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The map label for this gene is merR [H]

Identifier: 114799442

GI number: 114799442

Start: 1730095

End: 1730487

Strand: Reverse

Name: merR [H]

Synonym: HNE_1688

Alternate gene names: 114799442

Gene position: 1730487-1730095 (Counterclockwise)

Preceding gene: 114799672

Following gene: 114799392

Centisome position: 46.71

GC content: 54.96

Gene sequence:

>393_bases
ATGCTCAGGCGGGCCGAGTTGGCCAGCCGGCTTGGCTGCAACCTTGAAACCATCCGCTATTACGAAAAGATCGGACTTCT
ACCAGAACCAGCGCGCTCACCCAGTGGCCACCGGCTCTATTCAAACGTGGATCAGTTGCGTTTGCGATTTATCTTGCGGG
CGCGCGATCTGGGCTTCCGAACAGAGGACGTTCGCTCGCTCCTGGGGATCAATGATGGCATGCCTAGCTGTGCCGAAGTG
ATGGTCCTTGCCGAAGCGCATCTAAAGGACATCAGAAATCGTATCCTGGATCTGCAGCAGATGGAGAGGCAGCTCAGTGA
GATCATGATCGGCTGCACCGGAGGTCAAACATCTGATTGTGCGTTGACGGACAAGCTTTTTGAATCTCGGTGA

Upstream 100 bases:

>100_bases
CGTCGTTGTCCTTGGCCTTGTGTTCGTCTGCTTGATACGGTCTGTAGTTGGTACAGACGCAAGCGGAGAATTGAGCATGG
ACATCACATCGTCGCGAGCG

Downstream 100 bases:

>100_bases
ACAGGTGTTGCCGCAAACATCTATTCAGGCCTGTCCGCTCCTACTCAGACGAACGCTCGTCGAGCTAAGGCGCGACAACA
GCCAGGATTTTTGAGACTAA

Product: mercuric resistance operon regulatory protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 130; Mature: 130

Protein sequence:

>130_residues
MLRRAELASRLGCNLETIRYYEKIGLLPEPARSPSGHRLYSNVDQLRLRFILRARDLGFRTEDVRSLLGINDGMPSCAEV
MVLAEAHLKDIRNRILDLQQMERQLSEIMIGCTGGQTSDCALTDKLFESR

Sequences:

>Translated_130_residues
MLRRAELASRLGCNLETIRYYEKIGLLPEPARSPSGHRLYSNVDQLRLRFILRARDLGFRTEDVRSLLGINDGMPSCAEV
MVLAEAHLKDIRNRILDLQQMERQLSEIMIGCTGGQTSDCALTDKLFESR
>Mature_130_residues
MLRRAELASRLGCNLETIRYYEKIGLLPEPARSPSGHRLYSNVDQLRLRFILRARDLGFRTEDVRSLLGINDGMPSCAEV
MVLAEAHLKDIRNRILDLQQMERQLSEIMIGCTGGQTSDCALTDKLFESR

Specific function: Mediates the mercuric-dependent induction of mercury resistance operon. In the absence of mercury merR represses transcription by binding tightly to the mer operator region; when mercury is present the dimeric complex binds a single ion and becomes a pote

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789687, Length=130, Percent_Identity=36.1538461538462, Blast_Score=77, Evalue=3e-16,
Organism=Escherichia coli, GI1786695, Length=123, Percent_Identity=30.0813008130081, Blast_Score=61, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR011794
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 14809; Mature: 14809

Theoretical pI: Translated: 7.94; Mature: 7.94

Prosite motif: PS00552 HTH_MERR_1 ; PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRRAELASRLGCNLETIRYYEKIGLLPEPARSPSGHRLYSNVDQLRLRFILRARDLGFR
CCCHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
TEDVRSLLGINDGMPSCAEVMVLAEAHLKDIRNRILDLQQMERQLSEIMIGCTGGQTSDC
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCH
ALTDKLFESR
HHHHHHHHCC
>Mature Secondary Structure
MLRRAELASRLGCNLETIRYYEKIGLLPEPARSPSGHRLYSNVDQLRLRFILRARDLGFR
CCCHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
TEDVRSLLGINDGMPSCAEVMVLAEAHLKDIRNRILDLQQMERQLSEIMIGCTGGQTSDC
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCH
ALTDKLFESR
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2666393 [H]