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The map label for this gene is uvrB [H]

Identifier: 114800055

GI number: 114800055

Start: 3215337

End: 3217382

Strand: Direct

Name: uvrB [H]

Synonym: HNE_3045

Alternate gene names: 114800055

Gene position: 3215337-3217382 (Clockwise)

Preceding gene: 114798958

Following gene: 114798648

Centisome position: 86.78

GC content: 63.49

Gene sequence:

>2046_bases
GTGAAGCTGGAGGGCGGCAAGCGCTTCCGCGTCGCTGCCGAATACGAGCCCGCCGGCGACCAGCGCACCGCCATCCCCGA
ACTCGTCGAAGGCATCACCGCCGGCGAGCGCGACCAGGTCCTCCTCGGCGCCACTGGCACGGGCAAGACCTTCACCATGG
CCAAGATCATCGAGGCCACCCAGCGCCCCGCGCTCATCCTCGCCCCCAACAAGACCCTCGCCGCCCAGCTCTATGGCGAG
TTCAAATCCTTCTTCCCGGACAACTCGGTCGAGTATTTCGTCTCCTATTACGACTACTACCAGCCCGAAGCCTATGTTCC
GCGCTCGGACCTTTACATCGAGAAGGAAAGCTCCATCAACGAGGCCATCGACCGGATGCGCCACTCCGCCACCCGCGCCA
TCCTGGAGCGTGACGACGTCATCATCGTCTCCTCCGTCTCCTGCCTCTATGGCATCGGCTCAGTGGAATCCTACACCTCG
ATGACCTTCACCCTGAAGGCCGGCGACCGCATCGACCCCAAACAGGTCACCGCTCGCCTCGTCGCCAACCAGTACACCCG
CAACGATGTCGCCTTCGGCCGCGGCGCCTTCCGCGTGAAGGGCGACGTCATCGACATCTTCCCCGCCCACTATGAGGACC
GCGCCTGGAAGCTCTCCTTCTTCGGCGACGAGCTGGAATCCATCACCGAGTTCGACCCCCTCACCGGGCGCACGATGCAG
AAGCTCCCCCAGGTCAAGATCTACGCCAACAGCCACCACGTCACGCCGCGCCCGACGCTCAACCAGGCCATCGAGAAGAT
CAAGGCGGAGCTGAAGACCACCATCGCCCATTTCGAGAAGAACGGAAAACTCCTCGAAGCCCAGCGCATCGAGCAGCGCT
GCACCTACGACCTCGAAATGCTCGCCGCCACCGGCTCCTGCAACGGCATCGAGAACTATTCCCGCTACCTCACCGGCCGC
AAGCCCGGCGAGCCGCCCCCCACCCTCTTCGAATACCTGCCCGAGAACGCCCTCGTCTTCACCGACGAGTCCCACCAGAC
GATCCCCCAGATCGGCGCCATGTTCAAAGGCGACTTCTCGCGCAAGTCCACCCTCGCCGAATACGGCTTCCGCCTGCCTT
CCTGCATCGACAACCGCCCCCTCAAATTCGACGAATGGGACGCCATGCGCCCCCAGACGGTCCACGTCTCCGCCACCCCC
GGCAAATGGGAAATGGAGCGCACGGGCGGCGTGTTCACCGAACAGGTCATCCGCCCCACCGGCCTTATCGACCCACCCGT
CGAAGTCCGCCCCGTCTCCAATGATGGCGCCAACCAGGTCGACGACATCATGGCCGAGGCCAAGACCGCCGCCGCAAACG
GCATGCGCACATTGATCACCACCCTGACGAAAAAGATGGCGGAAAACCTGACAGACTTCCTCCACGAAAACGGGGTGAAG
GTCCGCTACATGCACTCGGACGTCGACACCATCGAGCGCATCGAGATCATCCGCGATCTGCGCCTCGGCGTGTTCGATGT
CCTCGTCGGCATCAACCTGCTGCGCGAGGGGCTCGACATTCCCGAATGCGGCCTCGTCGGCATTCTGGACGCCGACAAGG
AAGGGTTCCTGCGTTCAGAGACTTCCCTCGTCCAGACCATCGGCCGCGCCGCACGCAACGCCGACGCAAAAGTCATTCTG
TATGCGGACCGGGTCACCGGCTCCATGCAGCGCGCCATGGACGAAACCAGCCGCCGCCGCGAAAAGCAGATGGCCTACAA
TATCGAACACGGCATCACGCCGACCACGATCAAGCGCGCCGTGTCAGACATCCTCTCCGAACTCGGCGAAAAGCCCTCCG
CCAGCCGCTCCCGCCGCAACCGCGAACGCGGCGTCAGCGAAGAAAAGCCCTTGCCACTTCGGGGCGAAACCGGGCACAAC
CTCAAAGCTGCAATCGCCAGCCTCGAAAAACAGATGCGCGAAGCCGCCGCGAACCTCGAGTTCGAAACGGCCGCCCGCCT
TCGGGACGAGGTTAAGCGGCTGCGGGAAGAGGATTTGGGGATTTAG

Upstream 100 bases:

>100_bases
TGACGCCTCCGCTGCCTTCGCCCTCGACGGCGCCGCGCTCGATGCCGCCGGCAGCCTCCCCTCCGACCAGTGGACACCCC
ACCGGCCGGACCGCGACTGG

Downstream 100 bases:

>100_bases
AAAGACCTAGATTAAAATTTCTCCTACAGATAGTTGACTTAAGTTTCCTACAAGCGCAACGATTGACTACCGCTATTGCT
TTCGAGCAATAGTTGCGGGG

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 681; Mature: 681

Protein sequence:

>681_residues
MKLEGGKRFRVAAEYEPAGDQRTAIPELVEGITAGERDQVLLGATGTGKTFTMAKIIEATQRPALILAPNKTLAAQLYGE
FKSFFPDNSVEYFVSYYDYYQPEAYVPRSDLYIEKESSINEAIDRMRHSATRAILERDDVIIVSSVSCLYGIGSVESYTS
MTFTLKAGDRIDPKQVTARLVANQYTRNDVAFGRGAFRVKGDVIDIFPAHYEDRAWKLSFFGDELESITEFDPLTGRTMQ
KLPQVKIYANSHHVTPRPTLNQAIEKIKAELKTTIAHFEKNGKLLEAQRIEQRCTYDLEMLAATGSCNGIENYSRYLTGR
KPGEPPPTLFEYLPENALVFTDESHQTIPQIGAMFKGDFSRKSTLAEYGFRLPSCIDNRPLKFDEWDAMRPQTVHVSATP
GKWEMERTGGVFTEQVIRPTGLIDPPVEVRPVSNDGANQVDDIMAEAKTAAANGMRTLITTLTKKMAENLTDFLHENGVK
VRYMHSDVDTIERIEIIRDLRLGVFDVLVGINLLREGLDIPECGLVGILDADKEGFLRSETSLVQTIGRAARNADAKVIL
YADRVTGSMQRAMDETSRRREKQMAYNIEHGITPTTIKRAVSDILSELGEKPSASRSRRNRERGVSEEKPLPLRGETGHN
LKAAIASLEKQMREAAANLEFETAARLRDEVKRLREEDLGI

Sequences:

>Translated_681_residues
MKLEGGKRFRVAAEYEPAGDQRTAIPELVEGITAGERDQVLLGATGTGKTFTMAKIIEATQRPALILAPNKTLAAQLYGE
FKSFFPDNSVEYFVSYYDYYQPEAYVPRSDLYIEKESSINEAIDRMRHSATRAILERDDVIIVSSVSCLYGIGSVESYTS
MTFTLKAGDRIDPKQVTARLVANQYTRNDVAFGRGAFRVKGDVIDIFPAHYEDRAWKLSFFGDELESITEFDPLTGRTMQ
KLPQVKIYANSHHVTPRPTLNQAIEKIKAELKTTIAHFEKNGKLLEAQRIEQRCTYDLEMLAATGSCNGIENYSRYLTGR
KPGEPPPTLFEYLPENALVFTDESHQTIPQIGAMFKGDFSRKSTLAEYGFRLPSCIDNRPLKFDEWDAMRPQTVHVSATP
GKWEMERTGGVFTEQVIRPTGLIDPPVEVRPVSNDGANQVDDIMAEAKTAAANGMRTLITTLTKKMAENLTDFLHENGVK
VRYMHSDVDTIERIEIIRDLRLGVFDVLVGINLLREGLDIPECGLVGILDADKEGFLRSETSLVQTIGRAARNADAKVIL
YADRVTGSMQRAMDETSRRREKQMAYNIEHGITPTTIKRAVSDILSELGEKPSASRSRRNRERGVSEEKPLPLRGETGHN
LKAAIASLEKQMREAAANLEFETAARLRDEVKRLREEDLGI
>Mature_681_residues
MKLEGGKRFRVAAEYEPAGDQRTAIPELVEGITAGERDQVLLGATGTGKTFTMAKIIEATQRPALILAPNKTLAAQLYGE
FKSFFPDNSVEYFVSYYDYYQPEAYVPRSDLYIEKESSINEAIDRMRHSATRAILERDDVIIVSSVSCLYGIGSVESYTS
MTFTLKAGDRIDPKQVTARLVANQYTRNDVAFGRGAFRVKGDVIDIFPAHYEDRAWKLSFFGDELESITEFDPLTGRTMQ
KLPQVKIYANSHHVTPRPTLNQAIEKIKAELKTTIAHFEKNGKLLEAQRIEQRCTYDLEMLAATGSCNGIENYSRYLTGR
KPGEPPPTLFEYLPENALVFTDESHQTIPQIGAMFKGDFSRKSTLAEYGFRLPSCIDNRPLKFDEWDAMRPQTVHVSATP
GKWEMERTGGVFTEQVIRPTGLIDPPVEVRPVSNDGANQVDDIMAEAKTAAANGMRTLITTLTKKMAENLTDFLHENGVK
VRYMHSDVDTIERIEIIRDLRLGVFDVLVGINLLREGLDIPECGLVGILDADKEGFLRSETSLVQTIGRAARNADAKVIL
YADRVTGSMQRAMDETSRRREKQMAYNIEHGITPTTIKRAVSDILSELGEKPSASRSRRNRERGVSEEKPLPLRGETGHN
LKAAIASLEKQMREAAANLEFETAARLRDEVKRLREEDLGI

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=671, Percent_Identity=57.0789865871833, Blast_Score=775, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 76369; Mature: 76369

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLEGGKRFRVAAEYEPAGDQRTAIPELVEGITAGERDQVLLGATGTGKTFTMAKIIEAT
CCCCCCCEEEEEECCCCCCCCCCHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHH
QRPALILAPNKTLAAQLYGEFKSFFPDNSVEYFVSYYDYYQPEAYVPRSDLYIEKESSIN
CCCEEEECCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCEEEECCCHHH
EAIDRMRHSATRAILERDDVIIVSSVSCLYGIGSVESYTSMTFTLKAGDRIDPKQVTARL
HHHHHHHHHHHHHHHCCCCEEEEECHHHHHCCCCCCCCCEEEEEEECCCCCCHHHHHHHH
VANQYTRNDVAFGRGAFRVKGDVIDIFPAHYEDRAWKLSFFGDELESITEFDPLTGRTMQ
HHHHHCCCCCCCCCCCEEEECCEEEECCCCCCCCEEEEEECCHHHHHHHHCCCCCCHHHH
KLPQVKIYANSHHVTPRPTLNQAIEKIKAELKTTIAHFEKNGKLLEAQRIEQRCTYDLEM
HCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHCCCHHH
LAATGSCNGIENYSRYLTGRKPGEPPPTLFEYLPENALVFTDESHQTIPQIGAMFKGDFS
EEECCCCCCHHHHHHHHCCCCCCCCCCHHHHHCCCCCEEEECCCCCHHHHHHHHHCCCCH
RKSTLAEYGFRLPSCIDNRPLKFDEWDAMRPQTVHVSATPGKWEMERTGGVFTEQVIRPT
HHHHHHHHCCCCCHHHCCCCCCCCCCCCCCCCEEEEECCCCCEEHHHCCCHHHHHHHCCC
GLIDPPVEVRPVSNDGANQVDDIMAEAKTAAANGMRTLITTLTKKMAENLTDFLHENGVK
CCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
VRYMHSDVDTIERIEIIRDLRLGVFDVLVGINLLREGLDIPECGLVGILDADKEGFLRSE
EEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHH
TSLVQTIGRAARNADAKVILYADRVTGSMQRAMDETSRRREKQMAYNIEHGITPTTIKRA
HHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
VSDILSELGEKPSASRSRRNRERGVSEEKPLPLRGETGHNLKAAIASLEKQMREAAANLE
HHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
FETAARLRDEVKRLREEDLGI
HHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKLEGGKRFRVAAEYEPAGDQRTAIPELVEGITAGERDQVLLGATGTGKTFTMAKIIEAT
CCCCCCCEEEEEECCCCCCCCCCHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHH
QRPALILAPNKTLAAQLYGEFKSFFPDNSVEYFVSYYDYYQPEAYVPRSDLYIEKESSIN
CCCEEEECCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCEEEECCCHHH
EAIDRMRHSATRAILERDDVIIVSSVSCLYGIGSVESYTSMTFTLKAGDRIDPKQVTARL
HHHHHHHHHHHHHHHCCCCEEEEECHHHHHCCCCCCCCCEEEEEEECCCCCCHHHHHHHH
VANQYTRNDVAFGRGAFRVKGDVIDIFPAHYEDRAWKLSFFGDELESITEFDPLTGRTMQ
HHHHHCCCCCCCCCCCEEEECCEEEECCCCCCCCEEEEEECCHHHHHHHHCCCCCCHHHH
KLPQVKIYANSHHVTPRPTLNQAIEKIKAELKTTIAHFEKNGKLLEAQRIEQRCTYDLEM
HCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHCCCHHH
LAATGSCNGIENYSRYLTGRKPGEPPPTLFEYLPENALVFTDESHQTIPQIGAMFKGDFS
EEECCCCCCHHHHHHHHCCCCCCCCCCHHHHHCCCCCEEEECCCCCHHHHHHHHHCCCCH
RKSTLAEYGFRLPSCIDNRPLKFDEWDAMRPQTVHVSATPGKWEMERTGGVFTEQVIRPT
HHHHHHHHCCCCCHHHCCCCCCCCCCCCCCCCEEEEECCCCCEEHHHCCCHHHHHHHCCC
GLIDPPVEVRPVSNDGANQVDDIMAEAKTAAANGMRTLITTLTKKMAENLTDFLHENGVK
CCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
VRYMHSDVDTIERIEIIRDLRLGVFDVLVGINLLREGLDIPECGLVGILDADKEGFLRSE
EEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHH
TSLVQTIGRAARNADAKVILYADRVTGSMQRAMDETSRRREKQMAYNIEHGITPTTIKRA
HHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
VSDILSELGEKPSASRSRRNRERGVSEEKPLPLRGETGHNLKAAIASLEKQMREAAANLE
HHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
FETAARLRDEVKRLREEDLGI
HHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]