| Definition | Hyphomonas neptunium ATCC 15444 chromosome, complete genome. |
|---|---|
| Accession | NC_008358 |
| Length | 3,705,021 |
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The map label for this gene is grsB [H]
Identifier: 114799044
GI number: 114799044
Start: 1196829
End: 1201379
Strand: Direct
Name: grsB [H]
Synonym: HNE_1189
Alternate gene names: 114799044
Gene position: 1196829-1201379 (Clockwise)
Preceding gene: 114799078
Following gene: 114800495
Centisome position: 32.3
GC content: 63.77
Gene sequence:
>4551_bases GTGAACAATATTACTGCGCTTATCGTCGGCGATGGACCGCTGCTGTTGCAATGCCTTGAGGCATATATGGCATCGGGCGG GCAGGTTACTGCTGTCGTTACTCAGGACAGCGCGATTGCCAGCCATGGTGACGCCATCGGCGTGCGTGTGCTGAACAAAA GCTCGGTCGTCTCGGGCGAGCTTGAGGCGCTTGAGTTCGACTATCTGCTGAGCATTGCCAACCTCGACATGCTTCCGGAG TCGCTGCTGAAGCGCGCCCGCAAGATGGCGATCAACTTTCACGATGGCCCCCTGCCACGTTATGCGGGCCTCAACGCGAC GTCCTGGGCCATCCTTCAGGGCGAGACCGCGCATGGTGTCACCTGGCATGAGATGACCGGCAAAGCCGACATGGGCGGTA TTGTCGAAGCCGCACCATTGACGATTGACCCGAATGATACGGCCTTCAGCCTTAACGCCAAATGTTTCGAGGCGGGGCTG GCATCCTTCAAGGCGATGATCCCGTCGCTGCTTGCCGGCAATGTCACGGTCCGGCCGCAGGACGGCGCGCGGACCTATTT CGGCCGGTACAAACGGCCGGACGCCGCGGCGACGCTGCGGTTTGATGTTTCTGCAGACGACACGCTGGCGCTTTCGCGGG CGATGACGTTCGGGCCTTACACCAATACACTGTCTTTCCTGAAAGTGTGGACCGGGCAGCGCGTGCTGCTGGTGAGCGAT GTCGAGGCGGCGACGGGTGCGGCGTCTCTGGCGGCACATGGCACGGTGATCGCGCACGACGCGGATGGCGTTGTTGTGGC AGCGCAGGGCGGCCAGTTGCTGCGCCTGAGCGGGCTGACGGACAGTTCGGGCGCGGCGGTCGATCCGGCGCAGTCGGGCG ATCTCGCACTTGGCGCGCGCCTGCCGGATCTGGCCGCCAGCGATGTGGCTGAGCTGGACCGTCACACGGTTGCGGCGGCA AAGGCGGAAAGCTTCTGGATGGCGCATAGCGCGCGGGCGGTCGCCAGCGAAGCGGCGCCGTATCCCCGCGCGCTGAAGCC GGCGGCGGGCGTGCATACATTCCCGCTGGATGCCGGCGCGGAGCTGTCGCTTGGCTTGGCGGCGGTTGCGGTTTGGTCTG CACATGTGGGCGGGGCGTCTTCAGCAGCGATTGCCTTTCATGACGGCGCGCAATGGACCGGGCTTGGCAAATATGCGGCG TGGTTTGCGCCCTGGCGCCCGCTGGCGCTGGATGTGGCCGGTGACGCGCAACGCGGAGAGCTGGTTGCGCACGCGCGCGC CCTGGTGGACGCGGCGCGGGATAAAGGTCCCCTGGCCTGCGACGCTTATATGCGCCGGCCACGCGCCGAGCGCATGCAGG GGCGGGCGGATGATTTCTCGCTGGCTGTCGCCATCGGGGGAGACGCTCCAAAACATCCGAATGCGGATATTATTCTGCGC GCAGGCGAAGCCGGGCTGACGCTGGAGATTTCTGCAGGCGCTTACGACGCAGATGTGGCGGGCGTGATCGCCGGACATAT CGCGTCAGCGCTCGCCGGCCTTCGGGATGCGCCGCAAGAGGCTGTATCCGGGCTTGACGTTCGCCCGGCAGCTGAGCGTG GCGCACTGGCCGCGTTTGAAGCAGGCACAGCCACCCGCGTTCCCTTTGTGTCGATGCATCAGGGCGTGACCGATCAGACC GCCCGCTCGCCCGACCGGTTGGCACTGCGCACGCGTGACGGCGCGATGACCTATGCCGAGCTGGACGCCGCGTCGAGCCA GGTCGCCGAGCAGCTCATGGCGCGCGGCGTTCGCGCCGGCGAGACGGTTGGCGTCTGCATGAACCGGTCGATGGACCTGG TGGTGGCGTTGCTGGCCGTGCTGAAGACCGGCTGTGCCTATGTGCCGCTTGACCCGGCCTATCCGGCCGACCGGCTTGAT TTCATGCTGGAAGACAGCCAGTCGCATTTTGTCATCACGGATGCGCCCGGCGCGCAGGAGGGTGTGCGGGCCCAGCGGCT GGCATTTGGCGAGCTGCGCGGCGGCTCTGCGGGCGGATGGCGCGCGCCGGAGGTTGGCCCGCAGGATCTGGCCTATCTGA TTTACACTTCGGGATCGACGGGCCGCCCCAAGGGCGTGAAGGTTCAGCATGGCGCGCTGGCAAACTTCTTTGCGGCGATG GATGTTCGCCTTCCGTATAAAGAGGGTGATACCTGGCTGGCGGTGACCAGCCCCAACTTTGACATCTCCGTCCTTGAGCT GTTCTGGACGCTGTCGCGCGGCCTGACTGTGGCGCTGCATGGCGCGGAAACGCAGAAAACCAAGCCGTTCAGCCTGTTCT ATTTTGCGGCGTCCTCTGCCGCGAATGCCGATCAGTACAAGTTGTTGTTTGCGGGCGCGCGCTTTGCCGATGAAAACGGG TTTGAGGCGATCTGGACACCGGAACGCCACTTCCATGATTTCGGCGGTTCCTATCCTAACCCGGCCGTGACGAGCGCTGC GCTGGCGGCGATCACGAAGAATGTGCATATCCGTGCGGGCAGCTGCGTGCTGCCGCTGCATCACCCCATCCGGGTGGCGG AAGACTGGTCGGTGATCGACAATGTGTCCCGCGGCCGGGTCGGTCTTGCCATTGCGACGGGCTGGCAACCAAATGACTTT GTTCTGGCGCCGGACAATTTTGCGACGCGCCGTGATACGCTCAGCGAGCGGATCGACACGCTGAAGCGCCTGTGGCGCGG CGAGGCCGTGCCGTTTGTGAACCCGAACGGCGTTGAGGTGCCAACGCGTATTCATCCCCGCCCGATCCAGAAGGAACTGC CGATCTGGCTGACGATTGCCAAGGCGGCCGAAGCATTCGAGAGCGCAGGGCGGCAGGGCTTTAATGTGCTGACCCACCTG CTGGGCATGTCGGTAGCTGAGCTTGGCGGCAACATCGCCAGGTATCGTGAGGCCTGGCGGAAAGCCGGGCATCCGGGCGA AGGACGTGTGACGTTGATGTTGCACTCGTTTGCCGGCGAGACCGATGACGATGTTTGCGAGACCGTCCGTGAGCCAATGA AAGCGTATCTGCGCACCTCGGTTGATCTTGTGCGCGATGCGGCCTGGACTTTCCCGACGCTGGTTCAGAAGGGCGAAAAG ACAGGCCGCACGGCGCAAGAGGTGATGGACGCCGAGCCGCTGACGGACGAAGAGATGGACGCGCTGCTTGACCATGCGTT CGAGCGCTATTTCCAGACGAGTGGTCTTTTCGGATCGGTTGAGACCTGCGCCGAGATGGCGCGCCGGGTGCATGGTATTG GCGTGGACGAGATCGGCTGTCTGGTCGATTTCGGGGTGGATCAGGACCTGGCGATTGAGCATCTGCCCTATCTGAAACGC GTGATGGACCGTGCCGGAGCTTCGCCGTCGCATGAAGGGCGGCACACGGTTGCCGAGGATGTCGAATTTTTTGGTGCCTC ACATCTGCAATGCACACCGTCCATGGCGATGATGCTGGGCGGCGAAACCGAGAAGCTGGCCGGGCTGCAGGTGCTCTGCG TGGGCGGGGAAGCGCTGCCGATGGAGCTGGCCCGGTCGCTGCGCACGGCGGCGCCGCAGGCAAAACTGTTCAACATGTAT GGGCCGACCGAGACGACGATCTGGTCGACCATGTGTCATATCGATGAAGTGGGAAATTTCATTCCGCTGGGCGAAGCCCT GCTCAACACAACGCTGCGCATCGATTCGCCTTCGGGCCGGCCCCAGCCGGCGCTGGCTGCCGGAGAGCTGCTGATCGGCG GCGACGGCGTGACGCTGGGATACTGGAACCGGGAAGATCTGACGGCAGAGCGTTTTGTGACGCTGCCGGACAGGCCGGGT GAGGTGATGTATCGGACTGGTGACCTTGTGCGCCGTCATTCCGATGGGAAACTGGAATTCCTGGGGCGGATCGATCATCA GGTGAAGCTGCGCGGGCACCGGATCGAGCTTGGCGAGATCGAGGCGGCGCTGATTGCCGAAGCGGCGATCGCGCAGGCGG TGGTTGTTGCGCTTGGCGACAGCAATGAAAATAAGCGGCTTGTTGCCTATTGCGTTGTCAAACCGGGCGCCGAGCTTGAT ACCAAAGCGCTGAGATCGCAGCTGTTGCAAAGCCTGCCGGAAATCATGGTGCCGGCGCACATTGTTGTGCTGCCGAGTTT GCCGCTGACGCCGAATGGCAAGATTGACCGCAAGGCATTGCCTGCGCCGGAAGCGGCGGTTCAGGGCGCGGTTGAGACGC CCAGCGATGAAGTGGAGCAGAAGCTTGCCTCCACATGGAGCGATCTGCTTGGGCTTCCAGCGGTGGATGTGAACGCCAAT TTCTTTGACCTTGGCGGGCACTCCCTGCTGGCATTCCAGATGCTGCGGCGCGTGCAGAGCGACTTCTCGCGGGATGTAAC CATTACGGATGTCTTCCGTTTTCCGACCGTCCGTACACTGGCTGAGCGTATCCGCAAGGGTGGCAGTGATGACAAGGACA AGCCGAATGCGGGGCTCGGCCGGGCGCAGGCGCGCCTGGCTGCGCGCCGCCGTGATTCTGCAGGGGCCTGA
Upstream 100 bases:
>100_bases TCGCCTAAGCACCAGAGTGGCTGGCTTGATCGCGCATTGGCGCCGAGTTAGCTTGGGGTGGGGACATGTATTCAGTAAAT AAACGTATAGTGGGTGGCTC
Downstream 100 bases:
>100_bases AACTTATGGCCGATGAGAACAGCATCGCCATCGTTGGCATGGCTGGGCATTTTCCCGGCGCACGGTCGGTTCGGGAATAC TGGTCGATGCTTGAGGCTGG
Product: ATP-dependent AMP-binding enzyme family protein
Products: pyrophosphate; AMP; enterobactin; pyrophosphate; L-Seryl-AMP [C]
Alternate protein names: Gramicidin S synthase II; ATP-dependent proline adenylase; ProA; Proline activase; ATP-dependent valine adenylase; ValA; Valine activase; ATP-dependent ornithine adenylase; OrnA; Ornithine activase; ATP-dependent leucine adenylase; LeuA; Leucine activase [H]
Number of amino acids: Translated: 1516; Mature: 1516
Protein sequence:
>1516_residues MNNITALIVGDGPLLLQCLEAYMASGGQVTAVVTQDSAIASHGDAIGVRVLNKSSVVSGELEALEFDYLLSIANLDMLPE SLLKRARKMAINFHDGPLPRYAGLNATSWAILQGETAHGVTWHEMTGKADMGGIVEAAPLTIDPNDTAFSLNAKCFEAGL ASFKAMIPSLLAGNVTVRPQDGARTYFGRYKRPDAAATLRFDVSADDTLALSRAMTFGPYTNTLSFLKVWTGQRVLLVSD VEAATGAASLAAHGTVIAHDADGVVVAAQGGQLLRLSGLTDSSGAAVDPAQSGDLALGARLPDLAASDVAELDRHTVAAA KAESFWMAHSARAVASEAAPYPRALKPAAGVHTFPLDAGAELSLGLAAVAVWSAHVGGASSAAIAFHDGAQWTGLGKYAA WFAPWRPLALDVAGDAQRGELVAHARALVDAARDKGPLACDAYMRRPRAERMQGRADDFSLAVAIGGDAPKHPNADIILR AGEAGLTLEISAGAYDADVAGVIAGHIASALAGLRDAPQEAVSGLDVRPAAERGALAAFEAGTATRVPFVSMHQGVTDQT ARSPDRLALRTRDGAMTYAELDAASSQVAEQLMARGVRAGETVGVCMNRSMDLVVALLAVLKTGCAYVPLDPAYPADRLD FMLEDSQSHFVITDAPGAQEGVRAQRLAFGELRGGSAGGWRAPEVGPQDLAYLIYTSGSTGRPKGVKVQHGALANFFAAM DVRLPYKEGDTWLAVTSPNFDISVLELFWTLSRGLTVALHGAETQKTKPFSLFYFAASSAANADQYKLLFAGARFADENG FEAIWTPERHFHDFGGSYPNPAVTSAALAAITKNVHIRAGSCVLPLHHPIRVAEDWSVIDNVSRGRVGLAIATGWQPNDF VLAPDNFATRRDTLSERIDTLKRLWRGEAVPFVNPNGVEVPTRIHPRPIQKELPIWLTIAKAAEAFESAGRQGFNVLTHL LGMSVAELGGNIARYREAWRKAGHPGEGRVTLMLHSFAGETDDDVCETVREPMKAYLRTSVDLVRDAAWTFPTLVQKGEK TGRTAQEVMDAEPLTDEEMDALLDHAFERYFQTSGLFGSVETCAEMARRVHGIGVDEIGCLVDFGVDQDLAIEHLPYLKR VMDRAGASPSHEGRHTVAEDVEFFGASHLQCTPSMAMMLGGETEKLAGLQVLCVGGEALPMELARSLRTAAPQAKLFNMY GPTETTIWSTMCHIDEVGNFIPLGEALLNTTLRIDSPSGRPQPALAAGELLIGGDGVTLGYWNREDLTAERFVTLPDRPG EVMYRTGDLVRRHSDGKLEFLGRIDHQVKLRGHRIELGEIEAALIAEAAIAQAVVVALGDSNENKRLVAYCVVKPGAELD TKALRSQLLQSLPEIMVPAHIVVLPSLPLTPNGKIDRKALPAPEAAVQGAVETPSDEVEQKLASTWSDLLGLPAVDVNAN FFDLGGHSLLAFQMLRRVQSDFSRDVTITDVFRFPTVRTLAERIRKGGSDDKDKPNAGLGRAQARLAARRRDSAGA
Sequences:
>Translated_1516_residues MNNITALIVGDGPLLLQCLEAYMASGGQVTAVVTQDSAIASHGDAIGVRVLNKSSVVSGELEALEFDYLLSIANLDMLPE SLLKRARKMAINFHDGPLPRYAGLNATSWAILQGETAHGVTWHEMTGKADMGGIVEAAPLTIDPNDTAFSLNAKCFEAGL ASFKAMIPSLLAGNVTVRPQDGARTYFGRYKRPDAAATLRFDVSADDTLALSRAMTFGPYTNTLSFLKVWTGQRVLLVSD VEAATGAASLAAHGTVIAHDADGVVVAAQGGQLLRLSGLTDSSGAAVDPAQSGDLALGARLPDLAASDVAELDRHTVAAA KAESFWMAHSARAVASEAAPYPRALKPAAGVHTFPLDAGAELSLGLAAVAVWSAHVGGASSAAIAFHDGAQWTGLGKYAA WFAPWRPLALDVAGDAQRGELVAHARALVDAARDKGPLACDAYMRRPRAERMQGRADDFSLAVAIGGDAPKHPNADIILR AGEAGLTLEISAGAYDADVAGVIAGHIASALAGLRDAPQEAVSGLDVRPAAERGALAAFEAGTATRVPFVSMHQGVTDQT ARSPDRLALRTRDGAMTYAELDAASSQVAEQLMARGVRAGETVGVCMNRSMDLVVALLAVLKTGCAYVPLDPAYPADRLD FMLEDSQSHFVITDAPGAQEGVRAQRLAFGELRGGSAGGWRAPEVGPQDLAYLIYTSGSTGRPKGVKVQHGALANFFAAM DVRLPYKEGDTWLAVTSPNFDISVLELFWTLSRGLTVALHGAETQKTKPFSLFYFAASSAANADQYKLLFAGARFADENG FEAIWTPERHFHDFGGSYPNPAVTSAALAAITKNVHIRAGSCVLPLHHPIRVAEDWSVIDNVSRGRVGLAIATGWQPNDF VLAPDNFATRRDTLSERIDTLKRLWRGEAVPFVNPNGVEVPTRIHPRPIQKELPIWLTIAKAAEAFESAGRQGFNVLTHL LGMSVAELGGNIARYREAWRKAGHPGEGRVTLMLHSFAGETDDDVCETVREPMKAYLRTSVDLVRDAAWTFPTLVQKGEK TGRTAQEVMDAEPLTDEEMDALLDHAFERYFQTSGLFGSVETCAEMARRVHGIGVDEIGCLVDFGVDQDLAIEHLPYLKR VMDRAGASPSHEGRHTVAEDVEFFGASHLQCTPSMAMMLGGETEKLAGLQVLCVGGEALPMELARSLRTAAPQAKLFNMY GPTETTIWSTMCHIDEVGNFIPLGEALLNTTLRIDSPSGRPQPALAAGELLIGGDGVTLGYWNREDLTAERFVTLPDRPG EVMYRTGDLVRRHSDGKLEFLGRIDHQVKLRGHRIELGEIEAALIAEAAIAQAVVVALGDSNENKRLVAYCVVKPGAELD TKALRSQLLQSLPEIMVPAHIVVLPSLPLTPNGKIDRKALPAPEAAVQGAVETPSDEVEQKLASTWSDLLGLPAVDVNAN FFDLGGHSLLAFQMLRRVQSDFSRDVTITDVFRFPTVRTLAERIRKGGSDDKDKPNAGLGRAQARLAARRRDSAGA >Mature_1516_residues MNNITALIVGDGPLLLQCLEAYMASGGQVTAVVTQDSAIASHGDAIGVRVLNKSSVVSGELEALEFDYLLSIANLDMLPE SLLKRARKMAINFHDGPLPRYAGLNATSWAILQGETAHGVTWHEMTGKADMGGIVEAAPLTIDPNDTAFSLNAKCFEAGL ASFKAMIPSLLAGNVTVRPQDGARTYFGRYKRPDAAATLRFDVSADDTLALSRAMTFGPYTNTLSFLKVWTGQRVLLVSD VEAATGAASLAAHGTVIAHDADGVVVAAQGGQLLRLSGLTDSSGAAVDPAQSGDLALGARLPDLAASDVAELDRHTVAAA KAESFWMAHSARAVASEAAPYPRALKPAAGVHTFPLDAGAELSLGLAAVAVWSAHVGGASSAAIAFHDGAQWTGLGKYAA WFAPWRPLALDVAGDAQRGELVAHARALVDAARDKGPLACDAYMRRPRAERMQGRADDFSLAVAIGGDAPKHPNADIILR AGEAGLTLEISAGAYDADVAGVIAGHIASALAGLRDAPQEAVSGLDVRPAAERGALAAFEAGTATRVPFVSMHQGVTDQT ARSPDRLALRTRDGAMTYAELDAASSQVAEQLMARGVRAGETVGVCMNRSMDLVVALLAVLKTGCAYVPLDPAYPADRLD FMLEDSQSHFVITDAPGAQEGVRAQRLAFGELRGGSAGGWRAPEVGPQDLAYLIYTSGSTGRPKGVKVQHGALANFFAAM DVRLPYKEGDTWLAVTSPNFDISVLELFWTLSRGLTVALHGAETQKTKPFSLFYFAASSAANADQYKLLFAGARFADENG FEAIWTPERHFHDFGGSYPNPAVTSAALAAITKNVHIRAGSCVLPLHHPIRVAEDWSVIDNVSRGRVGLAIATGWQPNDF VLAPDNFATRRDTLSERIDTLKRLWRGEAVPFVNPNGVEVPTRIHPRPIQKELPIWLTIAKAAEAFESAGRQGFNVLTHL LGMSVAELGGNIARYREAWRKAGHPGEGRVTLMLHSFAGETDDDVCETVREPMKAYLRTSVDLVRDAAWTFPTLVQKGEK TGRTAQEVMDAEPLTDEEMDALLDHAFERYFQTSGLFGSVETCAEMARRVHGIGVDEIGCLVDFGVDQDLAIEHLPYLKR VMDRAGASPSHEGRHTVAEDVEFFGASHLQCTPSMAMMLGGETEKLAGLQVLCVGGEALPMELARSLRTAAPQAKLFNMY GPTETTIWSTMCHIDEVGNFIPLGEALLNTTLRIDSPSGRPQPALAAGELLIGGDGVTLGYWNREDLTAERFVTLPDRPG EVMYRTGDLVRRHSDGKLEFLGRIDHQVKLRGHRIELGEIEAALIAEAAIAQAVVVALGDSNENKRLVAYCVVKPGAELD TKALRSQLLQSLPEIMVPAHIVVLPSLPLTPNGKIDRKALPAPEAAVQGAVETPSDEVEQKLASTWSDLLGLPAVDVNAN FFDLGGHSLLAFQMLRRVQSDFSRDVTITDVFRFPTVRTLAERIRKGGSDDKDKPNAGLGRAQARLAARRRDSAGA
Specific function: This protein is a multifunctional enzyme, able to activate and polymerize the amino acids Pro, Val, Orn and Leu. Activation sites for these AA consist of individual domains [H]
COG id: COG2141
COG function: function code C; Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 4 acyl carrier domains [H]
Homologues:
Organism=Homo sapiens, GI45580730, Length=340, Percent_Identity=29.4117647058824, Blast_Score=94, Evalue=1e-18, Organism=Escherichia coli, GI1786801, Length=329, Percent_Identity=42.8571428571429, Blast_Score=200, Evalue=7e-52, Organism=Escherichia coli, GI145693145, Length=243, Percent_Identity=27.5720164609054, Blast_Score=78, Evalue=4e-15, Organism=Escherichia coli, GI1788589, Length=302, Percent_Identity=25.4966887417219, Blast_Score=77, Evalue=8e-15, Organism=Escherichia coli, GI1790505, Length=224, Percent_Identity=31.6964285714286, Blast_Score=67, Evalue=1e-11, Organism=Escherichia coli, GI1786810, Length=262, Percent_Identity=27.0992366412214, Blast_Score=67, Evalue=1e-11, Organism=Caenorhabditis elegans, GI17556356, Length=342, Percent_Identity=29.2397660818713, Blast_Score=115, Evalue=2e-25, Organism=Caenorhabditis elegans, GI17550940, Length=341, Percent_Identity=25.8064516129032, Blast_Score=105, Evalue=2e-22, Organism=Caenorhabditis elegans, GI32564420, Length=325, Percent_Identity=27.0769230769231, Blast_Score=99, Evalue=1e-20, Organism=Caenorhabditis elegans, GI32564422, Length=325, Percent_Identity=27.0769230769231, Blast_Score=99, Evalue=1e-20, Organism=Caenorhabditis elegans, GI17531443, Length=270, Percent_Identity=25.1851851851852, Blast_Score=75, Evalue=3e-13, Organism=Caenorhabditis elegans, GI17560308, Length=238, Percent_Identity=25.2100840336134, Blast_Score=70, Evalue=6e-12, Organism=Caenorhabditis elegans, GI17538037, Length=260, Percent_Identity=25.7692307692308, Blast_Score=67, Evalue=1e-10, Organism=Saccharomyces cerevisiae, GI6319591, Length=428, Percent_Identity=26.8691588785047, Blast_Score=139, Evalue=2e-33, Organism=Saccharomyces cerevisiae, GI6319699, Length=158, Percent_Identity=28.4810126582279, Blast_Score=67, Evalue=2e-11, Organism=Saccharomyces cerevisiae, GI6319264, Length=149, Percent_Identity=29.5302013422819, Blast_Score=65, Evalue=6e-11, Organism=Drosophila melanogaster, GI24648676, Length=324, Percent_Identity=28.3950617283951, Blast_Score=101, Evalue=4e-21, Organism=Drosophila melanogaster, GI24582852, Length=312, Percent_Identity=25.9615384615385, Blast_Score=71, Evalue=7e-12,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR010071 - InterPro: IPR009081 - InterPro: IPR020845 - InterPro: IPR000873 - InterPro: IPR001242 - InterPro: IPR006163 - InterPro: IPR006162 - InterPro: IPR001031 [H]
Pfam domain/function: PF00501 AMP-binding; PF00668 Condensation; PF00550 PP-binding; PF00975 Thioesterase [H]
EC number: 2.7.7.- [C]
Molecular weight: Translated: 161906; Mature: 161906
Theoretical pI: Translated: 5.61; Mature: 5.61
Prosite motif: PS50075 ACP_DOMAIN ; PS00455 AMP_BINDING
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.9 %Cys (Translated Protein) 2.2 %Met (Translated Protein) 3.1 %Cys+Met (Translated Protein) 0.9 %Cys (Mature Protein) 2.2 %Met (Mature Protein) 3.1 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MNNITALIVGDGPLLLQCLEAYMASGGQVTAVVTQDSAIASHGDAIGVRVLNKSSVVSGE CCCEEEEEECCCHHHHHHHHHHHHCCCEEEEEEECCCHHHCCCCEEEEEEECCCCCCCCC LEALEFDYLLSIANLDMLPESLLKRARKMAINFHDGPLPRYAGLNATSWAILQGETAHGV HHHHHHHHHHHHHHHHCCHHHHHHHHHHHEEECCCCCCCCCCCCCCCEEEEEECCCCCCE TWHEMTGKADMGGIVEAAPLTIDPNDTAFSLNAKCFEAGLASFKAMIPSLLAGNVTVRPQ EEECCCCCCCCCCCEEECCEEECCCCCEEEECHHHHHHHHHHHHHHHHHHHCCCEEECCC DGARTYFGRYKRPDAAATLRFDVSADDTLALSRAMTFGPYTNTLSFLKVWTGQRVLLVSD CCCHHHHCCCCCCCCCEEEEEECCCCCHHHHHHHHCCCCCHHHHHHHHHHCCCEEEEEEC VEAATGAASLAAHGTVIAHDADGVVVAAQGGQLLRLSGLTDSSGAAVDPAQSGDLALGAR CCHHCCHHHHHHCCEEEEECCCCEEEEECCCCEEEEECCCCCCCCCCCCCCCCCEEECCC LPDLAASDVAELDRHTVAAAKAESFWMAHSARAVASEAAPYPRALKPAAGVHTFPLDAGA CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCC ELSLGLAAVAVWSAHVGGASSAAIAFHDGAQWTGLGKYAAWFAPWRPLALDVAGDAQRGE CHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCHHHHHHCCCCCEEEEECCCCCCCH LVAHARALVDAARDKGPLACDAYMRRPRAERMQGRADDFSLAVAIGGDAPKHPNADIILR HHHHHHHHHHHHCCCCCEEHHHHHCCCHHHHHCCCCCCEEEEEEECCCCCCCCCCCEEEE AGEAGLTLEISAGAYDADVAGVIAGHIASALAGLRDAPQEAVSGLDVRPAAERGALAAFE ECCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCHHCCCEEEEC AGTATRVPFVSMHQGVTDQTARSPDRLALRTRDGAMTYAELDAASSQVAEQLMARGVRAG CCCCCCCCCHHHHCCCCCHHCCCCCCEEEEECCCCEEEHHHHHHHHHHHHHHHHCCCCCC ETVGVCMNRSMDLVVALLAVLKTGCAYVPLDPAYPADRLDFMLEDSQSHFVITDAPGAQE CEEEHHHCCCHHHHHHHHHHHHCCCEEEECCCCCCHHHHHEEEECCCCCEEEECCCCCHH GVRAQRLAFGELRGGSAGGWRAPEVGPQDLAYLIYTSGSTGRPKGVKVQHGALANFFAAM CHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCEEEECCHHHHHHHHH DVRLPYKEGDTWLAVTSPNFDISVLELFWTLSRGLTVALHGAETQKTKPFSLFYFAASSA EEEEECCCCCEEEEEECCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCEEEEEEECCCC ANADQYKLLFAGARFADENGFEAIWTPERHFHDFGGSYPNPAVTSAALAAITKNVHIRAG CCCCCEEEEEECCEECCCCCCEEEECCHHHHHHCCCCCCCHHHHHHHHHHHHCCEEEEEC SCVLPLHHPIRVAEDWSVIDNVSRGRVGLAIATGWQPNDFVLAPDNFATRRDTLSERIDT CEEECCCCCEEECCCCHHHHCCCCCCEEEEEEECCCCCCEEECCCCCHHHHHHHHHHHHH LKRLWRGEAVPFVNPNGVEVPTRIHPRPIQKELPIWLTIAKAAEAFESAGRQGFNVLTHL HHHHHCCCCCCEECCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHCCCCHHHHHHHH LGMSVAELGGNIARYREAWRKAGHPGEGRVTLMLHSFAGETDDDVCETVREPMKAYLRTS HHHHHHHHCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHH VDLVRDAAWTFPTLVQKGEKTGRTAQEVMDAEPLTDEEMDALLDHAFERYFQTSGLFGSV HHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCH ETCAEMARRVHGIGVDEIGCLVDFGVDQDLAIEHLPYLKRVMDRAGASPSHEGRHTVAED HHHHHHHHHHHCCCHHHHCEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHH VEFFGASHLQCTPSMAMMLGGETEKLAGLQVLCVGGEALPMELARSLRTAAPQAKLFNMY HHHHCCCCCEECCHHHHHCCCCCHHHCCEEEEEECCCCCHHHHHHHHHHCCCCHHEEECC GPTETTIWSTMCHIDEVGNFIPLGEALLNTTLRIDSPSGRPQPALAAGELLIGGDGVTLG CCCHHHHHHHHHHHHHHCCCCCCCHHHHCCEEEEECCCCCCCCCCCCCCEEECCCCEEEE YWNREDLTAERFVTLPDRPGEVMYRTGDLVRRHSDGKLEFLGRIDHQVKLRGHRIELGEI ECCCCCCCHHHEEECCCCCCCEEEECCHHHHCCCCCCEEEEECCCCEEEEECCEEEHHHH EAALIAEAAIAQAVVVALGDSNENKRLVAYCVVKPGAELDTKALRSQLLQSLPEIMVPAH HHHHHHHHHHHHEEEEEECCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCE IVVLPSLPLTPNGKIDRKALPAPEAAVQGAVETPSDEVEQKLASTWSDLLGLPAVDVNAN EEEECCCCCCCCCCCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEEECCCC FFDLGGHSLLAFQMLRRVQSDFSRDVTITDVFRFPTVRTLAERIRKGGSDDKDKPNAGLG EEECCCHHHHHHHHHHHHHHHHCCCCEEEEHHHCCHHHHHHHHHHCCCCCCCCCCCCCCC RAQARLAARRRDSAGA HHHHHHHHHHCCCCCC >Mature Secondary Structure MNNITALIVGDGPLLLQCLEAYMASGGQVTAVVTQDSAIASHGDAIGVRVLNKSSVVSGE CCCEEEEEECCCHHHHHHHHHHHHCCCEEEEEEECCCHHHCCCCEEEEEEECCCCCCCCC LEALEFDYLLSIANLDMLPESLLKRARKMAINFHDGPLPRYAGLNATSWAILQGETAHGV HHHHHHHHHHHHHHHHCCHHHHHHHHHHHEEECCCCCCCCCCCCCCCEEEEEECCCCCCE TWHEMTGKADMGGIVEAAPLTIDPNDTAFSLNAKCFEAGLASFKAMIPSLLAGNVTVRPQ EEECCCCCCCCCCCEEECCEEECCCCCEEEECHHHHHHHHHHHHHHHHHHHCCCEEECCC DGARTYFGRYKRPDAAATLRFDVSADDTLALSRAMTFGPYTNTLSFLKVWTGQRVLLVSD CCCHHHHCCCCCCCCCEEEEEECCCCCHHHHHHHHCCCCCHHHHHHHHHHCCCEEEEEEC VEAATGAASLAAHGTVIAHDADGVVVAAQGGQLLRLSGLTDSSGAAVDPAQSGDLALGAR CCHHCCHHHHHHCCEEEEECCCCEEEEECCCCEEEEECCCCCCCCCCCCCCCCCEEECCC LPDLAASDVAELDRHTVAAAKAESFWMAHSARAVASEAAPYPRALKPAAGVHTFPLDAGA CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCC ELSLGLAAVAVWSAHVGGASSAAIAFHDGAQWTGLGKYAAWFAPWRPLALDVAGDAQRGE CHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCHHHHHHCCCCCEEEEECCCCCCCH LVAHARALVDAARDKGPLACDAYMRRPRAERMQGRADDFSLAVAIGGDAPKHPNADIILR HHHHHHHHHHHHCCCCCEEHHHHHCCCHHHHHCCCCCCEEEEEEECCCCCCCCCCCEEEE AGEAGLTLEISAGAYDADVAGVIAGHIASALAGLRDAPQEAVSGLDVRPAAERGALAAFE ECCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCHHCCCEEEEC AGTATRVPFVSMHQGVTDQTARSPDRLALRTRDGAMTYAELDAASSQVAEQLMARGVRAG CCCCCCCCCHHHHCCCCCHHCCCCCCEEEEECCCCEEEHHHHHHHHHHHHHHHHCCCCCC ETVGVCMNRSMDLVVALLAVLKTGCAYVPLDPAYPADRLDFMLEDSQSHFVITDAPGAQE CEEEHHHCCCHHHHHHHHHHHHCCCEEEECCCCCCHHHHHEEEECCCCCEEEECCCCCHH GVRAQRLAFGELRGGSAGGWRAPEVGPQDLAYLIYTSGSTGRPKGVKVQHGALANFFAAM CHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCEEEECCHHHHHHHHH DVRLPYKEGDTWLAVTSPNFDISVLELFWTLSRGLTVALHGAETQKTKPFSLFYFAASSA EEEEECCCCCEEEEEECCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCEEEEEEECCCC ANADQYKLLFAGARFADENGFEAIWTPERHFHDFGGSYPNPAVTSAALAAITKNVHIRAG CCCCCEEEEEECCEECCCCCCEEEECCHHHHHHCCCCCCCHHHHHHHHHHHHCCEEEEEC SCVLPLHHPIRVAEDWSVIDNVSRGRVGLAIATGWQPNDFVLAPDNFATRRDTLSERIDT CEEECCCCCEEECCCCHHHHCCCCCCEEEEEEECCCCCCEEECCCCCHHHHHHHHHHHHH LKRLWRGEAVPFVNPNGVEVPTRIHPRPIQKELPIWLTIAKAAEAFESAGRQGFNVLTHL HHHHHCCCCCCEECCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHCCCCHHHHHHHH LGMSVAELGGNIARYREAWRKAGHPGEGRVTLMLHSFAGETDDDVCETVREPMKAYLRTS HHHHHHHHCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHH VDLVRDAAWTFPTLVQKGEKTGRTAQEVMDAEPLTDEEMDALLDHAFERYFQTSGLFGSV HHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCH ETCAEMARRVHGIGVDEIGCLVDFGVDQDLAIEHLPYLKRVMDRAGASPSHEGRHTVAED HHHHHHHHHHHCCCHHHHCEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHH VEFFGASHLQCTPSMAMMLGGETEKLAGLQVLCVGGEALPMELARSLRTAAPQAKLFNMY HHHHCCCCCEECCHHHHHCCCCCHHHCCEEEEEECCCCCHHHHHHHHHHCCCCHHEEECC GPTETTIWSTMCHIDEVGNFIPLGEALLNTTLRIDSPSGRPQPALAAGELLIGGDGVTLG CCCHHHHHHHHHHHHHHCCCCCCCHHHHCCEEEEECCCCCCCCCCCCCCEEECCCCEEEE YWNREDLTAERFVTLPDRPGEVMYRTGDLVRRHSDGKLEFLGRIDHQVKLRGHRIELGEI ECCCCCCCHHHEEECCCCCCCEEEECCHHHHCCCCCCEEEEECCCCEEEEECCEEEHHHH EAALIAEAAIAQAVVVALGDSNENKRLVAYCVVKPGAELDTKALRSQLLQSLPEIMVPAH HHHHHHHHHHHHEEEEEECCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCE IVVLPSLPLTPNGKIDRKALPAPEAAVQGAVETPSDEVEQKLASTWSDLLGLPAVDVNAN EEEECCCCCCCCCCCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEEECCCC FFDLGGHSLLAFQMLRRVQSDFSRDVTITDVFRFPTVRTLAERIRKGGSDDKDKPNAGLG EEECCCHHHHHHHHHHHHHHHHCCCCEEEEHHHCCHHHHHHHHHHCCCCCCCCCCCCCCC RAQARLAARRRDSAGA HHHHHHHHHHCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: Phosphopantetheine. [C]
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: 6 ATP; L-serine; 2,3-dihydroxybenzoate [C]
Specific reaction: 6 ATP + 3 L-serine + 3 2,3-dihydroxybenzoate = 6 pyrophosphate + 6 AMP + enterobactin ATP + L-serine = pyrophosphate + L-Seryl-AMP 6 ATP + 3 L-serine + 3 2,3-dihydroxybenzoate = 6 pyrophosphate + 6 AMP + enterobactin ATP + L-serine = pyrophosphate + L-Ser
General reaction: Transferases; Acyltransferases; Transferring groups other than amino-acyl groups [C]
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 1560782; 2477357 [H]