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The map label for this gene is dld [H]

Identifier: 114799766

GI number: 114799766

Start: 1694636

End: 1696297

Strand: Direct

Name: dld [H]

Synonym: HNE_1654

Alternate gene names: 114799766

Gene position: 1694636-1696297 (Clockwise)

Preceding gene: 114799533

Following gene: 114800530

Centisome position: 45.74

GC content: 63.36

Gene sequence:

>1662_bases
ATGATCTCAGACGCCGCCTTGATTCGAGAACTCAAAGTCATTGTCGGCTCTGGTCATGTAAACGTGCGTGACGACAGGCG
GGCCTCTGGCAAGCCGGTTACATTTGTGCGGCCGCGCACGCTGGTTGAGGTATGGCGCGTGGCCAGGGCGAGCGTGCGCG
CCGGGCGGATCATTCTGATGCGGGCGGGCGGCACCAGCCTTACGGGCGGATCGGCGCCGAACGGCGCGTATGATCGCGGT
GTGGTGGTCATCAACACGATGCGCCTGAAGGGTATTCACATGTTGAATGCCGGGGCGCAGGTGCTTTGCCTGCCGGGCAC
AACGCTGTTCGAACTGGAACGGGAATTGCGCCCCTTGCAGCGGGAGCCACATTCCGAGCTCGGATCAACCTGGCTCGGCG
CTTCCGTGATTGGGGGGGTCTGCAACAATTCCGGCGGCGCGCAGGTGCGGCGTGGCCCGGCTTATACTGAAGCGGCGCTT
TATGCGCATGTGGATGAGACGGGCGAACTGCGGCTGGTCAACGAGCTGGGCATGGATCTTGGGCGCGACCCGGAGGAGCA
GCTGGAAAGTCTGGAGCGTGGAGAATTCGTGCGGGTACTGCATGACATGCATGAGCGCGCCTGCTCGGCACATGGCTTTG
TGGAGCGGGTCCGCGATGTGGACGCCCCGTCTCCGGCGCGGTTCAATGCTGACCCGCGATACCTGAAGGGCGCGTCCGGA
AGTGCGGGCCGGTTGATCGTGTTTGCCGTGCGCCTGGATACATTTCCAAGGGCGGCGAATACCCAGGTGTTTCATGTCGC
GACCGACGATGCCGGTGTGCTGTCGGATGTCCGGCGGCGGATGCTGGGGCAGGCGGCTCTGGTGCCGATTTCGGCCGAGT
ATATGCACCGGGACACATTCCGGATGGCGGAGCGCGAGGGGAAGGATCTTCTTCTGGCCGTGCGGACGGCCGGAGCCGAC
AGGTTGCCTTTCCTGTTTGGATTCAAGGCTGGAGTTGATGGGGTTGCCCGATGGCTCGGATTTGGCCGTGCGTGTTTGAC
GGACCGGCTGCTTCAGGCGGTTGGGCGGCTGGCGCCGCCGCAACTTTCCGAGACGTTGCGGCAGATGGGCGAGCAATATG
CGCACCACCTGTTCCTCAAGGTGGAGGCCGATCAGGCCGCTGGCGTGCGCGCGCTGCTGGCCGATGTGGTGCCCGCACTT
AAGGGCGCGTGCCATGAATGCTCACCCGCAGAAGGCAGGCAGGTGTTCCTGCATCGGTTTGCGGCAACTGGCGCGGCGGC
GCGCCATGCCGCTATGAGCCGAGGCAAGGCGGGCGCCGTGGTGGAGTTGGACGTGGCGTTGAGGCGGAACGACAAGGCCT
GGTGGTATGTGTTGCCAGATCACCTGAAGGGCATGGTTGAGCATACGCTCGTACACGGTCATTTCTTTTGCCATGTGTTT
CAACAGGATTACATTCTGAAGAAGGGCGCTGACGCTGCCGCGTTCCGGCGGGGCATGGCGGCCCATTATGAGGCGCGGGG
CGCTGAATGCCCGGCAGAACATAATGTGGGGCATCGCCACAAGGCCAAGCCGGCGCTGGCGGCGTTTTACCGGAAGCTTG
ATCCCACGAACACGCTCAATCCCGGCATCGGCAGGACATCGCGCGACAAAAACTGGAAATAG

Upstream 100 bases:

>100_bases
CTGTTCATTTTCTGGGGAATTCTACCGCAATGCCTTCATTCGCTTGATGGTTTCCCGGTGACGTGGATCATCACCGGAAT
ATTGATGATACCTAATCGGC

Downstream 100 bases:

>100_bases
ACCGGCCTAGCTGTGGTCGTGCCAGACCACGCGCTTGGCAAGCTCGCGTGGGTACTCTGTCCGCATGGTGGCCAGATAAG
CCTCTTCCAGCCGCCGCAAG

Product: D-lactate dehydrogenase

Products: NA

Alternate protein names: Respiratory D-lactate dehydrogenase [H]

Number of amino acids: Translated: 553; Mature: 553

Protein sequence:

>553_residues
MISDAALIRELKVIVGSGHVNVRDDRRASGKPVTFVRPRTLVEVWRVARASVRAGRIILMRAGGTSLTGGSAPNGAYDRG
VVVINTMRLKGIHMLNAGAQVLCLPGTTLFELERELRPLQREPHSELGSTWLGASVIGGVCNNSGGAQVRRGPAYTEAAL
YAHVDETGELRLVNELGMDLGRDPEEQLESLERGEFVRVLHDMHERACSAHGFVERVRDVDAPSPARFNADPRYLKGASG
SAGRLIVFAVRLDTFPRAANTQVFHVATDDAGVLSDVRRRMLGQAALVPISAEYMHRDTFRMAEREGKDLLLAVRTAGAD
RLPFLFGFKAGVDGVARWLGFGRACLTDRLLQAVGRLAPPQLSETLRQMGEQYAHHLFLKVEADQAAGVRALLADVVPAL
KGACHECSPAEGRQVFLHRFAATGAAARHAAMSRGKAGAVVELDVALRRNDKAWWYVLPDHLKGMVEHTLVHGHFFCHVF
QQDYILKKGADAAAFRRGMAAHYEARGAECPAEHNVGHRHKAKPALAAFYRKLDPTNTLNPGIGRTSRDKNWK

Sequences:

>Translated_553_residues
MISDAALIRELKVIVGSGHVNVRDDRRASGKPVTFVRPRTLVEVWRVARASVRAGRIILMRAGGTSLTGGSAPNGAYDRG
VVVINTMRLKGIHMLNAGAQVLCLPGTTLFELERELRPLQREPHSELGSTWLGASVIGGVCNNSGGAQVRRGPAYTEAAL
YAHVDETGELRLVNELGMDLGRDPEEQLESLERGEFVRVLHDMHERACSAHGFVERVRDVDAPSPARFNADPRYLKGASG
SAGRLIVFAVRLDTFPRAANTQVFHVATDDAGVLSDVRRRMLGQAALVPISAEYMHRDTFRMAEREGKDLLLAVRTAGAD
RLPFLFGFKAGVDGVARWLGFGRACLTDRLLQAVGRLAPPQLSETLRQMGEQYAHHLFLKVEADQAAGVRALLADVVPAL
KGACHECSPAEGRQVFLHRFAATGAAARHAAMSRGKAGAVVELDVALRRNDKAWWYVLPDHLKGMVEHTLVHGHFFCHVF
QQDYILKKGADAAAFRRGMAAHYEARGAECPAEHNVGHRHKAKPALAAFYRKLDPTNTLNPGIGRTSRDKNWK
>Mature_553_residues
MISDAALIRELKVIVGSGHVNVRDDRRASGKPVTFVRPRTLVEVWRVARASVRAGRIILMRAGGTSLTGGSAPNGAYDRG
VVVINTMRLKGIHMLNAGAQVLCLPGTTLFELERELRPLQREPHSELGSTWLGASVIGGVCNNSGGAQVRRGPAYTEAAL
YAHVDETGELRLVNELGMDLGRDPEEQLESLERGEFVRVLHDMHERACSAHGFVERVRDVDAPSPARFNADPRYLKGASG
SAGRLIVFAVRLDTFPRAANTQVFHVATDDAGVLSDVRRRMLGQAALVPISAEYMHRDTFRMAEREGKDLLLAVRTAGAD
RLPFLFGFKAGVDGVARWLGFGRACLTDRLLQAVGRLAPPQLSETLRQMGEQYAHHLFLKVEADQAAGVRALLADVVPAL
KGACHECSPAEGRQVFLHRFAATGAAARHAAMSRGKAGAVVELDVALRRNDKAWWYVLPDHLKGMVEHTLVHGHFFCHVF
QQDYILKKGADAAAFRRGMAAHYEARGAECPAEHNVGHRHKAKPALAAFYRKLDPTNTLNPGIGRTSRDKNWK

Specific function: First component of the membrane-bound D-lactate oxidase, which is believed to play an important role in the energization of the active transport of a variety of sugars and amino acids [H]

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Escherichia coli, GI1788454, Length=563, Percent_Identity=46.1811722912966, Blast_Score=520, Evalue=1e-149,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016172
- InterPro:   IPR016173
- InterPro:   IPR012256
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR015409
- InterPro:   IPR006094 [H]

Pfam domain/function: PF01565 FAD_binding_4; PF09330 Lact-deh-memb [H]

EC number: =1.1.1.28 [H]

Molecular weight: Translated: 60508; Mature: 60508

Theoretical pI: Translated: 9.93; Mature: 9.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISDAALIRELKVIVGSGHVNVRDDRRASGKPVTFVRPRTLVEVWRVARASVRAGRIILM
CCCHHHHHHHHHHHEECCCEEECCCCCCCCCCEEEECCHHHHHHHHHHHHHHCCCEEEEE
RAGGTSLTGGSAPNGAYDRGVVVINTMRLKGIHMLNAGAQVLCLPGTTLFELERELRPLQ
ECCCCCCCCCCCCCCCCCCCEEEEEEEEECCEEEECCCCEEEEECCCHHHHHHHHHHHHH
REPHSELGSTWLGASVIGGVCNNSGGAQVRRGPAYTEAALYAHVDETGELRLVNELGMDL
CCCHHHHCCHHHHHHHHHHHHCCCCCCCEECCCCHHHHEEEEECCCCCCEEEHHHHCCCC
GRDPEEQLESLERGEFVRVLHDMHERACSAHGFVERVRDVDAPSPARFNADPRYLKGASG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEECCCCC
SAGRLIVFAVRLDTFPRAANTQVFHVATDDAGVLSDVRRRMLGQAALVPISAEYMHRDTF
CCCEEEEEEEEECCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCHHCCCCCHHHHHHHHH
RMAEREGKDLLLAVRTAGADRLPFLFGFKAGVDGVARWLGFGRACLTDRLLQAVGRLAPP
HHHHHCCCEEEEEEECCCCCCCCEEEEHHCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCH
QLSETLRQMGEQYAHHLFLKVEADQAAGVRALLADVVPALKGACHECSPAEGRQVFLHRF
HHHHHHHHHHHHHHHEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
AATGAAARHAAMSRGKAGAVVELDVALRRNDKAWWYVLPDHLKGMVEHTLVHGHFFCHVF
HHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHEEEEH
QQDYILKKGADAAAFRRGMAAHYEARGAECPAEHNVGHRHKAKPALAAFYRKLDPTNTLN
HHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCC
PGIGRTSRDKNWK
CCCCCCCCCCCCC
>Mature Secondary Structure
MISDAALIRELKVIVGSGHVNVRDDRRASGKPVTFVRPRTLVEVWRVARASVRAGRIILM
CCCHHHHHHHHHHHEECCCEEECCCCCCCCCCEEEECCHHHHHHHHHHHHHHCCCEEEEE
RAGGTSLTGGSAPNGAYDRGVVVINTMRLKGIHMLNAGAQVLCLPGTTLFELERELRPLQ
ECCCCCCCCCCCCCCCCCCCEEEEEEEEECCEEEECCCCEEEEECCCHHHHHHHHHHHHH
REPHSELGSTWLGASVIGGVCNNSGGAQVRRGPAYTEAALYAHVDETGELRLVNELGMDL
CCCHHHHCCHHHHHHHHHHHHCCCCCCCEECCCCHHHHEEEEECCCCCCEEEHHHHCCCC
GRDPEEQLESLERGEFVRVLHDMHERACSAHGFVERVRDVDAPSPARFNADPRYLKGASG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEECCCCC
SAGRLIVFAVRLDTFPRAANTQVFHVATDDAGVLSDVRRRMLGQAALVPISAEYMHRDTF
CCCEEEEEEEEECCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCHHCCCCCHHHHHHHHH
RMAEREGKDLLLAVRTAGADRLPFLFGFKAGVDGVARWLGFGRACLTDRLLQAVGRLAPP
HHHHHCCCEEEEEEECCCCCCCCEEEEHHCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCH
QLSETLRQMGEQYAHHLFLKVEADQAAGVRALLADVVPALKGACHECSPAEGRQVFLHRF
HHHHHHHHHHHHHHHEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
AATGAAARHAAMSRGKAGAVVELDVALRRNDKAWWYVLPDHLKGMVEHTLVHGHFFCHVF
HHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHEEEEH
QQDYILKKGADAAAFRRGMAAHYEARGAECPAEHNVGHRHKAKPALAAFYRKLDPTNTLN
HHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCC
PGIGRTSRDKNWK
CCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6386470; 3882663; 9278503; 10944213 [H]