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The map label for this gene is yngE [H]

Identifier: 114798965

GI number: 114798965

Start: 1307966

End: 1309573

Strand: Direct

Name: yngE [H]

Synonym: HNE_1277

Alternate gene names: 114798965

Gene position: 1307966-1309573 (Clockwise)

Preceding gene: 114799414

Following gene: 114800436

Centisome position: 35.3

GC content: 64.37

Gene sequence:

>1608_bases
ATGCCGGTCCTGAAGTCTGCGCTGGATGTTTCCGGCGCCAAATTCGCCGCCAATCGCGCCGCCATGCAGGCGCTGGTCGA
GGAATTGCGGGCCAAAACGGCTCAGGCCGCCCTGGGCGGGCCAGAAGACAGCCGCAAGCGCCACACCGAGCGGGGCAAGC
TGCTCCCGCGCGAGCGGGTGGAGCGGCTGATTGATCCGGGCAGCGCTTTCCTCGAGATCGGCGCGCTGGCGGCCAATGGC
ATGTATGACGGCGAGGCGCCGGGCGCGGGCCTCATCACCGGCGTTGGCCGGGTGGAAGGGCGTGAATGCCTGATCGTCTG
CAATGACGCGACCGTCAAAGGCGGGGCGTATTTCCCCGTCACTGTGAAGAAACACCTGCGGGCGCAGGAAGTGGCGATGG
AAAACCATCTGCCCTGCATCTACCTCGTCGACAGCGGCGGGGCGAACCTCCCCCACCAGTCTGAAGTTTTCCCGGACCGG
GAACATTTCGGCCGCATCTTCTACAATCAGGCCCAGATGAGCGCGAAGGGCATCCCCCAGATCGCCGCCGTGATGGGGAG
CTGCACCGCAGGTGGGGCGTATGTGCCTGCGATGAGCGACGAGACGGTGATTGTGCGCAAGCAGGGCACGATCTTTCTGG
GCGGCCCGCCGCTGGTGAAAGCGGCTACGGGGGAAGAGATTTCAGCCGAGGACCTTGGCGGGGCAGATGTGCATGCGCGC
CGTTCCGGCGTGGCGGATCACTATGCAGCCCATGACGCCCACGCGCTGGCGATTGTGCGGTCCATCGTCCGTACACTGGC
CAAGCCGAAGCCGCAGCCCTTCGAGATACAGGCGCCGGCCGAGCCGCTGTATGATCCGCGCGAGATGCACGGTCTGGTGC
CCCAGGATGTGCGCGAGCCGTATGACGCGCGTGAAGTGATCGCGCGCACGGTGGACGGCTCGGAATTCCATGAGTTCAAG
AAGCTCTATGGCGAAACGCTGGTCTGCGGCTTTGCGCATATCTATGGCATGCCGGTGGCGATCCTTGCGAACAACGGCAT
CCTGTTTTCTGAAAGCGCGCAAAAGGCAGCCCACTTTATCGAGCTGGCCGATCAGCGGCGCATTCCACTTGTCTTCCTGC
AAAACATTACTGGCTTCATGGTCGGCTCGAAATATGAAGCCGGCGGCATCGCCAAGGACGGCGCCAAGATGGTGACGGCG
GTGGCGACCGCGAGCGTGCCGAAATTCACCGTGGTGACCGGCGGCAGCTTTGGTGCGGGCAATTACGGCATGTGCGGGCG
GGCCTATTCCCCGCGTTTCCTGTTCATGTGGCCGAATGCGCGCATCTCCGTGATGGGCGGGGAGCAGGCCGCCAGCGTGC
TCGCCACGGTGAAGCGTGACGGCATTGAGCGGCGCGGCGGCCAGTGGAGCGCAGAGGAGGAACAGGGCTTCAAACAGCCG
ATCCGCGATCTCTACGAAACCGAAGGCAACCCGTATTTCTCCACCGCGCGCCTTTGGGACGATGGCATCATCGACCCGGC
AGACACGCGCCGCGTTCTGGGCCTCGCGCTTTCGGCCAGCCTCAACGCGCCGTTTGGCGAGCGGGGCTTTGGTCTGTTCC
GGATGTAA

Upstream 100 bases:

>100_bases
GGGGCAGCTTCAAGACCTGTAACACAAAAGAGTTTACCAACGGGTGACAGCGCAGCGGCAGACCGTTAATCCTGCCGCAA
CGAAAAGTAAGGGAGGGCCC

Downstream 100 bases:

>100_bases
AAAAAGCCCCTCACCGTGATAAGACGGGAGGGGCCAGAGTTTCTGACGATCTGCGGCGTCAGAGCTGGACCTGCTTGGAT
TTTCCAAGGTCAGGCTGTTC

Product: carboxyl transferase domain-containing protein

Products: ADP; phosphate; (S)-methylmalonyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 535; Mature: 534

Protein sequence:

>535_residues
MPVLKSALDVSGAKFAANRAAMQALVEELRAKTAQAALGGPEDSRKRHTERGKLLPRERVERLIDPGSAFLEIGALAANG
MYDGEAPGAGLITGVGRVEGRECLIVCNDATVKGGAYFPVTVKKHLRAQEVAMENHLPCIYLVDSGGANLPHQSEVFPDR
EHFGRIFYNQAQMSAKGIPQIAAVMGSCTAGGAYVPAMSDETVIVRKQGTIFLGGPPLVKAATGEEISAEDLGGADVHAR
RSGVADHYAAHDAHALAIVRSIVRTLAKPKPQPFEIQAPAEPLYDPREMHGLVPQDVREPYDAREVIARTVDGSEFHEFK
KLYGETLVCGFAHIYGMPVAILANNGILFSESAQKAAHFIELADQRRIPLVFLQNITGFMVGSKYEAGGIAKDGAKMVTA
VATASVPKFTVVTGGSFGAGNYGMCGRAYSPRFLFMWPNARISVMGGEQAASVLATVKRDGIERRGGQWSAEEEQGFKQP
IRDLYETEGNPYFSTARLWDDGIIDPADTRRVLGLALSASLNAPFGERGFGLFRM

Sequences:

>Translated_535_residues
MPVLKSALDVSGAKFAANRAAMQALVEELRAKTAQAALGGPEDSRKRHTERGKLLPRERVERLIDPGSAFLEIGALAANG
MYDGEAPGAGLITGVGRVEGRECLIVCNDATVKGGAYFPVTVKKHLRAQEVAMENHLPCIYLVDSGGANLPHQSEVFPDR
EHFGRIFYNQAQMSAKGIPQIAAVMGSCTAGGAYVPAMSDETVIVRKQGTIFLGGPPLVKAATGEEISAEDLGGADVHAR
RSGVADHYAAHDAHALAIVRSIVRTLAKPKPQPFEIQAPAEPLYDPREMHGLVPQDVREPYDAREVIARTVDGSEFHEFK
KLYGETLVCGFAHIYGMPVAILANNGILFSESAQKAAHFIELADQRRIPLVFLQNITGFMVGSKYEAGGIAKDGAKMVTA
VATASVPKFTVVTGGSFGAGNYGMCGRAYSPRFLFMWPNARISVMGGEQAASVLATVKRDGIERRGGQWSAEEEQGFKQP
IRDLYETEGNPYFSTARLWDDGIIDPADTRRVLGLALSASLNAPFGERGFGLFRM
>Mature_534_residues
PVLKSALDVSGAKFAANRAAMQALVEELRAKTAQAALGGPEDSRKRHTERGKLLPRERVERLIDPGSAFLEIGALAANGM
YDGEAPGAGLITGVGRVEGRECLIVCNDATVKGGAYFPVTVKKHLRAQEVAMENHLPCIYLVDSGGANLPHQSEVFPDRE
HFGRIFYNQAQMSAKGIPQIAAVMGSCTAGGAYVPAMSDETVIVRKQGTIFLGGPPLVKAATGEEISAEDLGGADVHARR
SGVADHYAAHDAHALAIVRSIVRTLAKPKPQPFEIQAPAEPLYDPREMHGLVPQDVREPYDAREVIARTVDGSEFHEFKK
LYGETLVCGFAHIYGMPVAILANNGILFSESAQKAAHFIELADQRRIPLVFLQNITGFMVGSKYEAGGIAKDGAKMVTAV
ATASVPKFTVVTGGSFGAGNYGMCGRAYSPRFLFMWPNARISVMGGEQAASVLATVKRDGIERRGGQWSAEEEQGFKQPI
RDLYETEGNPYFSTARLWDDGIIDPADTRRVLGLALSASLNAPFGERGFGLFRM

Specific function: Unknown

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI11545863, Length=528, Percent_Identity=64.9621212121212, Blast_Score=703, Evalue=0.0,
Organism=Homo sapiens, GI119943100, Length=516, Percent_Identity=31.5891472868217, Blast_Score=233, Evalue=4e-61,
Organism=Homo sapiens, GI295821216, Length=536, Percent_Identity=30.5970149253731, Blast_Score=220, Evalue=3e-57,
Organism=Homo sapiens, GI310133460, Length=138, Percent_Identity=57.9710144927536, Blast_Score=149, Evalue=8e-36,
Organism=Caenorhabditis elegans, GI17552936, Length=534, Percent_Identity=61.9850187265918, Blast_Score=691, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147362, Length=520, Percent_Identity=32.1153846153846, Blast_Score=238, Evalue=6e-63,
Organism=Caenorhabditis elegans, GI25147359, Length=520, Percent_Identity=32.1153846153846, Blast_Score=238, Evalue=7e-63,
Organism=Drosophila melanogaster, GI24586065, Length=550, Percent_Identity=63.4545454545455, Blast_Score=717, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: 6.4.1.3

Molecular weight: Translated: 57531; Mature: 57400

Theoretical pI: Translated: 6.99; Mature: 6.99

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVLKSALDVSGAKFAANRAAMQALVEELRAKTAQAALGGPEDSRKRHTERGKLLPRERV
CCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHH
ERLIDPGSAFLEIGALAANGMYDGEAPGAGLITGVGRVEGRECLIVCNDATVKGGAYFPV
HHHHCCCHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCEEEEEECCCEECCCEEEEE
TVKKHLRAQEVAMENHLPCIYLVDSGGANLPHQSEVFPDREHFGRIFYNQAQMSAKGIPQ
HHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHH
IAAVMGSCTAGGAYVPAMSDETVIVRKQGTIFLGGPPLVKAATGEEISAEDLGGADVHAR
HHHHHHCCCCCCEEECCCCCCEEEEEECCEEEECCCCEEEECCCCCCCHHHCCCCCHHHH
RSGVADHYAAHDAHALAIVRSIVRTLAKPKPQPFEIQAPAEPLYDPREMHGLVPQDVREP
HCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHCCCCCHHHHCC
YDAREVIARTVDGSEFHEFKKLYGETLVCGFAHIYGMPVAILANNGILFSESAQKAAHFI
CHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCEEEECCHHHHHHHH
ELADQRRIPLVFLQNITGFMVGSKYEAGGIAKDGAKMVTAVATASVPKFTVVTGGSFGAG
HHHCCCCCCEEEECCCCHHEECCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCC
NYGMCGRAYSPRFLFMWPNARISVMGGEQAASVLATVKRDGIERRGGQWSAEEEQGFKQP
CCCCCCCCCCCEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
IRDLYETEGNPYFSTARLWDDGIIDPADTRRVLGLALSASLNAPFGERGFGLFRM
HHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHEECCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PVLKSALDVSGAKFAANRAAMQALVEELRAKTAQAALGGPEDSRKRHTERGKLLPRERV
CCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHH
ERLIDPGSAFLEIGALAANGMYDGEAPGAGLITGVGRVEGRECLIVCNDATVKGGAYFPV
HHHHCCCHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCEEEEEECCCEECCCEEEEE
TVKKHLRAQEVAMENHLPCIYLVDSGGANLPHQSEVFPDREHFGRIFYNQAQMSAKGIPQ
HHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHH
IAAVMGSCTAGGAYVPAMSDETVIVRKQGTIFLGGPPLVKAATGEEISAEDLGGADVHAR
HHHHHHCCCCCCEEECCCCCCEEEEEECCEEEECCCCEEEECCCCCCCHHHCCCCCHHHH
RSGVADHYAAHDAHALAIVRSIVRTLAKPKPQPFEIQAPAEPLYDPREMHGLVPQDVREP
HCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHCCCCCHHHHCC
YDAREVIARTVDGSEFHEFKKLYGETLVCGFAHIYGMPVAILANNGILFSESAQKAAHFI
CHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCEEEECCHHHHHHHH
ELADQRRIPLVFLQNITGFMVGSKYEAGGIAKDGAKMVTAVATASVPKFTVVTGGSFGAG
HHHCCCCCCEEEECCCCHHEECCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCC
NYGMCGRAYSPRFLFMWPNARISVMGGEQAASVLATVKRDGIERRGGQWSAEEEQGFKQP
CCCCCCCCCCCEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
IRDLYETEGNPYFSTARLWDDGIIDPADTRRVLGLALSASLNAPFGERGFGLFRM
HHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHEECCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; propanoyl-CoA; HCO3-

Specific reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9387222 [H]