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The map label for this gene is fadH [H]

Identifier: 114799221

GI number: 114799221

Start: 591217

End: 592101

Strand: Reverse

Name: fadH [H]

Synonym: HNE_0595

Alternate gene names: 114799221

Gene position: 592101-591217 (Counterclockwise)

Preceding gene: 114800372

Following gene: 114799857

Centisome position: 15.98

GC content: 63.84

Gene sequence:

>885_bases
ATGTTCCGCGACGGCCTGATGAAGGATGAGCGGATTCTGGTGACCGGCGGCGGCACGGGCCTGGGCAAGGAAATGGCCGA
GGGCTTTCTGAAACTGGGCGCCGAGGTGCACATCTGCGGCCGCCGGGGCGGCGTGCTGGAAGAGACCGCCAAGGAACTGA
TGGCCAAGCATGGCGGCAAGGTTGTGCCCCATGCCTGCGACATCCGCGTGGCCGAAGCGATCACCGAGATGAACGATACT
ATCTGGTCGAAGCATGGCCCGCTGACGGGCCTGATCAACAACGCGGCCGGTAACTTCATTTCGCGCACGGAAGACCTGAC
GATCCGGGGCTTTGACGCGATTTCCAACATCGTGTTCCGCGGCACGTTCTACATGACGCACGACATCGGCAAGCGCTGGA
TTGCGGAAAAGCGGCGCGGCAATGTCTGCTCGATCCTGACGACCTGGGTGTGGAATGGCGGGCCGTTTGTGGTGCCCTCT
GCCATGTCGAAAGCGGGCGTCAATGTGATGACCCAGTCCCTCGCCATCGAGTGGGGCCGTCATGGCCTGCGCTTCAATGC
GATTGCGCCGGGGCCTTTCCCGACCGAAGGCATGTCCAAGCGCCTGTCGCCGGACGCAGAGGGCGCCGAGCGGATGGACC
GCGGCGTGACCAATCCGATGGGCCGCGTCGGCGAGATGCATGAGCTGGTCAACCTCGCCACCTTCCTGATGGCGCCGGGG
GCCGAATATGTGAATGGCCAGACGATTGCCATTGATGGCGCGATGTACAACGCTTCGGGCGGCAATTTCAGCATGCTGAC
GGCCTGGGGCGATGAGCAGTGGGTCGCGGCCCGCGAGGCCATCGAAGCAACCAACGCCAAGGACCGCGCCAAGCGCACCG
TCTAG

Upstream 100 bases:

>100_bases
CGGGCGGCTTCCGCGACGTCGCCGCTGGCGGGGGCATCAGGGCGCCTATACAGTTGTTAAGGACACAAGGGAGGAAAGCA
AAATGGACATATCGAAACTG

Downstream 100 bases:

>100_bases
GGTCGCGAGCCGGACACTGACCGGACACAGGCCGGACAAACCGGGACAGATCAGGACACTTCCAGACAGTTCTGGACACA
AAATGACAACGGGCGCGGGA

Product: short chain dehydrogenase/reductase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MFRDGLMKDERILVTGGGTGLGKEMAEGFLKLGAEVHICGRRGGVLEETAKELMAKHGGKVVPHACDIRVAEAITEMNDT
IWSKHGPLTGLINNAAGNFISRTEDLTIRGFDAISNIVFRGTFYMTHDIGKRWIAEKRRGNVCSILTTWVWNGGPFVVPS
AMSKAGVNVMTQSLAIEWGRHGLRFNAIAPGPFPTEGMSKRLSPDAEGAERMDRGVTNPMGRVGEMHELVNLATFLMAPG
AEYVNGQTIAIDGAMYNASGGNFSMLTAWGDEQWVAAREAIEATNAKDRAKRTV

Sequences:

>Translated_294_residues
MFRDGLMKDERILVTGGGTGLGKEMAEGFLKLGAEVHICGRRGGVLEETAKELMAKHGGKVVPHACDIRVAEAITEMNDT
IWSKHGPLTGLINNAAGNFISRTEDLTIRGFDAISNIVFRGTFYMTHDIGKRWIAEKRRGNVCSILTTWVWNGGPFVVPS
AMSKAGVNVMTQSLAIEWGRHGLRFNAIAPGPFPTEGMSKRLSPDAEGAERMDRGVTNPMGRVGEMHELVNLATFLMAPG
AEYVNGQTIAIDGAMYNASGGNFSMLTAWGDEQWVAAREAIEATNAKDRAKRTV
>Mature_294_residues
MFRDGLMKDERILVTGGGTGLGKEMAEGFLKLGAEVHICGRRGGVLEETAKELMAKHGGKVVPHACDIRVAEAITEMNDT
IWSKHGPLTGLINNAAGNFISRTEDLTIRGFDAISNIVFRGTFYMTHDIGKRWIAEKRRGNVCSILTTWVWNGGPFVVPS
AMSKAGVNVMTQSLAIEWGRHGLRFNAIAPGPFPTEGMSKRLSPDAEGAERMDRGVTNPMGRVGEMHELVNLATFLMAPG
AEYVNGQTIAIDGAMYNASGGNFSMLTAWGDEQWVAAREAIEATNAKDRAKRTV

Specific function: Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3- enoyl-CoA

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503301, Length=254, Percent_Identity=39.3700787401575, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI19923817, Length=262, Percent_Identity=30.5343511450382, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI10190704, Length=254, Percent_Identity=29.9212598425197, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI32483357, Length=255, Percent_Identity=27.4509803921569, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI15277342, Length=265, Percent_Identity=25.2830188679245, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI20149619, Length=221, Percent_Identity=27.1493212669683, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI7705925, Length=251, Percent_Identity=22.7091633466135, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1789208, Length=243, Percent_Identity=31.6872427983539, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1790717, Length=254, Percent_Identity=28.3464566929134, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI87082160, Length=250, Percent_Identity=26.4, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1787905, Length=256, Percent_Identity=27.34375, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI87082100, Length=248, Percent_Identity=27.8225806451613, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1787335, Length=251, Percent_Identity=28.2868525896414, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI2367175, Length=251, Percent_Identity=29.0836653386454, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1788459, Length=248, Percent_Identity=24.5967741935484, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17536651, Length=295, Percent_Identity=41.0169491525424, Blast_Score=206, Evalue=9e-54,
Organism=Caenorhabditis elegans, GI17536025, Length=294, Percent_Identity=41.156462585034, Blast_Score=204, Evalue=5e-53,
Organism=Caenorhabditis elegans, GI17561272, Length=278, Percent_Identity=41.0071942446043, Blast_Score=192, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI115534694, Length=249, Percent_Identity=26.1044176706827, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17562906, Length=260, Percent_Identity=28.8461538461538, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17560150, Length=258, Percent_Identity=27.5193798449612, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17562908, Length=257, Percent_Identity=29.5719844357977, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17562990, Length=261, Percent_Identity=27.5862068965517, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17531453, Length=259, Percent_Identity=28.957528957529, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17562910, Length=264, Percent_Identity=26.5151515151515, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17560220, Length=263, Percent_Identity=28.8973384030418, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI193204405, Length=263, Percent_Identity=27.3764258555133, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17544670, Length=259, Percent_Identity=27.027027027027, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71994600, Length=247, Percent_Identity=25.9109311740891, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17551412, Length=259, Percent_Identity=27.027027027027, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17562904, Length=262, Percent_Identity=25.1908396946565, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17559104, Length=258, Percent_Identity=26.3565891472868, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71994604, Length=244, Percent_Identity=25, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI25147288, Length=247, Percent_Identity=27.5303643724696, Blast_Score=68, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI71982365, Length=203, Percent_Identity=27.5862068965517, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17563726, Length=266, Percent_Identity=27.4436090225564, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6324126, Length=260, Percent_Identity=28.8461538461538, Blast_Score=105, Evalue=1e-23,
Organism=Drosophila melanogaster, GI21357041, Length=249, Percent_Identity=29.3172690763052, Blast_Score=107, Evalue=9e-24,
Organism=Drosophila melanogaster, GI28571526, Length=249, Percent_Identity=27.710843373494, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI23397609, Length=259, Percent_Identity=28.1853281853282, Blast_Score=88, Evalue=9e-18,
Organism=Drosophila melanogaster, GI24639444, Length=255, Percent_Identity=26.6666666666667, Blast_Score=85, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24643142, Length=242, Percent_Identity=26.8595041322314, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24644339, Length=248, Percent_Identity=27.0161290322581, Blast_Score=77, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.3.1.34 [H]

Molecular weight: Translated: 31869; Mature: 31869

Theoretical pI: Translated: 7.64; Mature: 7.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFRDGLMKDERILVTGGGTGLGKEMAEGFLKLGAEVHICGRRGGVLEETAKELMAKHGGK
CCCCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHCCCE
VVPHACDIRVAEAITEMNDTIWSKHGPLTGLINNAAGNFISRTEDLTIRGFDAISNIVFR
ECCCHHCHHHHHHHHHHHHHHHHCCCCCCEEHHHHCCCHHHCCCCEEEECHHHHHHHHHH
GTFYMTHDIGKRWIAEKRRGNVCSILTTWVWNGGPFVVPSAMSKAGVNVMTQSLAIEWGR
CEEEEEHHHHHHHHHHHHCCCEEEEEEEEEECCCCEEECCHHHHCCHHHHHHHHHHHHCC
HGLRFNAIAPGPFPTEGMSKRLSPDAEGAERMDRGVTNPMGRVGEMHELVNLATFLMAPG
CCEEEEEECCCCCCCCCHHHCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCC
AEYVNGQTIAIDGAMYNASGGNFSMLTAWGDEQWVAAREAIEATNAKDRAKRTV
CHHCCCEEEEEECEEEECCCCCEEEEEECCCCHHHHHHHHHHHCCCHHHHHCCC
>Mature Secondary Structure
MFRDGLMKDERILVTGGGTGLGKEMAEGFLKLGAEVHICGRRGGVLEETAKELMAKHGGK
CCCCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHCCCE
VVPHACDIRVAEAITEMNDTIWSKHGPLTGLINNAAGNFISRTEDLTIRGFDAISNIVFR
ECCCHHCHHHHHHHHHHHHHHHHCCCCCCEEHHHHCCCHHHCCCCEEEECHHHHHHHHHH
GTFYMTHDIGKRWIAEKRRGNVCSILTTWVWNGGPFVVPSAMSKAGVNVMTQSLAIEWGR
CEEEEEHHHHHHHHHHHHCCCEEEEEEEEEECCCCEEECCHHHHCCHHHHHHHHHHHHCC
HGLRFNAIAPGPFPTEGMSKRLSPDAEGAERMDRGVTNPMGRVGEMHELVNLATFLMAPG
CCEEEEEECCCCCCCCCHHHCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCC
AEYVNGQTIAIDGAMYNASGGNFSMLTAWGDEQWVAAREAIEATNAKDRAKRTV
CHHCCCEEEEEECEEEECCCCCEEEEEECCCCHHHHHHHHHHHCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]