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The map label for this gene is thrC [H]

Identifier: 114799665

GI number: 114799665

Start: 1053709

End: 1055091

Strand: Direct

Name: thrC [H]

Synonym: HNE_1045

Alternate gene names: 114799665

Gene position: 1053709-1055091 (Clockwise)

Preceding gene: 114797935

Following gene: 114800424

Centisome position: 28.44

GC content: 66.96

Gene sequence:

>1383_bases
GTGAAGTATATTTCGACCAGAGGTCAGGCGGAACCTGTTGATTTTGCAGGCGCTTGCCTGGCGGGCCTTGCCACGGACGG
CGGCCTCTACGTGCCCGAGAGCTGGCCGCAGATTGCCCCCGCCACGCCGGGTGAACCCTACGCCGAGACCGCCGCGCGCA
TCCTCTCCGCCTTTGCCGGCGACGCGATTCCCACCGACGTGATGCGCCGCCTCTGCACGCAGGCCTATGACCGCTTTGCC
CACCGCTCGGTTGCCCCGCTGACGCAGGCCGGGCCGGGTCTCTGGCTGATGGAGCTGCACCACGGGCCAACGCTCGCCTT
CAAGGATGTGGCGATGCAGATCATCGGCCAGATCTATGACTATCTCCTCGGCCTTTCCGGCCAGCGGATGACCGTAACCT
GCGCCACGTCCGGCGATACCGGCGGGGCCGCCGCCGGCGCGTTTGCGGGCGCGGAGAATGTGCGCCTCGTGATCCTGCAT
CCGCATGAGCGGGTCTCGCCGGTCCAGCGCCTGTTCATGACCACCACCGGGGCTGAGAACGTCCTCAATATCTCGGTCGA
TGGGGATTTTGACGACTGCCAGTCGATGGTCAAATCGATGTTCGCGGACAAGGCATTCTCAGCCAGTGTTGGCCTCTCAG
GTGTCAACTCGATCAACTGGGCGCGCATTGCTGCCCAGTCCGTCTACTACGCCACCGCCAGCGCCCAGCTGGGCCACCGC
CCGCTGCGCTTTGTGGTGCCCAGCGGCAATATGGGCGACGCGCTGGCAGGCTATGTTGCCGCCCGCTGCGGCCTCCTTCC
GGGTGGCCTCGAAATCCACTGCGCGGTGAACGAGAACGACACGCTGGCCCGCGTGTTCAACACCGGCAAGATGACCCGCC
AGGCGGCTGTGGCCACGCCCAGCCCGGCGATGGACATCTCCGTGCCGTCTAATTTCGAGCGCCTGCTGTTTGAAGTGACC
GGCCGGGACGCCGACGCGGTGCGCCGCACTTACGAGACCTATGCCCAGCAGGGCGAGGTGGACATTCCCGAGGCGGCCAG
GGCGCGCCTCTCCTGCACGGGGCTGTCGGCGGCGTCGGTGGGCAATGCCGATACCCTCGCCGAGATGGAGCGTTTCCGGC
AGGAGACCGGCTGGCTGATCTGTCCGCACACGGCGGTGGGCACGCAGATTGCGCGCCGCCTGAAGCCGTCTGACGCTGTC
GCCACAATCGTTCTGGCCACGGCAGCTGCCACGAAATTCCCTGAGACGGTCAAGGAAGCGACCGGGGAGGATGCGCCGCT
GCCCAGCCGCTGCGCCGAGCTGGTTGATCGCGGGGAGGTGTTCGAGCGGTTTGCTTCCGATCCGGCAGCCGTCCGCGCCC
GAATCGCCGCCTTCGCTGGCTAG

Upstream 100 bases:

>100_bases
ATGCAATCACCTGGTGGGGCCTCGCCATGGCGCTGATCGGTGTGTATCTGGCCTTCCATCACCAGCGCGGGCGGCTGCGT
TTCAGGCGGGAGAACATCCA

Downstream 100 bases:

>100_bases
GGCGTCTGCCATGGCGTTTGTTCCGCTCGATACGGTGATTGCGGGCAAGCGGGTGGCGCTGCTGGCGGCGCGGAAATCCG
ACTATGAAGAATGGGCGGCC

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 460; Mature: 460

Protein sequence:

>460_residues
MKYISTRGQAEPVDFAGACLAGLATDGGLYVPESWPQIAPATPGEPYAETAARILSAFAGDAIPTDVMRRLCTQAYDRFA
HRSVAPLTQAGPGLWLMELHHGPTLAFKDVAMQIIGQIYDYLLGLSGQRMTVTCATSGDTGGAAAGAFAGAENVRLVILH
PHERVSPVQRLFMTTTGAENVLNISVDGDFDDCQSMVKSMFADKAFSASVGLSGVNSINWARIAAQSVYYATASAQLGHR
PLRFVVPSGNMGDALAGYVAARCGLLPGGLEIHCAVNENDTLARVFNTGKMTRQAAVATPSPAMDISVPSNFERLLFEVT
GRDADAVRRTYETYAQQGEVDIPEAARARLSCTGLSAASVGNADTLAEMERFRQETGWLICPHTAVGTQIARRLKPSDAV
ATIVLATAAATKFPETVKEATGEDAPLPSRCAELVDRGEVFERFASDPAAVRARIAAFAG

Sequences:

>Translated_460_residues
MKYISTRGQAEPVDFAGACLAGLATDGGLYVPESWPQIAPATPGEPYAETAARILSAFAGDAIPTDVMRRLCTQAYDRFA
HRSVAPLTQAGPGLWLMELHHGPTLAFKDVAMQIIGQIYDYLLGLSGQRMTVTCATSGDTGGAAAGAFAGAENVRLVILH
PHERVSPVQRLFMTTTGAENVLNISVDGDFDDCQSMVKSMFADKAFSASVGLSGVNSINWARIAAQSVYYATASAQLGHR
PLRFVVPSGNMGDALAGYVAARCGLLPGGLEIHCAVNENDTLARVFNTGKMTRQAAVATPSPAMDISVPSNFERLLFEVT
GRDADAVRRTYETYAQQGEVDIPEAARARLSCTGLSAASVGNADTLAEMERFRQETGWLICPHTAVGTQIARRLKPSDAV
ATIVLATAAATKFPETVKEATGEDAPLPSRCAELVDRGEVFERFASDPAAVRARIAAFAG
>Mature_460_residues
MKYISTRGQAEPVDFAGACLAGLATDGGLYVPESWPQIAPATPGEPYAETAARILSAFAGDAIPTDVMRRLCTQAYDRFA
HRSVAPLTQAGPGLWLMELHHGPTLAFKDVAMQIIGQIYDYLLGLSGQRMTVTCATSGDTGGAAAGAFAGAENVRLVILH
PHERVSPVQRLFMTTTGAENVLNISVDGDFDDCQSMVKSMFADKAFSASVGLSGVNSINWARIAAQSVYYATASAQLGHR
PLRFVVPSGNMGDALAGYVAARCGLLPGGLEIHCAVNENDTLARVFNTGKMTRQAAVATPSPAMDISVPSNFERLLFEVT
GRDADAVRRTYETYAQQGEVDIPEAARARLSCTGLSAASVGNADTLAEMERFRQETGWLICPHTAVGTQIARRLKPSDAV
ATIVLATAAATKFPETVKEATGEDAPLPSRCAELVDRGEVFERFASDPAAVRARIAAFAG

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI149193323, Length=434, Percent_Identity=35.7142857142857, Blast_Score=248, Evalue=6e-66,
Organism=Homo sapiens, GI153792148, Length=454, Percent_Identity=29.7356828193833, Blast_Score=172, Evalue=6e-43,
Organism=Escherichia coli, GI1786185, Length=461, Percent_Identity=34.4902386117137, Blast_Score=217, Evalue=1e-57,
Organism=Saccharomyces cerevisiae, GI6319901, Length=458, Percent_Identity=36.8995633187773, Blast_Score=266, Evalue=4e-72,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 48722; Mature: 48722

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYISTRGQAEPVDFAGACLAGLATDGGLYVPESWPQIAPATPGEPYAETAARILSAFAG
CCCCCCCCCCCCCCHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHHCC
DAIPTDVMRRLCTQAYDRFAHRSVAPLTQAGPGLWLMELHHGPTLAFKDVAMQIIGQIYD
CCCCHHHHHHHHHHHHHHHHHCCCCCHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHH
YLLGLSGQRMTVTCATSGDTGGAAAGAFAGAENVRLVILHPHERVSPVQRLFMTTTGAEN
HHHCCCCCEEEEEEECCCCCCCCHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHCCCCCC
VLNISVDGDFDDCQSMVKSMFADKAFSASVGLSGVNSINWARIAAQSVYYATASAQLGHR
EEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHEEEHHHHCCCC
PLRFVVPSGNMGDALAGYVAARCGLLPGGLEIHCAVNENDTLARVFNTGKMTRQAAVATP
CEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHCCHHHHHHHCCCC
SPAMDISVPSNFERLLFEVTGRDADAVRRTYETYAQQGEVDIPEAARARLSCTGLSAASV
CCCEEECCCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCHHHHHEEEECCCCHHCC
GNADTLAEMERFRQETGWLICPHTAVGTQIARRLKPSDAVATIVLATAAATKFPETVKEA
CCHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHC
TGEDAPLPSRCAELVDRGEVFERFASDPAAVRARIAAFAG
CCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MKYISTRGQAEPVDFAGACLAGLATDGGLYVPESWPQIAPATPGEPYAETAARILSAFAG
CCCCCCCCCCCCCCHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHHCC
DAIPTDVMRRLCTQAYDRFAHRSVAPLTQAGPGLWLMELHHGPTLAFKDVAMQIIGQIYD
CCCCHHHHHHHHHHHHHHHHHCCCCCHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHH
YLLGLSGQRMTVTCATSGDTGGAAAGAFAGAENVRLVILHPHERVSPVQRLFMTTTGAEN
HHHCCCCCEEEEEEECCCCCCCCHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHCCCCCC
VLNISVDGDFDDCQSMVKSMFADKAFSASVGLSGVNSINWARIAAQSVYYATASAQLGHR
EEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHEEEHHHHCCCC
PLRFVVPSGNMGDALAGYVAARCGLLPGGLEIHCAVNENDTLARVFNTGKMTRQAAVATP
CEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHCCHHHHHHHCCCC
SPAMDISVPSNFERLLFEVTGRDADAVRRTYETYAQQGEVDIPEAARARLSCTGLSAASV
CCCEEECCCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCHHHHHEEEECCCCHHCC
GNADTLAEMERFRQETGWLICPHTAVGTQIARRLKPSDAVATIVLATAAATKFPETVKEA
CCHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHC
TGEDAPLPSRCAELVDRGEVFERFASDPAAVRARIAAFAG
CCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]