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The map label for this gene is xylB [H]

Identifier: 114800199

GI number: 114800199

Start: 2201169

End: 2202269

Strand: Reverse

Name: xylB [H]

Synonym: HNE_2119

Alternate gene names: 114800199

Gene position: 2202269-2201169 (Counterclockwise)

Preceding gene: 114799254

Following gene: 114800097

Centisome position: 59.44

GC content: 64.58

Gene sequence:

>1101_bases
ATGAAAACCCAGGCAGCGGTCGCGTATACAGGGCAACCCGGATTCAAATATGAAACGGTCGAGATTGAAGCCCCCCGCGC
AGATGAAATCCTCGTCCGCGTTCTGGGCGTCGGCCTCTGCCATACAGACCTCGTATTCAGCTCCGGCGCAGCGCCTTACC
CGTTCCCGGCCGTGCTTGGCCATGAAGGTTCCGGCGTGGTCGAGGCTGTCGGCGCAGACGTAAAAAAGGTAAAGCCCGGC
GACAGCGTGCTCATCACCTTCCGCTCCTGCGGCGCCTGCGATCGCTGCGCTGCCGGCGACGCTGCCTACTGCCGCACCAT
GCCGATGCTGAACTATATGGGCCGCCGCACAGACGGCACCTCTGCCCTCAGCAACGACGCCGGCCCCGTCTCGTCAAACT
TCTTCGGCCAGTCCTCTTTCGCCGGCCACGCCATCACCTATGAGCGTAATGTCGTGAAGGTCGATGCCGGTCTCCCGGTC
GAAATCATGGGCCCCCTCGGCTGCGGAATCCAGACCGGCGCGGGCGCCGTCATGCGCTCCCTCGCCGCGAAGAAAGGCTC
CAGCCTCCTCGTCACCGGCGGCGGTTCGGTTGGCCTCAGCGCCGTCATGGGCGGAAAGATCCAGGGCTGCGCCACCATCA
TCCTCGTCGAGCCAATGGAAAGCCGCCGCGCGCTGGCCATGGAGCTGGGCGCGACCCACTGTATAGATCCCACAGCGGTC
GAGGATGTCGCCGCCGCCGTCCGCGCCATTGCGCCGATGGGCATCGACAACGCGCTGGACACGACCGGCATCCCGGCCGT
GCAATCCTCCGCCCTTGCTACGCTCGGCTCCAAGGGCACGCTCGGCCTCGTTGGCGTCAGCGCGCCGGGCACGCCGATGC
CGGGCGACGTCAACACGGTGATGACCTTCGGCCAATCGGTCAAAGGCATCATCGAGGGCGATTCAAACCCGGATGAATTC
ATCCCGGAACTGATCGAACACTATAAGGCCGGCCGCCTCCCGTTCGACAGGCTGGTGAAGACCTACCGCCTCAGCGAAAT
CAACGAGGCCATCGCCGCCCAGCATCATGGCGACTGCGTCAAGGCAGTGCTGATCCCTTAA

Upstream 100 bases:

>100_bases
CTCCAGATATAATCCGTTTACGGGCATACTCCTACTCAACATGGTTGACGCTCATCCAGCGGGACCATAGCGTCTGCGCA
TAACTTTCAGGAACGATACC

Downstream 100 bases:

>100_bases
GCGTGGCAGATGCTGGCCTGGCGAATGTCCGTCAGTGTCCGGCAGCCCATCAGCGCCATGGTGATCTCCAGCTCCTCGCG
CAGTGTGCGGAGGAGGTGCG

Product: aryl-alcohol dehydrogenase

Products: NA

Alternate protein names: Benzyl alcohol dehydrogenase; BADH [H]

Number of amino acids: Translated: 366; Mature: 366

Protein sequence:

>366_residues
MKTQAAVAYTGQPGFKYETVEIEAPRADEILVRVLGVGLCHTDLVFSSGAAPYPFPAVLGHEGSGVVEAVGADVKKVKPG
DSVLITFRSCGACDRCAAGDAAYCRTMPMLNYMGRRTDGTSALSNDAGPVSSNFFGQSSFAGHAITYERNVVKVDAGLPV
EIMGPLGCGIQTGAGAVMRSLAAKKGSSLLVTGGGSVGLSAVMGGKIQGCATIILVEPMESRRALAMELGATHCIDPTAV
EDVAAAVRAIAPMGIDNALDTTGIPAVQSSALATLGSKGTLGLVGVSAPGTPMPGDVNTVMTFGQSVKGIIEGDSNPDEF
IPELIEHYKAGRLPFDRLVKTYRLSEINEAIAAQHHGDCVKAVLIP

Sequences:

>Translated_366_residues
MKTQAAVAYTGQPGFKYETVEIEAPRADEILVRVLGVGLCHTDLVFSSGAAPYPFPAVLGHEGSGVVEAVGADVKKVKPG
DSVLITFRSCGACDRCAAGDAAYCRTMPMLNYMGRRTDGTSALSNDAGPVSSNFFGQSSFAGHAITYERNVVKVDAGLPV
EIMGPLGCGIQTGAGAVMRSLAAKKGSSLLVTGGGSVGLSAVMGGKIQGCATIILVEPMESRRALAMELGATHCIDPTAV
EDVAAAVRAIAPMGIDNALDTTGIPAVQSSALATLGSKGTLGLVGVSAPGTPMPGDVNTVMTFGQSVKGIIEGDSNPDEF
IPELIEHYKAGRLPFDRLVKTYRLSEINEAIAAQHHGDCVKAVLIP
>Mature_366_residues
MKTQAAVAYTGQPGFKYETVEIEAPRADEILVRVLGVGLCHTDLVFSSGAAPYPFPAVLGHEGSGVVEAVGADVKKVKPG
DSVLITFRSCGACDRCAAGDAAYCRTMPMLNYMGRRTDGTSALSNDAGPVSSNFFGQSSFAGHAITYERNVVKVDAGLPV
EIMGPLGCGIQTGAGAVMRSLAAKKGSSLLVTGGGSVGLSAVMGGKIQGCATIILVEPMESRRALAMELGATHCIDPTAV
EDVAAAVRAIAPMGIDNALDTTGIPAVQSSALATLGSKGTLGLVGVSAPGTPMPGDVNTVMTFGQSVKGIIEGDSNPDEF
IPELIEHYKAGRLPFDRLVKTYRLSEINEAIAAQHHGDCVKAVLIP

Specific function: Oxidizes primary alcohols with an aromatic or cyclohex- 1-ene ring. It is highly specific for benzyl alcohol [H]

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI34577061, Length=369, Percent_Identity=34.1463414634146, Blast_Score=196, Evalue=4e-50,
Organism=Homo sapiens, GI4501929, Length=369, Percent_Identity=33.0623306233062, Blast_Score=193, Evalue=2e-49,
Organism=Homo sapiens, GI4501933, Length=368, Percent_Identity=32.6086956521739, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI156523966, Length=370, Percent_Identity=32.972972972973, Blast_Score=182, Evalue=4e-46,
Organism=Homo sapiens, GI4501939, Length=362, Percent_Identity=33.1491712707182, Blast_Score=173, Evalue=2e-43,
Organism=Homo sapiens, GI71565154, Length=372, Percent_Identity=31.1827956989247, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI71565152, Length=377, Percent_Identity=31.2997347480106, Blast_Score=166, Evalue=2e-41,
Organism=Homo sapiens, GI71743840, Length=368, Percent_Identity=29.3478260869565, Blast_Score=161, Evalue=9e-40,
Organism=Homo sapiens, GI262073058, Length=368, Percent_Identity=29.3478260869565, Blast_Score=161, Evalue=1e-39,
Organism=Escherichia coli, GI1786552, Length=374, Percent_Identity=32.3529411764706, Blast_Score=147, Evalue=9e-37,
Organism=Escherichia coli, GI1788073, Length=381, Percent_Identity=26.7716535433071, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1788407, Length=300, Percent_Identity=25, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1787863, Length=354, Percent_Identity=24.8587570621469, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790045, Length=296, Percent_Identity=26.3513513513513, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI87082125, Length=298, Percent_Identity=25.503355704698, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1786518, Length=369, Percent_Identity=25.4742547425474, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1786825, Length=405, Percent_Identity=23.2098765432099, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI87081918, Length=86, Percent_Identity=39.5348837209302, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI25146526, Length=373, Percent_Identity=30.5630026809651, Blast_Score=175, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI71997431, Length=375, Percent_Identity=30.4, Blast_Score=170, Evalue=9e-43,
Organism=Caenorhabditis elegans, GI17565904, Length=344, Percent_Identity=30.5232558139535, Blast_Score=144, Evalue=6e-35,
Organism=Caenorhabditis elegans, GI71988145, Length=292, Percent_Identity=25.6849315068493, Blast_Score=69, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17562584, Length=322, Percent_Identity=23.2919254658385, Blast_Score=65, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6320033, Length=377, Percent_Identity=32.8912466843501, Blast_Score=191, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6324486, Length=315, Percent_Identity=27.9365079365079, Blast_Score=80, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6319257, Length=312, Percent_Identity=26.6025641025641, Blast_Score=80, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6319621, Length=292, Percent_Identity=26.3698630136986, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6323729, Length=293, Percent_Identity=26.962457337884, Blast_Score=76, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6323961, Length=315, Percent_Identity=26.984126984127, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6319258, Length=317, Percent_Identity=25.8675078864353, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17737895, Length=368, Percent_Identity=31.25, Blast_Score=165, Evalue=6e-41,
Organism=Drosophila melanogaster, GI17137530, Length=263, Percent_Identity=26.615969581749, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI17737897, Length=283, Percent_Identity=24.7349823321555, Blast_Score=69, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.90 [H]

Molecular weight: Translated: 37637; Mature: 37637

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTQAAVAYTGQPGFKYETVEIEAPRADEILVRVLGVGLCHTDLVFSSGAAPYPFPAVLG
CCCCEEEEECCCCCCEEEEEEEECCCHHHHHHHHHHCCHHHHHHHCCCCCCCCCCHHHCC
HEGSGVVEAVGADVKKVKPGDSVLITFRSCGACDRCAAGDAAYCRTMPMLNYMGRRTDGT
CCCCCHHHHHCCCCEECCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCC
SALSNDAGPVSSNFFGQSSFAGHAITYERNVVKVDAGLPVEIMGPLGCGIQTGAGAVMRS
HHHCCCCCCCCCCCCCCCCCCCCEEEEECCEEEECCCCCEEEECCCCCCCCCCHHHHHHH
LAAKKGSSLLVTGGGSVGLSAVMGGKIQGCATIILVEPMESRRALAMELGATHCIDPTAV
HHHCCCCEEEEECCCCCCHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHCCCCCCCCHHH
EDVAAAVRAIAPMGIDNALDTTGIPAVQSSALATLGSKGTLGLVGVSAPGTPMPGDVNTV
HHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCHHHH
MTFGQSVKGIIEGDSNPDEFIPELIEHYKAGRLPFDRLVKTYRLSEINEAIAAQHHGDCV
HHHCHHHCEEECCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEE
KAVLIP
EEEECC
>Mature Secondary Structure
MKTQAAVAYTGQPGFKYETVEIEAPRADEILVRVLGVGLCHTDLVFSSGAAPYPFPAVLG
CCCCEEEEECCCCCCEEEEEEEECCCHHHHHHHHHHCCHHHHHHHCCCCCCCCCCHHHCC
HEGSGVVEAVGADVKKVKPGDSVLITFRSCGACDRCAAGDAAYCRTMPMLNYMGRRTDGT
CCCCCHHHHHCCCCEECCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCC
SALSNDAGPVSSNFFGQSSFAGHAITYERNVVKVDAGLPVEIMGPLGCGIQTGAGAVMRS
HHHCCCCCCCCCCCCCCCCCCCCEEEEECCEEEECCCCCEEEECCCCCCCCCCHHHHHHH
LAAKKGSSLLVTGGGSVGLSAVMGGKIQGCATIILVEPMESRRALAMELGATHCIDPTAV
HHHCCCCEEEEECCCCCCHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHCCCCCCCCHHH
EDVAAAVRAIAPMGIDNALDTTGIPAVQSSALATLGSKGTLGLVGVSAPGTPMPGDVNTV
HHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCHHHH
MTFGQSVKGIIEGDSNPDEFIPELIEHYKAGRLPFDRLVKTYRLSEINEAIAAQHHGDCV
HHHCHHHCEEECCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEE
KAVLIP
EEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8496150; 1989592 [H]