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The map label for this gene is hisB

Identifier: 114799970

GI number: 114799970

Start: 58991

End: 59617

Strand: Reverse

Name: hisB

Synonym: HNE_0073

Alternate gene names: 114799970

Gene position: 59617-58991 (Counterclockwise)

Preceding gene: 114798620

Following gene: 114798251

Centisome position: 1.61

GC content: 60.29

Gene sequence:

>627_bases
TTGCGCCTCCGGCAGTTTATATGGCTTTCCATGACCCAGACCCGCACCGCAGACGTCTCCCGCAGCACAAAGGAAACCGA
AATCTCGGTATCCGTTAACCTTGATGGCACCGGTAAAGCCGACATCGAGACGGGAATCGGCTTTTTCGATCACATGCTGG
ACAGCCTGGCGCGCCATTCGCTGATCGACCTGAAAGTGCGCTGCAAGGGCGACACCCATATCGACTTCCACCACTCGGTG
GAGGACACCGGCATCGTTATCGGCCAGGCGATTGCCAAGGCGCTGGGCGATTTTGGCGGCATCACGCGCTTTGGCCATGC
CTATATCCCGATGGACGAGACGCTGACCCGCGCCTCAGTCGACCTGTGCAAACGCCCCTACCTGATCTGGAAGGTGGAGT
TCCGGCGCGACAAGATCGGCGAGATGGATACTGAACTCTTCAAGGAGTTCTTCCATGCCCTGGCCGGCAATGGCGGCATG
TGCCTGCACGTCGAGAACATCTATGGCGAGAACAACCACCACATCGCCGAAAGCTGTTTCAAGGCGACAGCCCGCGCCCT
GCGCACCGCCATCACGGTGGACCCGCGCCTTGGCGGCAAACCGGCCAGCACCAAGGGCAGCCTCTAG

Upstream 100 bases:

>100_bases
CTGTTTCAGTCCATTGCCCACTCGGAAGCCCAACTCAGTAATTGCCGCAAAGACTGCGCCTTAGATGTTTAGGAATCCGT
GAACACAGATGCGCTAGCTG

Downstream 100 bases:

>100_bases
GCGCCCCTGCCCGGCTCAGCCTGAGGGGTCTTCATCCTTGGCGTTGACGCGCGAGACCAGCACCTTGTCGAGGCGCCGGC
CGTCCATGTCGATCACCTCG

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD

Number of amino acids: Translated: 208; Mature: 208

Protein sequence:

>208_residues
MRLRQFIWLSMTQTRTADVSRSTKETEISVSVNLDGTGKADIETGIGFFDHMLDSLARHSLIDLKVRCKGDTHIDFHHSV
EDTGIVIGQAIAKALGDFGGITRFGHAYIPMDETLTRASVDLCKRPYLIWKVEFRRDKIGEMDTELFKEFFHALAGNGGM
CLHVENIYGENNHHIAESCFKATARALRTAITVDPRLGGKPASTKGSL

Sequences:

>Translated_208_residues
MRLRQFIWLSMTQTRTADVSRSTKETEISVSVNLDGTGKADIETGIGFFDHMLDSLARHSLIDLKVRCKGDTHIDFHHSV
EDTGIVIGQAIAKALGDFGGITRFGHAYIPMDETLTRASVDLCKRPYLIWKVEFRRDKIGEMDTELFKEFFHALAGNGGM
CLHVENIYGENNHHIAESCFKATARALRTAITVDPRLGGKPASTKGSL
>Mature_208_residues
MRLRQFIWLSMTQTRTADVSRSTKETEISVSVNLDGTGKADIETGIGFFDHMLDSLARHSLIDLKVRCKGDTHIDFHHSV
EDTGIVIGQAIAKALGDFGGITRFGHAYIPMDETLTRASVDLCKRPYLIWKVEFRRDKIGEMDTELFKEFFHALAGNGGM
CLHVENIYGENNHHIAESCFKATARALRTAITVDPRLGGKPASTKGSL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family

Homologues:

Organism=Escherichia coli, GI87082027, Length=194, Percent_Identity=47.4226804123711, Blast_Score=172, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6324776, Length=222, Percent_Identity=39.6396396396396, Blast_Score=157, Evalue=1e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS7_HYPNA (Q0C636)

Other databases:

- EMBL:   CP000158
- RefSeq:   YP_758807.1
- ProteinModelPortal:   Q0C636
- SMR:   Q0C636
- STRING:   Q0C636
- GeneID:   4290184
- GenomeReviews:   CP000158_GR
- KEGG:   hne:HNE_0073
- NMPDR:   fig|228405.5.peg.72
- TIGR:   HNE_0073
- eggNOG:   COG0131
- HOGENOM:   HBG289010
- OMA:   TLHVETL
- PhylomeDB:   Q0C636
- ProtClustDB:   PRK00951
- BioCyc:   HNEP81032:HNE_0073-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00076
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568

Pfam domain/function: PF00475 IGPD; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =4.2.1.19

Molecular weight: Translated: 23125; Mature: 23125

Theoretical pI: Translated: 7.33; Mature: 7.33

Prosite motif: PS00954 IGP_DEHYDRATASE_1; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLRQFIWLSMTQTRTADVSRSTKETEISVSVNLDGTGKADIETGIGFFDHMLDSLARHS
CCCHHEEEEECCCCCCHHCCCCCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCC
LIDLKVRCKGDTHIDFHHSVEDTGIVIGQAIAKALGDFGGITRFGHAYIPMDETLTRASV
EEEEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCHHHCCCEECCCHHHHHHHHH
DLCKRPYLIWKVEFRRDKIGEMDTELFKEFFHALAGNGGMCLHVENIYGENNHHIAESCF
HHHHCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEEHHHCCCCCCHHHHHHH
KATARALRTAITVDPRLGGKPASTKGSL
HHHHHHHHHHEEECCCCCCCCCCCCCCC
>Mature Secondary Structure
MRLRQFIWLSMTQTRTADVSRSTKETEISVSVNLDGTGKADIETGIGFFDHMLDSLARHS
CCCHHEEEEECCCCCCHHCCCCCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCC
LIDLKVRCKGDTHIDFHHSVEDTGIVIGQAIAKALGDFGGITRFGHAYIPMDETLTRASV
EEEEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCHHHCCCEECCCHHHHHHHHH
DLCKRPYLIWKVEFRRDKIGEMDTELFKEFFHALAGNGGMCLHVENIYGENNHHIAESCF
HHHHCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEEHHHCCCCCCHHHHHHH
KATARALRTAITVDPRLGGKPASTKGSL
HHHHHHHHHHEEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA