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The map label for this gene is ccmA

Identifier: 114800037

GI number: 114800037

Start: 3651552

End: 3652133

Strand: Direct

Name: ccmA

Synonym: HNE_3515

Alternate gene names: 114800037

Gene position: 3651552-3652133 (Clockwise)

Preceding gene: 114799832

Following gene: 114800180

Centisome position: 98.56

GC content: 67.87

Gene sequence:

>582_bases
GTGACTGTCTCGACCGCCCCCCTGCTCAGCGCCAGCGGCCTCGCTATCCTGCGGGGAGAGCGGGTGCTGTTCCGCGGCAT
AGGGCTGACACTGCAACCGGGCGAGGCGATCGTGTTGCGCGGCGCCAATGGGGCGGGCAAGACGACGCTGCTGCGGATGC
TGGCGGGGCTGACACGGCCGGAGGCCGGGGAGATCGCGCGCCCGGCCGCTCATCACTGGATTGGCCACAAGGAAGGCATC
AAGCCGCAGGAAACCCCGCGAATCCATCTCGCCCTGTGGGCAAAGGCGTGGGGCTCGAGCGCCAGTATCGCTGATATTCT
CGATCAGCTGGCGCTGACACGGGCGGCGGATGTGCCGGGGCGGTATCTCTCGGCAGGCCAGAGACGGCGCACGGCGTTCG
CCCGGCTGCTGCTGGAGGCGCGCCCGCTCTGGTTGCTCGACGAGCCCTACACGGCGCTCGATGCGGCGGGCAAAACGATG
CTCGATCAGGTCATTTCAGGACATTTGAGGACAGGTGGGGCCATTATCGCGTCGATGCACGACGCGGCCGGCTTCCCGGT
GACTGCCGAGGTGACGCTTTGA

Upstream 100 bases:

>100_bases
GGCCCTGCCCTTCCGGCGCAATTGGGACAAAGGGTCAAAGCGTTAATAGCGGCGCAAGGCCTCGTTTGCAGACACTGCCG
AACAGGCTAAGCCTGCGCCG

Downstream 100 bases:

>100_bases
ACGCGGCGCCCATCTGGGCAGCGTTCCGGCAGGCGTTTGCCGAAGCATGGGCGGGCGGCGCAGGCGCGCTGCTGCCGCTT
GGCTTTCTGGGCGGGGCGGC

Product: heme exporter protein CcmA

Products: NA

Alternate protein names: Heme exporter protein A

Number of amino acids: Translated: 193; Mature: 192

Protein sequence:

>193_residues
MTVSTAPLLSASGLAILRGERVLFRGIGLTLQPGEAIVLRGANGAGKTTLLRMLAGLTRPEAGEIARPAAHHWIGHKEGI
KPQETPRIHLALWAKAWGSSASIADILDQLALTRAADVPGRYLSAGQRRRTAFARLLLEARPLWLLDEPYTALDAAGKTM
LDQVISGHLRTGGAIIASMHDAAGFPVTAEVTL

Sequences:

>Translated_193_residues
MTVSTAPLLSASGLAILRGERVLFRGIGLTLQPGEAIVLRGANGAGKTTLLRMLAGLTRPEAGEIARPAAHHWIGHKEGI
KPQETPRIHLALWAKAWGSSASIADILDQLALTRAADVPGRYLSAGQRRRTAFARLLLEARPLWLLDEPYTALDAAGKTM
LDQVISGHLRTGGAIIASMHDAAGFPVTAEVTL
>Mature_192_residues
TVSTAPLLSASGLAILRGERVLFRGIGLTLQPGEAIVLRGANGAGKTTLLRMLAGLTRPEAGEIARPAAHHWIGHKEGIK
PQETPRIHLALWAKAWGSSASIADILDQLALTRAADVPGRYLSAGQRRRTAFARLLLEARPLWLLDEPYTALDAAGKTML
DQVISGHLRTGGAIIASMHDAAGFPVTAEVTL

Specific function: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system

COG id: COG4133

COG function: function code O; ABC-type transport system involved in cytochrome c biogenesis, ATPase component

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain

Homologues:

