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The map label for this gene is copA [H]

Identifier: 114799240

GI number: 114799240

Start: 1749437

End: 1751290

Strand: Reverse

Name: copA [H]

Synonym: HNE_1707

Alternate gene names: 114799240

Gene position: 1751290-1749437 (Counterclockwise)

Preceding gene: 114798993

Following gene: 114799827

Centisome position: 47.27

GC content: 61.81

Gene sequence:

>1854_bases
ATGTTCACACGACGCAGTCTCCTCCGCACGGCCGCCGCTGGCGGCGTGCTCGCCGCCTCCACGTCCCTCCTGCCCGCCTG
GGCGCGAAGCGCCAATGCTGGCAACACAGGCATCTTCGAAACACGCGGTAACGCGTTTGACCTGACCATCGGCCACAGCG
CCGTAAAGATAGCAGGCCGCTCCGGCCATGCCATCACGATCAACGGAACACTGCCCGGGCCGCTTATCCGGTTCCGCGAG
GGCGAGAAGGTGACCCTCAAGGTCAACAATACCCTCGACGAAGACACATCGATCCACTGGCACGGGCTTCTGGTGCCCTT
CCATATGGACGGTGTGCCCGGTGTTTCGTTCCCCGGCATCAAGCCGAAGTCGACCTTCACCTATGAGTTCGCGGTCCCGC
AGAGCGGCACCTACTGGTATCACTCCCATTCCGGACTTCAGGAACAGCTGGGCCATTACGGCCCGCTGATCATCGATCCT
GCCGGCGCCGATCCCGTCGAAGCAGACCGTGAGTATGTGCTTGTTTTGTCCGACTGGACGTTCGAGCATCCGCACAAGGT
GTTTGCCCGCCTGAAGAAAGATGCGGCCGTTTATAACTTCCAGCAGCGCACGGTTGGTGACTTCCTGAAGGACGCCCGTG
AAGACGGTCTCGGCACAGCGCTTGCCGACCGGACTTCCTGGGGCGCCATGCGCATGTCGCCGACCGATATCTCGGATGTC
ACGGCCTCGGTCTATACCTACCTGATCAATGGTCATGCGACGCGAGACAACTGGACTGCAATCTTCAATTCCGGTGAACG
CATCCGGCTACGGATCATCAACGCCTCGGCGATGACGATCTTCAATTTCCGGATTCCGGGACTGCCGATGACGGTGGTTG
CCGCTGACGGGCTCAATGTCCAACCGGTGGAGACCGACGAGTTCCAGATCGGGGTGGCGGAGACCTATGACGTGATTGTC
AGTCCGACCCGAGCGCGGCCGTTTGCGCTGGTCGCGGAATCGATCGACCGGTCCGGTCAGGTGGTCGCCACTCTGGCGCC
CGAGGCGGGCCTGGTTGCCACCGCGCCTCTCCTGCGCGAGCCGCCCGTTCTGACCCACCGCGACATGGGCATGGACATGG
CATCCATGGATCACGGCTCAATGGCCGGCATGGACCATAGCGCCATGCCCGGCATGGATCACGGCGCGATGGACATGGCT
GTGTCAGTCCCGCAGGGTCATGAACACCGGATGGGCGCCGGTGTGGATAACGTCGCCATGGTTCAGGTAAGCCGGATCGA
TGAGCCGGGGCTGGGCCTCGAATCAGTCCCGCACCGGGCGCTCCGGTATTCACAGCTGAGGAGTCTCACACCCAACCCCG
ACACACGGGCGCCGGGCCGCGAGATAGAGATCCACCTCACCGGCAACATGGAACGCTACATGTGGTCCTTCGACGGCGTG
AAGCTCAGCGAGGTTACCGGTCCGATCATCTTCCATGAAGGCGAACGCCTGCGCGTGACGCTCGTTAACGATACGATGAT
GACGCACCCGATCCATCTGCATGGCATGTTCTTCGATCTCGTTGTCGGGGACACCGATCACAAGCCGCGCAAGCACACGG
TCACCGTCAAACCTGCCGAGCGCCTGTCCTTTGACGTGACAGCGGACCATGTCGGAGACTGGGCGTTTCACTGCCACCTG
CTCTTCCATATGCATGCTGGCATGATGCAGGTCGTCTCCGTCCTCCCACGAAGTGCGGCGGCTGGCATGGATGCTCCGCA
CAGGGATCACATGACTTCGTCTACTCTGCCGACGGACGAGCCTCCGCCAAAAGAAGCCCCAATGACGGGCATGAGCCACG
AAGGACACCGTTAA

