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The map label for this gene is helX [H]

Identifier: 114799338

GI number: 114799338

Start: 3653706

End: 3654230

Strand: Direct

Name: helX [H]

Synonym: HNE_3519

Alternate gene names: 114799338

Gene position: 3653706-3654230 (Clockwise)

Preceding gene: 114798547

Following gene: 114799173

Centisome position: 98.61

GC content: 63.05

Gene sequence:

>525_bases
ATGAAGCGCTGGATCTATGCCTTGCCCGTTCTGGCGTTGGTCATCGTCGCCGGGTTTGGCGGATGGCAGATGATGCGCCC
GTCCAAGGGCGAGTTTGAGCGCCTCTCCCGCGCCGCGCCGGAACATGTCTTTCCGCTGATGGATGGGAGCGGCGAGATTT
CCTTCGCTCCGCCTCCGGGTGGACAGACGGTTGCGGTGAACCTCTTTGCCAGCTGGTGCGCGCCGTGTGAGGCCGAGCAC
AAATATCTGGTTGCCCTCGGCGAAAAACATCCCGGCCAGGTGTATGGCATTCTCTACAAGGACAAGGTGGAGGACGGCGC
CGGCTTTCTGGAGCGGCTGGGCAATCCCTACACGCAGGTGGCGCTGGACCCGGAAGGGCGCGGCGGGCTTGATTTCGGCC
TGACAGGCGTGCCGGAAACTTTTGTCATCTCCGGTGACGGAGAAATCATCCTGCATATCGGCGGGCCGCTGGATGACGCG
CTGGCCCAAAAAGTAAGCGGGGCGCTCGAAGCGCCCCGCTCATGA

Upstream 100 bases:

>100_bases
CGGCGCTGATTGCCGGGGCCTGCCTTCAGGCCTGGCTTGCCGCGCGCGCGGCAAGAAAGCGGCTGGAGGCGCTGGTCGCC
AATGACGAGGACCTGCGCGT

Downstream 100 bases:

>100_bases
CTTCATCGAGAAGGAAGCGTGATTACTTCGCTTTCTTCTTTGCAGCCGCTTTCTTGGCGACCGGGGCCTTTTTGACAGCG
ACCGGGGCTTTTTTCACTTC

Product: putative thiol:disulfide interchange protein

Products: NA

Alternate protein names: Cytochrome c biogenesis protein helX [H]

Number of amino acids: Translated: 174; Mature: 174

Protein sequence:

>174_residues
MKRWIYALPVLALVIVAGFGGWQMMRPSKGEFERLSRAAPEHVFPLMDGSGEISFAPPPGGQTVAVNLFASWCAPCEAEH
KYLVALGEKHPGQVYGILYKDKVEDGAGFLERLGNPYTQVALDPEGRGGLDFGLTGVPETFVISGDGEIILHIGGPLDDA
LAQKVSGALEAPRS

Sequences:

>Translated_174_residues
MKRWIYALPVLALVIVAGFGGWQMMRPSKGEFERLSRAAPEHVFPLMDGSGEISFAPPPGGQTVAVNLFASWCAPCEAEH
KYLVALGEKHPGQVYGILYKDKVEDGAGFLERLGNPYTQVALDPEGRGGLDFGLTGVPETFVISGDGEIILHIGGPLDDA
LAQKVSGALEAPRS
>Mature_174_residues
MKRWIYALPVLALVIVAGFGGWQMMRPSKGEFERLSRAAPEHVFPLMDGSGEISFAPPPGGQTVAVNLFASWCAPCEAEH
KYLVALGEKHPGQVYGILYKDKVEDGAGFLERLGNPYTQVALDPEGRGGLDFGLTGVPETFVISGDGEIILHIGGPLDDA
LAQKVSGALEAPRS

Specific function: Required for disulfide bond formation in some periplasmic proteins. Also act as a disulfide oxidoreductase in cytochromes c biogenesis. The cysteines of apocytochromes c must be in the reduced state for covalent linkage between the two moieties to occur [

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1788523, Length=165, Percent_Identity=33.3333333333333, Blast_Score=92, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004799
- InterPro:   IPR013740
- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR012335 [H]

Pfam domain/function: PF08534 Redoxin [H]

EC number: NA

Molecular weight: Translated: 18577; Mature: 18577

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRWIYALPVLALVIVAGFGGWQMMRPSKGEFERLSRAAPEHVFPLMDGSGEISFAPPPG
CCCHHHHHHHHHHHHHHCCCCCEECCCCCCHHHHHHHCCCCCEEEEECCCCCEEECCCCC
GQTVAVNLFASWCAPCEAEHKYLVALGEKHPGQVYGILYKDKVEDGAGFLERLGNPYTQV
CCEEEEEEEHHHCCCCCCCCEEEEEECCCCCCEEEEEEEECCCCCHHHHHHHHCCCEEEE
ALDPEGRGGLDFGLTGVPETFVISGDGEIILHIGGPLDDALAQKVSGALEAPRS
EECCCCCCCCCCCCCCCCCEEEEECCCEEEEEECCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKRWIYALPVLALVIVAGFGGWQMMRPSKGEFERLSRAAPEHVFPLMDGSGEISFAPPPG
CCCHHHHHHHHHHHHHHCCCCCEECCCCCCHHHHHHHCCCCCEEEEECCCCCEEECCCCC
GQTVAVNLFASWCAPCEAEHKYLVALGEKHPGQVYGILYKDKVEDGAGFLERLGNPYTQV
CCEEEEEEEHHHCCCCCCCCEEEEEECCCCCCEEEEEEEECCCCCHHHHHHHHCCCEEEE
ALDPEGRGGLDFGLTGVPETFVISGDGEIILHIGGPLDDALAQKVSGALEAPRS
EECCCCCCCCCCCCCCCCCEEEEECCCEEEEEECCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8384715 [H]