Click here to switch to the map view.

The map label for this gene is fabD [H]

Identifier: 114799413

GI number: 114799413

Start: 2247432

End: 2248382

Strand: Reverse

Name: fabD [H]

Synonym: HNE_2160

Alternate gene names: 114799413

Gene position: 2248382-2247432 (Counterclockwise)

Preceding gene: 114798747

Following gene: 114799680

Centisome position: 60.68

GC content: 63.72

Gene sequence:

>951_bases
ATGACCCTCGCATTCATTTTCCCCGGACAGGGCAGCCAGGAAATCGGCATGGGCAAGGCACTCGCCGACGCCTTTCCTGC
CGCAAAAGCAGTGTTTGAAGAGGTGGACGCGGCGCTCAGCCAGAAGCTCTCCTCCGTGATGTGGGAAGGCGATATTGCCG
AGCTGACCCTCACCGCCAACACCCAGCCCGCCCTGATGGCCCACTCCGTGGCCGCCATGAGGGCGCTTGAGGCGCATTTC
GGCATTTCAGCGAAGGATGCGGCGTTTGTCGCCGGCCATTCGCTGGGCGAGTATTCCGCGCTGGCTTCGGCTGGTTCGAT
CAGTGTGTCTGATACCGCGCGCCTCCTGCGCATCCGCGGCAATGCCATGCAATCTGCCGTTCAGCCAGGGCAGGGCGCTA
TGGCGGCCCTTCTGGGGGCCGATTATGCCCAGGCTGAAGCTGCCTGCGCCGCGGGCCGCGAAACTGGCGGCGCGTGCGAC
ATTGCCAATGATAATGCCCCCGGCCAGCTTGTCATCTCTGGCACCAAGGCGGCGATTGACGCCGCCATTGTCTGGTCGCA
GGCCAATGGCGTGAAGAAGGCTATGGCGCTGAACGTATCGGCGCCGTTCCACTGCGCCCTGATGCAGCCAGCTGCCGACG
CGATGGCGGCAGCGCTGGCAGACACCGAGATCAAGGCCCCGGCTGTGCCCCTGGTGGCCAATGTCAGCGCCAGCGCAGTC
ACAGATCCTGAAACGATCCGCCAGAATCTGGTCAAACAGGTGACAGGACGGGTCCGCTGGACCGAAAGCGTGCAGTATAT
GGTCGGCCAGGGCGTTACCATGACGGGCGAGGCCGGGGCGGGCAAAGTGCTCACGGTGATGCAACGCCGGATCGAGAAAT
CGCTGAACGGCTTCACCCTCGGCACCCCTGAGGACCTGGAAGCCTTCGCCAAAGCCATCAAAGAGAGCTGA

Upstream 100 bases:

>100_bases
AAGAGGCGCTCTTAAGCCTATCCTTGTGGAAAATTCAAGCGCTTGCATGCCGGGAGGACGCGCTTTACGCACGCCAAAAA
ACGCAGGAGACAGGGTAAAC

Downstream 100 bases:

>100_bases
TCATGATGGAGCTCGCGGCGTTGCTGCTGAACGATTTCAGGACTTATGTGTTCGTGTTTGTTGTTCTCGTCGTCGCGCTC
GAGCTTTATCGGCGGCACAG

Product: malonyl CoA-acyl carrier protein transacylase

Products: NA

Alternate protein names: MCT [H]

Number of amino acids: Translated: 316; Mature: 315

Protein sequence:

>316_residues
MTLAFIFPGQGSQEIGMGKALADAFPAAKAVFEEVDAALSQKLSSVMWEGDIAELTLTANTQPALMAHSVAAMRALEAHF
GISAKDAAFVAGHSLGEYSALASAGSISVSDTARLLRIRGNAMQSAVQPGQGAMAALLGADYAQAEAACAAGRETGGACD
IANDNAPGQLVISGTKAAIDAAIVWSQANGVKKAMALNVSAPFHCALMQPAADAMAAALADTEIKAPAVPLVANVSASAV
TDPETIRQNLVKQVTGRVRWTESVQYMVGQGVTMTGEAGAGKVLTVMQRRIEKSLNGFTLGTPEDLEAFAKAIKES

Sequences:

>Translated_316_residues
MTLAFIFPGQGSQEIGMGKALADAFPAAKAVFEEVDAALSQKLSSVMWEGDIAELTLTANTQPALMAHSVAAMRALEAHF
GISAKDAAFVAGHSLGEYSALASAGSISVSDTARLLRIRGNAMQSAVQPGQGAMAALLGADYAQAEAACAAGRETGGACD
IANDNAPGQLVISGTKAAIDAAIVWSQANGVKKAMALNVSAPFHCALMQPAADAMAAALADTEIKAPAVPLVANVSASAV
TDPETIRQNLVKQVTGRVRWTESVQYMVGQGVTMTGEAGAGKVLTVMQRRIEKSLNGFTLGTPEDLEAFAKAIKES
>Mature_315_residues
TLAFIFPGQGSQEIGMGKALADAFPAAKAVFEEVDAALSQKLSSVMWEGDIAELTLTANTQPALMAHSVAAMRALEAHFG
ISAKDAAFVAGHSLGEYSALASAGSISVSDTARLLRIRGNAMQSAVQPGQGAMAALLGADYAQAEAACAAGRETGGACDI
ANDNAPGQLVISGTKAAIDAAIVWSQANGVKKAMALNVSAPFHCALMQPAADAMAAALADTEIKAPAVPLVANVSASAVT
DPETIRQNLVKQVTGRVRWTESVQYMVGQGVTMTGEAGAGKVLTVMQRRIEKSLNGFTLGTPEDLEAFAKAIKES

Specific function: Fatty acid biosynthesis. [C]

COG id: COG0331

COG function: function code I; (acyl-carrier-protein) S-malonyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabD family [H]

Homologues:

Organism=Homo sapiens, GI51243059, Length=292, Percent_Identity=30.1369863013699, Blast_Score=130, Evalue=2e-30,
Organism=Escherichia coli, GI1787334, Length=301, Percent_Identity=45.514950166113, Blast_Score=229, Evalue=2e-61,
Organism=Caenorhabditis elegans, GI71984332, Length=295, Percent_Identity=28.4745762711864, Blast_Score=114, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI17550940, Length=297, Percent_Identity=29.6296296296296, Blast_Score=101, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24665753, Length=294, Percent_Identity=31.6326530612245, Blast_Score=128, Evalue=4e-30,

Paralogues:

None

Copy number: 500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001227
- InterPro:   IPR014043
- InterPro:   IPR016035
- InterPro:   IPR004410
- InterPro:   IPR016036 [H]

Pfam domain/function: PF00698 Acyl_transf_1 [H]

EC number: =2.3.1.39 [H]

Molecular weight: Translated: 32378; Mature: 32247

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLAFIFPGQGSQEIGMGKALADAFPAAKAVFEEVDAALSQKLSSVMWEGDIAELTLTAN
CEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECC
TQPALMAHSVAAMRALEAHFGISAKDAAFVAGHSLGEYSALASAGSISVSDTARLLRIRG
CCCHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCHHHHHHCCCCCCHHHHHHHHHHHC
NAMQSAVQPGQGAMAALLGADYAQAEAACAAGRETGGACDIANDNAPGQLVISGTKAAID
HHHHHHCCCCCCHHHHHHCCCHHHHHHHHHCCCCCCCEEECCCCCCCCEEEEECCHHHHH
AAIVWSQANGVKKAMALNVSAPFHCALMQPAADAMAAALADTEIKAPAVPLVANVSASAV
HEEEEECCCCCHHHEEEECCCCEEEEECCHHHHHHHHHHHCCCCCCCCCCEEECCCCCCC
TDPETIRQNLVKQVTGRVRWTESVQYMVGQGVTMTGEAGAGKVLTVMQRRIEKSLNGFTL
CCHHHHHHHHHHHHHCCEEHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCC
GTPEDLEAFAKAIKES
CCCHHHHHHHHHHHCC
>Mature Secondary Structure 
TLAFIFPGQGSQEIGMGKALADAFPAAKAVFEEVDAALSQKLSSVMWEGDIAELTLTAN
EEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECC
TQPALMAHSVAAMRALEAHFGISAKDAAFVAGHSLGEYSALASAGSISVSDTARLLRIRG
CCCHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCHHHHHHCCCCCCHHHHHHHHHHHC
NAMQSAVQPGQGAMAALLGADYAQAEAACAAGRETGGACDIANDNAPGQLVISGTKAAID
HHHHHHCCCCCCHHHHHHCCCHHHHHHHHHCCCCCCCEEECCCCCCCCEEEEECCHHHHH
AAIVWSQANGVKKAMALNVSAPFHCALMQPAADAMAAALADTEIKAPAVPLVANVSASAV
HEEEEECCCCCHHHEEEECCCCEEEEECCHHHHHHHHHHHCCCCCCCCCCEEECCCCCCC
TDPETIRQNLVKQVTGRVRWTESVQYMVGQGVTMTGEAGAGKVLTVMQRRIEKSLNGFTL
CCHHHHHHHHHHHHHCCEEHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCC
GTPEDLEAFAKAIKES
CCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8759840; 9534248; 9384377 [H]