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The map label for this gene is lysA [H]

Identifier: 114799974

GI number: 114799974

Start: 3599697

End: 3600971

Strand: Reverse

Name: lysA [H]

Synonym: HNE_3463

Alternate gene names: 114799974

Gene position: 3600971-3599697 (Counterclockwise)

Preceding gene: 114800174

Following gene: 114800374

Centisome position: 97.19

GC content: 63.14

Gene sequence:

>1275_bases
ATGCATCATTTCAATTATGCCGGAGGCCGCCTCCAGTGTGAGGGCGTCGATCTTGGCCGCGTGGCGGACGAGGTTGGCAC
GCCGGTATACGTCTATTCGACCGCGACGCTGGAGCGTCACGCGCGGGTTATCGCCGAGGCGTTCAGCAGCCAGAAGGTGC
TGATTGCCTATTCGGTGAAGGCGAACGGAAACCTGGCCGTGCTGGCGACGCTGGCGGCTGAAGGCTGCGGCGCGGATGTC
GTCAGCGGCGGAGAAATGCAGCGGGCGATGAAGGCGGGTATTCCGGCCGCGCGCATCGTGTTTTCCGGCGTTGGCAAGAC
GGCGGCTGAAATGAAGCTGGCGCTTGAGGCCGGAATTCACCAGTTCAACGTCGAGAGCGCCGGCGAGCTGCGGCTCCTGT
CGAGGGTGGCCAGTGGACTTGGCCTTAAGGCGCCGATTGCGCTTCGGGTGAACCCCGATGTGGCGGCCGGCGGTCATCCC
AACATCTCCACCGGCAAATCGGGTGACAAGTTTGGTGTGCCCTGGGGCGAGGCGGAGGCGCTGTATGCCGAAGCAGGCAA
GCTTCCGGGCATTCAGGTCGTCGGCGTCGACGTGCACATCGGCAGCCAGATCGGCGAACTCGGGCCGATGCGCGCGGCCT
TCGAGAAAGTGGTGGCTCTTGCGCTTCGCCTGAGAGGGCAGGGGCATGATATTCGCCGGATTGATGTGGGCGGGGGCCTT
GGCATTCCCTATCGCGAGACTGATGCCCCGGCGCCCCCGTCTGCCTATGCCGCGATGATTGCCGAGGTCACCGCTGGCCA
TGGGTTTGAGGTTATTCTGGAGCCCGGCCGCGTGATCGCGGGCAATGCGGGCGTGTTGCTGACGACGGCACTGTATGAAA
AAGAAGCGCCCGACCGCACGTTTCTGATCATTGATGCGGGCATGAATGACCTCATCCGCCCGGCGCTTTATGGCGCCCAT
CACGACATCCGGCCCCTGGATGAACCTGCACAGGACGCGGCTGAGAAAGTTTATGATGTTGTTGGGCCGATCTGCGAGTC
GACCGACAAGTTTGCCACAGCGCGCACCCTGCCCAAGGTGACGCCCGGTGACCGCCTCGCCTTCATGTCTGCAGGCGCCT
ATGGCGCTGTGCTCTCATCGGCCTACAATGCCCGTCCATTGGTTCCCGAAGTCCTCGTCAGCGGTGATCGCTACAGTATT
GTGCGCCGCCGGCCGGACTTTGAAGAAATGACGATGCTGGAAGAGGTGCCCGATTGGATCACGGCGAAGGCCTGA

Upstream 100 bases:

>100_bases
GCCGCGCGTGAACGAATGGGGCGGAGAAGTTCCCGAGAACAAGCCCACCGGGGATGTCGATGAAGGCGGTCTCGGCGACC
TCTCCTGACCTGGAGTCTAC

Downstream 100 bases:

>100_bases
ACACGCTGGGGAAGAAGCTTGCGGCCACGCGCCGCCGGCTGACGCTTCTGGCGCTCGGCCGCGCCTGGTGGCCGGCATTT
GTGTTTATTGCCTTGTTTCT

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MHHFNYAGGRLQCEGVDLGRVADEVGTPVYVYSTATLERHARVIAEAFSSQKVLIAYSVKANGNLAVLATLAAEGCGADV
VSGGEMQRAMKAGIPAARIVFSGVGKTAAEMKLALEAGIHQFNVESAGELRLLSRVASGLGLKAPIALRVNPDVAAGGHP
NISTGKSGDKFGVPWGEAEALYAEAGKLPGIQVVGVDVHIGSQIGELGPMRAAFEKVVALALRLRGQGHDIRRIDVGGGL
GIPYRETDAPAPPSAYAAMIAEVTAGHGFEVILEPGRVIAGNAGVLLTTALYEKEAPDRTFLIIDAGMNDLIRPALYGAH
HDIRPLDEPAQDAAEKVYDVVGPICESTDKFATARTLPKVTPGDRLAFMSAGAYGAVLSSAYNARPLVPEVLVSGDRYSI
VRRRPDFEEMTMLEEVPDWITAKA

Sequences:

