTAWCVGPSTATAAREAGFDQVVEGDGDASDLARLILTARAELSGPLL
EECCCCCCCCCCCEEEEECCCHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHHHHCCCEE
HIANDAAAGHLVASLKAAGLDARFAAAYQTVAAPSLSAGALAALAEGPAILLIHSAKGAE
EEECCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHCCCCEEEEEECCCCHH
ALVQSGAALDRAAAIAISAPAAVPLEKTPLAGLWIAARPNEDALMAALEEAATSLRA
HHHHCCCHHHHHHEEEEECCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: hydroxymethylbilane

Specific reaction: hydroxymethylbilane = uroporphyrinogen III + H2O

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA