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The map label for this gene is ppi [H]

Identifier: 114798998

GI number: 114798998

Start: 1433429

End: 1433893

Strand: Reverse

Name: ppi [H]

Synonym: HNE_1405

Alternate gene names: 114798998

Gene position: 1433893-1433429 (Counterclockwise)

Preceding gene: 114798655

Following gene: 114798077

Centisome position: 38.7

GC content: 60.65

Gene sequence:

>465_bases
ATGTCCGACCCAGAAAACACGCTTCTCGTTGAAACCTCCAAGGGCAGCATCACCATCGAATTGCGCCCCGATCTTGCGCC
AGGTCACGTTGCGCGCATCAAGGAACTCGCCCGTGAAGGGTTTTATGATGGCATCGTCTTTCACCGCGTGATTGCCGGCT
TCATGGCGCAGGCCGGTTGCCCGAAAGGCAATGGTACCGGCGGGTCAAAAAAGCCGGACCTGAAAGCCGAGTTCAATGCC
GAGCCGCACGTGCGCGGCACCTGCTCGATGGCGCGCACCTCTGCGCCGCATTCGGCCAACAGCCAGTTCTTCATCTGCTT
CGACGAAGCCCGCTTCCTTGACCGGCAATATACCGTGTGGGGCAAGGTGAGCGAAGGGATGGACATCATTGACCAGCTGG
CCAAAGGCGAGCCGCCACGCAATCCGGACCGTATCGTGACGATGCGGGTCGCCGCCGACACCTGA

Upstream 100 bases:

>100_bases
GAACCAGAATGACTTAATAATACATGCAGGTAGCGCTTGCCGCCAGTGCCGCGATTGAATAGCCACAGTGCCAGCGACGG
CCCAGCCAGGAAAGAAAATT

Downstream 100 bases:

>100_bases
TGGCGGACGGGGGGCGCCAAGGCAGGAAAGCGATGGCGGAGACGACCCCTCCTCGCCGGAAGAACCAGAGGCGTGGCCCC
TCCCTCCTCGGCTCGCGCAT

Product: putative peptidyl-prolyl cis-trans isomerase, cyclophilin-type

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 154; Mature: 153

Protein sequence:

>154_residues
MSDPENTLLVETSKGSITIELRPDLAPGHVARIKELAREGFYDGIVFHRVIAGFMAQAGCPKGNGTGGSKKPDLKAEFNA
EPHVRGTCSMARTSAPHSANSQFFICFDEARFLDRQYTVWGKVSEGMDIIDQLAKGEPPRNPDRIVTMRVAADT

Sequences:

>Translated_154_residues
MSDPENTLLVETSKGSITIELRPDLAPGHVARIKELAREGFYDGIVFHRVIAGFMAQAGCPKGNGTGGSKKPDLKAEFNA
EPHVRGTCSMARTSAPHSANSQFFICFDEARFLDRQYTVWGKVSEGMDIIDQLAKGEPPRNPDRIVTMRVAADT
>Mature_153_residues
SDPENTLLVETSKGSITIELRPDLAPGHVARIKELAREGFYDGIVFHRVIAGFMAQAGCPKGNGTGGSKKPDLKAEFNAE
PHVRGTCSMARTSAPHSANSQFFICFDEARFLDRQYTVWGKVSEGMDIIDQLAKGEPPRNPDRIVTMRVAADT

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI19557636, Length=134, Percent_Identity=37.3134328358209, Blast_Score=88, Evalue=2e-18,
Organism=Homo sapiens, GI7706339, Length=138, Percent_Identity=35.5072463768116, Blast_Score=86, Evalue=1e-17,
Organism=Homo sapiens, GI24308049, Length=135, Percent_Identity=34.8148148148148, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI64276486, Length=154, Percent_Identity=33.7662337662338, Blast_Score=78, Evalue=3e-15,
Organism=Homo sapiens, GI22547212, Length=140, Percent_Identity=39.2857142857143, Blast_Score=77, Evalue=8e-15,
Organism=Homo sapiens, GI7657473, Length=140, Percent_Identity=39.2857142857143, Blast_Score=77, Evalue=8e-15,
Organism=Homo sapiens, GI22547215, Length=140, Percent_Identity=39.2857142857143, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI5031987, Length=128, Percent_Identity=38.28125, Blast_Score=74, Evalue=5e-14,
Organism=Homo sapiens, GI10863927, Length=130, Percent_Identity=36.9230769230769, Blast_Score=73, Evalue=1e-13,
Organism=Homo sapiens, GI45439316, Length=132, Percent_Identity=36.3636363636364, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI310127646, Length=132, Percent_Identity=33.3333333333333, Blast_Score=68, Evalue=3e-12,
Organism=Homo sapiens, GI310114371, Length=132, Percent_Identity=33.3333333333333, Blast_Score=68, Evalue=3e-12,
Organism=Homo sapiens, GI310119221, Length=132, Percent_Identity=33.3333333333333, Blast_Score=68, Evalue=3e-12,
Organism=Homo sapiens, GI5174637, Length=144, Percent_Identity=34.7222222222222, Blast_Score=67, Evalue=5e-12,
Organism=Homo sapiens, GI310129267, Length=128, Percent_Identity=35.15625, Blast_Score=67, Evalue=8e-12,
Organism=Homo sapiens, GI310120620, Length=128, Percent_Identity=35.15625, Blast_Score=67, Evalue=8e-12,
Organism=Escherichia coli, GI1786736, Length=131, Percent_Identity=39.6946564885496, Blast_Score=92, Evalue=2e-20,
Organism=Escherichia coli, GI1789763, Length=139, Percent_Identity=39.568345323741, Blast_Score=89, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI17539496, Length=139, Percent_Identity=32.3741007194245, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17506311, Length=131, Percent_Identity=38.1679389312977, Blast_Score=84, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17539498, Length=142, Percent_Identity=38.7323943661972, Blast_Score=82, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI71980594, Length=131, Percent_Identity=37.4045801526718, Blast_Score=79, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI71980590, Length=131, Percent_Identity=37.4045801526718, Blast_Score=79, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17532641, Length=146, Percent_Identity=32.1917808219178, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71997782, Length=150, Percent_Identity=34, Blast_Score=67, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17552780, Length=127, Percent_Identity=37.007874015748, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17559074, Length=135, Percent_Identity=34.8148148148148, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17566266, Length=135, Percent_Identity=34.0740740740741, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17506307, Length=154, Percent_Identity=35.7142857142857, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI17986117, Length=173, Percent_Identity=35.8381502890173, Blast_Score=97, Evalue=3e-21,
Organism=Drosophila melanogaster, GI19922376, Length=139, Percent_Identity=33.0935251798561, Blast_Score=77, Evalue=4e-15,
Organism=Drosophila melanogaster, GI45549139, Length=128, Percent_Identity=38.28125, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24664125, Length=128, Percent_Identity=39.84375, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI21357783, Length=128, Percent_Identity=39.84375, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24652460, Length=140, Percent_Identity=34.2857142857143, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17647301, Length=128, Percent_Identity=35.15625, Blast_Score=69, Evalue=9e-13,
Organism=Drosophila melanogaster, GI19922912, Length=160, Percent_Identity=33.125, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI21357249, Length=158, Percent_Identity=32.9113924050633, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 16836; Mature: 16705

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDPENTLLVETSKGSITIELRPDLAPGHVARIKELAREGFYDGIVFHRVIAGFMAQAGC
CCCCCCEEEEEECCCEEEEEECCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCC
PKGNGTGGSKKPDLKAEFNAEPHVRGTCSMARTSAPHSANSQFFICFDEARFLDRQYTVW
CCCCCCCCCCCCCCCEECCCCCCCCCCHHHHHCCCCCCCCCCEEEEECCCHHCCCEEEEE
GKVSEGMDIIDQLAKGEPPRNPDRIVTMRVAADT
ECCCCCHHHHHHHHCCCCCCCCCEEEEEEEECCC
>Mature Secondary Structure 
SDPENTLLVETSKGSITIELRPDLAPGHVARIKELAREGFYDGIVFHRVIAGFMAQAGC
CCCCCEEEEEECCCEEEEEECCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCC
PKGNGTGGSKKPDLKAEFNAEPHVRGTCSMARTSAPHSANSQFFICFDEARFLDRQYTVW
CCCCCCCCCCCCCCCEECCCCCCCCCCHHHHHCCCCCCCCCCEEEEECCCHHCCCEEEEE
GKVSEGMDIIDQLAKGEPPRNPDRIVTMRVAADT
ECCCCCHHHHHHHHCCCCCCCCCEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA