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The map label for this gene is pdhA [H]

Identifier: 114799576

GI number: 114799576

Start: 2049784

End: 2050794

Strand: Reverse

Name: pdhA [H]

Synonym: HNE_1977

Alternate gene names: 114799576

Gene position: 2050794-2049784 (Counterclockwise)

Preceding gene: 114800148

Following gene: 114798083

Centisome position: 55.35

GC content: 60.63

Gene sequence:

>1011_bases
ATGGCAACAAAACCAAAGAGTGCAAAAAAGGCACCCGCTAAGGCCACTAAGGCCGAAATGCTTGCCTTCTACCGGGAGAT
GCTGCTGATCCGGCGCTTCGAGGAGAAGGCTGGCCAGCTTTACGGCATGGGCAAGATCGCCGGCTTCTGCCACCTCTATA
TCGGGCAGGAAGCGGTCGTTACCGGCATGCAGGCCTGCCTCAAAGAGGGCGACCAGGTCATTACCGGTTACCGCGACCAC
GGCCACATGCTGGCCTGTCAGATGGACCCCAAGGGCGTCATGGCCGAGCTGACCGGACGGGTCGGCGGCTATTCGCGCGG
CAAGGGCGGCTCCATGCACATGTTCTCGAAAGAGAAGAATTTCTATGGCGGCCACGGTATCGTCGGCGCGCAGGTGCCTC
TGGGCACGGGCCTTGCCTTCGCCAACAAGTATCGCGGCAACGATAATGTCAGCCTCGCTTACTTCGGCGACGGCGCAGCC
AATCAGGGCCAGGTCTACGAAGCCTTCAACATGGCCTCCCTCTGGAAGCTGCCGGTTGTCTACGTGATCGAGAACAACAT
GTACGCCATGGGCACGAGCGTTGAGCGCCATGCCTCGGAAGTCGAGCTGTTCAAGCGCGGCATCTCCTTCGAGATCGAAG
GCGAGGAAGTCGACGGCATGGATGTGCTGGCGGTGCGCGAAGCCGGCGAGAAGGCGGTGAAGCATGCGCGCGCCGGAAAA
GGCCCCTATATCCTCGAGATGAAGACCTATCGCTATCGCGGCCACTCGATGTCCGACCCTGCGAAGTATCGCAAGCGGGA
AGAGGTCGACGACATCCGCTCGCACCATGACCCGATTGAGGGCCTCAAAGGCCAGATCCTTGAGCAGGGCCACGCCACCG
AGGACGAGCTGAAAAAGATCGACAACGAGATCAAGGCCATCGTGAAGGAGGCTGCGGATTTCTCCCTGGAGAGCCCGGAG
CCCGACGCGAGCGAGCTGTGGACAGATGTTCTGATCGAAGAGGCGGTGTGA

Upstream 100 bases:

>100_bases
TCTCCTTACACCAGAACGTAGCTCTGCAAATTGACAACGATGCTCTGACTTGTCGTTGCAAAAATGCAGCGCCATAAAGG
CCTCTGGGAGGCACAGAGTC

Downstream 100 bases:

>100_bases
TGCGCGTGAGTGCGCTTCGTTTGCTGCCCGCCCTAAATTCATTCCGTATTTCGGAGTTCAAATAATGTCCGTAGACATCC
TAATGCCTGCGCTGTCGCCA

Product: pyruvate dehydrogenase complex, E1 component, pyruvate dehydrogenase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 336; Mature: 335

Protein sequence:

>336_residues
MATKPKSAKKAPAKATKAEMLAFYREMLLIRRFEEKAGQLYGMGKIAGFCHLYIGQEAVVTGMQACLKEGDQVITGYRDH
GHMLACQMDPKGVMAELTGRVGGYSRGKGGSMHMFSKEKNFYGGHGIVGAQVPLGTGLAFANKYRGNDNVSLAYFGDGAA
NQGQVYEAFNMASLWKLPVVYVIENNMYAMGTSVERHASEVELFKRGISFEIEGEEVDGMDVLAVREAGEKAVKHARAGK
GPYILEMKTYRYRGHSMSDPAKYRKREEVDDIRSHHDPIEGLKGQILEQGHATEDELKKIDNEIKAIVKEAADFSLESPE
PDASELWTDVLIEEAV

Sequences:

>Translated_336_residues
MATKPKSAKKAPAKATKAEMLAFYREMLLIRRFEEKAGQLYGMGKIAGFCHLYIGQEAVVTGMQACLKEGDQVITGYRDH
GHMLACQMDPKGVMAELTGRVGGYSRGKGGSMHMFSKEKNFYGGHGIVGAQVPLGTGLAFANKYRGNDNVSLAYFGDGAA
NQGQVYEAFNMASLWKLPVVYVIENNMYAMGTSVERHASEVELFKRGISFEIEGEEVDGMDVLAVREAGEKAVKHARAGK
GPYILEMKTYRYRGHSMSDPAKYRKREEVDDIRSHHDPIEGLKGQILEQGHATEDELKKIDNEIKAIVKEAADFSLESPE
PDASELWTDVLIEEAV
>Mature_335_residues
ATKPKSAKKAPAKATKAEMLAFYREMLLIRRFEEKAGQLYGMGKIAGFCHLYIGQEAVVTGMQACLKEGDQVITGYRDHG
HMLACQMDPKGVMAELTGRVGGYSRGKGGSMHMFSKEKNFYGGHGIVGAQVPLGTGLAFANKYRGNDNVSLAYFGDGAAN
QGQVYEAFNMASLWKLPVVYVIENNMYAMGTSVERHASEVELFKRGISFEIEGEEVDGMDVLAVREAGEKAVKHARAGKG
PYILEMKTYRYRGHSMSDPAKYRKREEVDDIRSHHDPIEGLKGQILEQGHATEDELKKIDNEIKAIVKEAADFSLESPEP
DASELWTDVLIEEAV

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4885543, Length=312, Percent_Identity=54.1666666666667, Blast_Score=338, Evalue=4e-93,
Organism=Homo sapiens, GI291084742, Length=312, Percent_Identity=52.8846153846154, Blast_Score=313, Evalue=1e-85,
Organism=Homo sapiens, GI4505685, Length=312, Percent_Identity=52.8846153846154, Blast_Score=313, Evalue=2e-85,
Organism=Homo sapiens, GI291084744, Length=319, Percent_Identity=51.7241379310345, Blast_Score=306, Evalue=2e-83,
Organism=Homo sapiens, GI291084757, Length=312, Percent_Identity=46.474358974359, Blast_Score=255, Evalue=3e-68,
Organism=Homo sapiens, GI11386135, Length=318, Percent_Identity=29.2452830188679, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI258645172, Length=318, Percent_Identity=29.2452830188679, Blast_Score=131, Evalue=9e-31,
Organism=Caenorhabditis elegans, GI17536047, Length=315, Percent_Identity=52.0634920634921, Blast_Score=322, Evalue=2e-88,
Organism=Caenorhabditis elegans, GI32564172, Length=315, Percent_Identity=52.0634920634921, Blast_Score=322, Evalue=3e-88,
Organism=Caenorhabditis elegans, GI86563355, Length=267, Percent_Identity=30.7116104868914, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI86563357, Length=267, Percent_Identity=30.7116104868914, Blast_Score=119, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6321026, Length=323, Percent_Identity=48.6068111455108, Blast_Score=307, Evalue=1e-84,
Organism=Drosophila melanogaster, GI24639744, Length=318, Percent_Identity=52.5157232704402, Blast_Score=327, Evalue=7e-90,
Organism=Drosophila melanogaster, GI28571106, Length=318, Percent_Identity=52.5157232704402, Blast_Score=327, Evalue=7e-90,
Organism=Drosophila melanogaster, GI24639740, Length=318, Percent_Identity=52.5157232704402, Blast_Score=327, Evalue=8e-90,
Organism=Drosophila melanogaster, GI24639746, Length=305, Percent_Identity=53.1147540983606, Blast_Score=316, Evalue=2e-86,
Organism=Drosophila melanogaster, GI24639748, Length=316, Percent_Identity=49.6835443037975, Blast_Score=290, Evalue=8e-79,
Organism=Drosophila melanogaster, GI21355903, Length=313, Percent_Identity=28.1150159744409, Blast_Score=108, Evalue=5e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017597 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 37113; Mature: 36982

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATKPKSAKKAPAKATKAEMLAFYREMLLIRRFEEKAGQLYGMGKIAGFCHLYIGQEAVV
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECCHHHHHEEHEEECHHHHH
TGMQACLKEGDQVITGYRDHGHMLACQMDPKGVMAELTGRVGGYSRGKGGSMHMFSKEKN
HHHHHHHHCCCEEEEEECCCCCEEEEEECCCHHHHHHHHCCCCCCCCCCCCEEEEECCCC
FYGGHGIVGAQVPLGTGLAFANKYRGNDNVSLAYFGDGAANQGQVYEAFNMASLWKLPVV
CCCCCCEEECCCCCCCCHHHHHHCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCEE
YVIENNMYAMGTSVERHASEVELFKRGISFEIEGEEVDGMDVLAVREAGEKAVKHARAGK
EEEECCEEEECCCHHHHHHHHHHHHCCCCEEECCCCCCCCEEEHHHHHHHHHHHHHHCCC
GPYILEMKTYRYRGHSMSDPAKYRKREEVDDIRSHHDPIEGLKGQILEQGHATEDELKKI
CCEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHH
DNEIKAIVKEAADFSLESPEPDASELWTDVLIEEAV
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
ATKPKSAKKAPAKATKAEMLAFYREMLLIRRFEEKAGQLYGMGKIAGFCHLYIGQEAVV
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECCHHHHHEEHEEECHHHHH
TGMQACLKEGDQVITGYRDHGHMLACQMDPKGVMAELTGRVGGYSRGKGGSMHMFSKEKN
HHHHHHHHCCCEEEEEECCCCCEEEEEECCCHHHHHHHHCCCCCCCCCCCCEEEEECCCC
FYGGHGIVGAQVPLGTGLAFANKYRGNDNVSLAYFGDGAANQGQVYEAFNMASLWKLPVV
CCCCCCEEECCCCCCCCHHHHHHCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCEE
YVIENNMYAMGTSVERHASEVELFKRGISFEIEGEEVDGMDVLAVREAGEKAVKHARAGK
EEEECCEEEECCCHHHHHHHHHHHHCCCCEEECCCCCCCCEEEHHHHHHHHHHHHHHCCC
GPYILEMKTYRYRGHSMSDPAKYRKREEVDDIRSHHDPIEGLKGQILEQGHATEDELKKI
CCEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHH
DNEIKAIVKEAADFSLESPEPDASELWTDVLIEEAV
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10796014; 11481430 [H]