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The map label for this gene is ldh1 [H]

Identifier: 114799095

GI number: 114799095

Start: 1649609

End: 1650697

Strand: Direct

Name: ldh1 [H]

Synonym: HNE_1615

Alternate gene names: 114799095

Gene position: 1649609-1650697 (Clockwise)

Preceding gene: 114800015

Following gene: 114798465

Centisome position: 44.52

GC content: 61.07

Gene sequence:

>1089_bases
ATGTTTGAACATGAAAGCTATGACGGTCACGAGCAGGTGGTGCACGTACAGGACGCGGCGTCGGGCCTGAAAGCAATTAT
TGCGCTTCATTCCACGGCGCTGGGGCCTGCGGGAGGTGGGTGCAGGCTCTGGCATTATGAGGATCCCGGCAAAGCGCTGA
CGGATGCTTTAAGGCTCTCGCGCGGTATGTCCTACAAAAACGCGCTGGCCGGACTCCAGATGGGGGGCGGCAAAGCCGTT
ATCCTGGGACCTGTGCCAGACGACAGGCGCCAGGCCGTTTTCGAGGCTTTCGGGGATGCGGTGAACCGCCTGGGCGGGCG
TTATGTGACTGCTGAAGATGTGGGGGTCGGGGTTTCCGACATGAAGATGGTCGGTGCGCGCACGAAGTTCGTGTCCGGAT
TATCTGAAGAGGGCGGCGTAGGGGGCGATCCTTCGCCCTACACGGCCAGAGGGGTTCGCCTGGCGATGGAAGCGGTTGCC
CTGCATGTTCTTGGAGCCAGGTCGCTGGAGGGGGTCCGCGTCGCGGTGCAGGGACTTGGAGGTGTCGGGGCAAATCTTTG
CCGTGAACTGAGTGAGCGCGGTGCAAAATTGATTGTGGCGGATATCAATCAACAGCGCGTGGAGCGCATCTGCGACGAGT
TCCGCGCCGAACGTGCGGAGGCGGAAACAATTCTGTTCTCGGAGGTGGACATCCTTGCCCCATGCGCGCTCGGTGGTGTG
ATGACAGAGGCGAGCGTGCCAAAGGTGCGCGCCAGGGCTGTTGTCGGCGGGGCTAACAATCAGCTTCTGAACGCGGCAGC
CGGGCAGATGCTTTTCGATCGTCAGATTACCTACGCGCCTGATTACCTCGTCAACGCGGGCGGGATCATTATGGTCGCCG
CTGAGTATTTTGGTACCCACTCGCAGGCTGGCGTTCTTGCGGATGTGGAGCGCATATTTGACAGGACATGCCAGGTGCTT
CTGAGTTCGCGGAAGACGGGAGCGCCGCCTCACTTGATTGCGGACCATATGGCCGCCAAGGTCATCGAAACGGCGCGACA
GGCAGAGCCCGGCCGTCCGGCTGTTTCCCGCGCCGAGAACTTTGTGTAG

Upstream 100 bases:

>100_bases
GCAGACTCCTCTCCCTGCACTGAGCGGGTATTTGCCAAAATTGAAGCCCTGCCGGGACTTCTGGCCTTTGGGCGATCACA
TAATTCAGCGAGGAACTGCC

Downstream 100 bases:

>100_bases
CGCATGACAATGATCCTCATCACCGCCCAGAGGCCGGTGATGAGCGCGCAGCAGGCTCAGTTGCCGTATTGACCCGGACG
GTTGCTCGCTCAGTGTCCAA

Product: leucine dehydrogenase

Products: NA

Alternate protein names: LeuDH [H]

Number of amino acids: Translated: 362; Mature: 362

Protein sequence:

>362_residues
MFEHESYDGHEQVVHVQDAASGLKAIIALHSTALGPAGGGCRLWHYEDPGKALTDALRLSRGMSYKNALAGLQMGGGKAV
ILGPVPDDRRQAVFEAFGDAVNRLGGRYVTAEDVGVGVSDMKMVGARTKFVSGLSEEGGVGGDPSPYTARGVRLAMEAVA
LHVLGARSLEGVRVAVQGLGGVGANLCRELSERGAKLIVADINQQRVERICDEFRAERAEAETILFSEVDILAPCALGGV
MTEASVPKVRARAVVGGANNQLLNAAAGQMLFDRQITYAPDYLVNAGGIIMVAAEYFGTHSQAGVLADVERIFDRTCQVL
LSSRKTGAPPHLIADHMAAKVIETARQAEPGRPAVSRAENFV

Sequences:

>Translated_362_residues
MFEHESYDGHEQVVHVQDAASGLKAIIALHSTALGPAGGGCRLWHYEDPGKALTDALRLSRGMSYKNALAGLQMGGGKAV
ILGPVPDDRRQAVFEAFGDAVNRLGGRYVTAEDVGVGVSDMKMVGARTKFVSGLSEEGGVGGDPSPYTARGVRLAMEAVA
LHVLGARSLEGVRVAVQGLGGVGANLCRELSERGAKLIVADINQQRVERICDEFRAERAEAETILFSEVDILAPCALGGV
MTEASVPKVRARAVVGGANNQLLNAAAGQMLFDRQITYAPDYLVNAGGIIMVAAEYFGTHSQAGVLADVERIFDRTCQVL
LSSRKTGAPPHLIADHMAAKVIETARQAEPGRPAVSRAENFV
>Mature_362_residues
MFEHESYDGHEQVVHVQDAASGLKAIIALHSTALGPAGGGCRLWHYEDPGKALTDALRLSRGMSYKNALAGLQMGGGKAV
ILGPVPDDRRQAVFEAFGDAVNRLGGRYVTAEDVGVGVSDMKMVGARTKFVSGLSEEGGVGGDPSPYTARGVRLAMEAVA
LHVLGARSLEGVRVAVQGLGGVGANLCRELSERGAKLIVADINQQRVERICDEFRAERAEAETILFSEVDILAPCALGGV
MTEASVPKVRARAVVGGANNQLLNAAAGQMLFDRQITYAPDYLVNAGGIIMVAAEYFGTHSQAGVLADVERIFDRTCQVL
LSSRKTGAPPHLIADHMAAKVIETARQAEPGRPAVSRAENFV

Specific function: Functions catabolically in the bacterial metabolism of branched-chain L-amino acids, and plays an important role in spore germination in cooperation with alanine dehydrogenase [H]

COG id: COG0334

COG function: function code E; Glutamate dehydrogenase/leucine dehydrogenase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Glu/Leu/Phe/Val dehydrogenases family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006095
- InterPro:   IPR006096
- InterPro:   IPR006097
- InterPro:   IPR016211
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00208 ELFV_dehydrog; PF02812 ELFV_dehydrog_N [H]

EC number: =1.4.1.9 [H]

Molecular weight: Translated: 38200; Mature: 38200

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFEHESYDGHEQVVHVQDAASGLKAIIALHSTALGPAGGGCRLWHYEDPGKALTDALRLS
CCCCCCCCCHHHEEEHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHH
RGMSYKNALAGLQMGGGKAVILGPVPDDRRQAVFEAFGDAVNRLGGRYVTAEDVGVGVSD
HCCCHHHHHHHCEECCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCEEEEHHHCCCCHHH
MKMVGARTKFVSGLSEEGGVGGDPSPYTARGVRLAMEAVALHVLGARSLEGVRVAVQGLG
HHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHEEHHCC
GVGANLCRELSERGAKLIVADINQQRVERICDEFRAERAEAETILFSEVDILAPCALGGV
CCHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHCCH
MTEASVPKVRARAVVGGANNQLLNAAAGQMLFDRQITYAPDYLVNAGGIIMVAAEYFGTH
HCCCCCCCHHHHEEECCCCCHHHHHHHHHHHHHCCCCCCCCHHCCCCCEEEEEHHHHCCC
SQAGVLADVERIFDRTCQVLLSSRKTGAPPHLIADHMAAKVIETARQAEPGRPAVSRAEN
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCC
FV
CC
>Mature Secondary Structure
MFEHESYDGHEQVVHVQDAASGLKAIIALHSTALGPAGGGCRLWHYEDPGKALTDALRLS
CCCCCCCCCHHHEEEHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHH
RGMSYKNALAGLQMGGGKAVILGPVPDDRRQAVFEAFGDAVNRLGGRYVTAEDVGVGVSD
HCCCHHHHHHHCEECCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCEEEEHHHCCCCHHH
MKMVGARTKFVSGLSEEGGVGGDPSPYTARGVRLAMEAVALHVLGARSLEGVRVAVQGLG
HHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHEEHHCC
GVGANLCRELSERGAKLIVADINQQRVERICDEFRAERAEAETILFSEVDILAPCALGGV
CCHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHCCH
MTEASVPKVRARAVVGGANNQLLNAAAGQMLFDRQITYAPDYLVNAGGIIMVAAEYFGTH
HCCCCCCCHHHHEEECCCCCHHHHHHHHHHHHHCCCCCCCCHHCCCCCEEEEEHHHHCCC
SQAGVLADVERIFDRTCQVLLSSRKTGAPPHLIADHMAAKVIETARQAEPGRPAVSRAEN
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCC
FV
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3069133; 1400267 [H]