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The map label for this gene is hisC

Identifier: 114799119

GI number: 114799119

Start: 1136897

End: 1138000

Strand: Direct

Name: hisC

Synonym: HNE_1125

Alternate gene names: 114799119

Gene position: 1136897-1138000 (Clockwise)

Preceding gene: 114800444

Following gene: 114800100

Centisome position: 30.69

GC content: 64.76

Gene sequence:

>1104_bases
ATGAGCAAGCCCATCTCCCAGATCGAGCCCCTTCCGCACATCGCCGCCACCAAACCCTATGTACCGGGCGGAAAGCTGCA
TGGCGCCAAGGGTGCTGTGGCGATGCTTGCCTCCAATGAAAATCCCTTCGGGCCAAGTCCCAAAGCGGTCGAGGCCGCAA
AGGCTGCGGCGGCAAACGTGCACGTATATCCAGACCCAGACTACGGCCCTCTGCGCGCTGCCATCGCTGCCGCCAAGGGC
ATTGCCGATGCCTCCCGCGTCGTCACCTCGGCAGGCTCTGACGAGATCATCCACCTGCTCACCCAATGCTATGCCGGGCC
GGGCGACGAGGTGCTGTTCACCGAGCACGCCTTCTCCATGTACCGCGTCTCGGCCGGTGCCCACGGCGCCACCTCCGTCA
CCGTGCCCGAGACCGACATGACCGCCGGCGTCAACGCCATCCTCGGCGCGGTCAGCCCGCGCACCAAAATCCTGTTCCTC
GCCAACCCGAACAACCCCACCGGCACCATGCTTTCGGTCGATGAGCTGAAAGCCCTTCAGGACGCGTTGCCCCCGCATGT
CCTCTTCGTGGTCGATGGCGCCTATTCGGAATATCTCGGCCCCGATTACGAAGCGCAGCTGCGCGACCTGGTCGACCGGC
GCGACAACACGGTGATGATGCGCACCTTCTCCAAGATCTATGGCCTGGCCGCCATGCGTCTGGGCTGGGCTTACATGCCC
GCAGGCATCGCCGCGATCTACCAGCGCATCCGCGGGCCCTTCAACGTCAGCAGCATCGCTGCCGCTGCCGGCATCGCCTG
CGTGGGCGATGAGGCCTTCCTGAAGATGTCGCGCGATCACAACACCCACTGGCGCGCCATCATGACCGATGCGCTGAACG
CCATGGGCCTGCCCACGCCGCCCTCGCATGCCAACTTCATCGTCACCGAATTTGGCTCAGACGAGCGGGCGGCGGCCGCC
AACCAGCACCTCAAGGACAACGACATCCTCGTGCGCGCCATCGGCGGTTATGGCCTGCCCACCAAGCTGCGTATCTCGGT
GGGCAGCGCAGACGACAATCAGCGTTTCCTGGACGCCCTGAAAGCCTTCACCGCGTCACGCTGA

Upstream 100 bases:

>100_bases
AATCCTGCCTTACCGTCTCGTGGTGCGCGAAACCACCGCAGCGCCGGAGGTCTAACCGGCCAGTTCCCTGCGCGCGGCCT
TTGGTGTAATCGCCCAGCTC

Downstream 100 bases:

>100_bases
TATTGTCGATCAGCCGCGTCTTGCCGATCCATGCCGCTGCCAGCAGCCGCGCGGCTGCGCCGTCTTCTAGCGGCGTATCT
GCGGGCAGGGCCTGTAGCGT

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase

Number of amino acids: Translated: 367; Mature: 366

Protein sequence:

>367_residues
MSKPISQIEPLPHIAATKPYVPGGKLHGAKGAVAMLASNENPFGPSPKAVEAAKAAAANVHVYPDPDYGPLRAAIAAAKG
IADASRVVTSAGSDEIIHLLTQCYAGPGDEVLFTEHAFSMYRVSAGAHGATSVTVPETDMTAGVNAILGAVSPRTKILFL
ANPNNPTGTMLSVDELKALQDALPPHVLFVVDGAYSEYLGPDYEAQLRDLVDRRDNTVMMRTFSKIYGLAAMRLGWAYMP
AGIAAIYQRIRGPFNVSSIAAAAGIACVGDEAFLKMSRDHNTHWRAIMTDALNAMGLPTPPSHANFIVTEFGSDERAAAA
NQHLKDNDILVRAIGGYGLPTKLRISVGSADDNQRFLDALKAFTASR

Sequences:

>Translated_367_residues
MSKPISQIEPLPHIAATKPYVPGGKLHGAKGAVAMLASNENPFGPSPKAVEAAKAAAANVHVYPDPDYGPLRAAIAAAKG
IADASRVVTSAGSDEIIHLLTQCYAGPGDEVLFTEHAFSMYRVSAGAHGATSVTVPETDMTAGVNAILGAVSPRTKILFL
ANPNNPTGTMLSVDELKALQDALPPHVLFVVDGAYSEYLGPDYEAQLRDLVDRRDNTVMMRTFSKIYGLAAMRLGWAYMP
AGIAAIYQRIRGPFNVSSIAAAAGIACVGDEAFLKMSRDHNTHWRAIMTDALNAMGLPTPPSHANFIVTEFGSDERAAAA
NQHLKDNDILVRAIGGYGLPTKLRISVGSADDNQRFLDALKAFTASR
>Mature_366_residues
SKPISQIEPLPHIAATKPYVPGGKLHGAKGAVAMLASNENPFGPSPKAVEAAKAAAANVHVYPDPDYGPLRAAIAAAKGI
ADASRVVTSAGSDEIIHLLTQCYAGPGDEVLFTEHAFSMYRVSAGAHGATSVTVPETDMTAGVNAILGAVSPRTKILFLA
NPNNPTGTMLSVDELKALQDALPPHVLFVVDGAYSEYLGPDYEAQLRDLVDRRDNTVMMRTFSKIYGLAAMRLGWAYMPA
GIAAIYQRIRGPFNVSSIAAAAGIACVGDEAFLKMSRDHNTHWRAIMTDALNAMGLPTPPSHANFIVTEFGSDERAAAAN
QHLKDNDILVRAIGGYGLPTKLRISVGSADDNQRFLDALKAFTASR

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=354, Percent_Identity=25.9887005649718, Blast_Score=96, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6322075, Length=358, Percent_Identity=27.6536312849162, Blast_Score=106, Evalue=7e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS8_HYPNA (Q0C348)

Other databases:

- EMBL:   CP000158
- RefSeq:   YP_759845.1
- ProteinModelPortal:   Q0C348
- SMR:   Q0C348
- STRING:   Q0C348
- GeneID:   4289914
- GenomeReviews:   CP000158_GR
- KEGG:   hne:HNE_1125
- NMPDR:   fig|228405.5.peg.1095
- TIGR:   HNE_1125
- eggNOG:   COG0079
- HOGENOM:   HBG646350
- OMA:   HNIREAN
- BioCyc:   HNEP81032:HNE_1125-MONOMER
- HAMAP:   MF_01023
- InterPro:   IPR001176
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PRINTS:   PR00753
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 38866; Mature: 38734

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKPISQIEPLPHIAATKPYVPGGKLHGAKGAVAMLASNENPFGPSPKAVEAAKAAAANV
CCCCHHHHCCCCCCCCCCCCCCCCCEECCCCEEEEEECCCCCCCCCCHHHHHHHHHHCEE
HVYPDPDYGPLRAAIAAAKGIADASRVVTSAGSDEIIHLLTQCYAGPGDEVLFTEHAFSM
EECCCCCCCHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEEEHHHHEE
YRVSAGAHGATSVTVPETDMTAGVNAILGAVSPRTKILFLANPNNPTGTMLSVDELKALQ
EEEECCCCCCCEEEECCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCEEEHHHHHHHH
DALPPHVLFVVDGAYSEYLGPDYEAQLRDLVDRRDNTVMMRTFSKIYGLAAMRLGWAYMP
HCCCCEEEEEEECCHHHHCCCCHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHH
AGIAAIYQRIRGPFNVSSIAAAAGIACVGDEAFLKMSRDHNTHWRAIMTDALNAMGLPTP
HHHHHHHHHHCCCCCHHHHHHHHCEEEECCHHHHEECCCCCCHHHHHHHHHHHHCCCCCC
PSHANFIVTEFGSDERAAAANQHLKDNDILVRAIGGYGLPTKLRISVGSADDNQRFLDAL
CCCCCEEEEECCCCHHHHHHHCCCCCCCEEEEEECCCCCCEEEEEEECCCCCHHHHHHHH
KAFTASR
HHHHCCC
>Mature Secondary Structure 
SKPISQIEPLPHIAATKPYVPGGKLHGAKGAVAMLASNENPFGPSPKAVEAAKAAAANV
CCCHHHHCCCCCCCCCCCCCCCCCEECCCCEEEEEECCCCCCCCCCHHHHHHHHHHCEE
HVYPDPDYGPLRAAIAAAKGIADASRVVTSAGSDEIIHLLTQCYAGPGDEVLFTEHAFSM
EECCCCCCCHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEEEHHHHEE
YRVSAGAHGATSVTVPETDMTAGVNAILGAVSPRTKILFLANPNNPTGTMLSVDELKALQ
EEEECCCCCCCEEEECCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCEEEHHHHHHHH
DALPPHVLFVVDGAYSEYLGPDYEAQLRDLVDRRDNTVMMRTFSKIYGLAAMRLGWAYMP
HCCCCEEEEEEECCHHHHCCCCHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHH
AGIAAIYQRIRGPFNVSSIAAAAGIACVGDEAFLKMSRDHNTHWRAIMTDALNAMGLPTP
HHHHHHHHHHCCCCCHHHHHHHHCEEEECCHHHHEECCCCCCHHHHHHHHHHHHCCCCCC
PSHANFIVTEFGSDERAAAANQHLKDNDILVRAIGGYGLPTKLRISVGSADDNQRFLDAL
CCCCCEEEEECCCCHHHHHHHCCCCCCCEEEEEECCCCCCEEEEEEECCCCCHHHHHHHH
KAFTASR
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA