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The map label for this gene is pqqL [C]

Identifier: 114800347

GI number: 114800347

Start: 871036

End: 872394

Strand: Direct

Name: pqqL [C]

Synonym: HNE_0852

Alternate gene names: 114800347

Gene position: 871036-872394 (Clockwise)

Preceding gene: 114799408

Following gene: 114797798

Centisome position: 23.51

GC content: 63.28

Gene sequence:

>1359_bases
ATGAAACGGATACTCGTCGCTGCAGGGCTCCTCGCCTTCGCGGCCGCTGGCGCTTTGGCCGAGCCTGCTACCGAAACCAG
CGCGCCAAGCAGCTTCATGCTCGATAATGGCCTGCAGGTCGTGGTCGTGCCCGATCACCGCGCCCCGGTGGTCACGCATA
TGGTCTGGTACAAGGTCGGCGCCGTCGATGAGGCCCCCGGCAAGTCCGGCATCGCCCACCTGTTTGAACATGTGATGTTC
AAGGAAACCAGGAATATCGGCCCGGAGGAGTTCACCTCCATCGTCCAGCGGTCGGGCGGCCAGCTCAACGCTTTCACCAG
CTGGGACTACACCGCCTATTTCGAGCGGGTTCACAAGGACCAGCTCGGCAAGATGATGGAGCTGGAAGCCGAGCGGATGG
TGAACCTCATCATCAATGACGATCCCGAAGGCCCGTTCATCTCAGAGCGCGATGTCGTGAAGGAAGAACGCCGCCAGCGC
CTCGACAACAATCCCGCCGCGCTGCTGCAGGAAATGGTGCTGACCGAATTCTGGAAGGGCCACCCTTACGAGATCACCGT
CATCGGCCTGATGGATGAGGTGAACGCGCTGACCCCGCAGGACGGGCTGGATTTCTACCGCGAATATTACAGCCCGGAGA
ACGCCATCCTCGTCGTCGCCGGCGATGTCACCGAAGAGGGCGTGCGCGCCCTGGCCGAGCAGCATTATGGCCCGCTCCAG
CCCACCGGCGAAGCGCACGATCAGCGCAAATGGCAGCCCGTGGCGCCGCTCGCAGAAACCAAGCTGATCACCCATTCCGA
TCCCAAGGTGCGCCAGCCCGTCTGGAGCCGCTATTATCTCGGCACCTCGTTCAACCGCGATCCCGAACGCGCGCTCGCGC
TGGAAGTCGGCCTTGAAGTGCTCGGCGGCGGCCTCACCAGCCGCCTCTACCAGACGCTGGTCGAGGAGCAGAAGGTCGCC
ATCAATGTCGCCACCTTCGCCTGGACAACCCTGCATGATGAAGGCCCCGCGGTAATCTACGGCACGCCCGTTGACGGCGT
CAGCCTGGAAGACCTCGACGCTGCCGTGATGGCCGAGATCGAGAAGATCCTCGCCGAAGGCTTCACCGAAGATGAAGTCC
GCCGCGCCCGCAACAAGCTCGCCGCCACGGCCATCTACCAGACCGACAGCCAGTCAGCGATGGCCAACCATTACGGCGCC
AATCTCGCCCTCGGCTTCACGCTGGAAGAGATCGCCAGCTATCCCGATGAAGTGCGCGCGGTCACGCCGGACGAAGCGCT
CGCCGCCGTGCGCGCCGTCTTTGGCGCCGACCAGAACTATATCACTTCCCATCTTCTGCCGGCCGAAGGAGACCTCTGA

Upstream 100 bases:

>100_bases
GCCAGCCGCATCAAGCTGCCCGGAACCTGATGTTATTCCCTGGGGGCCGGCGCATGTCTGCGTGGCCCCCCTTCCTGCCC
CTCCAGATCGGAGCTTCCCC

Downstream 100 bases:

>100_bases
TGTTGAAACTCCGGCTTATCTCCGGCGCCGCTGCGGCCGTATTCCTCGCCGCCTGCGCCACGCCCGCCCCCCCACCTGAA
GCTGCGCCTGAAGCCTCGCT

Product: insulinase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 452; Mature: 452

Protein sequence:

>452_residues
MKRILVAAGLLAFAAAGALAEPATETSAPSSFMLDNGLQVVVVPDHRAPVVTHMVWYKVGAVDEAPGKSGIAHLFEHVMF
KETRNIGPEEFTSIVQRSGGQLNAFTSWDYTAYFERVHKDQLGKMMELEAERMVNLIINDDPEGPFISERDVVKEERRQR
LDNNPAALLQEMVLTEFWKGHPYEITVIGLMDEVNALTPQDGLDFYREYYSPENAILVVAGDVTEEGVRALAEQHYGPLQ
PTGEAHDQRKWQPVAPLAETKLITHSDPKVRQPVWSRYYLGTSFNRDPERALALEVGLEVLGGGLTSRLYQTLVEEQKVA
INVATFAWTTLHDEGPAVIYGTPVDGVSLEDLDAAVMAEIEKILAEGFTEDEVRRARNKLAATAIYQTDSQSAMANHYGA
NLALGFTLEEIASYPDEVRAVTPDEALAAVRAVFGADQNYITSHLLPAEGDL

Sequences:

>Translated_452_residues
MKRILVAAGLLAFAAAGALAEPATETSAPSSFMLDNGLQVVVVPDHRAPVVTHMVWYKVGAVDEAPGKSGIAHLFEHVMF
KETRNIGPEEFTSIVQRSGGQLNAFTSWDYTAYFERVHKDQLGKMMELEAERMVNLIINDDPEGPFISERDVVKEERRQR
LDNNPAALLQEMVLTEFWKGHPYEITVIGLMDEVNALTPQDGLDFYREYYSPENAILVVAGDVTEEGVRALAEQHYGPLQ
PTGEAHDQRKWQPVAPLAETKLITHSDPKVRQPVWSRYYLGTSFNRDPERALALEVGLEVLGGGLTSRLYQTLVEEQKVA
INVATFAWTTLHDEGPAVIYGTPVDGVSLEDLDAAVMAEIEKILAEGFTEDEVRRARNKLAATAIYQTDSQSAMANHYGA
NLALGFTLEEIASYPDEVRAVTPDEALAAVRAVFGADQNYITSHLLPAEGDL
>Mature_452_residues
MKRILVAAGLLAFAAAGALAEPATETSAPSSFMLDNGLQVVVVPDHRAPVVTHMVWYKVGAVDEAPGKSGIAHLFEHVMF
KETRNIGPEEFTSIVQRSGGQLNAFTSWDYTAYFERVHKDQLGKMMELEAERMVNLIINDDPEGPFISERDVVKEERRQR
LDNNPAALLQEMVLTEFWKGHPYEITVIGLMDEVNALTPQDGLDFYREYYSPENAILVVAGDVTEEGVRALAEQHYGPLQ
PTGEAHDQRKWQPVAPLAETKLITHSDPKVRQPVWSRYYLGTSFNRDPERALALEVGLEVLGGGLTSRLYQTLVEEQKVA
INVATFAWTTLHDEGPAVIYGTPVDGVSLEDLDAAVMAEIEKILAEGFTEDEVRRARNKLAATAIYQTDSQSAMANHYGA
NLALGFTLEEIASYPDEVRAVTPDEALAAVRAVFGADQNYITSHLLPAEGDL

Specific function: Unknown

COG id: COG0612

COG function: function code R; Predicted Zn-dependent peptidases

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M16 family [H]

Homologues:

Organism=Homo sapiens, GI46593007, Length=216, Percent_Identity=27.7777777777778, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI94538354, Length=388, Percent_Identity=24.2268041237113, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1787770, Length=351, Percent_Identity=25.6410256410256, Blast_Score=89, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI17553678, Length=433, Percent_Identity=23.7875288683603, Blast_Score=68, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI71999683, Length=212, Percent_Identity=24.5283018867925, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323192, Length=222, Percent_Identity=23.8738738738739, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI21357875, Length=234, Percent_Identity=26.0683760683761, Blast_Score=79, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24646943, Length=234, Percent_Identity=26.0683760683761, Blast_Score=79, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011249
- InterPro:   IPR011237
- InterPro:   IPR011765
- InterPro:   IPR001431
- InterPro:   IPR007863 [H]

Pfam domain/function: PF00675 Peptidase_M16; PF05193 Peptidase_M16_C [H]

EC number: 3.4.99.- [C]

Molecular weight: Translated: 49896; Mature: 49896

Theoretical pI: Translated: 4.42; Mature: 4.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRILVAAGLLAFAAAGALAEPATETSAPSSFMLDNGLQVVVVPDHRAPVVTHMVWYKVG
CCHHHHHHHHHHHHHHCHHCCCCCCCCCCCCEEECCCCEEEEECCCCCCHHHHHHHHHHC
AVDEAPGKSGIAHLFEHVMFKETRNIGPEEFTSIVQRSGGQLNAFTSWDYTAYFERVHKD
CCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHH
QLGKMMELEAERMVNLIINDDPEGPFISERDVVKEERRQRLDNNPAALLQEMVLTEFWKG
HHHHHHHHHHHHHEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC
HPYEITVIGLMDEVNALTPQDGLDFYREYYSPENAILVVAGDVTEEGVRALAEQHYGPLQ
CCEEEEEEEEEHHHCCCCCCCHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHCCCCCC
PTGEAHDQRKWQPVAPLAETKLITHSDPKVRQPVWSRYYLGTSFNRDPERALALEVGLEV
CCCCCCCCCCCCCCCCHHHCEEEECCCCCHHCCHHHHEEECCCCCCCHHHHHHHHHHHHH
LGGGLTSRLYQTLVEEQKVAINVATFAWTTLHDEGPAVIYGTPVDGVSLEDLDAAVMAEI
HCCHHHHHHHHHHHHHHHHEEEEEHEEEEEEECCCCEEEEECCCCCCCHHHHHHHHHHHH
EKILAEGFTEDEVRRARNKLAATAIYQTDSQSAMANHYGANLALGFTLEEIASYPDEVRA
HHHHHCCCCHHHHHHHHHHHHHHHEEECCCHHHHHHHCCCCEEEEEEHHHHHCCCHHHEE
VTPDEALAAVRAVFGADQNYITSHLLPAEGDL
CCCHHHHHHHHHHHCCCCHHHHHCCCCCCCCC
>Mature Secondary Structure
MKRILVAAGLLAFAAAGALAEPATETSAPSSFMLDNGLQVVVVPDHRAPVVTHMVWYKVG
CCHHHHHHHHHHHHHHCHHCCCCCCCCCCCCEEECCCCEEEEECCCCCCHHHHHHHHHHC
AVDEAPGKSGIAHLFEHVMFKETRNIGPEEFTSIVQRSGGQLNAFTSWDYTAYFERVHKD
CCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHH
QLGKMMELEAERMVNLIINDDPEGPFISERDVVKEERRQRLDNNPAALLQEMVLTEFWKG
HHHHHHHHHHHHHEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC
HPYEITVIGLMDEVNALTPQDGLDFYREYYSPENAILVVAGDVTEEGVRALAEQHYGPLQ
CCEEEEEEEEEHHHCCCCCCCHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHCCCCCC
PTGEAHDQRKWQPVAPLAETKLITHSDPKVRQPVWSRYYLGTSFNRDPERALALEVGLEV
CCCCCCCCCCCCCCCCHHHCEEEECCCCCHHCCHHHHEEECCCCCCCHHHHHHHHHHHHH
LGGGLTSRLYQTLVEEQKVAINVATFAWTTLHDEGPAVIYGTPVDGVSLEDLDAAVMAEI
HCCHHHHHHHHHHHHHHHHEEEEEHEEEEEEECCCCEEEEECCCCCCCHHHHHHHHHHHH
EKILAEGFTEDEVRRARNKLAATAIYQTDSQSAMANHYGANLALGFTLEEIASYPDEVRA
HHHHHCCCCHHHHHHHHHHHHHHHEEECCCHHHHHHHCCCCEEEEEEHHHHHCCCHHHEE
VTPDEALAAVRAVFGADQNYITSHLLPAEGDL
CCCHHHHHHHHHHHCCCCHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Endopeptidases of unknown catalytic mechanism [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]