>Translated_424_residues
MHHFNYAGGRLQCEGVDLGRVADEVGTPVYVYSTATLERHARVIAEAFSSQKVLIAYSVKANGNLAVLATLAAEGCGADV
VSGGEMQRAMKAGIPAARIVFSGVGKTAAEMKLALEAGIHQFNVESAGELRLLSRVASGLGLKAPIALRVNPDVAAGGHP
NISTGKSGDKFGVPWGEAEALYAEAGKLPGIQVVGVDVHIGSQIGELGPMRAAFEKVVALALRLRGQGHDIRRIDVGGGL
GIPYRETDAPAPPSAYAAMIAEVTAGHGFEVILEPGRVIAGNAGVLLTTALYEKEAPDRTFLIIDAGMNDLIRPALYGAH
HDIRPLDEPAQDAAEKVYDVVGPICESTDKFATARTLPKVTPGDRLAFMSAGAYGAVLSSAYNARPLVPEVLVSGDRYSI
VRRRPDFEEMTMLEEVPDWITAKA
>Mature_424_residues
MHHFNYAGGRLQCEGVDLGRVADEVGTPVYVYSTATLERHARVIAEAFSSQKVLIAYSVKANGNLAVLATLAAEGCGADV
VSGGEMQRAMKAGIPAARIVFSGVGKTAAEMKLALEAGIHQFNVESAGELRLLSRVASGLGLKAPIALRVNPDVAAGGHP
NISTGKSGDKFGVPWGEAEALYAEAGKLPGIQVVGVDVHIGSQIGELGPMRAAFEKVVALALRLRGQGHDIRRIDVGGGL
GIPYRETDAPAPPSAYAAMIAEVTAGHGFEVILEPGRVIAGNAGVLLTTALYEKEAPDRTFLIIDAGMNDLIRPALYGAH
HDIRPLDEPAQDAAEKVYDVVGPICESTDKFATARTLPKVTPGDRLAFMSAGAYGAVLSSAYNARPLVPEVLVSGDRYSI
VRRRPDFEEMTMLEEVPDWITAKA

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=397, Percent_Identity=25.6926952141058, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI22538418, Length=436, Percent_Identity=23.8532110091743, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI21361583, Length=436, Percent_Identity=23.8532110091743, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI16506287, Length=354, Percent_Identity=25.9887005649718, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI1789203, Length=409, Percent_Identity=33.0073349633252, Blast_Score=182, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI17562780, Length=364, Percent_Identity=27.1978021978022, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24586474, Length=363, Percent_Identity=25.3443526170799, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022644
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 44656; Mature: 44656

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHHFNYAGGRLQCEGVDLGRVADEVGTPVYVYSTATLERHARVIAEAFSSQKVLIAYSVK
CCCCCCCCCEEEECCCCHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHCCCEEEEEEEEE
ANGNLAVLATLAAEGCGADVVSGGEMQRAMKAGIPAARIVFSGVGKTAAEMKLALEAGIH
CCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHHCCE
QFNVESAGELRLLSRVASGLGLKAPIALRVNPDVAAGGHPNISTGKSGDKFGVPWGEAEA
EECCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHH
LYAEAGKLPGIQVVGVDVHIGSQIGELGPMRAAFEKVVALALRLRGQGHDIRRIDVGGGL
HHHHHCCCCCEEEEEEEEEECCHHHCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCC
GIPYRETDAPAPPSAYAAMIAEVTAGHGFEVILEPGRVIAGNAGVLLTTALYEKEAPDRT
CCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCEEEECCCCEEEEEEHHHCCCCCCE
FLIIDAGMNDLIRPALYGAHHDIRPLDEPAQDAAEKVYDVVGPICESTDKFATARTLPKV
EEEEECCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCC
TPGDRLAFMSAGAYGAVLSSAYNARPLVPEVLVSGDRYSIVRRRPDFEEMTMLEEVPDWI
CCCCCEEEEECCHHHHHHHHCCCCCCCCHHHHHCCCCEEEEECCCCHHHHHHHHHCCHHH
TAKA
CCCC
>Mature Secondary Structure
MHHFNYAGGRLQCEGVDLGRVADEVGTPVYVYSTATLERHARVIAEAFSSQKVLIAYSVK
CCCCCCCCCEEEECCCCHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHCCCEEEEEEEEE
ANGNLAVLATLAAEGCGADVVSGGEMQRAMKAGIPAARIVFSGVGKTAAEMKLALEAGIH
CCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHHCCE
QFNVESAGELRLLSRVASGLGLKAPIALRVNPDVAAGGHPNISTGKSGDKFGVPWGEAEA
EECCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHH
LYAEAGKLPGIQVVGVDVHIGSQIGELGPMRAAFEKVVALALRLRGQGHDIRRIDVGGGL
HHHHHCCCCCEEEEEEEEEECCHHHCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCC
GIPYRETDAPAPPSAYAAMIAEVTAGHGFEVILEPGRVIAGNAGVLLTTALYEKEAPDRT
CCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCEEEECCCCEEEEEEHHHCCCCCCE
FLIIDAGMNDLIRPALYGAHHDIRPLDEPAQDAAEKVYDVVGPICESTDKFATARTLPKV
EEEEECCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCC
TPGDRLAFMSAGAYGAVLSSAYNARPLVPEVLVSGDRYSIVRRRPDFEEMTMLEEVPDWI
CCCCCEEEEECCHHHHHHHHCCCCCCCCHHHHHCCCCEEEEECCCCHHHHHHHHHCCHHH
TAKA
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA