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The map label for this gene is yisK [H]

Identifier: 114798853

GI number: 114798853

Start: 2317501

End: 2318346

Strand: Reverse

Name: yisK [H]

Synonym: HNE_2217

Alternate gene names: 114798853

Gene position: 2318346-2317501 (Counterclockwise)

Preceding gene: 114799506

Following gene: 114798445

Centisome position: 62.57

GC content: 59.22

Gene sequence:

>846_bases
ATGAAGGTAGCAAAGATCCAGAGGGGCGGGCGCGTGGCGTCCGCCATTATCCGGGGCGATCGCGTGCATGTGGTGGGGCG
CTGGTATGAAGAGGCCGCGCTGGCGGCGCCGTTCGATGCACCGCGTTTGTCGCTCAGCCAGCTGGGGGAGATTGCAGATA
GCGCGGGTGAGACGCTGCCGCTTGATCAGGTCGGGCTGTTGATGCCGTCAGAGCCCCTGTCAAAGCTCGTTTGCCTCGGG
CTGAATTATAAGAATCATGTGGACGAAACCCATAATGATCTGCCGCCTAACCCCGCGCTGTTTACAAAGGTTGCCGATTC
GCTCGTGCCCCACGGAGAGGCTGTGCTTCGGCCGAAGGTATCCGAACAGTTTGATTATGAAGGCGAGATCTGCGTCGTCA
TTGGCAAGGGTGGACGGCACATTTCGCGTGAAACTGCCTTAGATCATGTGTTCGGATATACGATCATGCTCGATGGCAGC
GTGCGCGATTATCAGAAGCACTCGGTGTCGGCAGGCAAGAATTTCTGGCGCTCTGGCGCGCTTGGCCCGTGGATCGTCAC
GGCGGATGAGATTCCTGATCCGAGCGTGATGAAACTGGAAACCCGCCTGAATGGCGAGACGGTTCAGTCCACAACGGCTG
ATCTGATGTTGTACGACATTCCGACCGCGATTGCTTATGTGTCGCAATGGACGCCCCTGGCGCCGGGAGATGTGATTGCC
ACAGGGACGCCAGGCGGCGTTGGCGCGCGCCGCAAACCGCCCCTCTGGATGAAGGCGGGCGATGTGATTGAGGTGGACGT
TTCACAGATAGGGGTTCTGTCGAACCCGGTTGGCAGCGAGCACTGA

Upstream 100 bases:

>100_bases
GCCGGAGTGCCCCGGCGGGAATTGCTCTCCATCTGAGCGCGCGATGTCTGCCCGTGCGCAGACCTCTCTGATATAAAATC
CGTAAGCGGAGTATAGTGAT

Downstream 100 bases:

>100_bases
CGTGAGGCTCCGGGCTCCCCGACACATGATACGGGGGCGGAGGACACGCCTGTCCGCCGTGCCGGGAGAATCATCCCTTT
TCAGAGACCGTCTCCGTCGG

Product: fumarylacetoacetate hydrolase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MKVAKIQRGGRVASAIIRGDRVHVVGRWYEEAALAAPFDAPRLSLSQLGEIADSAGETLPLDQVGLLMPSEPLSKLVCLG
LNYKNHVDETHNDLPPNPALFTKVADSLVPHGEAVLRPKVSEQFDYEGEICVVIGKGGRHISRETALDHVFGYTIMLDGS
VRDYQKHSVSAGKNFWRSGALGPWIVTADEIPDPSVMKLETRLNGETVQSTTADLMLYDIPTAIAYVSQWTPLAPGDVIA
TGTPGGVGARRKPPLWMKAGDVIEVDVSQIGVLSNPVGSEH

Sequences:

>Translated_281_residues
MKVAKIQRGGRVASAIIRGDRVHVVGRWYEEAALAAPFDAPRLSLSQLGEIADSAGETLPLDQVGLLMPSEPLSKLVCLG
LNYKNHVDETHNDLPPNPALFTKVADSLVPHGEAVLRPKVSEQFDYEGEICVVIGKGGRHISRETALDHVFGYTIMLDGS
VRDYQKHSVSAGKNFWRSGALGPWIVTADEIPDPSVMKLETRLNGETVQSTTADLMLYDIPTAIAYVSQWTPLAPGDVIA
TGTPGGVGARRKPPLWMKAGDVIEVDVSQIGVLSNPVGSEH
>Mature_281_residues
MKVAKIQRGGRVASAIIRGDRVHVVGRWYEEAALAAPFDAPRLSLSQLGEIADSAGETLPLDQVGLLMPSEPLSKLVCLG
LNYKNHVDETHNDLPPNPALFTKVADSLVPHGEAVLRPKVSEQFDYEGEICVVIGKGGRHISRETALDHVFGYTIMLDGS
VRDYQKHSVSAGKNFWRSGALGPWIVTADEIPDPSVMKLETRLNGETVQSTTADLMLYDIPTAIAYVSQWTPLAPGDVIA
TGTPGGVGARRKPPLWMKAGDVIEVDVSQIGVLSNPVGSEH

