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The map label for this gene is pyrD [H]

Identifier: 114799261

GI number: 114799261

Start: 3621862

End: 3622911

Strand: Reverse

Name: pyrD [H]

Synonym: HNE_3488

Alternate gene names: 114799261

Gene position: 3622911-3621862 (Counterclockwise)

Preceding gene: 114800306

Following gene: 114799141

Centisome position: 97.78

GC content: 61.24

Gene sequence:

>1050_bases
ATGATTGCTGCTGCCGGCGCAAGGCTCGTCCGTATGCTGCCACCCGAAGCAGCCCATACATTGACGCTTCGTATGCTGAC
ATATGGCGCGGGTGTACCCGCCCATGCGCCGCAGCTTCCGGTCTCGACGCGGGTTGAGCTGCCCCGGTCCGGTCTCCGGC
TTTGCTCGCCGGTCGGGCTTGCCGCGGGCTTTGACAAGAATTGCGAAGTGCCAGAGGCCATGGCGCGGTTTGGCTTCGGC
TTTGTCGAATGCGGAACGGTGACGCCGAAGCCCCAACCGGGAAACCCCAAGCCGCGCCTTTTCCGCCTCAGTGAAGACCG
CGCGGTGATCAACCGGATGGGATTCAACAATTTCGGGCTCGATTATTTCGTCCGCCGGCTGGAGAAATATTCTCATGATG
TTCCGATCGGCGCCAATGTCGGCGCCAACAAGGATACCGAAGACCGTATCGCTGATTACGTAACCGGTATCGAAGCCGTT
GCGCCGTATGCCAACTATATAACCATCAATATCTCATCGCCAAATACGCCGGGCCTGCGCGGTCTTCAGGACAAGGCGTC
GCTCACCGAGTTGCTTTCCCGCTGCGGCGAGGCGGACCGGAAAGACCTGCCGGTGTTCCTGAAGGTGGCGCCGGATCTTG
ATGAAGATGCAATTGCCGACATCTGCGGCGTGGTCGGCGCACAAGGCGCGTGGCTTTCGGGCTTGATCGTGTCAAACACC
ACGCTGGCCCGGCCGCCAAGCCTTCGCAGTGATGACAAATCCGAAGCCGGCGGCCTCTCTGGCGTGCCGCTGCTTCAGCC
GTCTACGGAAGTCTTGCGTCAGTTTGCAAGGAAGCTGGATGGCGCGTTCGATCTGATCGGAGCAGGCGGGATTGGTACGG
GGAGGGATGCCTATGCCAAGATCCGCGCAGGCGCCTCGGCCGTGCAGCTTTATTCGCTGATGGTGTATGATGGCCCCGGC
ATTGCGGCGCGTGTCGCGCGCGAGCTCTCCCATTGCCTGGCCGAAGATGGGTTTTCTTCCATCGCGGACGCGGTAGGCAA
GGACCTCTAG

Upstream 100 bases:

>100_bases
TTCCACATCTCTACGGACCGCTGGAAATCGGCAAGGCGCAGGCGGGCTGGTGGCTGGAGCCTGACAAAGATGGCGCGCCG
GGCCTGCCGGAGGATTTGCA

Downstream 100 bases:

>100_bases
CCGATTGCGTCGATGCGGACGGCAACACAGCCATCCATCGCCGTAAAGGCAAGATAGGTGTATTTCACGCTCCGGGCGCT
GACGAATTCCTGCCAGGCTT

Product: dihydroorotate oxidase

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 349; Mature: 349

Protein sequence:

>349_residues
MIAAAGARLVRMLPPEAAHTLTLRMLTYGAGVPAHAPQLPVSTRVELPRSGLRLCSPVGLAAGFDKNCEVPEAMARFGFG
FVECGTVTPKPQPGNPKPRLFRLSEDRAVINRMGFNNFGLDYFVRRLEKYSHDVPIGANVGANKDTEDRIADYVTGIEAV
APYANYITINISSPNTPGLRGLQDKASLTELLSRCGEADRKDLPVFLKVAPDLDEDAIADICGVVGAQGAWLSGLIVSNT
TLARPPSLRSDDKSEAGGLSGVPLLQPSTEVLRQFARKLDGAFDLIGAGGIGTGRDAYAKIRAGASAVQLYSLMVYDGPG
IAARVARELSHCLAEDGFSSIADAVGKDL

Sequences:

>Translated_349_residues
MIAAAGARLVRMLPPEAAHTLTLRMLTYGAGVPAHAPQLPVSTRVELPRSGLRLCSPVGLAAGFDKNCEVPEAMARFGFG
FVECGTVTPKPQPGNPKPRLFRLSEDRAVINRMGFNNFGLDYFVRRLEKYSHDVPIGANVGANKDTEDRIADYVTGIEAV
APYANYITINISSPNTPGLRGLQDKASLTELLSRCGEADRKDLPVFLKVAPDLDEDAIADICGVVGAQGAWLSGLIVSNT
TLARPPSLRSDDKSEAGGLSGVPLLQPSTEVLRQFARKLDGAFDLIGAGGIGTGRDAYAKIRAGASAVQLYSLMVYDGPG
IAARVARELSHCLAEDGFSSIADAVGKDL
>Mature_349_residues
MIAAAGARLVRMLPPEAAHTLTLRMLTYGAGVPAHAPQLPVSTRVELPRSGLRLCSPVGLAAGFDKNCEVPEAMARFGFG
FVECGTVTPKPQPGNPKPRLFRLSEDRAVINRMGFNNFGLDYFVRRLEKYSHDVPIGANVGANKDTEDRIADYVTGIEAV
APYANYITINISSPNTPGLRGLQDKASLTELLSRCGEADRKDLPVFLKVAPDLDEDAIADICGVVGAQGAWLSGLIVSNT
TLARPPSLRSDDKSEAGGLSGVPLLQPSTEVLRQFARKLDGAFDLIGAGGIGTGRDAYAKIRAGASAVQLYSLMVYDGPG
IAARVARELSHCLAEDGFSSIADAVGKDL

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI45006951, Length=350, Percent_Identity=45.1428571428571, Blast_Score=278, Evalue=7e-75,
Organism=Escherichia coli, GI1787177, Length=332, Percent_Identity=41.2650602409639, Blast_Score=232, Evalue=3e-62,
Organism=Caenorhabditis elegans, GI17509475, Length=348, Percent_Identity=43.3908045977011, Blast_Score=274, Evalue=4e-74,
Organism=Saccharomyces cerevisiae, GI6322633, Length=280, Percent_Identity=25.3571428571429, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI281361352, Length=348, Percent_Identity=42.816091954023, Blast_Score=280, Evalue=1e-75,
Organism=Drosophila melanogaster, GI17137316, Length=348, Percent_Identity=42.816091954023, Blast_Score=280, Evalue=1e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.5.2 [H]

Molecular weight: Translated: 36964; Mature: 36964

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00911 DHODEHASE_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIAAAGARLVRMLPPEAAHTLTLRMLTYGAGVPAHAPQLPVSTRVELPRSGLRLCSPVGL
CCCCCCHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCH
AAGFDKNCEVPEAMARFGFGFVECGTVTPKPQPGNPKPRLFRLSEDRAVINRMGFNNFGL
HCCCCCCCCCHHHHHHHCCCEEEECCCCCCCCCCCCCCCEEEECCHHHHHHHCCCCCCCH
DYFVRRLEKYSHDVPIGANVGANKDTEDRIADYVTGIEAVAPYANYITINISSPNTPGLR
HHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCC
GLQDKASLTELLSRCGEADRKDLPVFLKVAPDLDEDAIADICGVVGAQGAWLSGLIVSNT
CCHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCHHCCEEECCC
TLARPPSLRSDDKSEAGGLSGVPLLQPSTEVLRQFARKLDGAFDLIGAGGIGTGRDAYAK
CCCCCCCCCCCCCHHCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHH
IRAGASAVQLYSLMVYDGPGIAARVARELSHCLAEDGFSSIADAVGKDL
HHCCHHHHHHEEEEEECCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCC
>Mature Secondary Structure
MIAAAGARLVRMLPPEAAHTLTLRMLTYGAGVPAHAPQLPVSTRVELPRSGLRLCSPVGL
CCCCCCHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCH
AAGFDKNCEVPEAMARFGFGFVECGTVTPKPQPGNPKPRLFRLSEDRAVINRMGFNNFGL
HCCCCCCCCCHHHHHHHCCCEEEECCCCCCCCCCCCCCCEEEECCHHHHHHHCCCCCCCH
DYFVRRLEKYSHDVPIGANVGANKDTEDRIADYVTGIEAVAPYANYITINISSPNTPGLR
HHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCC
GLQDKASLTELLSRCGEADRKDLPVFLKVAPDLDEDAIADICGVVGAQGAWLSGLIVSNT
CCHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCHHCCEEECCC
TLARPPSLRSDDKSEAGGLSGVPLLQPSTEVLRQFARKLDGAFDLIGAGGIGTGRDAYAK
CCCCCCCCCCCCCHHCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHH
IRAGASAVQLYSLMVYDGPGIAARVARELSHCLAEDGFSSIADAVGKDL
HHCCHHHHHHEEEEEECCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA