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The map label for this gene is gph [H]

Identifier: 114799903

GI number: 114799903

Start: 1014611

End: 1015324

Strand: Direct

Name: gph [H]

Synonym: HNE_1003

Alternate gene names: 114799903

Gene position: 1014611-1015324 (Clockwise)

Preceding gene: 114797120

Following gene: 114799379

Centisome position: 27.38

GC content: 66.11

Gene sequence:

>714_bases
ATGACGGAGCTGCGCCTTGCCATCTGGGACGTGGACGGAACGCTGGTGGACAGCCGCGACGTGATCCAGGCGTGTATGGA
AACGGCGTTTCGCGGCGCGGGCCTTCCGCCGCCGGAATATGATGCGACGCGGCGGATTGTGGGGCTGAGCCTGGGTGAGG
CTCTGGGCACGCTGGCCCCGCCCGATATTGGCGCAGACCAGCTGGCGGCGCTGGTGGAGGCGTATAAGCAGTCCTTCGTG
ACGCACCGCACGGCGCCGGGCTATCATGAGCCGCTGTATGACGGGGCGATTGAGCTGCTGGATCAGCTGAAAGCCGATGG
CTGGCTGATGGCGGTGGCGACGGGCAAGTCTCACCGGGGCGTCGACGCGCTGTTCGAGAAGCACAATCTGCGCAGCTATT
TCGACACCGTATGGTGCGCCGATGACGGGCCGGGCAAGCCCCATCCCTTCATGGTGGAGCAGGCGATGGGGGCGCTGGGA
TGCGCGCCGCAGGAGAGCCTGATGATTGGCGACGCCATCCACGACATGGCGATGGGCAAGGCGGCGGGCGTGCGGGCGCT
GGGGGTCAGCTGGGGCTTTGGCCGGGCTGACGAACTGGCGTCGGCAGGGGCGGACGAAATCCACCATGATTTCCGGACAC
TGACGCAGAGTCTGAAGGCATTTGCGGAAATCCGGCCGGTAAAAGCGCCCGGCGTGAACGAAGCCACAGGCTGA

Upstream 100 bases:

>100_bases
TTGTCGCGCCGCTGCCCCCGCATATGAAAGAGACGTTCGAGACGCTGGGCTTCCTCGAGCAGGAAGCGGGCAAAGATCCG
CTGGCGCCCTTTATCTGACG

Downstream 100 bases:

>100_bases
ACAGGCGGCCCGCTGTTTTGAGCGGCGACCTGAACATTTTTACACATTCTTAGGAACAACAGGCGCAATCGGCGCGTTGT
GGGAAAGACGGTCGCCAGAT

Product: HAD family hydrolase

Products: NA

Alternate protein names: PGP; PGPase [H]

Number of amino acids: Translated: 237; Mature: 236

Protein sequence:

>237_residues
MTELRLAIWDVDGTLVDSRDVIQACMETAFRGAGLPPPEYDATRRIVGLSLGEALGTLAPPDIGADQLAALVEAYKQSFV
THRTAPGYHEPLYDGAIELLDQLKADGWLMAVATGKSHRGVDALFEKHNLRSYFDTVWCADDGPGKPHPFMVEQAMGALG
CAPQESLMIGDAIHDMAMGKAAGVRALGVSWGFGRADELASAGADEIHHDFRTLTQSLKAFAEIRPVKAPGVNEATG

Sequences:

>Translated_237_residues
MTELRLAIWDVDGTLVDSRDVIQACMETAFRGAGLPPPEYDATRRIVGLSLGEALGTLAPPDIGADQLAALVEAYKQSFV
THRTAPGYHEPLYDGAIELLDQLKADGWLMAVATGKSHRGVDALFEKHNLRSYFDTVWCADDGPGKPHPFMVEQAMGALG
CAPQESLMIGDAIHDMAMGKAAGVRALGVSWGFGRADELASAGADEIHHDFRTLTQSLKAFAEIRPVKAPGVNEATG
>Mature_236_residues
TELRLAIWDVDGTLVDSRDVIQACMETAFRGAGLPPPEYDATRRIVGLSLGEALGTLAPPDIGADQLAALVEAYKQSFVT
HRTAPGYHEPLYDGAIELLDQLKADGWLMAVATGKSHRGVDALFEKHNLRSYFDTVWCADDGPGKPHPFMVEQAMGALGC
APQESLMIGDAIHDMAMGKAAGVRALGVSWGFGRADELASAGADEIHHDFRTLTQSLKAFAEIRPVKAPGVNEATG

Specific function: Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stres

COG id: COG0546

COG function: function code R; Predicted phosphatases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR006439
- InterPro:   IPR006402
- InterPro:   IPR006346
- InterPro:   IPR023198 [H]

Pfam domain/function: PF00702 Hydrolase [H]

EC number: =3.1.3.18 [H]

Molecular weight: Translated: 25343; Mature: 25212

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTELRLAIWDVDGTLVDSRDVIQACMETAFRGAGLPPPEYDATRRIVGLSLGEALGTLAP
CCCEEEEEEECCCCEECCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCC
PDIGADQLAALVEAYKQSFVTHRTAPGYHEPLYDGAIELLDQLKADGWLMAVATGKSHRG
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCC
VDALFEKHNLRSYFDTVWCADDGPGKPHPFMVEQAMGALGCAPQESLMIGDAIHDMAMGK
HHHHHHHHHHHHHHHEEEECCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
AAGVRALGVSWGFGRADELASAGADEIHHDFRTLTQSLKAFAEIRPVKAPGVNEATG
HCCCEEEECCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
TELRLAIWDVDGTLVDSRDVIQACMETAFRGAGLPPPEYDATRRIVGLSLGEALGTLAP
CCEEEEEEECCCCEECCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCC
PDIGADQLAALVEAYKQSFVTHRTAPGYHEPLYDGAIELLDQLKADGWLMAVATGKSHRG
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCC
VDALFEKHNLRSYFDTVWCADDGPGKPHPFMVEQAMGALGCAPQESLMIGDAIHDMAMGK
HHHHHHHHHHHHHHHEEEECCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
AAGVRALGVSWGFGRADELASAGADEIHHDFRTLTQSLKAFAEIRPVKAPGVNEATG
HCCCEEEECCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194 [H]