Upstream 100 bases:

>100_bases
CCAAGCCAGCCGCCGACCATTCACAGCACTAATTGGTGAGGTCCCTGCGCTGCTCCGGCCCTGCGCAGGGACTCAGTTCC
CCTTCGACAAGGCAAATCAC

Downstream 100 bases:

>100_bases
TGACCCGCGCTCAGATGATTGCGACGATTATCCTGCTTTCACCGCTCGCAGCAGCGCCTGCCTTTGCTCAGGAGACGCCC
GTACCTGGATCGCAGGCCGA

Product: CopA family copper resistance protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 617; Mature: 617

Protein sequence:

>617_residues
MFTRRSLLRTAAAGGVLAASTSLLPAWARSANAGNTGIFETRGNAFDLTIGHSAVKIAGRSGHAITINGTLPGPLIRFRE
GEKVTLKVNNTLDEDTSIHWHGLLVPFHMDGVPGVSFPGIKPKSTFTYEFAVPQSGTYWYHSHSGLQEQLGHYGPLIIDP
AGADPVEADREYVLVLSDWTFEHPHKVFARLKKDAAVYNFQQRTVGDFLKDAREDGLGTALADRTSWGAMRMSPTDISDV
TASVYTYLINGHATRDNWTAIFNSGERIRLRIINASAMTIFNFRIPGLPMTVVAADGLNVQPVETDEFQIGVAETYDVIV
SPTRARPFALVAESIDRSGQVVATLAPEAGLVATAPLLREPPVLTHRDMGMDMASMDHGSMAGMDHSAMPGMDHGAMDMA
VSVPQGHEHRMGAGVDNVAMVQVSRIDEPGLGLESVPHRALRYSQLRSLTPNPDTRAPGREIEIHLTGNMERYMWSFDGV
KLSEVTGPIIFHEGERLRVTLVNDTMMTHPIHLHGMFFDLVVGDTDHKPRKHTVTVKPAERLSFDVTADHVGDWAFHCHL
LFHMHAGMMQVVSVLPRSAAAGMDAPHRDHMTSSTLPTDEPPPKEAPMTGMSHEGHR

Sequences:

>Translated_617_residues
MFTRRSLLRTAAAGGVLAASTSLLPAWARSANAGNTGIFETRGNAFDLTIGHSAVKIAGRSGHAITINGTLPGPLIRFRE
GEKVTLKVNNTLDEDTSIHWHGLLVPFHMDGVPGVSFPGIKPKSTFTYEFAVPQSGTYWYHSHSGLQEQLGHYGPLIIDP
AGADPVEADREYVLVLSDWTFEHPHKVFARLKKDAAVYNFQQRTVGDFLKDAREDGLGTALADRTSWGAMRMSPTDISDV
TASVYTYLINGHATRDNWTAIFNSGERIRLRIINASAMTIFNFRIPGLPMTVVAADGLNVQPVETDEFQIGVAETYDVIV
SPTRARPFALVAESIDRSGQVVATLAPEAGLVATAPLLREPPVLTHRDMGMDMASMDHGSMAGMDHSAMPGMDHGAMDMA
VSVPQGHEHRMGAGVDNVAMVQVSRIDEPGLGLESVPHRALRYSQLRSLTPNPDTRAPGREIEIHLTGNMERYMWSFDGV
KLSEVTGPIIFHEGERLRVTLVNDTMMTHPIHLHGMFFDLVVGDTDHKPRKHTVTVKPAERLSFDVTADHVGDWAFHCHL
LFHMHAGMMQVVSVLPRSAAAGMDAPHRDHMTSSTLPTDEPPPKEAPMTGMSHEGHR
>Mature_617_residues
MFTRRSLLRTAAAGGVLAASTSLLPAWARSANAGNTGIFETRGNAFDLTIGHSAVKIAGRSGHAITINGTLPGPLIRFRE
GEKVTLKVNNTLDEDTSIHWHGLLVPFHMDGVPGVSFPGIKPKSTFTYEFAVPQSGTYWYHSHSGLQEQLGHYGPLIIDP
AGADPVEADREYVLVLSDWTFEHPHKVFARLKKDAAVYNFQQRTVGDFLKDAREDGLGTALADRTSWGAMRMSPTDISDV
TASVYTYLINGHATRDNWTAIFNSGERIRLRIINASAMTIFNFRIPGLPMTVVAADGLNVQPVETDEFQIGVAETYDVIV
SPTRARPFALVAESIDRSGQVVATLAPEAGLVATAPLLREPPVLTHRDMGMDMASMDHGSMAGMDHSAMPGMDHGAMDMA
VSVPQGHEHRMGAGVDNVAMVQVSRIDEPGLGLESVPHRALRYSQLRSLTPNPDTRAPGREIEIHLTGNMERYMWSFDGV
KLSEVTGPIIFHEGERLRVTLVNDTMMTHPIHLHGMFFDLVVGDTDHKPRKHTVTVKPAERLSFDVTADHVGDWAFHCHL
LFHMHAGMMQVVSVLPRSAAAGMDAPHRDHMTSSTLPTDEPPPKEAPMTGMSHEGHR

Specific function: Could be involved in copper resistance. May have oxidase activity [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family. CopA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=441, Percent_Identity=26.7573696145125, Blast_Score=108, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6321067, Length=558, Percent_Identity=23.6559139784946, Blast_Score=96, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6320714, Length=599, Percent_Identity=21.5358931552588, Blast_Score=88, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6323703, Length=282, Percent_Identity=29.7872340425532, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI28574104, Length=607, Percent_Identity=23.8879736408567, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI18859919, Length=566, Percent_Identity=23.8515901060071, Blast_Score=102, Evalue=9e-22,
Organism=Drosophila melanogaster, GI221329998, Length=614, Percent_Identity=23.2899022801303, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24650186, Length=582, Percent_Identity=21.3058419243986, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI281360167, Length=294, Percent_Identity=27.2108843537415, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24585842, Length=294, Percent_Identity=27.2108843537415, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI221330000, Length=294, Percent_Identity=27.5510204081633, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR006376
- InterPro:   IPR002355
- InterPro:   IPR008972
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 67501; Mature: 67501

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00079 MULTICOPPER_OXIDASE1 ; PS00080 MULTICOPPER_OXIDASE2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFTRRSLLRTAAAGGVLAASTSLLPAWARSANAGNTGIFETRGNAFDLTIGHSAVKIAGR
CCCHHHHHHHHHCCCEEEECCHHHHHHHHCCCCCCCCEEEECCCEEEEEECCCEEEEECC
SGHAITINGTLPGPLIRFREGEKVTLKVNNTLDEDTSIHWHGLLVPFHMDGVPGVSFPGI
CCCEEEEECCCCCCEEEECCCCEEEEEECCCCCCCCCEEEEEEEEEEECCCCCCCCCCCC
KPKSTFTYEFAVPQSGTYWYHSHSGLQEQLGHYGPLIIDPAGADPVEADREYVLVLSDWT
CCCCEEEEEEECCCCCEEEEECCCCHHHHHCCCCCEEECCCCCCCCCCCCCEEEEEECCC
FEHPHKVFARLKKDAAVYNFQQRTVGDFLKDAREDGLGTALADRTSWGAMRMSPTDISDV
CCCHHHHHHHHHHHHHHEEHHHHHHHHHHHHHHHCCCCEEHHCCCCCCEEEECCCCHHHH
TASVYTYLINGHATRDNWTAIFNSGERIRLRIINASAMTIFNFRIPGLPMTVVAADGLNV
HHEEEEEEECCCCCCCCEEEEECCCCEEEEEEEECCEEEEEEEECCCCCEEEEEECCCCC
QPVETDEFQIGVAETYDVIVSPTRARPFALVAESIDRSGQVVATLAPEAGLVATAPLLRE
CCCCCCCEEEEEEEEEEEEEECCCCCCHHHHHHHHCCCCCEEEEECCCCCCEEECCHHCC
PPVLTHRDMGMDMASMDHGSMAGMDHSAMPGMDHGAMDMAVSVPQGHEHRMGAGVDNVAM
CCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEE
VQVSRIDEPGLGLESVPHRALRYSQLRSLTPNPDTRAPGREIEIHLTGNMERYMWSFDGV
EEEECCCCCCCCHHHCCHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCEEEEEEECCE
KLSEVTGPIIFHEGERLRVTLVNDTMMTHPIHLHGMFFDLVVGDTDHKPRKHTVTVKPAE
EEHHCCCCEEEECCCEEEEEEECCCEEECCEEEEEEEEEEEECCCCCCCCCEEEEECCHH
RLSFDVTADHVGDWAFHCHLLFHMHAGMMQVVSVLPRSAAAGMDAPHRDHMTSSTLPTDE
HCEEEEEHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCCCCCCCC
PPPKEAPMTGMSHEGHR
CCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MFTRRSLLRTAAAGGVLAASTSLLPAWARSANAGNTGIFETRGNAFDLTIGHSAVKIAGR
CCCHHHHHHHHHCCCEEEECCHHHHHHHHCCCCCCCCEEEECCCEEEEEECCCEEEEECC
SGHAITINGTLPGPLIRFREGEKVTLKVNNTLDEDTSIHWHGLLVPFHMDGVPGVSFPGI
CCCEEEEECCCCCCEEEECCCCEEEEEECCCCCCCCCEEEEEEEEEEECCCCCCCCCCCC
KPKSTFTYEFAVPQSGTYWYHSHSGLQEQLGHYGPLIIDPAGADPVEADREYVLVLSDWT
CCCCEEEEEEECCCCCEEEEECCCCHHHHHCCCCCEEECCCCCCCCCCCCCEEEEEECCC
FEHPHKVFARLKKDAAVYNFQQRTVGDFLKDAREDGLGTALADRTSWGAMRMSPTDISDV
CCCHHHHHHHHHHHHHHEEHHHHHHHHHHHHHHHCCCCEEHHCCCCCCEEEECCCCHHHH
TASVYTYLINGHATRDNWTAIFNSGERIRLRIINASAMTIFNFRIPGLPMTVVAADGLNV
HHEEEEEEECCCCCCCCEEEEECCCCEEEEEEEECCEEEEEEEECCCCCEEEEEECCCCC
QPVETDEFQIGVAETYDVIVSPTRARPFALVAESIDRSGQVVATLAPEAGLVATAPLLRE
CCCCCCCEEEEEEEEEEEEEECCCCCCHHHHHHHHCCCCCEEEEECCCCCCEEECCHHCC
PPVLTHRDMGMDMASMDHGSMAGMDHSAMPGMDHGAMDMAVSVPQGHEHRMGAGVDNVAM
CCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEE
VQVSRIDEPGLGLESVPHRALRYSQLRSLTPNPDTRAPGREIEIHLTGNMERYMWSFDGV
EEEECCCCCCCCHHHCCHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCEEEEEEECCE
KLSEVTGPIIFHEGERLRVTLVNDTMMTHPIHLHGMFFDLVVGDTDHKPRKHTVTVKPAE
EEHHCCCCEEEECCCEEEEEEECCCEEECCEEEEEEEEEEEECCCCCCCCCEEEEECCHH
RLSFDVTADHVGDWAFHCHLLFHMHAGMMQVVSVLPRSAAAGMDAPHRDHMTSSTLPTDE
HCEEEEEHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCCCCCCCC
PPPKEAPMTGMSHEGHR
CCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12928499 [H]