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The map label for this gene is acdA [H]

Identifier: 114799270

GI number: 114799270

Start: 2553904

End: 2555028

Strand: Reverse

Name: acdA [H]

Synonym: HNE_2442

Alternate gene names: 114799270

Gene position: 2555028-2553904 (Counterclockwise)

Preceding gene: 114798363

Following gene: 114799144

Centisome position: 68.96

GC content: 62.22

Gene sequence:

>1125_bases
GTGAACCTGGATTTCTCGGACGAGCAGAAACAATTGCGCGAGCAGGTGCGCCGTTTTCTGAGTGAAAACTGCACATCTGA
AACCGTCCGCTCCATTCTGGAGGGACCTGAAAGCTATGATAAAGAGCTCTATCAGGGCCTTGCCGAACTGGGCGTACTTG
GCGCGGCGATCCCGGAAGAATATGGCGGCGTCGGCCTGACGCATCTGGAGCTCTGCGTTGTGGCCGAGGAACTTGGCCGC
GTGCTGGCGCCGGTGCCAGTCTCCTCATCCATTTATCTCACGGCTGAGTTTTTGATGCTCGCCGGCTCTGAGAAACAGAA
GGAAACCTGGTTGCCGAAACTGGCATCGGGCGAGGCCATCGGCGCCTTCGCCTTTGCCGAAGGGCAGGGCCGCATGGCGC
CCGCCAAGATCAAGGCAACCGTCTCCGGCGGAAAACTCAGCGGCACGAAGTCTCCCGTCGCAGATGGCGATGTGGCGGAT
GTCCTCGTCGTCGCCGCGAAGAACGAGAAGGGCAATGTCTCGCTCTATCTCGTCGAAGCTGCCGCCAAGGGTGTCTCCCG
CGAAACGCTGGAAACTATTGACCCGACGCGCAGCCAGGCCCGTATCACTTTTGACGGCGCCCCGGCAGAACTTCTCGGCG
CAGAAGGCGACGGGTGGCATATTGCCACCCAGGTGCTCGACCGCGCCGCCGTTCTCATGGCGTTTGAACAGGTCGGCGGC
GCAGACCGCTCGCTGGAAATCGCCCGCGACTACGCCCTTGAACGCATGGCCTTTGGCCGGCCCATCGGCTCTTTCCAGGC
GGTGAAGCACATCCTGGCAGACATGTACGTCTCCGCCACGCTCGCCCGTTCCAACTGTTACTATGGCGCTTGGGCGCTCA
ACTCCGGCGCGGCCGAATTCCCTGTCGCCGCCGCCACCGCGCGCGTGTCGGCAACAACCGCGTTCCAGCACTGCGCCAAG
AACAACATTCAGGTGCATGGCGGCATGGGCTTCACCTGGGCGTTTGACTGCCATCTTTATTATCGCCGCTCCAATGCGCT
GGCCGTGGCCCTCGGGTCGCTGTCGAGCTGGGAGAGCCAGCTGATTGAACGCATGAGCGCAGGCAACGCCGAGCAGGCCG
CGTAA

Upstream 100 bases:

>100_bases
GACCTGCCGCGGGGCGGCTTTGAAAGTTGTGCTATAACGATAACGGGAGTGAGGTTCGGGCCAAAACGGCGCGCATCTCT
TTTGAAACTGGAGGCCCTTC

Downstream 100 bases:

>100_bases
AGGGAGGAATGAGACATGGATTTCAAAGATACACCTGAAGAAGCCGCCTTCCGCGCTGAAGTCCGCGCCTGGATCGACGC
TAACGCCCCCAAGCATCTGG

Product: acyl-CoA dehydrogenase family protein

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 374; Mature: 374

Protein sequence:

>374_residues
MNLDFSDEQKQLREQVRRFLSENCTSETVRSILEGPESYDKELYQGLAELGVLGAAIPEEYGGVGLTHLELCVVAEELGR
VLAPVPVSSSIYLTAEFLMLAGSEKQKETWLPKLASGEAIGAFAFAEGQGRMAPAKIKATVSGGKLSGTKSPVADGDVAD
VLVVAAKNEKGNVSLYLVEAAAKGVSRETLETIDPTRSQARITFDGAPAELLGAEGDGWHIATQVLDRAAVLMAFEQVGG
ADRSLEIARDYALERMAFGRPIGSFQAVKHILADMYVSATLARSNCYYGAWALNSGAAEFPVAAATARVSATTAFQHCAK
NNIQVHGGMGFTWAFDCHLYYRRSNALAVALGSLSSWESQLIERMSAGNAEQAA

Sequences:

>Translated_374_residues
MNLDFSDEQKQLREQVRRFLSENCTSETVRSILEGPESYDKELYQGLAELGVLGAAIPEEYGGVGLTHLELCVVAEELGR
VLAPVPVSSSIYLTAEFLMLAGSEKQKETWLPKLASGEAIGAFAFAEGQGRMAPAKIKATVSGGKLSGTKSPVADGDVAD
VLVVAAKNEKGNVSLYLVEAAAKGVSRETLETIDPTRSQARITFDGAPAELLGAEGDGWHIATQVLDRAAVLMAFEQVGG
ADRSLEIARDYALERMAFGRPIGSFQAVKHILADMYVSATLARSNCYYGAWALNSGAAEFPVAAATARVSATTAFQHCAK
NNIQVHGGMGFTWAFDCHLYYRRSNALAVALGSLSSWESQLIERMSAGNAEQAA
>Mature_374_residues
MNLDFSDEQKQLREQVRRFLSENCTSETVRSILEGPESYDKELYQGLAELGVLGAAIPEEYGGVGLTHLELCVVAEELGR
VLAPVPVSSSIYLTAEFLMLAGSEKQKETWLPKLASGEAIGAFAFAEGQGRMAPAKIKATVSGGKLSGTKSPVADGDVAD
VLVVAAKNEKGNVSLYLVEAAAKGVSRETLETIDPTRSQARITFDGAPAELLGAEGDGWHIATQVLDRAAVLMAFEQVGG
ADRSLEIARDYALERMAFGRPIGSFQAVKHILADMYVSATLARSNCYYGAWALNSGAAEFPVAAATARVSATTAFQHCAK
NNIQVHGGMGFTWAFDCHLYYRRSNALAVALGSLSSWESQLIERMSAGNAEQAA

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI226958412, Length=368, Percent_Identity=30.7065217391304, Blast_Score=132, Evalue=4e-31,
Organism=Homo sapiens, GI76496475, Length=344, Percent_Identity=29.3604651162791, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI4557235, Length=344, Percent_Identity=29.3604651162791, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI226958414, Length=364, Percent_Identity=30.7692307692308, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI21361497, Length=373, Percent_Identity=27.8820375335121, Blast_Score=119, Evalue=6e-27,
Organism=Homo sapiens, GI4557233, Length=351, Percent_Identity=29.9145299145299, Blast_Score=118, Evalue=9e-27,
Organism=Homo sapiens, GI4501857, Length=352, Percent_Identity=27.5568181818182, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI4501859, Length=354, Percent_Identity=27.9661016949153, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI7669494, Length=266, Percent_Identity=31.9548872180451, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI4503943, Length=266, Percent_Identity=31.9548872180451, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI4557231, Length=370, Percent_Identity=26.2162162162162, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI187960098, Length=370, Percent_Identity=26.2162162162162, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI7656849, Length=334, Percent_Identity=26.0479041916168, Blast_Score=88, Evalue=1e-17,
Organism=Escherichia coli, GI1786223, Length=343, Percent_Identity=26.530612244898, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI87081958, Length=345, Percent_Identity=23.768115942029, Blast_Score=86, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17538396, Length=344, Percent_Identity=30.5232558139535, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17534899, Length=398, Percent_Identity=28.391959798995, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17508101, Length=361, Percent_Identity=29.6398891966759, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17570075, Length=383, Percent_Identity=26.1096605744125, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17569725, Length=396, Percent_Identity=27.5252525252525, Blast_Score=105, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI71985184, Length=352, Percent_Identity=26.9886363636364, Blast_Score=104, Evalue=9e-23,
Organism=Caenorhabditis elegans, GI17534353, Length=297, Percent_Identity=27.2727272727273, Blast_Score=99, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17506239, Length=347, Percent_Identity=26.8011527377522, Blast_Score=99, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI71985192, Length=330, Percent_Identity=25.4545454545455, Blast_Score=88, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI71990804, Length=284, Percent_Identity=28.169014084507, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI32563615, Length=234, Percent_Identity=28.2051282051282, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17533517, Length=313, Percent_Identity=24.9201277955272, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71982178, Length=276, Percent_Identity=26.0869565217391, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21356377, Length=355, Percent_Identity=30.1408450704225, Blast_Score=137, Evalue=8e-33,
Organism=Drosophila melanogaster, GI24646207, Length=335, Percent_Identity=30.4477611940298, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI21355753, Length=310, Percent_Identity=30, Blast_Score=111, Evalue=9e-25,
Organism=Drosophila melanogaster, GI24666513, Length=364, Percent_Identity=28.8461538461538, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI281363737, Length=353, Percent_Identity=25.2124645892351, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI19920834, Length=268, Percent_Identity=31.3432835820896, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24660351, Length=369, Percent_Identity=26.8292682926829, Blast_Score=99, Evalue=7e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 39907; Mature: 39907

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLDFSDEQKQLREQVRRFLSENCTSETVRSILEGPESYDKELYQGLAELGVLGAAIPEE
CCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHH
YGGVGLTHLELCVVAEELGRVLAPVPVSSSIYLTAEFLMLAGSEKQKETWLPKLASGEAI
HCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEHEEHHHHCCCCHHHHHCCCCCCCCCCE
GAFAFAEGQGRMAPAKIKATVSGGKLSGTKSPVADGDVADVLVVAAKNEKGNVSLYLVEA
EEEEEECCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCEEEEEEEECCCCCCEEEEEEEH
AAKGVSRETLETIDPTRSQARITFDGAPAELLGAEGDGWHIATQVLDRAAVLMAFEQVGG
HHCCCCHHHHHHCCCCCCCEEEEECCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
ADRSLEIARDYALERMAFGRPIGSFQAVKHILADMYVSATLARSNCYYGAWALNSGAAEF
CCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCC
PVAAATARVSATTAFQHCAKNNIQVHGGMGFTWAFDCHLYYRRSNALAVALGSLSSWESQ
CHHHHHHHHHHHHHHHHHHCCCEEEECCCCEEEEEEEEEEEEECCEEEEEECCHHHHHHH
LIERMSAGNAEQAA
HHHHHHCCCCCCCC
>Mature Secondary Structure
MNLDFSDEQKQLREQVRRFLSENCTSETVRSILEGPESYDKELYQGLAELGVLGAAIPEE
CCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHH
YGGVGLTHLELCVVAEELGRVLAPVPVSSSIYLTAEFLMLAGSEKQKETWLPKLASGEAI
HCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEHEEHHHHCCCCHHHHHCCCCCCCCCCE
GAFAFAEGQGRMAPAKIKATVSGGKLSGTKSPVADGDVADVLVVAAKNEKGNVSLYLVEA
EEEEEECCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCEEEEEEEECCCCCCEEEEEEEH
AAKGVSRETLETIDPTRSQARITFDGAPAELLGAEGDGWHIATQVLDRAAVLMAFEQVGG
HHCCCCHHHHHHCCCCCCCEEEEECCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
ADRSLEIARDYALERMAFGRPIGSFQAVKHILADMYVSATLARSNCYYGAWALNSGAAEF
CCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCC
PVAAATARVSATTAFQHCAKNNIQVHGGMGFTWAFDCHLYYRRSNALAVALGSLSSWESQ
CHHHHHHHHHHHHHHHHHHCCCEEEECCCCEEEEEEEEEEEEECCEEEEEECCHHHHHHH
LIERMSAGNAEQAA
HHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]