Specific function: Unknown

COG id: COG0179

COG function: function code Q; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAH family [H]

Homologues:

Organism=Homo sapiens, GI156231349, Length=224, Percent_Identity=42.4107142857143, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI40786394, Length=224, Percent_Identity=41.9642857142857, Blast_Score=174, Evalue=6e-44,
Organism=Homo sapiens, GI215422413, Length=198, Percent_Identity=35.8585858585859, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI66348062, Length=198, Percent_Identity=35.8585858585859, Blast_Score=121, Evalue=5e-28,
Organism=Homo sapiens, GI13654274, Length=198, Percent_Identity=35.8585858585859, Blast_Score=121, Evalue=6e-28,
Organism=Escherichia coli, GI1787428, Length=183, Percent_Identity=34.9726775956284, Blast_Score=99, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17557057, Length=201, Percent_Identity=36.81592039801, Blast_Score=137, Evalue=8e-33,
Organism=Saccharomyces cerevisiae, GI6324161, Length=232, Percent_Identity=23.7068965517241, Blast_Score=69, Evalue=6e-13,
Organism=Drosophila melanogaster, GI28572127, Length=238, Percent_Identity=34.453781512605, Blast_Score=148, Evalue=4e-36,
Organism=Drosophila melanogaster, GI24663695, Length=212, Percent_Identity=33.9622641509434, Blast_Score=127, Evalue=6e-30,
Organism=Drosophila melanogaster, GI28571789, Length=213, Percent_Identity=32.3943661971831, Blast_Score=98, Evalue=7e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002529
- InterPro:   IPR011234 [H]

Pfam domain/function: PF01557 FAA_hydrolase [H]

EC number: NA

Molecular weight: Translated: 30278; Mature: 30278

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVAKIQRGGRVASAIIRGDRVHVVGRWYEEAALAAPFDAPRLSLSQLGEIADSAGETLP
CCCCCCCCCCHHHHHHHCCCEEEEEEEHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCC
LDQVGLLMPSEPLSKLVCLGLNYKNHVDETHNDLPPNPALFTKVADSLVPHGEAVLRPKV
HHHHCCCCCCHHHHHHHHHCCCCHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCEEECCCC
SEQFDYEGEICVVIGKGGRHISRETALDHVFGYTIMLDGSVRDYQKHSVSAGKNFWRSGA
HHCCCCCCCEEEEECCCCCCCHHHHHHHHHEEEEEEECCCCHHHHHHHHHHHHHHHHCCC
LGPWIVTADEIPDPSVMKLETRLNGETVQSTTADLMLYDIPTAIAYVSQWTPLAPGDVIA
CCCEEEECCCCCCCCEEEEEECCCCCCHHCCHHEEEEEEHHHHHHHHHCCCCCCCCCEEE
TGTPGGVGARRKPPLWMKAGDVIEVDVSQIGVLSNPVGSEH
CCCCCCCCCCCCCCCEEECCCEEEECHHHCCEECCCCCCCC
>Mature Secondary Structure
MKVAKIQRGGRVASAIIRGDRVHVVGRWYEEAALAAPFDAPRLSLSQLGEIADSAGETLP
CCCCCCCCCCHHHHHHHCCCEEEEEEEHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCC
LDQVGLLMPSEPLSKLVCLGLNYKNHVDETHNDLPPNPALFTKVADSLVPHGEAVLRPKV
HHHHCCCCCCHHHHHHHHHCCCCHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCEEECCCC
SEQFDYEGEICVVIGKGGRHISRETALDHVFGYTIMLDGSVRDYQKHSVSAGKNFWRSGA
HHCCCCCCCEEEEECCCCCCCHHHHHHHHHEEEEEEECCCCHHHHHHHHHHHHHHHHCCC
LGPWIVTADEIPDPSVMKLETRLNGETVQSTTADLMLYDIPTAIAYVSQWTPLAPGDVIA
CCCEEEECCCCCCCCEEEEEECCCCCCHHCCHHEEEEEEHHHHHHHHHCCCCCCCCCEEE
TGTPGGVGARRKPPLWMKAGDVIEVDVSQIGVLSNPVGSEH
CCCCCCCCCCCCCCCEEECCCEEEECHHHCCEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9353931; 9384377 [H]