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The map label for this gene is ffh [H]

Identifier: 114799508

GI number: 114799508

Start: 27293

End: 28768

Strand: Direct

Name: ffh [H]

Synonym: HNE_0036

Alternate gene names: 114799508

Gene position: 27293-28768 (Clockwise)

Preceding gene: 114799210

Following gene: 114800523

Centisome position: 0.74

GC content: 63.89

Gene sequence:

>1476_bases
ATGTTCGACGCCCTAAGCGAACGTCTTGGCAGTATCTTCGACGGCCTCACCGGCCGCGGCGCGCTGTCTGATAAGGACGT
CAGCGAAGCTTTGCGCGAAATCCGCGTGGCCCTGCTCGAGGCCGATGTGGCCCTCCCGGTGGTCAAGGATTTCGTCGAAA
AGGTGCGCGAACGCGCTGTCGGCGAAGAAGTCATCCGCTCGGTCAAACCCGGCCAGCAGGTCATCAAGATCGTCTATGAC
GCGCTGGTGGATATGCTCGGCTCCGATGAGGAGGAAAACCACCTTCGCGTCGATACGCCCCCGGCCGTGGTGATGATGGC
GGGCCTTCAGGGCTCGGGTAAAACCACCACCACCGGCAAGATCGCCAAACGCCTGGCCGATCGCGGCAAGAAGAAAGTCC
TCCTCGCCTCGCTCGACGTACGCCGCCCGGCGGCCATGGAACAGCTTGCGATCCTCGCCAAACAAGCCGGCGAAACCGTC
AGCTCCTTGCCGATCATTCCTGGCCAGCTTCCCGCTGACATCGCCCGCCGCGCGCTTCAGGCTGCCAAGATCGGCGGCTA
TGATGTCCTCTTCCTCGATACGGCAGGGCGCACCTCGATTGACGAACAGATGATGAGCGAGGCGGCCGAGATTGCCGCCA
TCGCCAATCCGTCTGAAGTGCTTCTCGTGGCCGACGCCCTCACCGGCCAGGACGCGGTTGAAACCGCTCGCCGCTTCCAT
GAGCGCCTGCCGCTCACCGGTCTCGTCCTGACACGGATGGACGGCGATGGCCGGGGAGGCGCGGCGCTCTCCATGCGCGC
GGTCACCGGGCTGCCGATCAAATTCCTCGGCGTCGGCGAAAAGCTTGATGGGCTGGACGCGTTTGATGCCAAGCGCGTCG
CCGGCCGCATCCTCGGCCAGGGCGACATTATCAGCCTCGTCGAGAAAGCGGCTGAGCACTACGACGCCGAAAAAGCTGAG
CGCATGGCCGCCAAGCTCAAGAAAGGCGAGTTCGATCTGGAAGACCTCGCCGAGCAGCTTCGCCAGATGCAGCGCATGGG
CGGCCTTGGCGGCATCATGGGCATGATGCCCGGCGTGCGCAAAGCCAAGGAAGCCATGGCCAGCTCCAATATAGATGACC
GTGTGCTGAAACGTCAGGAGGCGATCATTTCGTCGATGACGCGGCAAGAGCGCCGCAAGCCTGCGCTTCTCAACGCATCG
CGCCGCAAGCGCATTGCGGCCGGCGCCGGCGTGGATGTGGCGGACGTCAACAAGGTGCTGAAGATGCACCAGCAGATGGC
CACCATGATGAAGAAGATGCGCACCAAGGGCGGCATGAAAAACCTGATGGGCATGGCCCAGCAGGCCGGCATCTCGCAAT
CAGACCTCGCCAAGATGGGCGGCGGCGGCATGCCACCCGGCGGTCTGCCGGGTCTCGGTGGCGGTGGCCTTCCCGGCGGC
TTGCCCGGACTTCCAGGGGGAACGAAGAAGAAATGA

Upstream 100 bases:

>100_bases
CTATATGACAGGGACGGGAGGCCGGCGGGGCCCCCCGCCCGGCGATACCTCGCTCAGCGGGGCTTTCATCGTTTTGTGCG
GAAAAGAGGAGTGTAGCGGT

Downstream 100 bases:

>100_bases
CCAATCCCGATCAGACCCTTGCCCAGTTCCAGCTCGGCCAGCTGCGCGCGTCCATCGACAATATGGACTCGATCCTCATC
CATACGCTGGCGGAGCGTTT

Product: signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 491; Mature: 491

Protein sequence:

>491_residues
MFDALSERLGSIFDGLTGRGALSDKDVSEALREIRVALLEADVALPVVKDFVEKVRERAVGEEVIRSVKPGQQVIKIVYD
ALVDMLGSDEEENHLRVDTPPAVVMMAGLQGSGKTTTTGKIAKRLADRGKKKVLLASLDVRRPAAMEQLAILAKQAGETV
SSLPIIPGQLPADIARRALQAAKIGGYDVLFLDTAGRTSIDEQMMSEAAEIAAIANPSEVLLVADALTGQDAVETARRFH
ERLPLTGLVLTRMDGDGRGGAALSMRAVTGLPIKFLGVGEKLDGLDAFDAKRVAGRILGQGDIISLVEKAAEHYDAEKAE
RMAAKLKKGEFDLEDLAEQLRQMQRMGGLGGIMGMMPGVRKAKEAMASSNIDDRVLKRQEAIISSMTRQERRKPALLNAS
RRKRIAAGAGVDVADVNKVLKMHQQMATMMKKMRTKGGMKNLMGMAQQAGISQSDLAKMGGGGMPPGGLPGLGGGGLPGG
LPGLPGGTKKK

Sequences:

>Translated_491_residues
MFDALSERLGSIFDGLTGRGALSDKDVSEALREIRVALLEADVALPVVKDFVEKVRERAVGEEVIRSVKPGQQVIKIVYD
ALVDMLGSDEEENHLRVDTPPAVVMMAGLQGSGKTTTTGKIAKRLADRGKKKVLLASLDVRRPAAMEQLAILAKQAGETV
SSLPIIPGQLPADIARRALQAAKIGGYDVLFLDTAGRTSIDEQMMSEAAEIAAIANPSEVLLVADALTGQDAVETARRFH
ERLPLTGLVLTRMDGDGRGGAALSMRAVTGLPIKFLGVGEKLDGLDAFDAKRVAGRILGQGDIISLVEKAAEHYDAEKAE
RMAAKLKKGEFDLEDLAEQLRQMQRMGGLGGIMGMMPGVRKAKEAMASSNIDDRVLKRQEAIISSMTRQERRKPALLNAS
RRKRIAAGAGVDVADVNKVLKMHQQMATMMKKMRTKGGMKNLMGMAQQAGISQSDLAKMGGGGMPPGGLPGLGGGGLPGG
LPGLPGGTKKK
>Mature_491_residues
MFDALSERLGSIFDGLTGRGALSDKDVSEALREIRVALLEADVALPVVKDFVEKVRERAVGEEVIRSVKPGQQVIKIVYD
ALVDMLGSDEEENHLRVDTPPAVVMMAGLQGSGKTTTTGKIAKRLADRGKKKVLLASLDVRRPAAMEQLAILAKQAGETV
SSLPIIPGQLPADIARRALQAAKIGGYDVLFLDTAGRTSIDEQMMSEAAEIAAIANPSEVLLVADALTGQDAVETARRFH
ERLPLTGLVLTRMDGDGRGGAALSMRAVTGLPIKFLGVGEKLDGLDAFDAKRVAGRILGQGDIISLVEKAAEHYDAEKAE
RMAAKLKKGEFDLEDLAEQLRQMQRMGGLGGIMGMMPGVRKAKEAMASSNIDDRVLKRQEAIISSMTRQERRKPALLNAS
RRKRIAAGAGVDVADVNKVLKMHQQMATMMKKMRTKGGMKNLMGMAQQAGISQSDLAKMGGGGMPPGGLPGLGGGGLPGG
LPGLPGGTKKK