Organism=Homo sapiens, GI27436953, Length=179, Percent_Identity=32.9608938547486, Blast_Score=92, Evalue=3e-19,
Organism=Homo sapiens, GI27477115, Length=191, Percent_Identity=28.7958115183246, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI153792144, Length=172, Percent_Identity=27.906976744186, Blast_Score=77, Evalue=7e-15,
Organism=Homo sapiens, GI6005701, Length=191, Percent_Identity=27.7486910994764, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI105990541, Length=167, Percent_Identity=33.5329341317365, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI45446740, Length=172, Percent_Identity=30.2325581395349, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI47078218, Length=172, Percent_Identity=30.2325581395349, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI87082064, Length=185, Percent_Identity=42.7027027027027, Blast_Score=117, Evalue=6e-28,
Organism=Escherichia coli, GI1790467, Length=180, Percent_Identity=31.1111111111111, Blast_Score=74, Evalue=7e-15,
Organism=Escherichia coli, GI1788165, Length=161, Percent_Identity=28.5714285714286, Blast_Score=67, Evalue=6e-13,
Organism=Escherichia coli, GI1790739, Length=198, Percent_Identity=29.7979797979798, Blast_Score=67, Evalue=6e-13,
Organism=Escherichia coli, GI1787041, Length=166, Percent_Identity=27.1084337349398, Blast_Score=65, Evalue=2e-12,
Organism=Escherichia coli, GI1788002, Length=167, Percent_Identity=32.9341317365269, Blast_Score=63, Evalue=1e-11,
Organism=Escherichia coli, GI1789751, Length=180, Percent_Identity=30.5555555555556, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1787772, Length=169, Percent_Identity=29.585798816568, Blast_Score=62, Evalue=2e-11,
Organism=Escherichia coli, GI1787112, Length=178, Percent_Identity=30.3370786516854, Blast_Score=61, Evalue=4e-11,
Organism=Drosophila melanogaster, GI221500365, Length=177, Percent_Identity=29.9435028248588, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI116007184, Length=177, Percent_Identity=29.9435028248588, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CCMA_HYPNA (Q0BWF7)

Other databases:

- EMBL:   CP000158
- RefSeq:   YP_762186.1
- ProteinModelPortal:   Q0BWF7
- SMR:   Q0BWF7
- STRING:   Q0BWF7
- GeneID:   4288829
- GenomeReviews:   CP000158_GR
- KEGG:   hne:HNE_3515
- NMPDR:   fig|228405.5.peg.3365
- TIGR:   HNE_3515
- eggNOG:   COG4133
- HOGENOM:   HBG758042
- OMA:   VRRPIWL
- PhylomeDB:   Q0BWF7
- BioCyc:   HNEP81032:HNE_3515-MONOMER
- HAMAP:   MF_01707
- InterPro:   IPR003439
- InterPro:   IPR005895
- InterPro:   IPR003593
- PANTHER:   PTHR19222:SF5
- SMART:   SM00382
- TIGRFAMs:   TIGR01189

Pfam domain/function: PF00005 ABC_tran

EC number: =3.6.3.41

Molecular weight: Translated: 20476; Mature: 20345

Theoretical pI: Translated: 10.69; Mature: 10.69

Prosite motif: PS00211 ABC_TRANSPORTER_1; PS50893 ABC_TRANSPORTER_2; PS51243 CCMA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVSTAPLLSASGLAILRGERVLFRGIGLTLQPGEAIVLRGANGAGKTTLLRMLAGLTRP
CCCCCCCCCCCCCEEEEECCEEEEEECCCEECCCCEEEEECCCCCCHHHHHHHHHHCCCC
EAGEIARPAAHHWIGHKEGIKPQETPRIHLALWAKAWGSSASIADILDQLALTRAADVPG
CCCCCCCCHHHHHCCCCCCCCCCCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCC
RYLSAGQRRRTAFARLLLEARPLWLLDEPYTALDAAGKTMLDQVISGHLRTGGAIIASMH
HHHHCCHHHHHHHHHHHHHCCCEEEECCCCHHHHHCCHHHHHHHHHCCCCCCCEEEEECC
DAAGFPVTAEVTL
CCCCCCEEEEEEC
>Mature Secondary Structure 
TVSTAPLLSASGLAILRGERVLFRGIGLTLQPGEAIVLRGANGAGKTTLLRMLAGLTRP
CCCCCCCCCCCCEEEEECCEEEEEECCCEECCCCEEEEECCCCCCHHHHHHHHHHCCCC
EAGEIARPAAHHWIGHKEGIKPQETPRIHLALWAKAWGSSASIADILDQLALTRAADVPG
CCCCCCCCHHHHHCCCCCCCCCCCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCC
RYLSAGQRRRTAFARLLLEARPLWLLDEPYTALDAAGKTMLDQVISGHLRTGGAIIASMH
HHHHCCHHHHHHHHHHHHHCCCEEEECCCCHHHHHCCHHHHHHHHHCCCCCCCEEEEECC
DAAGFPVTAEVTL
CCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA