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The map label for this gene is yleA [C]

Identifier: 114800325

GI number: 114800325

Start: 3661527

End: 3662804

Strand: Reverse

Name: yleA [C]

Synonym: HNE_3527

Alternate gene names: 114800325

Gene position: 3662804-3661527 (Counterclockwise)

Preceding gene: 114799327

Following gene: 114799634

Centisome position: 98.86

GC content: 65.1

Gene sequence:

>1278_bases
ATGGCTGATACCGCCCCGCCTTCCAGCCCGACCGTCATCACGCTCGGATGCCGCCTCAACACCTACGAGTCCGAGGTGAT
GCGCCGCCATGCCCATGCGGCAGGGCTGGGCGACGCTGTCATCATCAACACCTGCGCGGTCACCTCCGAAGCCGTGCGCG
GCGCCCGTCAGGCCATCCGCCGGGCGGCTCGCGACAATCCTGGCGCGCCGATCCTCGTCACCGGTTGCGCCGCCCAGACC
GACCCGGAGGCCTTCGCGGCGATGCCGGAGGTTACCCGCGTCATCGGCAATCACGACAAGATGAAAGCCGAGACATGGAA
ACCCGCAGACCTGCTCGGCGGGGAAGAGAAGATCCGCGTCAACGACATCATGAGCGTGCGCGAAACCGCCGCCCATCTGA
TCGACGGCATGGAAGGCCGGGCGCGGGCCTATGTGCAGGTCCAGAACGGCTGCGACCATCGTTGCACCTTCTGCATCATT
CCCTATGGCCGCGGAAACTCCCGCTCGGTTCCGGCAGGGGAAGTGGTGGCCCAGGTGCGCGCCCTCGCTGCCAGCGGGCA
TTATGAGGTCGTGCTGACGGGCGTGGACCTCACCAGCTGGGGCGCAGACCTTCCAGGGACGCCCGAGCTCGGTAATCTCG
TCCAGCGCATCCTGAAGCTTGTGCCCGAACTCCGCGCGCTGCGAATTTCCTCCATCGACGCGATCGAGATGGATGATGCC
CTCATCGAAGCGCTCGCCGATCCGCGCGTGGCGCCGTATCTGCACCTCTCGCTGCAGCATGGCGATAATCTTATCCTCAA
GCGGATGAAACGCCGCCATAGCCGCGATCAGGCCATTCAGCTTACAGAGCGTCTTCGCGCCATGCGGCCGGACATTGCTC
TGGGGGCGGACATAATCGCCGGTTTCCCGACCGAGACCGAGGCGCACTTTGAAAACTCCCTCCGCCTCATTGATGAGTGC
GGTCTCTCCTTCCTGCATGCCTTCCCCTACAGCCCGCGCCCCGGCACGCCGGCAGCCAAGATGCCCCAGCTGGCAAAGCC
GCTGATCAAGGACCGCGCCGCGCGTTTGCGGGCAGCGGGCGAAGCCGCGCTCCTCCGGCATTTTGAACGCCATCTCGGTC
AGGTGCGCCTGGCATTGATTGAACGCGATACCGCCGCCCGCCTACCCGATTTCACCCAGGTCAAACTCAGTCGCGCGGCA
GGGGAGGGTGGACGGATGACGCCTGTGCAGATAACCGGCCATGACGGCAAGCAGCTTCTGGGAACACCCCTTTCATGA

Upstream 100 bases:

>100_bases
GCACGGGCGCCTGCCAGGGTCCGGGCTGAGGCGTCCGGCTGAGGCAAAACAGGCGTATCCGCTTGCAATTGGGTCTCATC
GGCGCGATCTGACGGGGCTT

Downstream 100 bases:

>100_bases
TCCTCTGGTTCGGCAAGAAGAAGAAACTCGACGAGGCCAAAGCCGCCGGCGAGGTAATGAAAGCGCCGGAATTGAGCGCG
GAAGAAATCGCCGCGCAGGA

Product: tRNA-i(6)A37 thiotransferase enzyme MiaB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 425; Mature: 424

Protein sequence:

>425_residues
MADTAPPSSPTVITLGCRLNTYESEVMRRHAHAAGLGDAVIINTCAVTSEAVRGARQAIRRAARDNPGAPILVTGCAAQT
DPEAFAAMPEVTRVIGNHDKMKAETWKPADLLGGEEKIRVNDIMSVRETAAHLIDGMEGRARAYVQVQNGCDHRCTFCII
PYGRGNSRSVPAGEVVAQVRALAASGHYEVVLTGVDLTSWGADLPGTPELGNLVQRILKLVPELRALRISSIDAIEMDDA
LIEALADPRVAPYLHLSLQHGDNLILKRMKRRHSRDQAIQLTERLRAMRPDIALGADIIAGFPTETEAHFENSLRLIDEC
GLSFLHAFPYSPRPGTPAAKMPQLAKPLIKDRAARLRAAGEAALLRHFERHLGQVRLALIERDTAARLPDFTQVKLSRAA
GEGGRMTPVQITGHDGKQLLGTPLS

Sequences:

>Translated_425_residues
MADTAPPSSPTVITLGCRLNTYESEVMRRHAHAAGLGDAVIINTCAVTSEAVRGARQAIRRAARDNPGAPILVTGCAAQT
DPEAFAAMPEVTRVIGNHDKMKAETWKPADLLGGEEKIRVNDIMSVRETAAHLIDGMEGRARAYVQVQNGCDHRCTFCII
PYGRGNSRSVPAGEVVAQVRALAASGHYEVVLTGVDLTSWGADLPGTPELGNLVQRILKLVPELRALRISSIDAIEMDDA
LIEALADPRVAPYLHLSLQHGDNLILKRMKRRHSRDQAIQLTERLRAMRPDIALGADIIAGFPTETEAHFENSLRLIDEC
GLSFLHAFPYSPRPGTPAAKMPQLAKPLIKDRAARLRAAGEAALLRHFERHLGQVRLALIERDTAARLPDFTQVKLSRAA
GEGGRMTPVQITGHDGKQLLGTPLS
>Mature_424_residues
ADTAPPSSPTVITLGCRLNTYESEVMRRHAHAAGLGDAVIINTCAVTSEAVRGARQAIRRAARDNPGAPILVTGCAAQTD
PEAFAAMPEVTRVIGNHDKMKAETWKPADLLGGEEKIRVNDIMSVRETAAHLIDGMEGRARAYVQVQNGCDHRCTFCIIP
YGRGNSRSVPAGEVVAQVRALAASGHYEVVLTGVDLTSWGADLPGTPELGNLVQRILKLVPELRALRISSIDAIEMDDAL
IEALADPRVAPYLHLSLQHGDNLILKRMKRRHSRDQAIQLTERLRAMRPDIALGADIIAGFPTETEAHFENSLRLIDECG
LSFLHAFPYSPRPGTPAAKMPQLAKPLIKDRAARLRAAGEAALLRHFERHLGQVRLALIERDTAARLPDFTQVKLSRAAG
EGGRMTPVQITGHDGKQLLGTPLS

Specific function: Unknown

COG id: COG0621

COG function: function code J; 2-methylthioadenine synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 MTTase N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI93277076, Length=467, Percent_Identity=24.8394004282655, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI28872782, Length=366, Percent_Identity=23.224043715847, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI28872784, Length=366, Percent_Identity=23.224043715847, Blast_Score=108, Evalue=1e-23,
Organism=Escherichia coli, GI1786882, Length=360, Percent_Identity=29.7222222222222, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI1787057, Length=402, Percent_Identity=27.8606965174129, Blast_Score=151, Evalue=7e-38,
Organism=Caenorhabditis elegans, GI17553146, Length=365, Percent_Identity=27.3972602739726, Blast_Score=137, Evalue=8e-33,
Organism=Caenorhabditis elegans, GI71996771, Length=295, Percent_Identity=28.4745762711864, Blast_Score=123, Evalue=1e-28,
Organism=Drosophila melanogaster, GI21356207, Length=420, Percent_Identity=29.2857142857143, Blast_Score=148, Evalue=7e-36,
Organism=Drosophila melanogaster, GI19922432, Length=365, Percent_Identity=29.041095890411, Blast_Score=145, Evalue=5e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR005839
- InterPro:   IPR020612
- InterPro:   IPR013848
- InterPro:   IPR006467
- InterPro:   IPR007197 [H]

Pfam domain/function: PF04055 Radical_SAM; PF00919 UPF0004 [H]

EC number: NA

Molecular weight: Translated: 46083; Mature: 45951

Theoretical pI: Translated: 8.31; Mature: 8.31

Prosite motif: PS01278 UPF0004

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADTAPPSSPTVITLGCRLNTYESEVMRRHAHAAGLGDAVIINTCAVTSEAVRGARQAIR
CCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHH
RAARDNPGAPILVTGCAAQTDPEAFAAMPEVTRVIGNHDKMKAETWKPADLLGGEEKIRV
HHHCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCCEEEH
NDIMSVRETAAHLIDGMEGRARAYVQVQNGCDHRCTFCIIPYGRGNSRSVPAGEVVAQVR
HHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHH
ALAASGHYEVVLTGVDLTSWGADLPGTPELGNLVQRILKLVPELRALRISSIDAIEMDDA
HHHCCCCEEEEEEECCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
LIEALADPRVAPYLHLSLQHGDNLILKRMKRRHSRDQAIQLTERLRAMRPDIALGADIIA
HHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHCHHHHHHHHHHHHHHCCCHHHCCHHHC
GFPTETEAHFENSLRLIDECGLSFLHAFPYSPRPGTPAAKMPQLAKPLIKDRAARLRAAG
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
EAALLRHFERHLGQVRLALIERDTAARLPDFTQVKLSRAAGEGGRMTPVQITGHDGKQLL
HHHHHHHHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHCCCCCCCCEEEEECCCCHHCC
GTPLS
CCCCC
>Mature Secondary Structure 
ADTAPPSSPTVITLGCRLNTYESEVMRRHAHAAGLGDAVIINTCAVTSEAVRGARQAIR
CCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHH
RAARDNPGAPILVTGCAAQTDPEAFAAMPEVTRVIGNHDKMKAETWKPADLLGGEEKIRV
HHHCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCCEEEH
NDIMSVRETAAHLIDGMEGRARAYVQVQNGCDHRCTFCIIPYGRGNSRSVPAGEVVAQVR
HHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHH
ALAASGHYEVVLTGVDLTSWGADLPGTPELGNLVQRILKLVPELRALRISSIDAIEMDDA
HHHCCCCEEEEEEECCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
LIEALADPRVAPYLHLSLQHGDNLILKRMKRRHSRDQAIQLTERLRAMRPDIALGADIIA
HHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHCHHHHHHHHHHHHHHCCCHHHCCHHHC
GFPTETEAHFENSLRLIDECGLSFLHAFPYSPRPGTPAAKMPQLAKPLIKDRAARLRAAG
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
EAALLRHFERHLGQVRLALIERDTAARLPDFTQVKLSRAAGEGGRMTPVQITGHDGKQLL
HHHHHHHHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHCCCCCCCCEEEEECCCCHHCC
GTPLS
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9823893 [H]