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The map label for this gene is nuoD

Identifier: 114800277

GI number: 114800277

Start: 1787064

End: 1788242

Strand: Direct

Name: nuoD

Synonym: HNE_1745

Alternate gene names: 114800277

Gene position: 1787064-1788242 (Clockwise)

Preceding gene: 114799741

Following gene: 114799343

Centisome position: 48.23

GC content: 62.17

Gene sequence:

>1179_bases
ATGGACGACCGCAAGTTCACGCTGAACTTCGGCCCTCAGCACCCCGCCGCTCACGGCGTGCTCCGCATGATCCTCGATCT
CGACGGCGAGATCGTTACCCGCGTGGACAGCCATATAGGCCTTCTCCACCGCGGCACGGAAAAGCTGCTCGAATACAAGA
CCTACCTGCAGGGCATGCCGTATTTCGACCGGCTCGATTACTGCGCGCCGATGAACCAGGAGCATGCCTGGTGCCTCGCC
ATCGAGAAGCTTCTCGGTGTCGAAGTGCCCCGCCGCGCCAGCATCATCCGCGTCATGTACTCGGAAATCGGCCGCATCAT
GTCCCACCTCCTCAACGTCGGCACCGGCGTGATGGACGTCGGTGCCCTGACGCCCATTACCTGGTGCTTCGAGGAGCGCG
AGAAGCTCTGCGTCTTCTACGAGCGCGCCTCTGGCAGCCGGATGCACGCGGCCTATTTTCGTCCCGGCGGCGTCCACCAG
GACCTGCCCCAGCGCCTGATCGACGACATTGCGACCTGGTGTGACCAGTTCCCCGGCAAGCTCGACCAGATCGAAGGCCT
CGTCACCGAGAACCGTATCTTCAAGCAGCGCAACGTGGACATTGGCGTAGTCGACCAGCGCACGATCCTCGATTGGGGGT
TCAGCGGCGTCATGGTGCGTGGTTCGGGCCTCGCCTGGGATCTGCGCCGTTCGCAGCCTTACGAGTGCTACAGCGAACTC
GATTTCAAAGTCCCGGTCGGCCGCCACGGCGACAATTACGACCGTTATGTCTGCCGCATGGATGAGATGCGCGAGTCCGT
GAAGATCATCCTCCAGTGTATCGACCTGATGGCCAAGGACGGCCCCGGTCCAGTCCTGCTGGCAGGCTCCAAGCTTTCCC
CGCCACGCCGGGCTGACATGAAGAATTCGATGGAAGCGCTGATCCATCACTTCAAGCTGTACACGGAAGGTTTCCACGTT
CCGGAAGGCGAATGCTACGCTGCCGTCGAAGCGCCCAAGGGCGAGTTCGGCGTGTATCTGGTGGCCGACGGCACAAACCG
TCCCTACCGCGCCAAAATCCGTGCGCCGGGCTATCCCCACCTCCAGGCCATGGACTATCTCTGCAAAGGCCACCAGCTGG
CCGACGTCTCGGCCGTTCTCGGAACGCTCGACATCGTGTTCGGGGAGATTGACCGTTGA

Upstream 100 bases:

>100_bases
GATTTCCTCTCGCCCTGGGAAGGCATGACGACCGTCATCCCCGGCGACGAGAAAGCGAAGGAAGGCTGATCAGATGGCCG
ACACCGTGCACATCGCAGAC

Downstream 100 bases:

>100_bases
CCGCGTCTTTCGACCTCATCCAGCGCCAGCTTGACGCCTACAATGCGCAGGACATCAACGCCTTCCTCGCCTGTTATGCT
GACGACGCAGAGCTCGCGAC

Product: NADH dehydrogenase subunit D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D; NDH-1 subunit D

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MDDRKFTLNFGPQHPAAHGVLRMILDLDGEIVTRVDSHIGLLHRGTEKLLEYKTYLQGMPYFDRLDYCAPMNQEHAWCLA
IEKLLGVEVPRRASIIRVMYSEIGRIMSHLLNVGTGVMDVGALTPITWCFEEREKLCVFYERASGSRMHAAYFRPGGVHQ
DLPQRLIDDIATWCDQFPGKLDQIEGLVTENRIFKQRNVDIGVVDQRTILDWGFSGVMVRGSGLAWDLRRSQPYECYSEL
DFKVPVGRHGDNYDRYVCRMDEMRESVKIILQCIDLMAKDGPGPVLLAGSKLSPPRRADMKNSMEALIHHFKLYTEGFHV
PEGECYAAVEAPKGEFGVYLVADGTNRPYRAKIRAPGYPHLQAMDYLCKGHQLADVSAVLGTLDIVFGEIDR

Sequences:

>Translated_392_residues
MDDRKFTLNFGPQHPAAHGVLRMILDLDGEIVTRVDSHIGLLHRGTEKLLEYKTYLQGMPYFDRLDYCAPMNQEHAWCLA
IEKLLGVEVPRRASIIRVMYSEIGRIMSHLLNVGTGVMDVGALTPITWCFEEREKLCVFYERASGSRMHAAYFRPGGVHQ
DLPQRLIDDIATWCDQFPGKLDQIEGLVTENRIFKQRNVDIGVVDQRTILDWGFSGVMVRGSGLAWDLRRSQPYECYSEL
DFKVPVGRHGDNYDRYVCRMDEMRESVKIILQCIDLMAKDGPGPVLLAGSKLSPPRRADMKNSMEALIHHFKLYTEGFHV
PEGECYAAVEAPKGEFGVYLVADGTNRPYRAKIRAPGYPHLQAMDYLCKGHQLADVSAVLGTLDIVFGEIDR
>Mature_392_residues
MDDRKFTLNFGPQHPAAHGVLRMILDLDGEIVTRVDSHIGLLHRGTEKLLEYKTYLQGMPYFDRLDYCAPMNQEHAWCLA
IEKLLGVEVPRRASIIRVMYSEIGRIMSHLLNVGTGVMDVGALTPITWCFEEREKLCVFYERASGSRMHAAYFRPGGVHQ
DLPQRLIDDIATWCDQFPGKLDQIEGLVTENRIFKQRNVDIGVVDQRTILDWGFSGVMVRGSGLAWDLRRSQPYECYSEL
DFKVPVGRHGDNYDRYVCRMDEMRESVKIILQCIDLMAKDGPGPVLLAGSKLSPPRRADMKNSMEALIHHFKLYTEGFHV
PEGECYAAVEAPKGEFGVYLVADGTNRPYRAKIRAPGYPHLQAMDYLCKGHQLADVSAVLGTLDIVFGEIDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family

Homologues:

Organism=Homo sapiens, GI4758786, Length=389, Percent_Identity=60.6683804627249, Blast_Score=504, Evalue=1e-143,
Organism=Homo sapiens, GI260898743, Length=383, Percent_Identity=60.0522193211488, Blast_Score=489, Evalue=1e-138,
Organism=Escherichia coli, GI145693162, Length=386, Percent_Identity=37.0466321243523, Blast_Score=281, Evalue=4e-77,
Organism=Escherichia coli, GI1789076, Length=392, Percent_Identity=25.2551020408163, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1788832, Length=384, Percent_Identity=25.2604166666667, Blast_Score=109, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17568379, Length=385, Percent_Identity=57.1428571428571, Blast_Score=485, Evalue=1e-137,
Organism=Caenorhabditis elegans, GI17555284, Length=385, Percent_Identity=57.6623376623377, Blast_Score=484, Evalue=1e-137,
Organism=Drosophila melanogaster, GI24638644, Length=389, Percent_Identity=59.6401028277635, Blast_Score=509, Evalue=1e-144,
Organism=Drosophila melanogaster, GI221459469, Length=393, Percent_Identity=57.5063613231552, Blast_Score=474, Evalue=1e-134,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOD_HYPNA (Q0C1E4)

Other databases:

- EMBL:   CP000158
- RefSeq:   YP_760449.1
- STRING:   Q0C1E4
- GeneID:   4287922
- GenomeReviews:   CP000158_GR
- KEGG:   hne:HNE_1745
- NMPDR:   fig|228405.5.peg.1680
- TIGR:   HNE_1745
- eggNOG:   COG0649
- HOGENOM:   HBG459705
- OMA:   IFYERAC
- PhylomeDB:   Q0C1E4
- ProtClustDB:   PRK06075
- BioCyc:   HNEP81032:HNE_1745-MONOMER
- GO:   GO:0006810
- HAMAP:   MF_01358
- InterPro:   IPR010219
- InterPro:   IPR001135
- InterPro:   IPR014029
- InterPro:   IPR022885
- TIGRFAMs:   TIGR01962

Pfam domain/function: PF00346 Complex1_49kDa

EC number: =1.6.99.5

Molecular weight: Translated: 44456; Mature: 44456

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00535 COMPLEX1_49K; PS00503 PECTINESTERASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDDRKFTLNFGPQHPAAHGVLRMILDLDGEIVTRVDSHIGLLHRGTEKLLEYKTYLQGMP
CCCCEEEEECCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
YFDRLDYCAPMNQEHAWCLAIEKLLGVEVPRRASIIRVMYSEIGRIMSHLLNVGTGVMDV
CHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
GALTPITWCFEEREKLCVFYERASGSRMHAAYFRPGGVHQDLPQRLIDDIATWCDQFPGK
CCCCHHHHHHHHCCCEEEEEECCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCC
LDQIEGLVTENRIFKQRNVDIGVVDQRTILDWGFSGVMVRGSGLAWDLRRSQPYECYSEL
HHHHHHHHHHHHHHHHCCCCEEEECCCCHHHCCCCEEEEECCCCEEECCCCCCHHHHHCC
DFKVPVGRHGDNYDRYVCRMDEMRESVKIILQCIDLMAKDGPGPVLLAGSKLSPPRRADM
CEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHH
KNSMEALIHHFKLYTEGFHVPEGECYAAVEAPKGEFGVYLVADGTNRPYRAKIRAPGYPH
HHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCEEEEECCCCCCH
LQAMDYLCKGHQLADVSAVLGTLDIVFGEIDR
HHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MDDRKFTLNFGPQHPAAHGVLRMILDLDGEIVTRVDSHIGLLHRGTEKLLEYKTYLQGMP
CCCCEEEEECCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
YFDRLDYCAPMNQEHAWCLAIEKLLGVEVPRRASIIRVMYSEIGRIMSHLLNVGTGVMDV
CHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
GALTPITWCFEEREKLCVFYERASGSRMHAAYFRPGGVHQDLPQRLIDDIATWCDQFPGK
CCCCHHHHHHHHCCCEEEEEECCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCC
LDQIEGLVTENRIFKQRNVDIGVVDQRTILDWGFSGVMVRGSGLAWDLRRSQPYECYSEL
HHHHHHHHHHHHHHHHCCCCEEEECCCCHHHCCCCEEEEECCCCEEECCCCCCHHHHHCC
DFKVPVGRHGDNYDRYVCRMDEMRESVKIILQCIDLMAKDGPGPVLLAGSKLSPPRRADM
CEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHH
KNSMEALIHHFKLYTEGFHVPEGECYAAVEAPKGEFGVYLVADGTNRPYRAKIRAPGYPH
HHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCEEEEECCCCCCH
LQAMDYLCKGHQLADVSAVLGTLDIVFGEIDR
HHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA