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The map label for this gene is sdhB [H]

Identifier: 114799946

GI number: 114799946

Start: 3415494

End: 3416276

Strand: Direct

Name: sdhB [H]

Synonym: HNE_3247

Alternate gene names: 114799946

Gene position: 3415494-3416276 (Clockwise)

Preceding gene: 114799101

Following gene: 114797183

Centisome position: 92.19

GC content: 61.05

Gene sequence:

>783_bases
ATGGTACAGCTGACCCTTCCCCAGAACTCGAAGGTCAAAAAAGGCAAGACTTGGCCCAAGCCCCAGGGCGCGACCAATCT
GCGCGCTTTCAAGATCTACCGGTTCAGCCCTGAAGAGGGCGGCAATCCGCGCTGGGACACCTATTGGGTGGATATGGACC
GCGCCGGCACGATGATCCTCGACGTGCTGATCTACATCAAGAACAACATCGACCCGACCCTCGCCTTCCGCCGCTCCTGC
CGCGAAGGCGTGTGCGGTTCCTGCGCGATGAACATTGCGGGCCGCAACACGATTGCCTGCACCAAGGGCTTTGAAGAACT
TCCCTCCGGCGAAGTCATCATCGCGCCCCTGCCCCACCAGCCCGTCGTCAAGGACCTGATCCCGGACCTGACGAACTTCT
ACGCCCAGCACGCCTATGTGCAGCCCTTCCTGAGAACCTCCACGCCCACGCCGGAGAAGGAATGGCGCCAGTCGGCCGAA
GACCGCACCAAGCTCGACGGCCTCTATGAGTGTATCCTGTGCGCCTCCTGCTCCACCTCCTGCCCATCCTATTGGTGGAA
TGGCGACAAATATCTCGGCCCTGCCGCGCTTCTGCAGGCTTATCGCTGGCTGATCGACAGCCGCGACGAAGCCACCGGCG
AACGCCTTGACGATCTGGAAGATCCCTTCAAGCTCTATCGCTGCCACACGATCATGAACTGCACGCAGGTCTGCCCGAAA
GGCCTCAACCCCGCCGAGGCCATTGCCAAGATCAAGCACATGATGGTCGAGCGCGTGGCGTAA

Upstream 100 bases:

>100_bases
TACGGTTTCGGATTTAGCATAACCGATGGCGCGGTGATCACAGCGCGCCGCAAGACAACAGACTGAAAGACGGCACGCAC
AGCCCGAGGGAATTGAAGAC

Downstream 100 bases:

>100_bases
GGCATTTCCTGCTTATTCAATATGATCGAGCCCCTGAACCGGAAGGTTTCAGGGGCTCTTCATTTCCTGCCCAAGCACAA
CGCCAAACCCCTTGTATGTC

Product: succinate dehydrogenase iron-sulfur subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 260; Mature: 260

Protein sequence:

>260_residues
MVQLTLPQNSKVKKGKTWPKPQGATNLRAFKIYRFSPEEGGNPRWDTYWVDMDRAGTMILDVLIYIKNNIDPTLAFRRSC
REGVCGSCAMNIAGRNTIACTKGFEELPSGEVIIAPLPHQPVVKDLIPDLTNFYAQHAYVQPFLRTSTPTPEKEWRQSAE
DRTKLDGLYECILCASCSTSCPSYWWNGDKYLGPAALLQAYRWLIDSRDEATGERLDDLEDPFKLYRCHTIMNCTQVCPK
GLNPAEAIAKIKHMMVERVA

Sequences:

>Translated_260_residues
MVQLTLPQNSKVKKGKTWPKPQGATNLRAFKIYRFSPEEGGNPRWDTYWVDMDRAGTMILDVLIYIKNNIDPTLAFRRSC
REGVCGSCAMNIAGRNTIACTKGFEELPSGEVIIAPLPHQPVVKDLIPDLTNFYAQHAYVQPFLRTSTPTPEKEWRQSAE
DRTKLDGLYECILCASCSTSCPSYWWNGDKYLGPAALLQAYRWLIDSRDEATGERLDDLEDPFKLYRCHTIMNCTQVCPK
GLNPAEAIAKIKHMMVERVA
>Mature_260_residues
MVQLTLPQNSKVKKGKTWPKPQGATNLRAFKIYRFSPEEGGNPRWDTYWVDMDRAGTMILDVLIYIKNNIDPTLAFRRSC
REGVCGSCAMNIAGRNTIACTKGFEELPSGEVIIAPLPHQPVVKDLIPDLTNFYAQHAYVQPFLRTSTPTPEKEWRQSAE
DRTKLDGLYECILCASCSTSCPSYWWNGDKYLGPAALLQAYRWLIDSRDEATGERLDDLEDPFKLYRCHTIMNCTQVCPK
GLNPAEAIAKIKHMMVERVA

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG0479

COG function: function code C; Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 4Fe-4S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI115387094, Length=236, Percent_Identity=61.4406779661017, Blast_Score=314, Evalue=4e-86,
Organism=Escherichia coli, GI1786943, Length=235, Percent_Identity=52.7659574468085, Blast_Score=258, Evalue=3e-70,
Organism=Escherichia coli, GI1790596, Length=228, Percent_Identity=32.8947368421053, Blast_Score=127, Evalue=6e-31,
Organism=Caenorhabditis elegans, GI17533915, Length=233, Percent_Identity=59.656652360515, Blast_Score=302, Evalue=1e-82,
Organism=Saccharomyces cerevisiae, GI6322987, Length=232, Percent_Identity=60.3448275862069, Blast_Score=296, Evalue=3e-81,
Organism=Drosophila melanogaster, GI17137106, Length=242, Percent_Identity=58.6776859504132, Blast_Score=308, Evalue=2e-84,
Organism=Drosophila melanogaster, GI24643156, Length=233, Percent_Identity=59.2274678111588, Blast_Score=294, Evalue=3e-80,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006058
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR012285
- InterPro:   IPR009051
- InterPro:   IPR004489 [H]

Pfam domain/function: NA

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 29469; Mature: 29469

Theoretical pI: Translated: 7.84; Mature: 7.84

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2 ; PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
4.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVQLTLPQNSKVKKGKTWPKPQGATNLRAFKIYRFSPEEGGNPRWDTYWVDMDRAGTMIL
CEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCEEEEECCCCHHHHH
DVLIYIKNNIDPTLAFRRSCREGVCGSCAMNIAGRNTIACTKGFEELPSGEVIIAPLPHQ
HHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHCCCCCEEEECCCHHHCCCCCEEEEECCCC
PVVKDLIPDLTNFYAQHAYVQPFLRTSTPTPEKEWRQSAEDRTKLDGLYECILCASCSTS
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
CPSYWWNGDKYLGPAALLQAYRWLIDSRDEATGERLDDLEDPFKLYRCHTIMNCTQVCPK
CCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GLNPAEAIAKIKHMMVERVA
CCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVQLTLPQNSKVKKGKTWPKPQGATNLRAFKIYRFSPEEGGNPRWDTYWVDMDRAGTMIL
CEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCEEEEECCCCHHHHH
DVLIYIKNNIDPTLAFRRSCREGVCGSCAMNIAGRNTIACTKGFEELPSGEVIIAPLPHQ
HHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHCCCCCEEEECCCHHHCCCCCEEEEECCCC
PVVKDLIPDLTNFYAQHAYVQPFLRTSTPTPEKEWRQSAEDRTKLDGLYECILCASCSTS
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
CPSYWWNGDKYLGPAALLQAYRWLIDSRDEATGERLDDLEDPFKLYRCHTIMNCTQVCPK
CCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GLNPAEAIAKIKHMMVERVA
CCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA