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The map label for this gene is pyrC [H]

Identifier: 114799203

GI number: 114799203

Start: 879289

End: 880629

Strand: Direct

Name: pyrC [H]

Synonym: HNE_0862

Alternate gene names: 114799203

Gene position: 879289-880629 (Clockwise)

Preceding gene: 114799853

Following gene: 114799838

Centisome position: 23.73

GC content: 64.35

Gene sequence:

>1341_bases
ATGACCCAAGTTTACGACCTGATCCTGCGCGGCGGCACCGTCGTCACCCCCGGCGGCGAAGCCCAGACTGACATCGGCAT
CATCGGCGAGCGCATTGCCCATATCGGCGACCTTTCAAAGGCCTCAGCCGGCGAAATCTATGGCGCCGCTGGCCTCCACA
TCCTGCCCGGCGTGATCGACACGCAGGTCCACTTCCGGGAGCCTGGCCTGGAATACAAGGCAGACCTCGAAACCGAGGCC
CGCTCGGCCGCGCTCGGCGGCGTTGTTGCCGTTTTCGAGATGCCCAACACCAATCCCTCGACCATCACGCCTGACCGGAT
GCTGGACAAGCTCGCCCGCGCCAGGGGCCGGATGGACATTGACCACGCCTTCTATGCCGGCGCGACACATGACAACGTGG
CGTTGCTGCCCGAAATGGAGCGGATGCTCGGATGTTGCGGCGTGAAGGTGTTCATGGGCGCCTCGACCGGCGACCTCCTC
ATCAAGGATGACGCGGGCGTTGAGGCCGTGCTGCGCGCCATCAAGCGCCGCGCTGCCTTTCATTCCGAAGACGAATACCG
CCTCGAAGAGCGCCGCCACCTCGCCGTGACGGGTGATTGGAACAGCCATATCGTCGTGCGCGATGTTGAGGCGGCTGTCT
CCTCCACGCGCCGCCTGCTGCGCCTTGCCCGCAAGACCGGCAAGCGTATCCATGTGCTGCACATCTCCACCGCCGAGGAG
ATGGAGCTGCTGCGCGACGCCAAAGATGTGGCGAGCGTTGAAGTCCTCCCCAACCACCTCACTCTGGCCGCGCCTGATTG
CTATGACCGGCTGAAAGGCTTTGCCCAGCAGAACCCGCCTGTGCGTGAGGCCCGCCACCGTGACGCCCTCTGGCGCGCGC
TCAATGCAGGCATTGTCGATGTTCTGGCGACGGACCATGCCCCGCACACAATCGAAGAGAAGCAGCGGCCTTATCCGGCT
TCGCCGTCCGGCATGCCCGGCGTGCAGACGCTGGTGCCGGTGATGCTGACGCATGTGAATGACGGTAAGCTCAGCCTGCA
ACGCTTTGTCGAACTGACCAGCGCCGGCCCGCAGCGCGTCTTCGGCCTCGCCGACAAGGGCCGCATCGCCGAAGGTAACC
ATGCCGACTTCACGATTGTGGACTTGAAGCGCAAGGCCACGATCACCGCTGACTGGTCAAAATCCAAATGCGGCTGGACC
CAGTTTGATGGCTTCGAAGCCACCGGCTGGCCGGTCGGCACCATCGTGCGCGGCGGCTTCGTCATGCGCGACGGCGAGAT
CGTCCAGAAAGGCGGCGGCAAGCCTGTCCGCTTCAACGAAACGCTCGAGCCTGCTGCCTGA

Upstream 100 bases:

>100_bases
CATGGGGTTGATCTAAGCCCCCGCTGGCGCCGCCGCAATGCCCGGCGCGAAACGGCAGGGCCGCGCGTGACTTTTACCCC
AAGCGGCGCGATAACGCGCC

Downstream 100 bases:

>100_bases
ACCTGATTTATATCCCGAGAGAACGCTCATGACCTTCAAACCTGCCTTGCTCATTTCGGCTGCCCTGCTGCTCTCTATGC
CTTCGGCTTTCGCGCAGGAG

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 446; Mature: 445

Protein sequence:

>446_residues
MTQVYDLILRGGTVVTPGGEAQTDIGIIGERIAHIGDLSKASAGEIYGAAGLHILPGVIDTQVHFREPGLEYKADLETEA
RSAALGGVVAVFEMPNTNPSTITPDRMLDKLARARGRMDIDHAFYAGATHDNVALLPEMERMLGCCGVKVFMGASTGDLL
IKDDAGVEAVLRAIKRRAAFHSEDEYRLEERRHLAVTGDWNSHIVVRDVEAAVSSTRRLLRLARKTGKRIHVLHISTAEE
MELLRDAKDVASVEVLPNHLTLAAPDCYDRLKGFAQQNPPVREARHRDALWRALNAGIVDVLATDHAPHTIEEKQRPYPA
SPSGMPGVQTLVPVMLTHVNDGKLSLQRFVELTSAGPQRVFGLADKGRIAEGNHADFTIVDLKRKATITADWSKSKCGWT
QFDGFEATGWPVGTIVRGGFVMRDGEIVQKGGGKPVRFNETLEPAA

Sequences:

>Translated_446_residues
MTQVYDLILRGGTVVTPGGEAQTDIGIIGERIAHIGDLSKASAGEIYGAAGLHILPGVIDTQVHFREPGLEYKADLETEA
RSAALGGVVAVFEMPNTNPSTITPDRMLDKLARARGRMDIDHAFYAGATHDNVALLPEMERMLGCCGVKVFMGASTGDLL
IKDDAGVEAVLRAIKRRAAFHSEDEYRLEERRHLAVTGDWNSHIVVRDVEAAVSSTRRLLRLARKTGKRIHVLHISTAEE
MELLRDAKDVASVEVLPNHLTLAAPDCYDRLKGFAQQNPPVREARHRDALWRALNAGIVDVLATDHAPHTIEEKQRPYPA
SPSGMPGVQTLVPVMLTHVNDGKLSLQRFVELTSAGPQRVFGLADKGRIAEGNHADFTIVDLKRKATITADWSKSKCGWT
QFDGFEATGWPVGTIVRGGFVMRDGEIVQKGGGKPVRFNETLEPAA
>Mature_445_residues
TQVYDLILRGGTVVTPGGEAQTDIGIIGERIAHIGDLSKASAGEIYGAAGLHILPGVIDTQVHFREPGLEYKADLETEAR
SAALGGVVAVFEMPNTNPSTITPDRMLDKLARARGRMDIDHAFYAGATHDNVALLPEMERMLGCCGVKVFMGASTGDLLI
KDDAGVEAVLRAIKRRAAFHSEDEYRLEERRHLAVTGDWNSHIVVRDVEAAVSSTRRLLRLARKTGKRIHVLHISTAEEM
ELLRDAKDVASVEVLPNHLTLAAPDCYDRLKGFAQQNPPVREARHRDALWRALNAGIVDVLATDHAPHTIEEKQRPYPAS
PSGMPGVQTLVPVMLTHVNDGKLSLQRFVELTSAGPQRVFGLADKGRIAEGNHADFTIVDLKRKATITADWSKSKCGWTQ
FDGFEATGWPVGTIVRGGFVMRDGEIVQKGGGKPVRFNETLEPAA

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=389, Percent_Identity=30.5912596401028, Blast_Score=156, Evalue=4e-38,
Organism=Homo sapiens, GI19923821, Length=470, Percent_Identity=26.1702127659574, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI4503379, Length=452, Percent_Identity=23.6725663716814, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI4503377, Length=452, Percent_Identity=23.6725663716814, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI4503051, Length=454, Percent_Identity=24.0088105726872, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI62422571, Length=454, Percent_Identity=24.0088105726872, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI4503375, Length=458, Percent_Identity=26.2008733624454, Blast_Score=83, Evalue=5e-16,
Organism=Escherichia coli, GI1786722, Length=409, Percent_Identity=31.5403422982885, Blast_Score=172, Evalue=6e-44,
Organism=Escherichia coli, GI87082175, Length=452, Percent_Identity=27.212389380531, Blast_Score=151, Evalue=6e-38,
Organism=Caenorhabditis elegans, GI193204318, Length=416, Percent_Identity=30.2884615384615, Blast_Score=173, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17539558, Length=459, Percent_Identity=25.7080610021786, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71989490, Length=463, Percent_Identity=24.4060475161987, Blast_Score=79, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6322218, Length=423, Percent_Identity=26.4775413711584, Blast_Score=112, Evalue=9e-26,
Organism=Drosophila melanogaster, GI24642586, Length=391, Percent_Identity=33.2480818414322, Blast_Score=190, Evalue=2e-48,
Organism=Drosophila melanogaster, GI18859883, Length=430, Percent_Identity=27.2093023255814, Blast_Score=111, Evalue=9e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 48618; Mature: 48487

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQVYDLILRGGTVVTPGGEAQTDIGIIGERIAHIGDLSKASAGEIYGAAGLHILPGVID
CCHHHHHHHCCCEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEECCCCCCCCCCHHC
TQVHFREPGLEYKADLETEARSAALGGVVAVFEMPNTNPSTITPDRMLDKLARARGRMDI
CEEEECCCCCCEECCCCHHHHHHHHCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCC
DHAFYAGATHDNVALLPEMERMLGCCGVKVFMGASTGDLLIKDDAGVEAVLRAIKRRAAF
CHHEECCCCCCCEEECHHHHHHHHHCCEEEEECCCCCCEEEECCCCHHHHHHHHHHHHHC
HSEDEYRLEERRHLAVTGDWNSHIVVRDVEAAVSSTRRLLRLARKTGKRIHVLHISTAEE
CCCCHHHHHCCCEEEEECCCCCEEEEEEHHHHHHHHHHHHHHHHHCCCEEEEEEECCHHH
MELLRDAKDVASVEVLPNHLTLAAPDCYDRLKGFAQQNPPVREARHRDALWRALNAGIVD
HHHHHHHHHHHEEEEECCCEEEECCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEE
VLATDHAPHTIEEKQRPYPASPSGMPGVQTLVPVMLTHVNDGKLSLQRFVELTSAGPQRV
EEECCCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHE
FGLADKGRIAEGNHADFTIVDLKRKATITADWSKSKCGWTQFDGFEATGWPVGTIVRGGF
EECCCCCCCCCCCCCCEEEEEEECCEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHCCCE
VMRDGEIVQKGGGKPVRFNETLEPAA
EEECCHHHCCCCCCCEEECCCCCCCC
>Mature Secondary Structure 
TQVYDLILRGGTVVTPGGEAQTDIGIIGERIAHIGDLSKASAGEIYGAAGLHILPGVID
CHHHHHHHCCCEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEECCCCCCCCCCHHC
TQVHFREPGLEYKADLETEARSAALGGVVAVFEMPNTNPSTITPDRMLDKLARARGRMDI
CEEEECCCCCCEECCCCHHHHHHHHCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCC
DHAFYAGATHDNVALLPEMERMLGCCGVKVFMGASTGDLLIKDDAGVEAVLRAIKRRAAF
CHHEECCCCCCCEEECHHHHHHHHHCCEEEEECCCCCCEEEECCCCHHHHHHHHHHHHHC
HSEDEYRLEERRHLAVTGDWNSHIVVRDVEAAVSSTRRLLRLARKTGKRIHVLHISTAEE
CCCCHHHHHCCCEEEEECCCCCEEEEEEHHHHHHHHHHHHHHHHHCCCEEEEEEECCHHH
MELLRDAKDVASVEVLPNHLTLAAPDCYDRLKGFAQQNPPVREARHRDALWRALNAGIVD
HHHHHHHHHHHEEEEECCCEEEECCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEE
VLATDHAPHTIEEKQRPYPASPSGMPGVQTLVPVMLTHVNDGKLSLQRFVELTSAGPQRV
EEECCCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHE
FGLADKGRIAEGNHADFTIVDLKRKATITADWSKSKCGWTQFDGFEATGWPVGTIVRGGF
EECCCCCCCCCCCCCCEEEEEEECCEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHCCCE
VMRDGEIVQKGGGKPVRFNETLEPAA
EEECCHHHCCCCCCCEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]