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=493, Percent_Identity=29.8174442190669, Blast_Score=202, Evalue=6e-52,
Organism=Homo sapiens, GI226371618, Length=444, Percent_Identity=29.954954954955, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI295424842, Length=321, Percent_Identity=30.2180685358255, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI23308697, Length=321, Percent_Identity=30.2180685358255, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI89061728, Length=159, Percent_Identity=30.8176100628931, Blast_Score=94, Evalue=3e-19,
Organism=Escherichia coli, GI1788963, Length=427, Percent_Identity=53.1615925058548, Blast_Score=438, Evalue=1e-124,
Organism=Escherichia coli, GI1789874, Length=227, Percent_Identity=38.7665198237885, Blast_Score=139, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI17539958, Length=471, Percent_Identity=29.2993630573248, Blast_Score=184, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI193206261, Length=311, Percent_Identity=30.2250803858521, Blast_Score=114, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6325345, Length=472, Percent_Identity=30.5084745762712, Blast_Score=195, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6320498, Length=226, Percent_Identity=25.6637168141593, Blast_Score=87, Evalue=8e-18,
Organism=Drosophila melanogaster, GI17647949, Length=456, Percent_Identity=28.9473684210526, Blast_Score=176, Evalue=4e-44,
Organism=Drosophila melanogaster, GI24641198, Length=330, Percent_Identity=28.7878787878788, Blast_Score=105, Evalue=6e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 52113; Mature: 52113

Theoretical pI: Translated: 10.20; Mature: 10.20

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.5 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDALSERLGSIFDGLTGRGALSDKDVSEALREIRVALLEADVALPVVKDFVEKVRERAV
CCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GEEVIRSVKPGQQVIKIVYDALVDMLGSDEEENHLRVDTPPAVVMMAGLQGSGKTTTTGK
HHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCEEEEECCCCCCCCCHHHH
IAKRLADRGKKKVLLASLDVRRPAAMEQLAILAKQAGETVSSLPIIPGQLPADIARRALQ
HHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCHHHHCCCCCCCCCHHHHHHHHH
AAKIGGYDVLFLDTAGRTSIDEQMMSEAAEIAAIANPSEVLLVADALTGQDAVETARRFH
HHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHH
ERLPLTGLVLTRMDGDGRGGAALSMRAVTGLPIKFLGVGEKLDGLDAFDAKRVAGRILGQ
HHCCCCCEEEEEECCCCCCCCCEEEHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHCCC
GDIISLVEKAAEHYDAEKAERMAAKLKKGEFDLEDLAEQLRQMQRMGGLGGIMGMMPGVR
CHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHCCCHH
KAKEAMASSNIDDRVLKRQEAIISSMTRQERRKPALLNASRRKRIAAGAGVDVADVNKVL
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHCHHHHHHHHCCCCCCHHHHHHHH
KMHQQMATMMKKMRTKGGMKNLMGMAQQAGISQSDLAKMGGGGMPPGGLPGLGGGGLPGG
HHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCC
LPGLPGGTKKK
CCCCCCCCCCC
>Mature Secondary Structure
MFDALSERLGSIFDGLTGRGALSDKDVSEALREIRVALLEADVALPVVKDFVEKVRERAV
CCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GEEVIRSVKPGQQVIKIVYDALVDMLGSDEEENHLRVDTPPAVVMMAGLQGSGKTTTTGK
HHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCEEEEECCCCCCCCCHHHH
IAKRLADRGKKKVLLASLDVRRPAAMEQLAILAKQAGETVSSLPIIPGQLPADIARRALQ
HHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCHHHHCCCCCCCCCHHHHHHHHH
AAKIGGYDVLFLDTAGRTSIDEQMMSEAAEIAAIANPSEVLLVADALTGQDAVETARRFH
HHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHH
ERLPLTGLVLTRMDGDGRGGAALSMRAVTGLPIKFLGVGEKLDGLDAFDAKRVAGRILGQ
HHCCCCCEEEEEECCCCCCCCCEEEHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHCCC
GDIISLVEKAAEHYDAEKAERMAAKLKKGEFDLEDLAEQLRQMQRMGGLGGIMGMMPGVR
CHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHCCCHH
KAKEAMASSNIDDRVLKRQEAIISSMTRQERRKPALLNASRRKRIAAGAGVDVADVNKVL
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHCHHHHHHHHCCCCCCHHHHHHHH
KMHQQMATMMKKMRTKGGMKNLMGMAQQAGISQSDLAKMGGGGMPPGGLPGLGGGGLPGG
HHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCC
LPGLPGGTKKK
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11557893 [H]